Case Study on Intelligent Road Lighting in Foreign Countries under the Background of Smart City

With the development of the city, the relationship between the city and wisdom has become more and more close. In this process, the attention of smart lighting construction has gradually increased, and many cities regard smart lighting as a promotion point for building smart cities. This paper adopts a qualitative research method to explore the typical road smart lighting construction cases in some foreign cities. By analyzing the cases of developing urban smart lighting construction in various countries, it is found that the functions of the transformed smart lighting can play an important role in energy saving, urban security, data collection, and citizen services for cities in various countries. Finally, by further summarizing the main content of its construction, it provides some reference suggestions for the development of smart lighting in my country

Case Study on Intelligent Road Lighting in Foreign Countries Under the Background of Smart City

With the development of the city, the relationship between the city and wisdom has become more and more close. In this process, the attention of smart lighting construction has gradually increased, and many cities regard smart lighting as a promotion point for building smart cities. This paper adopts a qualitative research method to explore the typical road smart lighting construction cases in some foreign cities. By analyzing the cases of developing urban smart lighting construction in various countries, it is found that the functions of the transformed smart lighting can play an important role in energy saving, urban security, data collection, and citizen services for cities in various countries. Finally, by further summarizing the main content of its construction, it provides some reference suggestions for the development of smart lighting in my country

Optimization and Coordination of the Fresh Agricultural Product Supply Chain Considering the Freshness-Keeping Effort and Information Sharing

To solve freshness-keeping problems and analyse a retailer’s information sharing strategies in the fresh agricultural product supply chain (FAPSC), often confronted with challenges in keeping agri-products fresh in an uncertain market, we study an FAPSC via a decentralized mode in which the supplier or retailer exerts the freshness-keeping effort while the retailer decides its information sharing strategies regarding private demand forecasting. We consider a contract coordination mode including three incentive contracts, cost-sharing (cs), revenue-sharing (re) and revenue-and-cost-sharing (rc), to facilitate supply chain coordination. The results show that, as opposed to the case where the supplier takes on the freshness-keeping effort, the optimal freshness-keeping effort level, wholesale price and retail price are not only affected by the retailer’s information sharing strategy but also the freshness-keeping efficiency as the retailer exerts the freshness-keeping effort. Regarding the information sharing strategy, when the freshness-keeping effort is undertaken by the retailer, sharing information sometimes benefits the supplier; however, information sharing is never preferable for the retailer. Consequently, it is necessary to explore the supply chain coordination mode via effective incentive contracts which can improve the supplier and retailer’s profit. We also numerically analyze the effects of freshness-keeping efficiency on equilibrium decisions and expected profits in the decentralized mode, and the effects of the three contract parameters on the expected profits in equilibrium in the coordination mode

Localizing Failure Root Causes in a Microservice through Causality Inference

An increasing number of Internet applications are applying microservice architecture due to its flexibility and clear logic. The stability of microservice is thus vitally important for these applications' quality of service. Accurate failure root cause localization can help operators quickly recover microservice failures and mitigate loss. Although cross-microservice failure root cause localization has been well studied, how to localize failure root causes in a microservice so as to quickly mitigate this microservice has not yet been studied. In this work, we propose a framework, MicroCause, to accurately localize the root cause monitoring indicators in a microservice. MicroCause combines a simple yet effective path condition time series (PCTS) algorithm which accurately captures the sequential relationship of time series data, and a novel temporal cause oriented random walk (TCORW) method integrating the causal relationship, temporal order, and priority information of monitoring data. We evaluate MicroCause based on 86 real-world failure tickets collected from a top tier global online shopping service. Our experiments show that the top 5 accuracy (AC@5) of MicroCause for intra-microservice failure root cause localization is 98.7%, which is greatly higher (by 33.4 %) than the best baseline method

Beneficial Effects of Catalpol Supplementation during In Vitro Maturation of Porcine Cumulus-Oocyte Complexes

Oxidative stress degrades oocytes during in vitro maturation (IVM). Catalpol, a well-known iridoid glycoside, exhibits antioxidant, anti-inflammatory, and antihyperglycemic effects. In this study, catalpol supplementation was tested on porcine oocyte IVM and its mechanisms. Corticalgranule (GC) distribution, mitochondrial function, antioxidant capacity, DNA damage degree, and real-time quantitative polymerase chain reaction were used to confirm the effects of 10 μmol/L catalpol in the maturation medium during IVM. Catalpol treatment significantly increased the first-pole rate and cytoplasmic maturation in mature oocytes. It also increased oocyte glutathione (GSH), mitochondrial membrane potential and blastocyst cell number. However, DNA damage as well as reactive oxygen species (ROS) and malondialdehyde (MDA) levels. Mitochondrial membrane potential and blastocyst cell number were also increased. Thus, the supplementation of 10 μmol/L catalpol in the IVM medium improves porcine oocyte maturation and embryonic development

