The anxiety of writing : A reading of the Old English "Journey charm"

For my analysis of Journey Charm I am mainly interested in the manuscript, not only as physical evidence of transitional literacy but also in the literal sense of the word of writing by hand. Therefore my focus will be on the scribe's relationship with the charm's speaking subject that is silenced in the process of being written down. By the same token, the entire charm is transformed from spoken words to voiceless signs. Inescapably, a written Journey Charm replaces enchanting activities with a semiotic representation, thus losing some of its original spell.Not

Getting Modern on Alisoun's Ass: The BBC and Chaucer's Miller's Tale

This paper examines the way the BBC adapted Chaucer's Miller's Tale for their 2003 telefilm series of six selected Canterbury Tales. Focusing in particular on the two "bottom scenes”, it will be demonstrated how the BBC translate and adapt these scenes to suit the tastes of the early evening TV spectators by eliminating the most explicit passages found in the medieval source

Corporate Governance and Shareholder Value in Deutschland

Deutschland wird häufig als klassisches Beispiel einer Ökonomie herangezogen, die nicht am Shareholder Value orientiert ist. Die produktionistische, langfristige und auf Konsens gerichtete Orientierung hier wurde oft als Gegenmodell zum „angelsächsischem Ansatz“ herangezogen. Der Einfluss von Aktionären, die am Shareholder Value orientiert sind, und die Bedeutung des Aktienmarktes sind in Deutschland traditionell gering. Es gibt allerdings Anzeichen eines Wandels. In diesem Diskussionspapier beschreiben wir einige dieser Anzeichen und versuchen die Dynamik des Veränderungsprozesses nachzuvollziehen. Wir zeigen auf, dass die begrenzte Bedeutung des Aktienmarktes für die Unternehmensfinanzierung und die Vermögensanlage der privaten Haushalte nur eine sehr schmale Basis für eine Shareholder-Value-Ökonomie in Deutschland schafft. Die tragenden Säulen des deutschen Systems des Corporate Governance – die dominierende Rolle der Banken, das System der Mitbestimmung und das unternehmenszentrierte Managementsystem – bröckeln noch nicht. Veränderungen in Richtung einer verstärkten Shareholder- Value-Orientierung sind deshalb begrenzt. Die Übernahme von Mannesmann durch Vordafone im Frebruar 2000 wurde von vielen Beobachtern als Signal für das Ende der „Deutschland AG“ angesehen. Die Veränderungen in dem deutschen System der Corporate Governance sind damit viel schneller verlaufen, als wir im obigen Paper vermutet haben. In einem Postscript werden daher vor dem Hintergrund der jüngsten Entwicklungen die zentralen Einschätzungen des Papers noch einmal überprüft.The German political economy has often been cited as a classical case of non-shareholder value orientation. Its productionist, long-term, consensus orientation has often been contrasted with the „Anglo-Saxon approach“. The influence of shareholders who press for shareholder value and the importance of the equity market have traditionally been low. But there are signs of change. In this discussion paper we describe some of these changes and try to assess the dynamics of this change process. First we show that the limited role of the equity market for company financing and private household savings still provides a very narrow base for a shareholder value economy in Germany. The central pillars of the German system of corporate governance – the dominating role of banks, the system of co-determination and the company-centred management system – are not crumbling. Change in the direction of shareholder value is therefore limited. The take-over of Mannesmann by Vodafone after a 3-months-battle in February 2000 was regarded as a sign of “the end of the Deutschland AG” by many observers. Thus the change process of the German corporate governance system seems to develop much faster than we thought. In a post-script these assessments shall be revisited from the background of this new development

