Dynamic screening and energy loss of antiprotons colliding with excited Al clusters

We use time-dependent density functional theory to calculate the energy loss of an antiproton colliding with a small Al cluster previously excited. The velocity of the antiproton is such that non-linear effects in the electronic response of the Al cluster are relevant. We obtain that an antiproton penetrating an excited cluster transfers less energy to the cluster than an antiproton penetrating a ground state cluster. We quantify this difference and analyze it in terms of the cluster excitation spectrum.Comment: 23 pages, 4 figures, to be published in Nuclear Instruments and Methods B as a proceeding of the IISC-19 Workshop on Inelastic Ion-Surface Collision

Towards a more realistic evaluation: Testing the ability to predict future tastes of matrix factorization-based recommenders

This is the author's version of the work. It is posted here for your personal use. Not for redistribution. The definitive Version of Record was published in RecSys '11 Proceedings of the fifth ACM conference on Recommender systems, http://dx.doi.org/10.1145/2043932.2043990.The use of temporal dynamic terms in Matrix Factorization (MF) models of recommendation have been proposed as a means to obtain better accuracy in rating prediction task. However, the way such models have been tested may not be a realistic setting for recommendation. In this paper, we evaluated rating prediction and top-N recommendation tasks using a MF model with and without temporal dynamic terms under two evaluation settings. Our experiments show that the addition of dynamic parameters do not necessarily yield to better results on these tasks when a more strict time-aware separation of train/test data is performed, and moreover, results may vary notably when different evaluation schemes are used.This work is supported by the Spanish Government (TIN 2008-06566-C04-02) and by the Comunidad de Madrid and Universidad Autónoma de Madrid (CCG10-UAM/TIC-5877)

Detoxifying enzymes at the cross-roads of inflammation, oxidative stress, and drug hypersensitivity: role of glutathione transferase P1-1 and aldose reductase

9 p.-2 figPhase I and II enzymes are involved in the metabolism of endogenous reactive compounds as well as xenobiotics, including toxicants and drugs. Genotyping studies have established several drug metabolizing enzymes as markers for risk of drug hypersensitivity. However, other candidates are emerging that are involved in drug metabolism but also in the generation of danger or costimulatory signals. Enzymes such as aldo-keto reductases (AKR) and glutathione transferases (GST) metabolize prostaglandins and reactive aldehydes with proinflammatory activity, as well as drugs and/or their reactive metabolites. In addition, their metabolic activity can have important consequences for the cellular redox status, and impacts the inflammatory response as well as the balance of inflammatory mediators, which can modulate epigenetic factors and cooperate or interfere with drug-adduct formation. These enzymes are, in turn, targets for covalent modification and regulation by oxidative stress, inflammatory mediators, and drugs. Therefore, they constitute a platform for a complex set of interactions involving drug metabolism, protein haptenation, modulation of the inflammatory response, and/or generation of danger signals with implications in drug hypersensitivity reactions. Moreover, increasing evidence supports their involvement in allergic processes. Here, we will focus on GSTP1-1 and aldose reductase (AKR1B1) and provide a perspective for their involvement in drug hypersensitivityThis work has been supported by grants SAF2012-36519 from MINECO and SAF-2015-68590-R from MINECO/FEDER and ISCIII RETIC RIRAAF RD12/0013/0008 to DP,and RD12/0013/0002 to J A.Peer reviewe

Clinical and economic burden of respiratory syncytial virus in Spanish children: the BARI study

