258 research outputs found
H. pylori-infection and antibody immune response in a rural Tanzanian population
- Author
- A Agha
- AC Templeton
- AE Williams
- B Khanna
- BD Gold
- Benjamin D Gold
- BH Teh
- C Holcombe
- D Rothenbacher
- DI Campbell
- DI Campbell
- DM Parkin
- EJ Kuipers
- F Mawas
- G Brubaker
- G McFarlane
- G Poggensee
- Glen R Brubaker
- HM Malaty
- HM Mitchell
- I Segal
- JE Thomas
- JG Fox
- JL Eshleman
- JN Kitinya
- John Shao
- KB Bamford
- KJ Goodman
- LE Bravo
- LK Selin
- M Hisada
- Michie Hisada
- MT Whary
- P Lindkvist
- RM Maizels
- Robert J Biggar
- Ruth M Pfeiffer
- Sam M Mbulaiteye
- SM Mbulaiteye
- T Handzel
- T Madebo
- Y Yamashita
- Publication venue
- BioMed Central
- Publication date
- 01/01/2006
- Field of study
BACKGROUND: Helicobacter pylori (H. pylori) infection is ubiquitous in sub-Saharan Africa, but paradoxically gastric cancer is rare. METHODS: Sera collected during a household-based survey in rural Tanzania in 1985 were tested for anti-H. pylori IgG and IgG subclass antibodies by enzyme immunoassay. Odds ratios (OR) and confidence intervals (CI) of association of seropositivity with demographic variables were computed by logistic regression models. RESULTS: Of 788 participants, 513 were aged ≤17 years. H. pylori seropositivity increased from 76% at 0–4 years to 99% by ≥18 years of age. Seropositivity was associated with age (OR 11.5, 95% CI 4.2–31.4 for 10–17 vs. 0–4 years), higher birth-order (11.1; 3.6–34.1 for ≥3(rd )vs. 1(st )born), and having a seropositive next-older sibling (2.7; 0.9–8.3). Median values of IgG subclass were 7.2 for IgG1 and 2.0 for IgG2. The median IgG1/IgG2 ratio was 3.1 (IQR: 1.7–5.6), consistent with a Th2-dominant immune profile. Th2-dominant response was more frequent in children than adults (OR 2.4, 95% CI 1.3–4.4). CONCLUSION: H. pylori seropositivity was highly prevalent in Tanzania and the immunological response was Th2-dominant. Th2-dominant immune response, possibly caused by concurrent bacterial or parasitic infections, could explain, in part, the lower risk of H. pylori-associated gastric cancer in Africa
Beauty Is in the Eye of the Beholder: Proteins Can Recognize Binding Sites of Homologous Proteins in More than One Way
- Author
- A Aytuna
- A Bogan
- A Henschel
- A Murzin
- A Shulman-Peleg
- A Shulman-Peleg
- A Wallace
- AH Elcock
- C Chothia
- C Li
- C Tsai
- C Winter
- CE Chang
- CJ Jeffery
- D Beckett
- D Fischer
- D Korkin
- DR Caffrey
- EL Humphris
- F Glaser
- G Kleywegt
- G Launay
- G Nicola
- H Ruffner
- H Zhao
- H Zhu
- HM Berman
- I Nobeli
- IS Moreira
- J Barker
- J Gruber
- J Konc
- J Li
- J Mintseris
- Juliette Martin
- K Henrick
- K Kinoshita
- LC James
- M Fromer
- M Guharoy
- M Jambon
- M Jambon
- M Shatsky
- M Tyagi
- M Zacharias
- N Gold
- N Rekha
- N Tuncbag
- NV Grishin
- O Goldenberg
- O Keskin
- O Keskin
- O Keskin
- O Khersonsky
- P Aloy
- P Artymiuk
- P Block
- P Carbonell
- P Chakrabarti
- R Minai
- R Najmanovich
- R Russell
- RP Bahadur
- RP Bahadur
- Ruth Nussinov
- S De
- S Fletcher
- S Jones
- S Mintz
- S Schmitt
- S Yin
- U Ogmen
- V Ivanisenko
- WK Kim
- WL DeLano
- WL Delano
- WS Valdar
- Y Ofran
- YS Choi
- YY Tseng
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Understanding the mechanisms of protein–protein interaction is a fundamental problem with many practical applications. The fact that different proteins can bind similar partners suggests that convergently evolved binding interfaces are reused in different complexes. A set of protein complexes composed of non-homologous domains interacting with homologous partners at equivalent binding sites was collected in 2006, offering an opportunity to investigate this point. We considered 433 pairs of protein–protein complexes from the ABAC database (AB and AC binary protein complexes sharing a homologous partner A) and analyzed the extent of physico-chemical similarity at the atomic and residue level at the protein–protein interface. Homologous partners of the complexes were superimposed using Multiprot, and similar atoms at the interface were quantified using a five class grouping scheme and a distance cut-off. We found that the number of interfacial atoms with similar properties is systematically lower in the non-homologous proteins than in the homologous ones. We assessed the significance of the similarity by bootstrapping the atomic properties at the interfaces. We found that the similarity of binding sites is very significant between homologous proteins, as expected, but generally insignificant between the non-homologous proteins that bind to homologous partners. Furthermore, evolutionarily conserved residues are not colocalized within the binding sites of non-homologous proteins. We could only identify a limited number of cases of structural mimicry at the interface, suggesting that this property is less generic than previously thought. Our results support the hypothesis that different proteins can interact with similar partners using alternate strategies, but do not support convergent evolution
Reframing professional development through understanding authentic professional learning
- Author
- Alvesson M
- Ann Webster-Wright
- Antonacopoulou E
- Apple MW
- Apple MW
- Apple MW
- Ariizumi Y
- Aubrey R
- Ball DL
- Barnett R
- Beckett D
- Benner P
- Biggs J
- Billett S
- Billett S
- Block AA
- Boud D
- Boud D
- Boud D
- Boud D
- Bourdieu P
- Brockbank A
- Brockbank A
- Brookfield S
- Brookfield S
- Brookfield S
- Burchell BJ
- Bury TJ
- Butler J
- Carr W
- Clandinin DJ
- Clark C
- Coffield F
- Cranton P
- Cranton P
- Darling-Hammond L
- Darling-Hammond L
- Darling-Hammond L
- Darling-Hammond L
- Day C
- Dewey J
- Dewey J
- Dilworth RL
- Dreyfus HL
- Eraut M
- Fenwick T
- Foucault M
- Freidson E
- Freire P
- Friedman A
- Fullan M
- Gee JP
- Giddens A
- Gold S
- Hampton G
- Hargreaves A
- Hargreaves A
- Hargreaves A
- Hawley WD
- Hickey S
- Higgs J
- Hochschild AR
- Hochschild AR
- Honey P
- Hyland NE
- Imel S
- Ingham J
- Jarvis P
- Knapper CK
- Knowles MS
- Kolb D
- Lakoff G
- Lieberman A
- Lieberman A
- Lieberman A
- Lieberman A
- Luke H
- Lyotard J–F
- Macintyre C
- Madden SJ
- McDermott R
- McGill I
- McRae D
- Merleau-Ponty M
- Mezirow J
- Mezirow J
- Moon JA
- Mott VW
- Murrell PC
- Noddings N
- Oakes J
- Organisation for Economic Co-operation and Development
- Organisation for Economic Co-operation and Development