Corporate Governance and Shareholder Value in Deutschland

Deutschland wird häufig als klassisches Beispiel einer Ökonomie herangezogen, die nicht am Shareholder Value orientiert ist. Die produktionistische, langfristige und auf Konsens gerichtete Orientierung hier wurde oft als Gegenmodell zum „angelsächsischem Ansatz“ herangezogen. Der Einfluss von Aktionären, die am Shareholder Value orientiert sind, und die Bedeutung des Aktienmarktes sind in Deutschland traditionell gering. Es gibt allerdings Anzeichen eines Wandels. In diesem Diskussionspapier beschreiben wir einige dieser Anzeichen und versuchen die Dynamik des Veränderungsprozesses nachzuvollziehen. Wir zeigen auf, dass die begrenzte Bedeutung des Aktienmarktes für die Unternehmensfinanzierung und die Vermögensanlage der privaten Haushalte nur eine sehr schmale Basis für eine Shareholder-Value-Ökonomie in Deutschland schafft. Die tragenden Säulen des deutschen Systems des Corporate Governance – die dominierende Rolle der Banken, das System der Mitbestimmung und das unternehmenszentrierte Managementsystem – bröckeln noch nicht. Veränderungen in Richtung einer verstärkten Shareholder- Value-Orientierung sind deshalb begrenzt. Die Übernahme von Mannesmann durch Vordafone im Frebruar 2000 wurde von vielen Beobachtern als Signal für das Ende der „Deutschland AG“ angesehen. Die Veränderungen in dem deutschen System der Corporate Governance sind damit viel schneller verlaufen, als wir im obigen Paper vermutet haben. In einem Postscript werden daher vor dem Hintergrund der jüngsten Entwicklungen die zentralen Einschätzungen des Papers noch einmal überprüft. -- The German political economy has often been cited as a classical case of non-shareholder value orientation. Its productionist, long-term, consensus orientation has often been contrasted with the „Anglo-Saxon approach“. The influence of shareholders who press for shareholder value and the importance of the equity market have traditionally been low. But there are signs of change. In this discussion paper we describe some of these changes and try to assess the dynamics of this change process. First we show that the limited role of the equity market for company financing and private household savings still provides a very narrow base for a shareholder value economy in Germany. The central pillars of the German system of corporate governance – the dominating role of banks, the system of co-determination and the company-centred management system – are not crumbling. Change in the direction of shareholder value is therefore limited. The take-over of Mannesmann by Vodafone after a 3-months-battle in February 2000 was regarded as a sign of “the end of the Deutschland AG” by many observers. Thus the change process of the German corporate governance system seems to develop much faster than we thought. In a post-script these assessments shall be revisited from the background of this new development.

Corporate Governance and Shareholder Value in Deutschland

"Deutschland wird häufig als klassisches Beispiel einer Ökonomie herangezogen, die nicht am Shareholder Value orientiert ist. Die produktionistische, langfristige und auf Konsens gerichtete Orientierung hier wurde oft als Gegenmodell zum 'angelsächsischem Ansatz' herangezogen. Der Einfluss von Aktionären, die am Shareholder Value orientiert sind, und die Bedeutung des Aktienmarktes sind in Deutschland traditionell gering. Es gibt allerdings Anzeichen eines Wandels. In diesem Diskussionspapier beschreiben wir einige dieser Anzeichen und versuchen die Dynamik des Veränderungsprozesses nachzuvollziehen. Wir zeigen auf, dass die begrenzte Bedeutung des Aktienmarktes für die Unternehmensfinanzierung und die Vermögensanlage der privaten Haushalte nur eine sehr schmale Basis für eine Shareholder-Value-Ökonomie in Deutschland schafft. Die tragenden Säulen des deutschen Systems des Corporate Governance - die dominierende Rolle der Banken, das System der Mitbestimmung und das unternehmenszentrierte Managementsystem - bröckeln noch nicht. Veränderungen in Richtung einer verstärkten Shareholder-Value-Orientierung sind deshalb begrenzt. Die Übernahme von Mannesmann durch Vordafone im Frebruar 2000 wurde von vielen Beobachtern als Signal für das Ende der 'Deutschland AG' angesehen. Die Veränderungen in dem deutschen System der Corporate Governance sind damit viel schneller verlaufen, als wir im obigen Paper vermutet haben. In einem Postscript werden daher vor dem Hintergrund der jüngsten Entwicklungen die zentralen Einschätzungen des Papers noch einmal überprüft." (Autorenreferat)"The German political economy has often been cited as a classical case of non-share-holder value orientation. Its productionist, long-term, consensus orientation has often been contrasted with the 'Anglo-Saxon approach'. The influence of shareholders who press for shareholder value and the importance of the equity market have traditionally been low. But there are signs of change. In this discussion paper we describe some of these changes and try to assess the dynamics of this change process. First we show that the limited role of the equity market for company financing and private household savings still provides a very narrow base for a shareholder value economy in Germany. The central pillars of the German system of corporate governance - the dominating role of banks, the system of co-determination and the company-centred management system - are not crumbling. Change in the direction of shareholder value is therefore limited. The take-over of Mannesmann by Vodafone after a 3-months-battle in February 2000 was regarded as a sign of 'the end of the Deutschland AG' by many observers. Thus the change process of the German corporate governance system seems to develop much faster than we thought. In a post-script these assessments shall be revisited from the background of this new development." (author's abstract

What's behind 68 Ga-PSMA-11 uptake in primary prostate cancer PET? Investigation of histopathological parameters and immunohistochemical PSMA expression patterns

