An Automated Design-flow for FPGA-based Sequential Simulation

In this paper we describe the automated design flow that will transform and map a given homogeneous or heterogeneous hardware design into an FPGA that performs a cycle accurate simulation. The flow replaces the required manually performed transformation and can be embedded in existing standard synthesis flows. Compared to the earlier manually translated designs, this automated flow resulted in a reduced number of FPGA hardware resources and higher simulation frequencies. The implementation of the complete design flow is work in progress.\u

Portable Memory Consistency for Software Managed Distributed Memory in Many-Core SoC

Porting software to different platforms can require modifications of the application. One of the issues is that the targeted hardware supports another memory consistency model. As a consequence, the completion order of reads and writes in a multi-threaded application can change, which may result in improper synchronization. For example, a processor with out-of-order execution could break synchronization if proper fence instructions are missing. Such a bug can cause sporadic errors, which are hard to debug. This paper presents an approach that makes applications independent of the memory model of the hardware, hence they can be compiled to hardware with any memory architecture. The key is having a memory model that only guarantees the most fundamental orderings of reads and writes, and annotations to specify additional ordering constraints. As a result, tooling can transparently and properly implement fences, cache flushes, etc. when appropriate, without losing flexibility of the hardware design. In a case study, several SPLASH-2 applications are run on a 32-core software cache coherent MicroBlaze system in FPGA. Moreover, this approach also allows mapping to scratch-pad memories and a distributed shared memory architecture

Workshop: Praktijklessen uit de Krimpenerwaard Triade : adviezen voor de verdere ontwikkeling en toepassing van de Triade als methode voor locatiespecifieke ecologische risicobeoordeling van bodemverontreiniging

De Triade geldt als een geaccepteerd instrument om de effecten van bodemverontreiniging op het bodemecosysteem te meten. In dit rapport zijn adviezen verwoord voor de verdere ontwikkeling en toepassing van de Triade, als methode om ecologische risico's van bodemverontreiniging te bepalen. Zij zijn gebaseerd op de ervaringen uit het Krimpenerwaard project en de discussies gevoerd in de workshop "Praktijkervaringen met de Krimpenerwaard Triade" op 12 september 200

Clinical characteristics and survival patterns of subsequent sarcoma, breast cancer, and melanoma after childhood cancer in the DCOG-LATER cohort

Purpose Childhood cancer survivors are at increased risk of developing subsequent malignant neoplasms (SMNs). We compared survival and clinical characteristics of survivors with SMNs (sarcoma, breast cancer, or melanoma) an

Fine-Scale Mapping of the 4q24 Locus Identifies Two Independent Loci Associated with Breast Cancer Risk

Background: A recent association study identified a common variant (rs9790517) at 4q24 to be associated with breast cancer risk. Independent association signals and potential functional variants in this locus have not been explored. Methods: We conducted a fine-mapping analysis in 55,540 breast cancer cases and 51,168 controls from the Breast Cancer Association Consortium. Results: Conditional analyses identified two independent association signals among women of European ancestry, represented by rs9790517 [conditional P = 2.51 × 10−4; OR, 1.04; 95% confidence interval (CI), 1.02–1.07] and rs77928427 (P = 1.86 × 10−4; OR, 1.04; 95% CI, 1.02–1.07). Functional annotation using data from the Encyclopedia of DNA Elements (ENCODE) project revealed two putative functional variants, rs62331150 and rs73838678 in linkage disequilibrium (LD) with rs9790517 (r2 ≥ 0.90) residing in the active promoter or enhancer, respectively, of the nearest gene, TET2. Both variants are located in DNase I hypersensitivity and transcription factor–binding sites. Using data from both The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC), we showed that rs62331150 was associated with level of expression of TET2 in breast normal and tumor tissue. Conclusion: Our study identified two independent association signals at 4q24 in relation to breast cancer risk and suggested that observed association in this locus may be mediated through the regulation of TET2. Impact: Fine-mapping study with large sample size warranted for identification of independent loci for breast cancer risk

Duurzaam bodembeheer en ecosysteemdiensten van de bodem: aan de slag

Duurzaam bodembeheer richt zich op de instandhouding van een gezonde en productieve bodem, hier en nu - straks en elders. De mens profiteert van een gezonde bodem via de ecosysteemdiensten, zoals het vermogen om groei van gewassen te ondersteunen, om natuurontwikkeling te ondersteunen, en om het klimaat en onze leefomgeving aangenaam te houden. De bodembeheerder speelt hierbij een cruciale rol via ingrepen die de kwaliteit en de gezondheid van de bodem beïnvloeden, in positieve of in negatieve zin. Onderzoek belicht de relaties tussen bodembeheer en de prestaties van de bode

Morphology of a 19th century industrial city : the Tilburg case

No abstract