1,547 research outputs found

    Locality-Sensitive Hashing for large scale image retrieval

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    En este artículo proporcionamos una descripción general del hash sensible a la ubicación (LSH) utilizado para la recuperación de imágenes a gran escala y para resolver el problema del vecino más cercano. El objetivo es experimentar con diferentes configuraciones de parámetros de LSH sobre un conjunto de huellas dactilares de video para ver cuál es la mejor en términos de precisión e indexación para que luego, dado un objeto de consulta, devuelva los objetos (vecinos más cercanos) que sean más similares a la consulta. Los parámetros de configuración que ofrecieron mejores resultados fueron un tamaño de cubo de 24 con 15 tablas y tamaños de hash de 15 bits, obteniendo aproximadamente el 50% de las coincidencias correctas con los métodos de recuperación P @ 4 y P @ 6

    How selection for reproduction or foundation for longevity could have affected blood lymphocyte populations of rabbit does under conventional and heat stress conditions

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    [EN] The present work characterises how selection for reproduction (by comparing two generations - 16th and 36th - of the V line selected for litter size at weaning) or foundation for reproductive longevity (the LP line) can affect the blood lymphocytes populations of reproductive rabbit does under normal [conventional housing, average daily minimum and maximum temperatures of 14 degrees C and 20 degrees C, respectively] and heat stress conditions [climatic chamber, 25 degrees C and 36 degrees C] from the first to the second parturition. Housing under heat stress conditions significantly reduced the B lymphocytes counts in female rabbits (-34 x 10(6)/L; P < 0.05). The highest lymphocytes population value in blood (total, T CD5(+), CD4(+) and CD8(+)) was noted at the first parturition, while the B lymphocytes count was significantly lower at the second parturition (-61 x 10(6)/L; P < 0.05). Selection for litter size at weaning (V females) reduced the average counts of total and B lymphocytes in blood (-502 and -60 x 10(6)/L, respectively; P < 0.01), mainly because these populations in V36 females continuously lowered from the first to the second parturition under normal housing conditions. Thus, more selected females (V36) at the second parturition showed significantly lower counts in blood for total, T CD5(+) and CD25(+) lymphocytes (-1303, -446 and -33 x 10(6)/L, respectively; P < 0.05). The main differences in blood counts between V36 and V16 females disappeared when housed under heat stress conditions, except for T CD5(+) and CD25(+), which significantly increased (T CD5(+): +428 x 10(6)/L; CD25(+): +41 x 10(6)/L; P < 0.01) in the V16 vs. V36 females on day 10 post-partum. Under normal conditions, no differences between LP and V36 females were found for most lymphocyte populations; only higher counts were noted in CD25(+) (+20 x 10(6)/L; P < 0.05) for LP females. However, the lymphocytes counts [especially total (+1327 x 10(6)/L; P < 0.01) and T CD5(+) (+376 x 10(6)/L; P < 0.10)] of LP females increased under heat vs. normal conditions when lymphocytes populations presented the lowest values (second parturition), while V36 females' counts remained invariable. Positive correlations were found between feed intake (r = +0.51; P < 0.001) and females' perirenal fat thickness (r = +0.40; P < 0.001) with B lymphocytes counts in the blood of primiparous rabbit females in the week 2 of lactation. These results indicate that selection for litter size at weaning might diminish their immune system's response and adaptation capacity, while the foundation for reproductive longevity criteria leads to more robust rabbit females as they present greater modulation under heat stress conditions when the immune system is affected. (c) 2012 Elsevier B.V. All rights reserved.This study has been supported by grants from the CEU-Cardenal Herrera University (Banco Santander/CEU-UCH: Copernicus Program), Generalitat Valenciana (ACOMP/2009/207 and ACOMP/2010/062) and the Comision Interministerial de Ciencia y Tecnologia (AGL2008-00273/GAN, AGL2008-03274/GAN and AGL2011-30170-CO2-02). Grants for Selena Ferrian and Irene Guerrero from Generalitat Valenciana (the Santiago Grisolia programme) and from the Universidad CEU-Cardenal Herrera, respectively, are also gratefully acknowledged.Ferrian, S.; Guerrero, I.; Blas Ferrer, E.; García Diego, FJ.; Viana, D.; Pascual Amorós, JJ.; Corpa, JM. (2012). How selection for reproduction or foundation for longevity could have affected blood lymphocyte populations of rabbit does under conventional and heat stress conditions. Veterinary Immunology and Immunopathology. 150(1-2):53-60. doi:10.1016/j.vetimm.2012.08.007S53601501-

    H- ras deletion protects against angiotensin II-induced arterial hypertension and cardiac remodeling through protein kinase G-Ibeta pathway activation

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    15 p.Ras proteins regulate cell survival, growth, differentiation, blood pressure, and fibrosis in some organs.We have demonstrated that H-rasgene deletion produces mice hypotensionviaa soluble guanylate cyclase-proteinkinase G (PKG)–dependent mechanism. In this study, we analyzed the consequences of H-rasdeletiononcardiacremodeling induced by continuous angiotensin II (AngII) infusion and the molecular mechanisms implied. Leftventricular posterior wall thickness and mass and cardiomyocyte cross-sectional area were similar between AngII-treated H-Ras knockout (H-ras2/2) and control wild-type (H-ras+/+) mice, as were extracellular matrix proteinexpression. Increased cardiac PKG-Ibprotein expression in H-ras2/2mice suggests the involvement of this proteinin heart protection.Ex vivoexperiments on cardiac explants could support this mechanism, as PKG blockadeblunted protection against AngII-induced cardiac hypertrophy and fibrosis markers in H-ras2/2mice. Geneticmodulation studies in cardiomyocytes and cardiac and embryonic fibroblasts revealed that the lack of H-Ras down-regulates the B-RAF/MEK/ERK pathway, which induces the glycogen synthase kinase-3b-dependent activation ofthe transcription factor, cAMP response element-binding protein, which is responsible for PKG-Iboverexpressionin H-ras2/2mouse embryonic fibroblasts. This study demonstrates that H-rasdeletion protects against AngII-induced cardiac remodeling, possiblyviaa mechanism in which PKG-Iboverexpression could play a partial role, andpoints to H-Ras and/or downstream proteins as potential therapeutic targets in cardiovascular disease.Instituto de Salud Carlos IIIUniversidad de AlcaláFundación SenefroFEDE