Purpose: Prostate-specific membrane antigen (PSMA-) PET has become a promising tool in staging and restaging of prostate carcinoma (PCa). However, specific primary tumour features might impact accuracy of PSMA-PET for PCa detection. We investigated histopathological parameters and immunohistochemical PSMA expression patterns on radical prostatectomy (RPE) specimens and correlated them to the corresponding 68Ga-PSMA-11-PET examinations. Methods: RPE specimens of 62 patients with preoperative 68Ga-PSMA-11-PET between 2016 and 2018 were analysed. WHO/ISUP grade groups, growth pattern (expansive vs. infiltrative), tumour area and diameter as well as immunohistochemical PSMA heterogeneity, intensity and negative tumour area (PSMA%neg) were correlated with spatially corresponding SUVmax on 68Ga-PSMA-11-PET in a multidisciplinary analysis. Results: All tumours showed medium to strong membranous (2-3 +) and weak to strong cytoplasmic (1-3 +) PSMA expression. Heterogeneously expressed PSMA was found in 38 cases (61%). Twenty-five cases (40%) showed at least 5% and up to 80% PSMA%neg. PSMA%neg, infiltrative growth pattern, smaller tumour area and diameter and WHO/ISUP grade group 2 significantly correlated with lower SUVmax values. A ROC curve analysis revealed 20% PSMA%neg as an optimal cutoff with the highest sensitivity and specificity (89% and 86%, AUC 0.923) for a negative PSMA-PET scan. A multiple logistic regression model revealed tumoural PSMA%neg (p < 0.01, OR = 9.629) and growth pattern (p = 0.0497, OR = 306.537) as significant predictors for a negative PSMA-PET scan. Conclusions: We describe PSMA%neg, infiltrative growth pattern, smaller tumour size and WHO/ISUP grade group 2 as parameters associated with a lower 68Ga-PSMA-11 uptake in prostate cancer. These findings can serve as fundament for future biopsy-based biomarker development to enable an individualized, tumour-adapted imaging approach. Keywords: Glutamate carboxypeptidase II; Immunohistochemistry; Neoplasm staging; Positron emission tomography; Prostatic neoplasm

2018 Proceedings of the International Conference on Trauma Surgery Technology in Giessen

The overarching goal of the gathering was to define a concept for technology design research in Giessen to improve patient outcomes through the design of assistive technology that assists both patients and surgeons. The emerging field of regenerative rehabilitation where trauma patients are treated by methods of regenerative medicine promises great improvements for our field, but clinical success is yet to be realised. The symposium was specifically organised to acknowledge and address these issues

Relationship between magnetic resonance imaging findings and histological grade in spinal peripheral nerve sheath tumors in dogs

BackgroundPeripheral nerve sheath tumors (PNSTs) are a group of neoplasms originating from Schwann cells or pluripotent cell of the neural crest. Therapeutic options and prognosis are influenced by their degree of malignancy and location.Hypothesis/ObjectivesIdentify magnetic resonance imaging (MRI) features predictive of PNST histologic grade.AnimalsForty‐four dogs with histopathological diagnosis of spinal PNSTs and previous MRI investigation.MethodsA multicenter retrospective study including cases with (a) histopathologic diagnosis of PNST and (b) MRI studies available for review. Histologic slides were reviewed and graded by a board‐certified pathologist according to a modified French system (FNCLCC) for grading soft tissue sarcomas. The MRI studies were reviewed by 2 board‐certified radiologists blinded to the grade of the tumor and the final decision on the imaging characteristics was reached by consensus. Relationships between tumor grade and histological and MRI findings were assessed using statistical analysis.ResultsForty‐four cases met inclusion criteria; 16 patients were PNSTs Grade 1 (low‐grade), 19 were PNSTs Grade 2 (medium‐grade), and 9 were PNSTs Grade 3 (high‐grade). Large volume (P = .03) and severe peripheral contrast enhancement (P = .04) were significantly associated with high tumor grade. Degree of muscle atrophy, heterogeneous signal and tumor growth into the vertebral canal were not associated with grade.Conclusions and Clinical ImportanceGrade of malignancy was difficult to identify based on diagnostic imaging alone. However, some MRI features were predictive of high‐grade PNSTs including tumor size and peripheral contrast enhancement

The centrosome neither persistently leads migration nor determines the site of axonogenesis in migrating neurons in vivo

In vivo analysis of subcellular dynamics in the zebrafish cerebellum provides new insights into centrosome positioning during vertebrate brain differentiation

Commissioning of the vacuum system of the KATRIN Main Spectrometer

The KATRIN experiment will probe the neutrino mass by measuring the beta-electron energy spectrum near the endpoint of tritium beta-decay. An integral energy analysis will be performed by an electro-static spectrometer (Main Spectrometer), an ultra-high vacuum vessel with a length of 23.2 m, a volume of 1240 m^3, and a complex inner electrode system with about 120000 individual parts. The strong magnetic field that guides the beta-electrons is provided by super-conducting solenoids at both ends of the spectrometer. Its influence on turbo-molecular pumps and vacuum gauges had to be considered. A system consisting of 6 turbo-molecular pumps and 3 km of non-evaporable getter strips has been deployed and was tested during the commissioning of the spectrometer. In this paper the configuration, the commissioning with bake-out at 300{\deg}C, and the performance of this system are presented in detail. The vacuum system has to maintain a pressure in the 10^{-11} mbar range. It is demonstrated that the performance of the system is already close to these stringent functional requirements for the KATRIN experiment, which will start at the end of 2016.Comment: submitted for publication in JINST, 39 pages, 15 figure