Upgrading glass melting technology by model-based processing

[no abstract available

Methylphenidate improves motor functions in children diagnosed with Hyperkinetic Disorder

<p>Abstract</p> <p>Background</p> <p>A previous study showed that a high percentage of children diagnosed with Hyperkinetic Disorder (HKD) displayed a consistent pattern of motor function problems. The purpose of this study was to investigate the effect of methylphenidate (MPH) on such motor performance in children with HKD</p> <p>Methods</p> <p>25 drug-naïve boys, aged 8–12 yr with a HKD-F90.0 diagnosis, were randomly assigned into two groups within a double blind cross-over design, and tested with a motor assessment instrument, during MPH and placebo conditions.</p> <p>Results</p> <p>The percentage of MFNU scores in the sample indicating 'severe motor problems' ranged from 44–84%, typically over 60%. Highly significant improvements in motor performance were observed with MPH compared to baseline ratings on all the 17 subtests of the MFNU 1–2 hr after administration of MPH. There were no significant placebo effects. The motor improvement was consistent with improvement of clinical symptoms.</p> <p>Conclusion</p> <p>The study confirmed our prior clinical observations showing that children with ADHD typically demonstrate marked improvements of motor functions after a single dose of 10 mg MPH. The most pronounced positive MPH response was seen in subtests measuring either neuromotor inhibition, or heightened muscular tone in the gross movement muscles involved in maintaining the alignment and balance of the body. Introduction of MPH generally led to improved balance and a generally more coordinated and controlled body movement.</p

Evaluating (linked) metadata transformations across cultural heritage domains

This paper describes an approach to the evaluation of different aspects in the transformation of existing metadata into Linked data-compliant knowledge bases. At Oslo and Akershus University College of Applied Sciences, in the TORCH project, we are working on three different experimental case studies on extraction and mapping of broadcasting data and the interlinking of these with transformed library data. The case studies are investigating problems of heterogeneity and ambiguity in and between the domains, as well as problems arising in the interlinking process. The proposed approach makes it possible to collaborate on evaluation across different experiments, and to rationalize and streamline the process

Associations between exposure to sexual abuse, substance use, adverse health outcomes, and use of youth health services among Norwegian adolescents

Background A strong association between sexual abuse and adverse health outcomes has been reported among adolescents. The present study aimed to provide more information about adverse health outcomes associated with sexual abuse and substance use, and to examine the use of youth health services among Norwegian adolescents. Methods National representative cross-sectional study among 16–19-year-old Norwegian adolescents (n = 9784). Multivariable regression analyses, adjusted for socioeconomic status and age, were used to examine the association between exposure to sexual abuse, substance use and health risk factors, and the use of youth health services. Results Adolescents exposed to sexual abuse had higher odds of depressive symptoms (males: OR:3.8; 95% CI:2.5–5.8, females: 2.9;2.4–3.5), daily headache (males: 5.3;2.8–10.1, females:1.9; 1.5–2.4), high medication use (males: 3.2;1.7-6.0, females: 2.0;1.6–2.6), self-harm (males: 3.8;2.4-6.0, females:3.2; 2.6–3.9), suicidal thoughts (males: 3.3; 2.2-5.0, females:3.0; 2.5–3.6) and suicide attempts (males: 9.5;5.6–16.0, females:3.6;2.7–4.9). Furthermore, exposure to sexual abuse was associated with higher odds of using school health services (males: 3.9;2.6–5.9, females: 1.6;1.3–1.9) and health services for youth (males: 4.8;3.1–7.6, females: 2.1;1.7–2.5). In general, substance use was associated with increased odds of adverse health related outcomes and use of youth health services, but the strength of the relationships varied according to sex. Finally, results indicated a significant interaction between sexual abuse and smoking that was associated with increased odds of having suicidal thoughts for males (2.6;1.1–6.5) but a decreased odds of having suicidal thoughts and have conducted suicide attempts once or more for females (0.6;0.4-1.0 and 0.5;0.3–0.9, respectively). Conclusions The present study confirmed a strong relationship between exposure to sexual abuse and health risks, especially among males. Moreover, males exposed to sexual abuse were much more likely to use youth health services compared to sexually abused females. Substance use was also associated with adverse health outcomes and use of youth health services, and interactions between sexual abuse and smoking seemed to influence risk of suicidal thoughts and attempts differently according to sex. Results from this study increase knowledge about possible health related effects of sexual abuse which should be used to identify victims and provide targeted treatment by youth health services.publishedVersio

Education for optimized Life Cycle Management : The Project e-CIRP and its insights into embedding circular economy aspects to product design via teaching

Publisher Copyright: © The Authors, published by EDP Sciences.The integration of circular economy-based life cycle management (LCM) into product design and optimisation is essential for the transformation towards a circular economy (CE). However, companies often lack the expertise to adapt life-cycle design (LCD) thinking in their business operations and are in need of respective capacity building. To close this apparent gap is the aim of the project e-CirP (Embedding Circular Economy into Product Design and Optimization) where LUT University, Fraunhofer, Technical University of Denmark, University of Padova, Delft University of Technology, University of Helsinki and Metso Outotec have worked together to develop a program that allows Master students across Europe to learn how to integrate CE and Life Cycle Thinking principles into product design by analysing real industrial cases. In the project, modern pedagogical approaches have been applied. A modular training package covering general circular economy aspects, as well as detailed value chain perspectives, has been created. Next to the content-related aspects, a great focus was also on the support of so-called soft-skills development, e.g. through international student cooperation on case studies. The paper presents the perspective of participating students as well as the cooperating companies that supplied the industry cases to allow an overview of opportunities and challenges.Peer reviewe

Social support and health in diabetes patients: an observational study in six European countries in an era of austerity

Introduction: support from individual social networks, community organizations and neighborhoods is associated with better self-management and health outcomes. This international study examined the relative impact of different types of support on health and health-related behaviors in patients with type 2 diabetes.Methods: observational study (using interviews and questionnaires) in a sample of 1,692 type 2 diabetes patients with 5,433 connections from Bulgaria, Greece, Netherlands, Norway, Spain, and the United Kingdom. Outcomes were patient-reported health status (SF-12), physical exercise (RAPA), diet and smoking (SDCSCA). Random coefficient regression models were used to examine linkages with individual networks, community organizations, and neighborhood type (deprived rural, deprived urban, or affluent urban).Results: patients had a median of 3 support connections and 34.6% participated in community organizations. Controlled for patients’ age, sex, education, income and comorbidities, large emotional support networks were associated with decrease of non-smoking (OR = 0.87). Large practical support networks were associated with worse physical and mental health (B = -0.46 and -0.27 respectively) and less physical activity (OR = 0.90). Participation in community organizations was associated with better physical and mental health (B = 1.39 and 1.22, respectively) and, in patients with low income, with more physical activity (OR = 1.53).Discussion: participation in community organizations was most consistently related to better health status. Many diabetes patients have individual support networks, but this study did not provide evidence to increase their size as a public health strategy. The consistent association between participation in community organizations and health status provides a clear target for interventions and policie