- Pocock B
- Pollard A
- Rainbird H
- Ramsden P
- Reason P
- Rhodes C
- Rodrigues S
- Rogoff B
- Rothberg HN
- Ruth-Sahd LA
- Sankaran S
- Schön DA
- Schön DA
- Senge PM
- Solomon N
- Stevenson J
- Sullivan WM
- Trede F
- Tripp D
- Usher R
- Walker M
- Webster-Wright A
- Willis P
- Wood D
- Publication venue
- 'American Educational Research Association (AERA)'
- Publication date
- 01/06/2009
- Field of study
Continuing to learn is universally accepted and expected by professionals and other stakeholders across all professions. However, despite changes in response to research findings about how professionals learn, many professional development practices still focus on delivering content rather than enhancing learning. In exploring reasons for the continuation of didactic practices in professional development, this article critiques the usual conceptualization of professional development through a review of recent literature across professions. An alternative conceptualization is proposed, based on philosophical assumptions congruent with evidence about professional learning from seminal educational research of the past two decades. An argument is presented for a shift in discourse and focus from delivering and evaluating professional development programs to understanding and supporting authentic professional learning
Effects of extreme temperatures on cardiovascular emergency hospitalizations in a Mediterranean region: a self-controlled case series study
- Author
- A Gasparrini
- A Ponjoan
- Anna Ponjoan
- B Bolíbar
- B Ostro
- C Linares
- C Sartini
- CJ Gronlund
- D Phung
- D Phung
- D Shaposhnikov
- DO Åström
- DR Gold
- Dídac Parramon
- E Lavigne
- F Giorgi
- H Davídkovová
- H Hanzlíková
- H Marti-Soler
- HJ Whitaker
- I Petersen
- Irene Petersen
- J Kyselý
- J Madrigano
- J Wichmann
- J-M Robine
- J-P Empana
- JC Semenza
- JF Bobb
- Jordi Blanch
- K Bhaskaran
- K Bhaskaran
- KL Ebi
- LA Hopstock
- Lia Alves-Cabratosa
- LR Turner
- LR Turner
- M Carder
- M García-Gil
- M Shah
- Marc Comas-Cufí
- María del Mar Garcia-Gil
- MC Bernhard
- MDM García-Gil
- ME Loughnan
- MG Zhou
- NRI Ryti
- P Michelozzi
- R Basu
- R Ramos
- Rafel Ramos
- RS Green
- Ruth Martí-Lluch
- S Kolb
- S Paz
- S Stanišić Stojić
- SM Langan
- W Ma
- W Yu
- WQ Gan
- X Ye
- Y Guo
- Z Xu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
International Study Group Progress Report On Linear Collider Development
- Author
- Adolphsen C E
- Akemoto M
- Akre R
- Anami S
- Balakin V
- Bane Karl Leopold Freitag
- Barry W
- Bowden G B
- Burke D
- Caryotakis G
- Cassel R L
- Chin Y H
- Clendenin J E
- Cook E
- Corlett J
- Cornuelle J
- De Lamare J
- Donaldson A R
- Doyle E
- Eichner J
- Emma P
- Fant K
- Farkas Z D
- Fowkes R
- Frisch J
- Fukuda S
- Funahashi Y
- Gold S
- Gronberg J B
- Hawkins S
- Hayano H
- Hertzbach S S
- Higashi Y
- Higo T
- Hitomi N
- Honma A K
- Horinaka H
- Jobe R Keith
- Jones R
- Jongewaard E
- Kashiwagi S
- Kazakov S
- Keller L
- Klingmann J
- Ko K
- Koontz R F
- Korhonen T T
- Kotseroglou T
- Krasnykh Anatoly K
- Krejcik P
- Kroll N M
- Kubo K
- Kudoh N
- Kurihara Y
- Kuriki M
- Kuroda S
- Larionov A
- Larsen R
- Li Z
- Loew G A
- Loewen R
- Markiewicz T W
- Maruyama T
- Matsumoto S
- McCormick D J
- McKee B
- Merritt B
- Michizono S
- Millage K K
- Miller R
- Minty Michiko G
- Miyamoto A
- Mizuno H
- Naito T
- Nakanishi T
- Nakayama H
- Namito Y
- Nantista C D
- Neubauer M S
- Ng C
- Nguyen M
- Nosochkov Yu M
- Ohya K
- Oide K
- Okugi T
- Okumi S
- Omori T
- Pappas C
- Paterson J M
- Pearson C
- Phillips R M
- Phinney N
- Raubenheimer T O
- Rifkin J
- Ringwall A D
- Ross M C
- Ruth Ronald D
- Schultz D C
- Sheppard J C
- Skarpaas K V
- Sprehn D
- Stupakov G
- Sugimoto Y
- Sullivan J
- Suzuki C
- Suzuki T
- Takahashi C
- Takata K
- Takatomi T
- Takeda S
- Tamura F
- Tantawi S G
- Tauchi T
- Tenenbaum P G
- Terunuma N
- Teryaev V E
- Thompson K
- Togawa K
- Toge N
- Tokumoto S
- Tsutsui H
- Turner J L
- Urakawa J
- Van Bibber K
- Vlieks A E
- Vogel E
- Wada K
- Wang J Q
- Wang J W
- Watanabe Y
- Wilson P
- Wilson Z
- Woodley M D
- Woods M
- Yamaguchi S
- Yamaoka H
- Yokoya K
- Zimmermann Frank
- Publication venue
- 'Bishkek Humanities University'
- Publication date
- 01/01/2000
- Field of study
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
- Author
- Abadia M
- Abassy J
- Abate E
- Abbott Tom EF
- Abdelaal Samir A
- Abdeldayem H
- Abdelkabir M
- Abdelsamed A
- Abdulwahed E
- Abiyere H
- Abou Chaar MK
- Abukhalaf SA
- Abukhalaf Sadi
- Adamina Michel
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Adeyeye A
- Adisa Adewale
- Afzal MF
- Agarwal Arnav
- Aggarwal M
- Agnes A
- Agostini C
- Agrawal A
- Agrawal N
- Agresta F
- Aguiar Junior S
- Ahmed A
- Ahmed K
- Ahmed Nafees R
- Ahmed Z
- Ahn JH
- Aime A
- Akhtar N
- Akkulak Murat
- Akrivou D
- Al Abdallah M
- Al Riyami S
- Al Sayed M
- Al-Masri M
- Al-Najjar H
- Al-Slaibi I
- Alaa S
- Alakaloko Felix
- Alameer Ehab
- Alamri Alex
- Alawneh F
- Albertsmeier M
- Albertsmeier Markus
- Alderson Derek
- Aldokali N
- Alemanno G
- Alfieri S
- Algallai M
- Ali AA
- Alkadiki Ghadah Z
- Almaadany Faraj S
- Almeida AC
- Almeida-Reis R
- Almezghwi H
- Almond Max
- Alrahawy M
- Alser Osaid
- Alshaar Muhammad
- Alshareea E
- Alshareef K
- Alshryda Sattar
- Alsoufi A
- Altamirano Riquoir C
- Altomare DF
- Altomi I
- Alurralde C
- Alvarez MR
- Alvi A
- Alwarfly S
- AlZAEDE S
- Alzeerelhouseini IAH
- Amaral MJ
- Amira G
- Amorim E
- Amrani L
- Anania G
- Anastasi A
- Andrade Kam da Silva A
- Andrade R
- Annessi V
- Annicchiarico A
- Antonakis P
- Antonopoulou M
- Aprile A
- Aremu M
- Arias-Amezquita F
- Aribi N
- Aribi S
- Arkadopoulos N
- Armao T
- Armatura G
- Arminio A
- Arnaud Alexis P
- Arora A
- Arslan K
- Ashoush F
- Athanasakis E
- Attia D
- Augestad Knut Magne
- Aversano A
- Avlund T
- Awada Barakat J
- Ayasra F
- Ayasra Faris
- Ayasra Y
- Ayub B
- Ayubi A
- Ayyaz M
- Azevedo C
- Azevedo J
- Azevedo Jose
- Azevedo P
- Azman Mohd ZA
- Azzam AY
- Babalola O
- Badra R
- Bagraith K
- Baili E
- Balabel M
- Balconi A
- Baldari L
- Baldi C
- Baldini E
- Bali K
- Ballabio M
- Ballouhey Q
- Baloyiannis I
- Bandovas JP
- Bankhead-Kendall Brittany K
- Banky B
- Banuelos Romero E
- Baptista VH
- Barker D
- Barlow Emma
- Barod Ravi
- Barone R
- Baronio G
- Barrat B
- Barros Vieira A
- Bartalucci B
- Bartolini I
- Bashir Y
- Bass G