Respiratory syncytial virus (RSV) infection is a major cause of morbidity in children. However, its disease burden remains poorly understood, particularly outside of the hospital setting. Our study aimed to estimate the burden of medically attended acute lower respiratory infection (ALRI) cases potentially related to RSV in Spanish children. Longitudinal data from September 2017 to June 2018 of 51,292 children aged < 5 years old from the National Health‑ care System (NHS) of two Spanish regions were used. Three case definitions were considered: (a) RSV‑specific; (b) RSV‑specific and unspecified acute bronchiolitis (RSV‑specific and Bronchiolitis), and; (c) RSV‑specific and unspecified ALRI (RSV‑specific and ALRI). A total of 3460 medically attended ALRI cases potentially due to RSV were identified, of which 257 (7.4%), 164 (4.7%), and 3039 (87.8%) coded with RSV‑specific, unspecific bronchiolitis, and unspecific ALRI codes, respectively. Medically attended RSV‑specific and ALRI cases per 1000 children was 134.4 in the first year of life, 119.4 in the second, and 35.3 between 2 and 5 years old. Most cases were observed in otherwise healthy children (93.1%). Mean direct healthcare cost per medically attended RSV‑specific and ALRI case was €1753 in the first year of life, €896 in the second, and €683 between 2 and 5 years old. Hospitalization was the main driver of these costs, accounting for 55.6%, 38.0% and 33.4%, in each respective age group. In RSV‑specific cases, mean direct healthcare cost per medically attended case was higher, mostly due to hospitalization: €3362 in the first year of life (72.9% from hospitalizations), €3252 in the second (72.1%), and €3514 between 2 and 5 years old (74.2%). These findings suggest that hospitalization data alone will underestimate the RSV infections requiring medical care, as will relying only on RSV‑specific codes. RSV testing and codification must be improved and preventive solutions adopted, to protect all infants, particularly during the first year of life.The BARI study was funded by Sanofi.Medicin

Dynamic screening of a localized hole during photoemission from a metal cluster

Recent advances in attosecond spectroscopy techniques have fueled the interest in the theoretical description of electronic processes taking place in the subfemtosecond time scale. Here we study the coupled dynamic screening of a localized hole and a photoelectron emitted from a metal cluster using a semi-classical model. Electron density dynamics in the cluster is calculated with Time-Dependent Density Functional Theory and the motion of the photoemitted electron is described classically. We show that the dynamic screening of the hole by the cluster electrons affects the motion of the photoemitted electron. At the very beginning of its trajectory, the photoemitted electron interacts with the cluster electrons that pile up to screen the hole. Within our model, this gives rise to a significant reduction of the energy lost by the photoelectron. Thus, this is a velocity dependent effect that should be accounted for when calculating the average losses suffered by photoemitted electrons in metals.Comment: 15 pages, 5 figure

A 800 kW wind-diesel test bench based on the MADE AE-52 variable speed wind turbine

A field work have been made about the practical installation of a wind-diesel autonomous power system. A remarkable innovation on the control of the latter wind-diesel system is the ability of taking advantage of the kinetic energy available from the wind turbine. With such an extra energy, a power quality improvement can be achieved in the presence of load commutations. Besides of that, a convenient power sharing out can be obtained, allowing a high renewable energy penetration and fuel savings. Several results show the behaviour of the whole system, apart of the power quality improvement. Index Terms—Renewable hybrid system, isolated power system, power quality, diesel generator, wind turbine

Social, economic, and health impact of the respiratory syncytial virus: a systematic search

BACKGROUND: Bronchiolitis caused by the respiratory syncytial virus (RSV) and its related complications are common in infants born prematurely, with severe congenital heart disease, or bronchopulmonary dysplasia, as well as in immunosuppressed infants. There is a rich literature on the different aspects of RSV infection with a focus, for the most part, on specific risk populations. However, there is a need for a systematic global analysis of the impact of RSV infection in terms of use of resources and health impact on both children and adults. With this aim, we performed a systematic search of scientific evidence on the social, economic, and health impact of RSV infection. METHODS: A systematic search of the following databases was performed: MEDLINE, EMBASE, Spanish Medical Index, MEDES-MEDicina in Spanish, Cochrane Plus Library, and Google without time limits. We selected 421 abstracts based on the 6,598 articles identified. From these abstracts, 4 RSV experts selected the most relevant articles. They selected 65 articles. After reading the full articles, 23 of their references were also selected. Finally, one more article found through a literature information alert system was included. RESULTS: The information collected was summarized and organized into the following topics: 1. Impact on health (infections and respiratory complications, mid- to long-term lung function decline, recurrent wheezing, asthma, other complications such as otitis and rhino-conjunctivitis, and mortality; 2. Impact on resources (visits to primary care and specialists offices, emergency room visits, hospital admissions, ICU admissions, diagnostic tests, and treatments); 3. Impact on costs (direct and indirect costs); 4. Impact on quality of life; and 5. Strategies to reduce the impact (interventions on social and hygienic factors and prophylactic treatments). CONCLUSIONS: We concluded that 1. The health impact of RSV infection is relevant and goes beyond the acute episode phase; 2. The health impact of RSV infection on children is much better documented than the impact on adults; 3. Further research is needed on mid- and long-term impact of RSV infection on the adult population, especially those at high-risk; 4. There is a need for interventions aimed at reducing the impact of RSV infection by targeting health education, information, and prophylaxis in high-risk populations.The project was funded by an unrestricted grant from AbbVie.S