Signal Transducer and Activator of Transcription 3 Hyperactivation Associates With Follicular Helper T Cell Differentiation and Disease Activity in Rheumatoid Arthritis

Follicular helper T (Tfh) cells are the specialized CD4(+) T cell subset that supports B cells to produce high-affinity antibodies and generate humoral memory Not only is the function of Tfh cells instrumental to mount protect antibodies but also to support autoantibody production and promote systemic inflammation in autoimmune diseases However, it remains unclear how the activation of Tfh cells is driven in autoimmune diseases Here, we report that in patients with rheumatoid arthritis (RA), excessive generation of CXCR5(+)PD-1(+) memory Tfh cells was observed and the frequency of memory Tfh cells correlated with disease activity score calculator for RA (DAS28) The differentiation of Tfh cells is dependent on signal transducer and activator of transcription 3 (STAT3), the key transcription factor downstream of cytokine signal pathways A drastic increase of phosphorylated STAT3 (pSTATS) in CD4(+) T cells were detected in RA patients who also produced larger amounts of STAT3-stimulatmg cytokines, including IL-6, IL-21, IL-10, and leptin than those of healthy controls Importantly, the phosphorylation status of STAT3 in CD4(+) T cells positively correlated with the plasma concentration of IL-6 and the frequency of memory Tfh cells This study reveals an IL 6 pSTAT3 Tfh immunoregulatory axis in the pathogenesis of RA and reinforces its candidature as biomarkers and targets for diagnosis and therapy

Signal Transducer and Activator of Transcription 3 Hyperactivation Associates With Follicular Helper T Cell Differentiation and Disease Activity in Rheumatoid Arthritis

Follicular helper T (Tfh) cells are the specialized CD4+ T cell subset that supports B cells to produce high-affinity antibodies and generate humoral memory. Not only is the function of Tfh cells instrumental to mount protect antibodies but also to support autoantibody production and promote systemic inflammation in autoimmune diseases. However, it remains unclear how the activation of Tfh cells is driven in autoimmune diseases. Here, we report that in patients with rheumatoid arthritis (RA), excessive generation of CXCR5+PD-1+ memory Tfh cells was observed and the frequency of memory Tfh cells correlated with disease activity score calculator for RA (DAS28). The differentiation of Tfh cells is dependent on signal transducer and activator of transcription 3 (STAT3), the key transcription factor downstream of cytokine signal pathways. A drastic increase of phosphorylated STAT3 (pSTAT3) in CD4+ T cells were detected in RA patients who also produced larger amounts of STAT3-stimulating cytokines, including IL-6, IL-21, IL-10, and leptin than those of healthy controls. Importantly, the phosphorylation status of STAT3 in CD4+ T cells positively correlated with the plasma concentration of IL-6 and the frequency of memory Tfh cells. This study reveals an IL-6-pSTAT3-Tfh immunoregulatory axis in the pathogenesis of RA and reinforces its candidature as biomarkers and targets for diagnosis and therapy

data_sheet_1_Signal Transducer and Activator of Transcription 3 Hyperactivation Associates With Follicular Helper T Cell Differentiation and Disease Activity in Rheumatoid Arthritis.PDF

<p>Follicular helper T (Tfh) cells are the specialized CD4⁺ T cell subset that supports B cells to produce high-affinity antibodies and generate humoral memory. Not only is the function of Tfh cells instrumental to mount protect antibodies but also to support autoantibody production and promote systemic inflammation in autoimmune diseases. However, it remains unclear how the activation of Tfh cells is driven in autoimmune diseases. Here, we report that in patients with rheumatoid arthritis (RA), excessive generation of CXCR5⁺PD-1⁺ memory Tfh cells was observed and the frequency of memory Tfh cells correlated with disease activity score calculator for RA (DAS28). The differentiation of Tfh cells is dependent on signal transducer and activator of transcription 3 (STAT3), the key transcription factor downstream of cytokine signal pathways. A drastic increase of phosphorylated STAT3 (pSTAT3) in CD4⁺ T cells were detected in RA patients who also produced larger amounts of STAT3-stimulating cytokines, including IL-6, IL-21, IL-10, and leptin than those of healthy controls. Importantly, the phosphorylation status of STAT3 in CD4⁺ T cells positively correlated with the plasma concentration of IL-6 and the frequency of memory Tfh cells. This study reveals an IL-6-pSTAT3-Tfh immunoregulatory axis in the pathogenesis of RA and reinforces its candidature as biomarkers and targets for diagnosis and therapy.</p