- Batistotti P
- Batstone Martin
- Baxevanidou K
- Beard David
- Becker R
- Bekele K
- Belia F
- Belkhadir ZH
- Bellacci A
- Belli A
- Bellolio F
- Bellora P
- Belluco C
- Belvedere A
- Bendjemar L
- Benkabbou A
- Benson Ruth A
- Bergamini C
- Bergeat D
- Bernante P
- Berselli M
- Bertelli G
- Bertolani E
- Besser N
- Beyer K
- Beyrne C
- Bezerra Santos T
- Bhangu Aneel A
- Bhat GA
- Bhat MA
- Biala M
- Bianchini M
- Bianco F
- Biel Juan Rey
- Bigam D
- Biondi A
- Birolo SL
- Bisagni P
- Blanco-Colino Ruth
- Bodanese B
- Boeker C
- Bondurri A
- Bong C
- Boni L
- Bonilla A
- Bonnet S
- Bordoni P
- Borges Castro F
- Borges N
- Borghi F
- Bork U
- Borroni G
- Bouchagier K
- Bouche PA
- Bouliaris K
- Boutros M
- Bowman S
- Boyce R
- Brachini G
- Bradulskis S
- Braham H
- Brar Amanpreet
- Bravo Ana Minaya
- Breen Kerry A
- Bretherton Chris
- Bristow Rob
- Bromage Steve
- Brown C
- Brunelli Alessandro
- Bruscino A
- Buarque Igor Lima
- Buarque Lima
- Bucci Fares A
- Buerba GA
- Burgan D
- Burke Joshua
- Butt U
- Bywater Edward
- Caccetta M
- Calabro M
- Camacho C
- Camara P
- Camarneiro R
- Caminsky N
- Campagnaro T
- Canas-Martinez A
- Canonico G
- Capelli P
- Capezzuoli L
- Capolupo GT
- Capunge I
- Caram EL
- Carannante F
- Carbone F
- Carcoforo P
- Cardoso N
- Cardoso P
- Carissimi F
- Caruana Edward J
- Carvello MM
- Casati M
- Cassinotti E
- Catena F
- Cecire J
- Ceelen W
- Ceretti Pisani A
- Cervellera M
- Cetares C
- Chaar Mohammad
- Chakrabortee Sohini
- Chan E
- Charalabopoulos A
- Charre L
- Chaturvedi A
- Chaturvedi H
- Chatzikomnitsa P
- Chaudhry Daoud
- Chebaro A
- Chen S
- Chessa A
- Chiappini A
- Chiarugi M
- Chinda J
- Chiozza M
- Chisthi M
- Chiva Luis
- Choong E
- Chowdri N
- Christensen P
- Christensen Peter
- Christidis P
- Christou C
- Chrysos E
- Chumbinho B
- Cianflocca D
- Cicerchia PM
- Cirillo B
- Clarizia G
- Claro M
- Coccolini F
- Cocozza E
- Coelho Nunes M
- Coffey JC
- Cohen Paul
- Colletti G
- Colombo F
- Colquhoun Alexandra
- Confalonieri M
- Connelly T
- Conti L
- Contis I
- Coonar Aman S
- Corbellini C
- Cordera F
- Corless K
- Corrigan M
- Cosentino Marino L
- Cosimelli M
- Costa M
- Costa Matos P
- Costa MJMA
- Costanzi A
- Costeira B
- Cotoia A
- Cotte E
- Cox Daniel
- Cozza V
- Creavin B
- Cremonini C
- Crespo A
- Cuasquen Velasquez BG
- Cukier M
- Cukier Moises
- Cullivan O
- Cunha C
- Cunha MF
- Cunha Miguel F
- Cunha R
- Cunningham RM
- D'Aloisio G
- D'Ugo D
- D'Ugo S
- D'Urso A
- da Cruz Lima L
- da Silva Abreu A
- da Silva Lima C
- Dainius E
- Dajani K
- Daly A
- Danias N
- Davidson Giana H
- Dawson AC
- Dawson Brett E
- de Almeida Ramalho F
- de Barros Figueiredo
- De Lima RK
- De Lucia F
- De Nardi P
- De Palma G
- de Sa Correia T
- de Sampaio Regina L
- De Simone V
- De Sousa X
- De Toma G
- De Troia A
- De Vincenti R
- Deirino A
- Delinasios G
- Dell A
- Della Giustina E
- Dellaportas D
- Delrio P
- Demetriades Andreas K
- Demyttenaere S
- Denet C
- Depalma N
- Derksen T
- Desai Anant
- Desio M
- Desoouza A
- Deus AC
- Devarakonda S
- Devezas V
- Devine M
- Dhamija P
- Dharanipragada K
- Di Bella A
- Di Franco G
- Di Lauro K
- Di Martino C
- Di Marzo F
- Di Saverio Salomone
- Diamantis A
- Diaz P
- Dijan E
- Domingues J
- Donati D
- dos Santos Martins G
- Doudakmanis C
- Dowdy Sean
- Doyle A
- Drake Thomas M
- Drane A
- Droghetti M
- Duchalais E
- Dudi-Venkata NN
- Dumitra Sinziana
- Duran Sosa EE
- Earley H
- Eastmond A
- Ebbehoj AL
- Ebben L
- Economopoulou P
- Edwards John
- Edwards John G
- Efthimiou M
- Egoroff N
- El Ahmadi B
- El Amrani M
- El Arbi N
- El Bouazizi Y
- El Kassas M
- Elazzazy E
- Eldaly A
- Elghazaly MS
- Elhadi Muhammed
- Elliott JA
- Ellojli I
- Elmorsi R
- Emile Sameh
- Emmanuel K
- Enoch E
- Esene Ignatius
- Eskinazi DG
- Esposito G
- Esquide Ruiz M
- Essam E
- Evans Jonathan P
- Evans Richard PT
- Eveno C
- Ewedah M
- Ezanno AC
- Fabbri N
- Facundo H
- Fagotti Anna
- Fahey BA
- Fahmawee T
- Farik Shebani
- Farnesi F
- Farooka MW
- Fathi NQ
- Faustino A
- Fayed Y
- Federico P
- Federico Pipitone NS
- Feo C
- Feo CF
- Fernandes Sousa M
- Fernandes U
- Fernandes V
- Ferrari M
- Ferrario L
- Ferraz I
- Ferreira C
- Ferreira Peralta M
- Ferro Carvalho C
- Ferro Rey M
- Finnegan L
- Fiore M
- Fiore Marco
- Fiori E
- Fiorini A
- Fitzgerald J Edward
- Flamey N
- Fleming CA
- Fleres F
- Fonsi GB
- Foo CC
- Foppa C
- Ford Samuel
- Fortuna L
- Fotopoulou Christina
- Fountain Daniel M
- Fowler A
- Frade S
- Fragoso M
- Francone E
- Franken J
- Frantzeskou K
- Franzini M
- Frattaruolo C
- Frazao J
- Fredon F
- Freitas A
- Frena A
- Freyschlag Christian
- Fritzmann J
- Frongia F
- Frountzas M
- Fujiwar Keiichi
- Fuks D
- Furbetta N
- Futaba K
- Gahwagi M
- Gallo G
- Gallo Gaetano
- Galvao D
- Gani J
- Ganly Ian
- Garba S
- Garberini De Manzoni A
- Garcia JS
- Garfinkle R
- Garg PK
- Garino M
- Garmanova Tatiana
- Garrido R
- Gattolin A
- Gauri N
- Gaziants V
- Gelarda E
- Gennari S
- Gentilli S
- George G
- Gerns N
- Geroukalis A
- Ghaly G
- Ghamgh R
- Ghannam A
- Ghebre Rahel
- Ghitulescu G
- Ghosh Dhruva
- Giacometti M
- Giaglaras A
- Gianardi D
- Gill R
- Gillis AE
- Giraudo G
- Giuffrida M
- Giuffrida MC
- Giunta A
- Gklavas A
- Glasbey James C
- Glehen O
- Gold-Deutch R
- Gomes GMA
- Gomes Gustavo Mendonca Ataide
- Gomes J
- Gomez-Mayorga JL
- Gori A
- Gouvas N
- Grasset E
- Grasso M
- Grechenig M
- Grechi A
- Grecinos Gustavo
- Gribnev P
- Griffiths Ewen A
- Grilo J
- Grimaldi Di Maria S
- Gronchi Alessandro
- Groot G
- Grossi U
- Grotenhuis BA
- Gruber R
- Gruendl Magdalena
- Guadagni S
- Guaglio M
- Guerci C
- Guerra GR
- Guevara O
- Guglielmi A
- Guidi G
- Gujjuri Rohan R
- Gundara J
- Gupta S
- Gutelkin Murat
- Hakami I
- Halkias Constantine
- Hamdan KH
- Hamdy R
- Hamza HM
- Hanly A
- Haque PD
- Harald M
- Harbjerg JL
- Hardy NP
- Harris Benjamin
- Harrison Ewen M
- Hartveld L
- Hasan Aboharp Z
- Hassan E
- Hayati F
- Helminen O
- Heneghan H
- Henriques P
- Henriques S
- Heritage Emily
- Hernandez R
- Herzberg J
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- Publication venue
- 'Royal College of Obstetricians & Gynaecologists (RCOG)'
- Publication date
- 01/06/2022
- Field of study
AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease
Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic
- Author
- 14 | COVIDSurg COllabOratIVe Tzovaras G. (General University Hospital of Larissa)
- Aawsaj Y.