Dating violence and associated factors among male and female adolescents in Spain

Background: Dating Violence (DV) is a public health problem that is on the rise. In this paper, we aim to analyse different factors associated with DV victimization among female and male adolescents in Spain, considering socioeconomic circumstances, sexual orientation and the presence of different attitudes and experiences related to violence. Methods: Cross-sectional data from a convenience sample of 640 ever-partnered adolescents aged 13 to 17 at schools in the cities of Alicante (n = 359, 50.1% girls) and Terrassa (n = 281, 51.9%) in the context of an educational intervention to promote healthy relationships. We calculated the prevalence of different forms of DV (physical, sexual and control and fear) and carried out multivariate regression models by sex. Results: 5.5% of girls and 8.7% of boys declared having suffered lifetime physical and/or sexual violence, while 22% of girls and 20.5% of boys reported control and/or fear victimization. The likelihood of DV was higher among migrants and those with foreign-born parents (aPR girls = 2.1 CI95%: 1.1-3.9; aPR boys = 1.9: CI95%: 1.0-3.6); prior experiences of abuse (aPR girls = 1.6; CI95%: 1.0-2.6; aPR boys = 1.7; CI95%: 1.1-2.6); and those who showed higher levels of machismo (aPR girls = 1.0; CI95%: 1.0-1.1; aPR boys = 1.0; CI95%: 1.0-1.1). In girls, DV increased among those who reported lesbian/bisexual orientation and poor relationship with teachers. Conclusions: DV is socially patterned and increases among LGB adolescents (especially in the case of girls), migrants, and those with foreign-born parents, and adolescents who reported prior experiences of violence in childhood. Future DV prevention programs should consider social inequalities in the likelihood of DV and by reinforcing adolescents' abilities to recognize social support sources and reject machismo and violence.The project was funded by the Spanish Ministry of Economy, Industry and Competitiveness and the Carlos III Institute (Ref. PI18/00590 and PI18/00544) in 2019 and 2021. This study has also been conducted within the grant received from Instituto de Salud Carlos III & FEDER of which VP is recipient of Predoctora Contract for Training in Health Research (PFIS) grant from European Social Found (FSE) (FI19/00201).S

Dating Violence and Associated Factors Among Male and Female Adolescents in Spain

Background: Dating Violence (DV) is a public health problem that is on the rise. In this paper, we aim to analyse different factors associated with DV victimization among female and male adolescents in Spain, considering socioeconomic circumstances, sexual orientation and the presence of different attitudes and experiences related to violence. Methods: Cross-sectional data from a convenience sample of 640 ever-partnered adolescents aged 13 to 17 at schools in the cities of Alicante (n=359, 50.1% girls) and Terrassa (n=281, 51.9%) in the context of an educational intervention to promote healthy relationships. We calculated the prevalence of different forms of DV (physical, sexual and control and fear) and carried out multivariate regression models by sex. Results: 5.5% of girls and 8.7% of boys declared having suffered lifetime physical and/or sexual violence, while 22% of girls and 20.5% of boys reported control and/or fear victimization. The likelihood of DV was higher among migrants and those with foreign-born parents (aPR girls=2.1 CI95%: 1.1-3.9; aPR boys= 1.9: CI95%: 1.0-3.6); prior experiences of abuse (aPR girls= 1.6; CI95%: 1.0-2.6; aPR boys= 1.7; CI95%: 1.1-2.6); and those who showed higher levels of machismo (aPR girls= 1.0; CI95%: 1.0-1.1; aPR boys= 1.0; CI95%: 1.0-1.1). In girls, DV increased among those who reported lesbian/bisexual orientation and poor relationship with teachers. Conclusions: DV is socially patterned and increases among LGB adolescents, migrants, and those with foreign-born parents. Future DV prevention programs should reinforce adolescents’ abilities to recognize social support sources and reject machismo and violence.This study was funded by the multi-centre project "Promotion of Protective Assets Against Gender Violence in Adolescence and Preadolescence" (Ref. PI18/00590 and PI18/00544) of the Carlos III Institute of Health, as an intermediary body of the European Regional Development Fund (ERDF) and the European Social Fund (ESF)