Assessing neural responses towards objectified human targets and objects to identify processes of sexual objectification that go beyond the metaphor

Objectification - reducing a someone to a something - represents a powerful and potentially damaging way in which we can see and treat others. Women are often victims of processes of objectification that occur whenever a woman is reduced to her body or certain body parts. What remains unclear is the extent to which a woman becomes an object when objectified. Using the oddball paradigm in three experiments, participants' neural activity was measured while they analyzed frequently presented male and female human stimuli and infrequently presented gender-matched doll-like objects. The infrequent doll-like objects were expected to trigger a late event-related neurophysiological response (P300) the more they were perceived different from the repeated, human stimuli (i.e., the oddball effect). In Experiment 1, the oddball effect was significantly smaller for objectified women compared to objectified men. Results of Experiment 2 confirmed that this effect was confined to objectified depictions of women. In Experiment 3, no semantic references to the human-object divide were provided, but objectified women were still perceived more similar to real objects. Taken together, these results are the first to demonstrate that the perception of women, when objectified, changes in essence beyond the metaphor

Effective ways for reducing dehumanization: interpersonal and intergroup strategies

Up to date, research on dehumanization has widely been explored showing the consequences of the denial of humanity to others, the groups that are affected by this refusal, or even the cognitive and neural networks that are involved when perceiving others as less human. Dehumanization is still so grounded in human nature that it is now fundamental to understand how this phenomenon can be prevented. For this reason, in this paper, we aimed at showing what specific strategies, that can operate and impact at the interpersonal or intergroup level, can be used to avert dehumanization and its consequences

Validation of close‐kin mark–recapture (CKMR) methods for estimating population abundance

Under embargo until: 2020-06-181. Knowing how many individuals there are in a population is a fundamental problem in the management and conservation of freshwater and marine fish. We compare abundance estimates (census size, Nc) in seven brook trout Salvelinus fontinalis populations using standard mark–recapture (MR) and the close‐kin mark–recapture (CKMR) method. Our purpose is to validate CKMR as a method for estimating population size. 2. Close‐kin mark–recapture is based on the principle that an individual's genotype can be considered a “recapture” of the genotypes of each of its parents. Assuming offspring and parents are sampled independently, the number of parent–offspring pairs (POPs) genetically identified in these samples can be used to estimate abundance. We genotyped (33 microsatellites) and aged c. 2,400 brook trout individuals collected over 5 consecutive years (2014–2018). 3. We provide an alternative interpretation of CKMR in terms of the Lincoln– Petersen estimator in which the parents are considered as tagging the offspring rather than the offspring “recapturing” the parents. 4. Despite various sources of uncertainty, we find close agreement between standard MR abundance estimates obtained through double‐pass electrofishing and CKMR estimates, which require information on age‐specific fecundity, and population‐ and age‐specific survival rates. Population sizes (N) are estimated to range between 300 and 6,000 adult individuals. Our study constitutes the first in situ validation of CKMR and establishes it as a useful method for estimating population size in aquatic systems where assumptions of random sampling and thorough mixing of individuals can be met.acceptedVersio

Configural face processing and its influences on the timeline of mentalization

When mentalization fails, dehumanization can occur. Perceiving others as lacking fundamental mental states is the basic principle of dehumanization. Past research has already demonstrated the influence of both perceptual and contextual information on mentalization, while a recent line of research has tried to distinguish mentalization in a two-stage process: a mind detection phase in which we first identify a mind in others thanks to primary visual cues and a mind attribution phase in which both perceptual and contextual information are integrated to finalize the attribution of mental states to others. The current research aimed at deepening our understanding of the timeline of the mentalization process by specifically manipulating a perceptual, visual cue that has been related to dehumanization: the configural face process. This process was tested adapting the inversion effect that allowed us to show for the first time how and when this effect impacts and modulates the timeline of mentalization. Results indicated that the inversion effect impacted the early mind detection phase and resulted later in time in the elaboration of inverted human stimuli as more object-like

Validation of close‐kin mark–recapture (CKMR) methods for estimating population abundance

1. Knowing how many individuals there are in a population is a fundamental problem in the management and conservation of freshwater and marine fish. We compare abundance estimates (census size, Nc) in seven brook trout Salvelinus fontinalis populations using standard mark–recapture (MR) and the close‐kin mark–recapture (CKMR) method. Our purpose is to validate CKMR as a method for estimating population size. 2. Close‐kin mark–recapture is based on the principle that an individual's genotype can be considered a “recapture” of the genotypes of each of its parents. Assuming offspring and parents are sampled independently, the number of parent–offspring pairs (POPs) genetically identified in these samples can be used to estimate abundance. We genotyped (33 microsatellites) and aged c. 2,400 brook trout individuals collected over 5 consecutive years (2014–2018). 3. We provide an alternative interpretation of CKMR in terms of the Lincoln– Petersen estimator in which the parents are considered as tagging the offspring rather than the offspring “recapturing” the parents. 4. Despite various sources of uncertainty, we find close agreement between standard MR abundance estimates obtained through double‐pass electrofishing and CKMR estimates, which require information on age‐specific fecundity, and population‐ and age‐specific survival rates. Population sizes (N) are estimated to range between 300 and 6,000 adult individuals. Our study constitutes the first in situ validation of CKMR and establishes it as a useful method for estimating population size in aquatic systems where assumptions of random sampling and thorough mixing of individuals can be met

Why Might Women Justify Dating Violence? The Role of Men's Sexual Objectification of Their Romantic Partners Within Heterosexual Relationships

: Men's partner-sexual objectification has been linked to increased self-objectification and diminished well-being in women. Some recent findings have also demonstrated that men's partner-sexual objectification is related to increased violence in the relationship. However, mechanisms driving this association remain unexplored. In the present research, we collected data on women and men involved in heterosexual romantic relationships and investigated the associations between men's partner-sexual objectification, women's self-objectification, and both partners' attitudes toward dating violence. Study 1 (N = 171 heterosexual couples) provided first evidence for the link between men's partner-sexual objectification and their attitudes toward dating violence. Furthermore, men's attitudes toward dating violence mediated the relationship between sexual objectification of their partners and women's attitudes toward dating violence. These results were replicated in Study 2 (N = 235 heterosexual couples). Findings of this study also revealed that, along with men's attitudes toward dating violence, women's self-objectification acted as a mediating mechanism linking experiences of being sexually objectified by the romantic partner and attitudes toward dating violence in women. Implications of our findings for the issue of dating violence are discussed

Structure-based optimization of a fragment like TLR8 binding screening hit to an in vivo efficacious TLR7/8 antagonist

Inappropriate activation of TLR7 and TLR8 is linked to several autoimmune diseases, such as e.g. lupus erythematosus. Here we report on the efficient structure-based optimization of the inhibition of TLR8 starting from a co-crystal structure of a small screening hit. Further optimization of the physico-chemical properties for cellular potency and expansion of SAR for dual potency finally resulted in a highly potent TLR7/8 antagonist with demonstrated in vivo efficacy after oral dosing