- Abad Gurumeta A.
- Abad-Motos A.
- Abate E.
- Abbott D.
- Abdalla M.
- Abdeldayem H.
- Abdelkader Salama I.
- Abdelkarim M.
- Abdur-Rahman L.
- Abel M. K.
- Aboelkassem Ibrahim A.
- Abou Chaar M. K.
- Abreu da Silva A.
- Abubakar A.
- Acebes García F.
- Achalandabaso Boira M. Sales Mallafré R. (Hospital Universitari de Tarragona Joan XXIII)
- Acher A.
- Acrich E.
- Adamina M.
- Aderombi A.
- Adeyeye A.
- Adiamah A.
- Afonso J.
- Agapov M.
- Agnes A.
- Agostini C.
- Agresta F.
- Aguado H. (Hellín Hospital)
- Aguilar Gonzalez M. Talukder S. (West Suffolk Hospital)
- Ahmed Z.
- Ahmeidat A.
- Ahn J. H.
- Aiken T.
- Aimé A.
- Akalin M.
- Akaydin E.
- Akhtar M. A.
- Akhter Rahman M. M.
- Akin E.
- Al Awwad S.
- Al Habes H.
- Al Maadany F. S. (Al-Jalaa Hospital)
- Al- Khayal K.
- Al- Najjar H.
- Al-Habsi R.
- Al-Masri M.
- Al-Mohammad A.
- Alaa S.
- AlAamer O.
- Aladeojebi A.
- Alam F.
- Alawneh F. (King Hussein Cancer Center). Libya: Alkadeeki G.
- Albertsmeier M.
- Alcaide Matas F.
- Aldokali N.
- Alemanno G.
- Alfieri S.
- Alghamdi M.
- Alhamed A.
- Alharthi M.
- Alhassan N.
- Ali M.
- Ali S.
- Aliyeva Z.
- Aljiffry M.
- Alma Mater Studiorum University of Bologna)
- Almeida A. C.
- Almeida J. I.
- Almeida-Reis R.
- Alnumani T. (King Fahad 16 | COVIDSurg COllabOratIVe General Hospital)
- Alobeed O.
- Alonso de la Fuente N. Jimenez Toscano M. (Hospital del Mar)
- Alonso Poza A.
- Alonso- Lamberti L.
- Alqannas M.
- Alselaim N. (King Saud Bin Abdulaziz University for Health Sciences
- Alshammari S.
- Alsharif F.
- Altintoprak F.
- Alvarez E.
- Alyami M.
- Alzamanan M.
- Amaral M. J.
- Amin Sahid N.
- Amira G.
- Amorim E.
- Anania G.
- Anastasi A.
- Andrade R.
- Angelou D.
- Annamalai S.
- Annessi V.
- Antic A.
- Antonopoulou M. I.
- Anula R.
- Aou Sassari)
- Aprile A.
- Argentina: Alurralde C.
- Arican C.
- Arikan A. E.
- Arkadopoulos N.
- Armao T.
- Armatura G.
- Arminio A.
- Arrowsmith L. Campbell W. (Causeway Hospital)
- Asaad P.
- Ashcroft J.
- Ashmore C.
- Ashoush F.
- Askari A.
- Asqalan A.
- Athanasakis E.
- Athanasiou A.
- Atherton R.
- Attia D.
- Avci E. K.
- Aversano A.
- Ayasra F.
- Ayasra Y.
- Aydin C.
- Ayorinde J.
- Aytac E.
- Ayub B.
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- Ayyaz M. (Services Hospital Lahore)
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- Babar M. S.
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- Badra R.
- Baena Sanfeliu E.
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- Bandara G. B. K. D.
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- Bartalucci B.
- Bartolini I.
- Basendowah M.
- Bashir Y.
- Bass G. A.
- Bates H.
- Batistotti P.
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- Belia F.
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- Belluco C.
- Beltrán de Heredia J.
- Belvedere A.
- Benavides Buleje J. A.
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- Bergamini C.
- Bergeat D. Merdrignac A. (CHU Rennes – General Surgery)
- Bernante P.
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- Berselli M.
- Bertolani E.
- Beyer K.
- Bhalla A.
- Bhangu A.
- Bhangu Aneel
- Bhasin S.
- Bhat M. A.
- Bhatti M. I.
- Bianchini M.
- Bianco F.
- Bianco F. (ASST Papa Giovanni XXIII – Bergamo)
- Bigelow B. (Johns Hopkins Hospital)
- Bilgin I. A.
- Bin Nasser A.
- Bin Traiki T.
- Biondi A.
- Bisagni P.
- Bisset C. Moug S. J. (Royal Alexandra Hospital)
- Blackwell L.
- Blanco-Colino R.
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- Bodla A. S.
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- Boeker C.
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- Bond-Smith G.
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- Bong C. Gundara J. (Logan Hospital)
- Boni L.
- Bonnet S.
- Borges F.
- Borges N.
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- Oguttu B. (Kampala International University Teaching Hospital). UK: Agilinko J.
- Olasehinde O.
- Oliva Mompean F.
- Oliveira A.
- Olivier J. (Weston General Hospital)
- Olivieri M.
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- Opocher E.
- Ortega Vázquez I.
- Ortiz de Solórzano Aurusa F. J.
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- Osorio A.
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- Owen H.
- Owens P.
- Oyende O.
- Ozben V.
- Ozgediz D.
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- O’Brien H.
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- Parseliunas A.
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- Pascale IRCCS)
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- Paspaliari D.
- Passot G. (Hopital Lyon Sud)
- Patel K.
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- Patel P.
- Patil S.
- Patrone R. (HPB Surgical Oncology Unit – Istituto Nazionale Tumori Fondazione
- Patrício B.
- Pattyn P. (Az Delta)
- Pavlov M.
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- Peirce C. (University Hospital Limerick)
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- Pellegrino L.
- Pellino G. (Vall d’Hebron University Hospital). Sri Lanka: Arulanantham A.
- Peluso C.
- Peralta Ferreira M.
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- Pereira C.
- Pereira R.
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- Perez D.
- Perez Gonzalez M.
- Pergolini I. Reim D. (Klinikum Rechts der Isar TUM School of Medicine)
- Perivoliotis K.
- Peros G. (Kantonsspital Winterthur). Turkey: Aghayeva A.
- Perotto L. O.
- Perra T.
- Persiani R.
- Pertile D.
- Petrillo A.
- Petropoulos K.
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- Piessen G.
- Pieve Emanuele (Mi))
- Pina S.
- Pinto J. Tojal A. (Centro Hospitalar Tondela-Viseu)
- Pipitone Federico N. S. (Edoardo Agnelli)
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- Pisanu A.
- Pizarro M. J.
- Pizzini P. (Ospedale Maggiore di Lodi)
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- Provozina A. (Immanuel Kant Baltic Federal University
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- Ramcharan S.
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- Regional Clinical Hospital)
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- Rimonda R.
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- Rose J.
- Roslani A. C. (University Malaya Medical Centre). Mexico: Buerba G. A.
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- Rozzano (Mi) and Humanitas University
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- Ruivo A.
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- Ruiz Soriano M.
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- Russ J.
- Rutegård M. (Umea University Hospital). Switzerland: Arigoni M.