    Electronic consequences of chemical doping of 7-Armchair Graphene Nanoribbons

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    Resumen del trabajo presentado a la International Conference on Nanoscience + Technology (ICN+T), celebrada en Brno (Czech Republic) del 22 al 27 de julio de 2018.The tunable electronic structure of Graphene Nanoribbons (GNRs) with different edge types has provoked great interest due to potential applications in electronic devices as molecular diodes or transistors. Thanks to the on-surface synthesis of chemically customized molecular precursors, nanoribbons with atomically defined structure can be grown. This high precision in their bottom-up growth allows to tune their electronic structure via width control or chemical doping. Here we use two different strategies to chemically modify 7-armchair GNRs (7-AGNRs) to clarify how the chemical modifications on the nanoribbons’ structure affect their electronic properties. By means of Scanning Tunneling Spectroscopy we tackle with atomic precision this issue on 7-AGNRs with substitutional nitrile functional groups at the ribbons’ edges and on 7-AGNRs with substitutional boron atoms within the ribbons’ backbone. We find that in the first case the CN groups lead to an efficient n-like doping of the ribbon, while in the second case B atoms induce the formation of a new acceptor band and bandgap renormalization.Peer Reviewe

    The thirty gigahertz instrument receiver for the Q-U-I Joint Tenerife experiment: concept and experimental results

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    This paper presents the analysis, design, and characterization of the thirty gigahertz instrument receiver developed for the Q-U-I Joint Tenerife experiment. The receiver is aimed to obtain polarization data of the cosmic microwave background radiation from the sky, obtaining the Q,U, and I Stokes parameters of the incoming signal simultaneously. A comprehensive analysis of the theory behind the proposed receiver is presented for a linearly polarized input signal, and the functionality tests have demonstrated adequate results in terms of Stokes parameters, which validate the concept of the receiver based on electronic phase switching

    Iberian Ordovician chronostratigraphy

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    La nuevas divisiones de la escala global del Sistema Ordovícico, con excepción de los pisos Tremadociense e Hirnantiense, son difíciles de aplicar en la Península Ibérica, pues sus estratotipos de límite radican en facies y faunas de aguas profundas, desconocidas en las plataformas someras y de paleolatitud elevada del ámbito peri-gondwánico. Antes de ello, la escala regional británico-avalónica fue utilizada en Iberia durante todo el siglo XX, pero presenta serios inconvenientes de correlación vinculados con la propia evolución, conceptual y de criterio, registrada en las áreas tipo británicas durante los últimos 40 años. Sin embargo, la escala regional bohemo-ibérica es la que actualmente aporta una mayor precisión a las correlaciones, pues se basa en elementos bioestratigráficos y biocronológicos de distribución común a todo el margen peri-gondwánico europeo y norteafricano, y la que mantiene vínculos episódicos con otras escalas regionales, que permitirán resolver progresivamente las equivalencias con la escala global.The new divisions from the global scale for the Ordovician System, except for the Tremadocian and Hirnantian stages, are difficult to correlate in the Iberian Ordovician, because their GSSPs involve deep-water facies and faunas not recorded in the shallow, high-paleolatitudinal settings of the peri-Gondwanan area. Previously to the Global scale, the British-Avalonian regional scale had been widely adopted in the Iberian Ordovician during all the 20th Century, but there are serious correlation problems due to the former’s conceptual evolution and variable criteria used for the British type areas during the last 40 years. However, the use of the Bohemo-Iberian scale instead, provides better precision to Iberian correlations, because it is based in some local biostratigraphical and biochronological markers, widely recorded over an extensive area of the European and North African peri-Gondwanan margin. The Bohemo-Iberian scale shows episodic links with other regional scales, which will provide indirect correlations also with the global Ordovician scale.Depto. de Geodinámica, Estratigrafía y PaleontologíaFac. de Ciencias GeológicasTRUEMinisterio de Economía y Competitividad (MINECO)pu

    Estrategia marina demarcación marina levantino-balear parte IV. Descriptores del buen estado ambiental. Descriptor 1: biodiversidad evaluación inicial y buen estado ambiental

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    El descriptor 1 de la Ley 41/2010 de protección del medio marino, trasposición a la ley española de la Directiva Marco sobre la Estrategia Marina (DMEM: 2008/56/CE) dice textualmente "Se mantiene la biodiversidad. La calidad y la frecuencia de los hábitats y la distribución y abundancia de las especies están en consonancia con las condiciones fisiográficas, geográficas y climáticas". Según el Convenio sobre la Diversidad Biológica (UNCED, 1992), ésta se define como: "La variabilidad de organismos vivos de cualquier fuente, incluidos, entre otras cosas, los ecosistemas terrestres y marinos y otros ecosistemas acuáticos y los complejos ecológicos de los que forman parte; comprende la diversidad dentro de cada especie, entre especies y de los ecosistemas"
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