- Rutherford D.
- Ruzzenente A.
- Ryan M. (University Hospital Waterford/University College Cork). Italy: Macina S. (ASST Mantua)
- Ryan É. (University Hospital Galway)
- Ryska O. (Royal Lancaster Infirmary)
- Río Lafuente F. D.
- Saad M. M.
- Saafan T.
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- Sabah)
- Sabratha)
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- Salimoğlu S.
- Salindera S.
- Sallam I.
- Samih A.
- Samir Abdelaal A.
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- Samkari A.
- Sammarco G.
- Sammour T. (Royal Adelaide Hospital)
- Sampaio da Nóvoa Gomes Miguel I. I. (Centro Hospitalar Universitário do Algarve – Unidade de Portimão)
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- San Francisco (UCSF))
- Sanchez Cabezudo Noguera F.
- Sanchez Gonzalez J.
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- Santanach C.
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- Sasapu K. (Diana Princess of Wales Hospital Grimsby)
- Sasia D.
- Saudí S. (Hospital Universitario Miguel Servet)
- Sauvain M. (Pourtales Neuchatel Hospital)
- Sauvat F. (CHU Réunion). Romania: Bezede C.
- Savković N.
- Sayyed R. (Patel Hospital)
- Scabini S.
- Scalabre A. (Chu Saint Etienne)
- Scanu A. M. (Cliniche San Pietro
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- Scott L. (Pinderfields Hospital)
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- Scrima O.
- Sechenov Medical State University)
- Seebah K.
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- Selmani J.
- Semina E. (Moscow Research and Educational Center
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- Serrano González J. (Hospital Universitario de Torrejón de Ardoz)
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- Seymour Z. (Ysbyty Gwynedd). USA: Haynes A.
- Sganga G. (Fondazione Policlinico Universitario Agostino Gemelli IRCCS)
- Sgrò A.
- Shah J. (North Manchester General Hospital)
- Shah S. (The Whittington Hospital)
- Shah Z. A.
- Shaikh I.
- Shaikh S.
- Sharabiany S. (Amsterdam UMC
- Sharma P. (Aberdeen Royal Infirmary)
- Shehata S.
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- Sheridan K.
- Sherief M.
- Sherif A. (Misr Cancer Center)
- Sherif A. E. (National Liver Institute
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- Shokuhi P.
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- Sian T.
- Sibilla M. G.
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- Silva M.
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- Silveira Nunes I.
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- Singh A.
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- Smith H. (Bispebjerg Hospital). Egypt: Al Sayed M.
- Smith L.
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- Soares A. P.
- Soh J. Y.
- Sohrabi C.
- Solari F.
- Soriero D. (IRCCS Ospedale Policlinico San Martino)
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- Sorribas Grifell M.
- Soto Montesinos C. (Fundació Althaia – Xarxa Assistencial Universitària de Manresa)
- Souadka A. (Institut National d’Oncologie
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- Subhi M. T. (Alkhadra Hospital)
- Subocius A.
- Subramaniam S. (Queen Elizabeth Hospital and Universiti Malaysia Sabah
- Sundaram Venkatesan G. (Glan Clwyd Hospital)
- Suszták N. (Szent Borbála Kórház). India: Bhat G. A.
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- Swinson B. (Royal Brisbane and Women’s Hospital). Austria: Messner F.
- Syed W. A. S.
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- Taibi A. (Chu Limoges)
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- Tanal M.
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- Tartaglia D. (Azienda Ospedaliero Universitaria Pisana)
- Tasis N. (Athens Naval and Veterans Hospital)
- Tatar O. C.
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- Tebala G. D.
- Teixeira J. (Centro Hospitalar Universitário do Algarve – Unidade de Faro)
- Teixeira M. (Centro Hospitalar do Tamega e Sousa)
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- Testa V. (Santa Croce E. Carle Hospital
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- Thaha M.
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- Thulasiraman S. V.
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- TU Dresden)
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- Uludağ S. S.
- Umair M.
- Universiti Sains Malaysia)
- University of Amsterdam)
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- Velidedeoglu M.
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- Vera Mansilla C. (Hospital Universitario Principe de Asturias)
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- Vervoort D.
- Vescio G. (University ‘Magna Graecia’ of Catanzaro)
- Vezakis A. (Aretaieion Hospital)
- Videira J. F. (IPO Porto). Réunion: Kassir R.
- Vieira B. (Centro Hospitalar de Trás-Os-Montes e Alto Douro
- Vieira Caroço T. (IPO Coimbra)
- Vieira Paiva Lopes A. C. (Hospital de Torres Vedras – Centro Hospitalar do Oeste)
- Vignali A. (San Raffaele Scientific Institute
- Vigorita V. (Álvaro Cunqueiro Hospital)
- Vijayan D. (Queen Elizabeth Hospital Birmingham)
- Villalabeitia Ateca I. (Hospital Universitario Cruces)
- Vimalachandran D. (Countess of Chester Hospital)
- Viswanath Y. K. S. (James Cook University Hospital)
- Vitali A. (Ospedale San Giovanni di Dio)
- Vitone L. (Royal Blackburn Hospital)
- Vives R. V. (Bellvitge University Hospital)
- Vo U. G. (Fiona Stanley Hospital)
- Von Papen M.
- Vovola F. (Ospedali Riuniti Azienda Ospedaliera Universitaria Foggia)
- Vucic N.
- Vázquez Fernández A. (Hospital Clínico Universitario de Valladolid)
- Wadham B. (The University Hospital of South Manchester)
- Walkes K. (Queen Elizabeth Hospital). Belgium: Flamey N.
- Wani R. (Sher-I-Kashmir Institute of Medical Sciences)
- Waqar S. H. (Pakistan Institute of Medical Sciences). Poland: Major P. (Jagiellonian University Medical College). Portugal: Azevedo C.
- Warren O. (Chelsea and Westminster Hospital)
- Watson L. J. (Sunderland Royal Hospital)
- Watson N. (King’s Mill Hospital)
- Weitz J.
- Welsch T. (Carl-Gustav-Carus University Hospital
- Werner J. (LMU Klinikum Campus Innenstadt)
- Westwood E. (James Paget University NHS Foundation Trust Hospital)
- Whelan M. (Tallaght University Hospital)
- Whitmore H. (Torbay and South Devon NHS Trust)
- Wilkin R. J. W. (South Warwickshire NHS Foundation Trust)
- Wilkins A. (Hull University Teaching Hospitals NHS Trust)
- Williams G. (Royal Gwent Hospital)
- Williams K. (St George’s Hospital)
- Wilson M. (Forth Valley Royal Hospital)
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- Wong M.
- Worku D. (Queens Medical Centre)
- Wullschleger M. (Gold Coast University Hospital)
- Xavier R. G.
- Xenaki S.
- Xynos E. (University Hospital of Heraklion Crete and Interclinic Hospital of Crete). Hong Kong: Futaba K.
- Yang W.
- Yassin N. (Royal Wolverhampton NHS Trust)
- Ye G.
- Yesantharao P.
- Yetkin S. G. (Sisli Hamidiye Etfal Training and Research Hospital)
- Yeşilyurt D. (University of Health Sciences Tepecik Training and Research Hospital)
- Yiallourou A. (Nicosia General Hospital). Czechia: Martinek L.
- Yıldırım A.
- Yildiz A. (Yildirim Beyazit University Yenimahalle Training and Research Hospital). Uganda: Lule H.
- Young R. (York Teaching Hospitals NHS Trust)
- Yousof E. A. (Assiut University Hospital)
- Youssef M. (Norfolk and Norwich University Hospital)
- Yurttas C. (University Hospital Tuebingen)
- Yánez C. (Royo Villanova)
- Yüksel E. (Kocaeli University Teaching Hospital)
- Zafar S. N. (University of Wisconsin)
- Zakaria A. D.
- Zakaria Z. (School of Medical Sciences and Hospital
- Zambon M. (Policlinico Umberto I Sapienza University of Rome)
- Zanus G. (Ca’ Foncello Treviso – DISCOG – Università di Padova)
- Zegarac M. (Institute for Oncology and Radiology of Serbia)
- Zelić M. (University Hospital Center Rijeka)
- Zengin A. K. (Istanbul Universty – Cerrahpaşa Medical Faculty)
- Zerbib P. (CHU Lille)
- Zervas K.
- Zese M. (Santa Maria degli Angeli Hospital ULSS 5 – Adria)
- Zhang H. (Concord Repatriation General Hospital)
- Zizzo M. (Azienda Unità Sanitaria Locale – IRCCS di Reggio Emilia)
- Zografos C. (Laiko University Hospital)
- Zorrilla Ortúzar J. (Hospital General Universitario Gregorio Marañón)
- Zourntou S. (General Hospital of Larissa ‘Koutlimpaneio and Triantafylleio’)
- Zubaidi A. M. (King Saud University). Serbia: Aleksić L.
- Ângelo M.
- Çelebi F.
- Çolak E.
- Öfner D. (Medical University of Innsbruck)
- Öhlberger L.
- Özçelık M. F.
- Öğücü H.
- Überrück L.
- Ćoza I.
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
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- Bellard Terell M.
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- Bemrose Richard
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- Benke J
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- Cinkowsky Michael J.
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- Hamza Khalid
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- Hancock Julie
- Harbes Brandy A.
- Harding Adam
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- Heyen Joshua
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- Hitchens Matthew Edward
- Ho Issac
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- Imo Kelvin C.
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- Ishibashi Akiko
- Ishikawa Sabine K.
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- Keenan Stephen
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- Kettleborough Ross
- Keys David
- Khan Arsi
- Khan Umer F.
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- Kong Yi
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- Kosiura Anna
- Kou Zhaohui
- Kovar Christie L.
- Krawczyk Marie-Claude
- Kremitzki Colin
- Kremmidiotis Gabriel
- Krogh Anders
- Kronmiller Brent
- Kruchowski Scott S.
- Kube Michael
- Kubischta Duane
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- Lander Eric S.
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- Levy Michaël
- Lewis Doreen
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- Li Jiayang
- Li Jihong
- Li Jing
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- Lowry Stephen
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- Madabhushi Ramki
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- Murayama Yuji
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- Ung Quyen
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- Urban Jeremy B.
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- Watanabe Hidemi
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- White P. Scott
- White Scott P.
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- Wickremasinghe Manosha I.
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- Wilkinson Jane
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- Williams Andy
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- Williamson Helen
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- Wills Richard
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- Wong Gane K-S
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- Wooden Hailey S.
- Wooden Steven H.
- Woodeson Sharon
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- Worley Kim Carlyle
- Woyke Tanja
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- Wright Debbie
- Wright Kathrine
- Wright Kristin
- Wright Rita A.
- Wu Chungen
- Wu Dongying
- Wu Jiaqian
- Wu Jung-Rung
- Wu Kevin
- Wu Qingfa
- Wu Qingfa
- Wu Ruiming
- Wu Xiao
- Wu Xiaojing
- Wu Zaining
- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
- Wyman Stacia
- Xi Yan
- Xi Yingying
- Xie Fei
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- Xiong Hui
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- Xu Alex
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- Xu Jing
- Xu Ruqin
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- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
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- Yang Shudong
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- Yang Xiaonan
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- Yao Zhijian
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- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
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- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
- Author
- Abajobir Amanuel Alemu
- Abate Kalkidan Hassen
- Abbafati Cristiana
- Abbas Kaja M.
- Abd-Allah Foad
- Abdulle Abdishakur M.
- Abebo Teshome Abuka
- Abera Semaw Ferede
- Aboyans Victor
- Abu-Raddad Laith J.
- Ackerman Ilana N.
- Adamu Abdu Abdullahi
- Adetokunboh Olatunji
- Afarideh Mohsen
- Afshin Ashkan
- Agarwal Sanjay Kumar
- Aggarwal Rakesh
- Agrawal Anurag
- Agrawal Sutapa
- Ahmad Kiadaliri Aliasghar
- Ahmadieh Hamid
- Ahmed Muktar Beshir
- Aichour Amani Nidhal
- Aichour Ibtihel
- Aichour Miloud Taki Eddine
- Aiyar Sneha
- Akinyemi Rufus Olusola
- Akseer Nadia
- Al Lami Faris Hasan
- Al-Aly Ziyad
- Al-Maskari Fatma
- Al-Raddadi Rajaa
- Alahdab Fares
- Alam Khurshid
- Alam Noore
- Alam Tahiya
- Alasfoor Deena
- Alene Kefyalew Addis
- Ali Raghib
- Alizadeh-Navaei Reza
- Alkerwi Ala'a
- Alla François
- Allebeck Peter
- Allen Christine
- Alsharif Ubai
- Alsowaidi Shirina
- Altirkawi Khalid A.
- Amare Azmeraw T.
- Amini Erfan
- Ammar Walid
- Amoako Yaw Ampem
- Andersen Hjalte H.
- Antonio Carl Abelardo T.
- Anwari Palwasha
- Artaman Al
- Aryal Krishna Kumar
- Asayesh Hamid
- Asgedom Solomon W.
- Assadi Reza
- Atey Tesfay Mehari
- Atnafu Niguse Tadele
- Atre Sachin R.
- Avila-Burgos Leticia
- Avokpaho Euripide Frinel G. Arthur
- Awasthi Ashish
- Ayala Quintanilla Beatriz Paulina
- Ba Saleem Huda Omer
- Bacha Umar
- Badawi Alaa
- Balakrishnan Kalpana
- Banerjee Amitava
- Bannick Marlena S.
- Barac Aleksandra
- Barber Ryan M.
- Barker-Collo Suzanne L.
- Barquera Simon
- Barregard Lars
- Barrero Lope H.
- Basu Sanjay
- Battista Bob
- Battle Katherine E.
- Baune Bernhard T.
- Bazargan-Hejazi Shahrzad
- Beardsley Justin
- Bedi Neeraj
- Beghi Ettore
- Bekele Bayu Begashaw
- Bell Michelle L.
- Bennett Derrick A.
- Bensenor Isabela M.
- Benson Jennifer
- Berhane Adugnaw
- Berhe Derbew Fikadu
- Bernabé Eduardo
- Betsu Balem Demtsu
- Beuran Mircea
- Beyene Addisu Shunu
- Bhala Neeraj
- Bhansali Anil
- Bhatt Samir
- Bhutta Zulfiqar A.
- Biadgilign Sibhatu
- Bienhoff Kelly
- Bikbov Boris
- Birungi Charles
- Biryukov Stan
- Bisanzio Donal
- Bizuayehu Habtamu Mellie
- Boneya Dube Jara
- Boufous Soufiane
- Bourne Rupert R.A.
- Brazinova Alexandra
- Brugha Traolach S.
- Buchbinder Rachelle
- Bulto Lemma Negesa Bulto
- Bumgarner Blair R.
- Butt Zahid A.
- Bärnighausen Till
- Béjot Yannick
- Cahuana-Hurtado Lucero
- Cameron Ewan
- Car Mate
- Carabin Hélène
- Carapetis Jonathan R.
- Carpenter David O.
- Carrero Juan Jesus
- Carter Austin
- Carvalho Felix
- Casey Daniel C.
- Caso Valeria
- Castañeda-Orjuela Carlos A.
- Castle Chris D.
- Catalá-López Ferrán
- Chang Hsing-Yi
- Chang Jung-Chen
- Charlson Fiona J.
- Chen Honglei
- Chibalabala Mirriam
- Chibueze Chioma Ezinne
- Chisumpa Vesper Hichilombwe
- Chitheer Abdulaal A.
- Christopher Devasahayam Jesudas
- Ciobanu Liliana G.
- Cirillo Massimo
- Colombara Danny
- Cooper Cyrus
- Cortesi Paolo Angelo
- Criqui Michael H.
- Crump John A.
- Cárdenas Rosario
- Dadi Abel Fekadu
- Dalal Koustuv
- Dandona Lalit
- Dandona Rakhi
- Das Neves José
- Davitoiu Dragos V.
- De Courten Barbora
- De Leo Diego
- Degenhardt Louisa
- Deiparine Selina
- Dellavalle Robert P.
- Deribe Kebede
- Des Jarlais Don C.
- Dey Subhojit
- Dharmaratne Samath D.
- Dhillon Preet Kaur
- Dicker Daniel
- Ding Eric L.
- Djalalinia Shirin
- Do Huyen Phuc
- Dorsey E. Ray
- Dos Santos Kadine Priscila Bender
- Douwes-Schultz Dirk
- Doyle Kerrie E.
- Driscoll Tim R.
- Dubey Manisha
- Duncan Bruce Bartholow
- El-Khatib Ziad Ziad
- Ellerstrand Jerisha
- Enayati Ahmadali
- Endries Aman Yesuf
- Ermakov Sergey Petrovich
- Erskine Holly E.
- Eshrati Babak
- Eskandarieh Sharareh
- Esteghamati Alireza
- Estep Kara
- Fanuel Fanuel Belayneh Bekele
- Farinha Carla Sofia E. Sa
- Faro André
- Farzadfar Farshad
- Fazeli Mir Sohail
- Feigin Valery L.
- Fereshtehnejad Seyed-Mohammad
- Fernandes João C.
- Ferrari Alize J.
- Feyissa Tesfaye Regassa
- Filip Irina
- Fischer Florian
- Fitzmaurice Christina
- Flaxman Abraham D.
- Flor Luisa Sorio
- Foigt Nataliya
- Foreman Kyle J.
- Franklin Richard C.
- Fullman Nancy
- Furtado Joao M.
- Futran Neal D.
- Fürst Thomas
- Gakidou Emmanuela
- Ganji Morsaleh
- Garcia-Basteiro Alberto L.
- Gebre Teshome
- Gebrehiwot Tsegaye Tewelde
- Geleto Ayele
- Gemechu Bikila Lencha
- Gesesew Hailay Abrha
- Gething Peter W.
- Ghajar Alireza
- Gibney Katherine B.
- Gill Paramjit Singh
- Gillum Richard F.
- Ginawi Ibrahim Abdelmageem Mohamed
- Giref Ababi Zergay
- Gishu Melkamu Dedefo
- Giussani Giorgia
- Godwin William W.
- Gold Audra L.
- Goldberg Ellen M.
- Gona Philimon N.
- Goodridge Amador
- Gopalani Sameer Vali
- Goto Atsushi
- Goulart Alessandra Carvalho
- Griswold Max
- Gugnani Harish Chander
- Gupta Rahul
- Gupta Rajeev
- Gupta Tanush
- Gupta Vipin
- Hafezi-Nejad Nima
- Hailu Alemayehu Desalegne
- Hailu Gessessew Bugssa
- Hamadeh Randah Ribhi
- Hamidi Samer
- Handal Alexis J.
- Hankey Graeme J.
- Hao Yuantao
- Harb Hilda L.
- Hareri Habtamu Abera
- Haro Josep Maria
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- Havmoeller Rasmus
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- Hernandez Julio Montañez
- Heydarpour Pouria
- Hoek Hans W.
- Hoffman Howard J.
- Horita Nobuyuki
- Hosgood H. Dean
- Hostiuc Sorin
- Hotez Peter J.
- Hoy Damian G.
- Htet Aung Soe
- Hu Guoqing
- Huang Hsiang
- Huynh Chantal
- Iburg Kim Moesgaard
- Igumbor Ehimario Uche
- Ikeda Chad
- Irvine Caleb Mackay Salpeter
- Jacobsen Kathryn H.
- Jahanmehr Nader
- Jakovljevic Mihajlo B.
- Jassal Simerjot K.
- Javanbakht Mehdi
- Jayaraman Sudha P.
- Jeemon Panniyammakal
- Jensen Paul N.
- Jha Vivekanand
- Jiang Guohong
- John Denny
- Johnson Catherine O.
- Johnson Sarah Charlotte
- Jonas Jost B.
- Jürisson Mikk
- Kabir Zubair
- Kadel Rajendra
- Kahsay Amaha
- Kamal Ritul
- Kan Haidong
- Karam Nadim E.
- Karch André
- Karema Corine Kakizi
- Kasaeian Amir
- Kassa Getachew Mullu
- Kassaw Nigussie Assefa
- Kassebaum Nicholas J.
- Kastor Anshul
- Katikireddi Srinivasa Vittal
- Kaul Anil
- Kawakami Norito
- Keiyoro Peter Njenga
- Kengne Andre Pascal
- Keren Andre
- Khader Yousef Saleh
- Khalil Ibrahim A.
- Khan Ejaz Ahmad
- Khang Young-Ho
- Khosravi Ardeshir
- Khubchandani Jagdish
- Kieling Christian
- Kim Daniel
- Kim Pauline
- Kim Yun Jin
- Kimokoti Ruth W.
- Kinfu Yohannes
- Kisa Adnan
- Kissimova-Skarbek Katarzyna A.
- Kivimaki Mika
- Knudsen Ann Kristin
- Kokubo Yoshihiro
- Kolte Dhaval
- Kopec Jacek A.
- Kosen Soewarta
- Koul Parvaiz A.
- Koyanagi Ai
- Kravchenko Michael
- Krishnaswami Sanjay
- Krohn Kristopher J.
- Kuate Defo Barthelemy
- Kucuk Bicer Burcu
- Kumar G. Anil
- Kumar Pushpendra
- Kumar Sanjiv
- Kyu Hmwe H.
- Lal Dharmesh Kumar
- Lalloo Ratilal
- Lambert Nkurunziza
- Lan Qing
- Larsson Anders
- Lavados Pablo M.
- Leasher Janet L.
- Lee Jong-Tae
- Lee Paul H.
- Leigh James
- Leshargie Cheru Tesema
- Leung Janni
- Leung Ricky
- Levi Miriam
- Li Kappe Darya
- Li Yichong
- Li Yongmei
- Liang Xiaofeng
- Liben Misgan Legesse
- Lim Stephen S.
- Linn Shai
- Liu Angela
- Liu Patrick Y.
- Liu Shiwei
- Liu Yang
- Lodha Rakesh
- Logroscino Giancarlo
- London Stephanie J.
- Looker Katharine J.
- Lopez Alan D.
- Lorkowski Stefan
- Lotufo Paulo A.
- Low Nicola
- Lozano Rafael
- Lucas Timothy C.D.
- Macarayan Erlyn Rachelle King
- Magdy Abd El Razek Hassan
- Magdy Abd El Razek Mohammed
- Mahdavi Mahdi
- Majdan Marek
- Majdzadeh Reza
- Majeed Azeem
- Malekzadeh Reza
- Malhotra Rajesh
- Malta Deborah Carvalho
- Mamun Abdullah A.
- Manguerra Helena
- Manhertz Treh
- Mantilla Ana
- Mantovani Lorenzo G.
- Mapoma Chabila C.
- Marczak Laurie B.
- Martinez-Raga Jose
- Martins-Melo Francisco Rogerlândio
- Martopullo Ira
- Mathur Manu Raj
- Mazidi Mohsen
- McAlinden Colm
- McGaughey Madeline
- McGrath John J.
- McKee Martin
- McNellan Claire
- Mehata Suresh
- Mehndiratta Man Mohan
- Mekonnen Tefera Chane
- Memiah Peter
- Memish Ziad A.
- Mendoza Walter
- Mengistie Mubarek Abera
- Mengistu Desalegn Tadese
- Mensah George A.
- Meretoja Atte
- Meretoja Tuomo J.
- Mezgebe Haftay Berhane
- Micha Renata
- Millear Anoushka
- Miller Ted R.
- Mills Edward J.
- Mirarefin Mojde
- Mirrakhimov Erkin M.
- Misganaw Awoke
- Mishra Shiva Raj
- Mitchell Philip B.
- Mohammad Karzan Abdulmuhsin
- Mohammadi Alireza
- Mohammed Kedir Endris
- Mohammed Shafiu
- Mohanty Sanjay K.
- Mokdad Ali H.
- Mollenkopf Sarah K.
- Monasta Lorenzo
- Montico Marcella
- Moradi-Lakeh Maziar
- Moraga Paula
- Mori Rintaro
- Morozoff Chloe
- Morrison Shane D.
- Moses Mark
- Mountjoy-Venning Cliff
- Mruts Kalayu Birhane
- Mueller Ulrich O.
- Muller Kate
- Murdoch Michele E.
- Murray Christopher J.L.
- Murthy Gudlavalleti Venkata Satyanarayana
- Musa Kamarul Imran
- März Winfried
- Nachega Jean B.
- Nagel Gabriele
- Naghavi Mohsen
- Naheed Aliya
- Naidoo Kovin S.
- Naldi Luigi
- Nangia Vinay
- Natarajan Gopalakrishnan
- Negasa Dumessa Edessa
- Negoi Ionut
- Negoi Ruxandra Irina
- Newton Charles R.
- Ngunjiri Josephine Wanjiku
- Nguyen Cuong Tat
- Nguyen Grant
- Nguyen Minh
- Nguyen Quyen Le
- Nguyen Trang Huyen
- Nichols Emma
- Ningrum Dina Nur Anggraini
- Nolte Sandra
- Nong Vuong Minh
- Norrving Bo
- Noubiap Jean Jacques N.
- O'Donnell Martin J.
- Ogbo Felix Akpojene
- Oh In-Hwan
- Okoro Anselm
- Oladimeji Olanrewaju
- Olagunju Andrew Toyin
- Olagunju Tinuke Oluwasefunmi
- Olsen Helen E.
- Olusanya Bolajoko Olubukunola
- Olusanya Jacob Olusegun
- Ong Kanyin
- Opio John Nelson
- Oren Eyal
- Ortiz Alberto
- Osgood-Zimmerman Aaron
- Osman Majdi
- Owolabi Mayowa O.
- Pa Mahesh
- Pacella Rosana E.
- Pana Adrian
- Panda Basant Kumar
- Papachristou Christina
- Park Eun-Kee
- Parry Charles D.
- Parsaeian Mahboubeh
- Patten Scott B.
- Patton George C.
- Paulson Katherine
- Pearce Neil
- Pereira David M.
- Perico Norberto
- Pesudovs Konrad
- Peterson Carrie Beth
- Petzold Max
- Phillips Michael Robert
- Pigott David M.
- Pillay Julian David
- Pinho Christine
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- Pletcher Martin A.
- Popova Svetlana
- Poulton Richie G.
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- Prabhakaran Dorairaj
- Prasad Narayan
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- Rahimi Kazem
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- Rahimi-Movaghar Vafa
- Rahman Mahfuzar
- Rahman Mohammad Hifz Ur
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- Sahathevan Ramesh
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- Seedat Soraya
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- Shackelford Katya Anne
- Shaheen Amira
- Shaikh Masood Ali
- Shamsipour Mansour
- Shariful Islam Sheikh Mohammed
- Sharma Jayendra
- Sharma Rajesh
- She Jun
- Shi Peilin
- Shields Chloe
- Shigematsu Mika
- Shinohara Yukito
- Shiri Rahman
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- Shirude Shreya
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- Silva João Pedro
- Silveira Dayane Gabriele Alves
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- Sinha Dhirendra Narain
- Skiadaresi Eirini
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- Sobngwi Eugene
- Sorensen Reed J.D.
- Sousa Tatiane Cristina Moraes
- Sposato Luciano A.
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- Srinivasan Vinay
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- Subart Michelle
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- Suliankatchi Abdulkader Rizwan
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- Tekelab Tesfalidet
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- Thrift Amanda G.
- Tiruye Tenaw Yimer
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- Tortajada Miguel
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- Tran Bach Xuan
- Tripathi Suryakant
- Troeger Christopher
- Truelsen Thomas
- Tsoi Derrick
- Tuem Kald Beshir
- Tuzcu Emin Murat
- Tyrovolas Stefanos
- Ukwaja Kingsley N.
- Undurraga Eduardo A.
- Uneke Chigozie Jesse
- Updike Rachel
- Uthman Olalekan A.
- Uzochukwu Benjamin S. Chudi
- Van Boven Job F.M.
- Varughese Santosh
- Vasankari Tommi
- Venkatesh
- Venketasubramanian Narayanaswamy
- Vidavalur Ramesh
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- Weichenthal Scott
- Weiderpass Elisabete
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- Wiysonge Charles Shey
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- Woolf Anthony D.
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- Wulf Hanson Sarah
- Xavier Denis
- Xu Gelin
- Yadgir Simon
- Yaghoubi Mohsen
- Yakob Bereket
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- Yano Yuichiro
- Ye Pengpeng
- Yimam Hassen Hamid
- Yip Paul
- Yonemoto Naohiro
- Yoon Seok-Jun
- Yotebieng Marcel
- Younis Mustafa Z.
- Zaidi Zoubida
- Zaki Maysaa El Sayed
- Zegeye Elias Asfaw
- Zenebe Zerihun Menlkalew
- Zhang Xueying
- Zhou Maigeng
- Zipkin Ben
- Zodpey Sanjay
- Zuhlke Liesl Joanna
- Ärnlöv Johan
- Publication venue
- Publication date
- 01/01/2017
- Field of study
As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016
Effects of interpersonal violence-related post-traumatic stress disorder (PTSD) on mother and child diurnal cortisol rhythm and cortisol reactivity to a laboratory stressor involving separation
- Author
- A.P.A.
- Adolphs
- Alexandre G. Dayer
- Ana Sancho-Rossignol
- Aurelia Manini
- Bader
- Bagby
- Blake
- Bober
- Bright
- Cima
- Cordero
- Crockett
- Daniel S. Schechter
- Dannlowski
- Daskalakis
- De Kloet
- de Kloet
- Debono
- Dominik A. Moser
- Ellsberg
- Essex
- Fernald
- First
- Francesca Suardi
- François Ansermet
- Gold
- Gonul
- Gordon
- Gostisha
- Granger
- Griffin
- Griffin
- Harkness
- Holsboer
- Koenen
- Labonte
- Lagdon
- Largo
- Lehrner
- Loas
- Lyons-Ruth
- MacMillan
- Maddoux
- Maria I. Cordero
- Michel F. Rossier
- Morris
- Moser
- Moser
- Moser
- Ouellet-Morin
- Palma-Gudiel
- Phillips
- Pinto Pereira
- Quaedflieg
- Raffaella Torrisi
- Sancho-Rossignol
- Sandra Rusconi-Serpa
- Sapolsky
- Satyanarayana
- Schechter
- Schechter
- Schechter
- Schechter
- Schechter
- Schechter
- Schulte-Ruther
- Seeman
- Shirtcliff
- Shirtcliff
- Shoal
- Sifneos
- Sturge-Apple
- Symes
- Talge
- Trevillion
- Ventureyra
- Watamura
- Weathers
- Yehuda
- Yehuda
- Yehuda
- Yehuda
- Zeanah
- Zoladz
- Zoladz
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Women who have experienced interpersonal violence (IPV) are at a higher risk to develop posttraumatic stress disorder (PTSD), with dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and impaired social behavior. Previously, we had reported impaired maternal sensitivity and increased difficulty in identifying emotions (i.e. alexithymia) among IPV-PTSD mothers. One of the aims of the present study was to examine maternal IPV-PTSD salivary cortisol levels diurnally and reactive to their child’s distress in relation to maternal alexithymia. Given that mother-child interaction during infancy and early childhood has important long-term consequences on the stress response system, toddlers’ cortisol levels were assessed during the day and in response to a laboratory stressor. Mothers collected their own and their 12-48 month-old toddlers’ salivary samples at home three times: 30 min after waking up, between 2-3 pm and at bedtime. Moreover, mother-child dyads articipated in a 120-min laboratory session, consisting of 3 phases: baseline, stress situation (involving mother-child separation and exposure to novelty) and a 60-min regulation phase. Compared to non-PTSD controls, IPV-PTSD mothers -but not their toddlers-, had lower morning cortisol and higher bedtime cortisol levels. As expected, IPV-PTSD mothers and their children showed blunted cortisol reactivity to the laboratory stressor. Maternal cortisol levels were negatively correlated to difficulty in identifying emotions. Our data highlights PTSDIPV-related alterations in the HPA system and its relevance to maternal behavior. Toddlers of IPV-PTSD mothers also showed an altered pattern of cortisol reactivity to stress that potentially may predispose them to later psychological disorders
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