О некоторых аспектах проблемы формирования рынка труда в Украине и в Крыму

В статье дан анализ современного состояния рынка труда в Украине и в Крыму, выявлены причины и особенности безработицы, определены задачи государства в этой связи, предложены мероприятия по их разрешению.Про деякі аспекти проблеми формування ринку праці в Україні і в Криму. У статті даний аналіз сучасного стану ринку праці в Україні й у Криму, виявлено причини й особливості безробіття, визначені завдання держави в цьому зв'язку, запропоновані заходи щодо їхнього вирішення.In article the analysis of a modern condition of a labour market in Ukraine and in Crimea is given, the reasons and features of unemployment are revealed, problems of the state in this connection are determined, actions under their sanction are offered

EGFR Targeted Theranostic Nanoemulsion for Image-Guided Ovarian Cancer Therapy

Platinum-based therapies are the first line treatments for most types of cancer including ovarian cancer. However, their use is associated with dose-limiting toxicities and resistance. We report initial translational studies of a theranostic nanoemulsion loaded with a cisplatin derivative, myrisplatin and pro-apoptotic agent, C6-ceramide

Influence of Different Landuse Management on Soil Biological Properties and other C Fractions under Semi-Arid Benchmark Soils of India: Global Theme on Agroecosystems Report no. 41

Fifty two pedons spread over 28 benchmark spots of Vertisols and Alfisols were studied for soil biological properties and other C fractions (soil microbial biomass c, soil respiration dehydrogenase activity, soil microbial biomass N, mineralizable N, water soluble C and soluble carbohydrates, water stable aggregates, water stable aggregates C, humic and fulvic acid C, etc.) in different systems viz., agricultural, horticultural, forest and wasteland. The agricultural system represents dominant crops namely cereals, soybean and cotton. The horticultural system represents mandarins. The forest systems represent teak and sal. The selections of benchmark spots were limited to a mean annual rainfall range from 1448 to 520 mm in semi-arid tropics. The present experiment was conducted under various bio-climatic condition such as sub-humid moist (>1200 mm), sub-humid dry (1200-100 mm), semiarid dry (1000-850mm), semi-arid moist (850-550 mm) and arid (<550 mm). The active pools of SMBC comprised 3.2 to 5.6 % of SOC in Vertisols and 1.2 to 5.7 % of SOC in Alfisols. WSC comprised 0.80 to14.1 % of SOC in Vertisols and 1.5 to 4.9 % of SOC in Alfisols. WSCarbohydrates comprised 15-40.3 % of SOC in Vertisols and 10.5 to 25 % of SOC in Alfisols. In sub-humid moist regions, the SMBC content followed the order: forest (teak)> soybean-wheat>paddy-wheat>cotton (HM). In sub-humid dry regions of Vertisols, the SMBC was maximum under horticultural system (citrus), followed by intercropping (cotton + pigeonpea) and mango-orchard. In semi-arid moist regions, SMBC and SR were higher under intercropping system (soybean+ pigeon pea) compared to soybean –gram system. The soil biological activity in terms of SMBC, SMBN can be improved with concomitant increase of water-soluble carbon and carbohydrates by better management practices. Among field crops, legume-based intercropping system (soybean + pigeonpea and greengram + pigeonpea) restored higher amount of SOC, SMBC compared to double crop in rotation (soybean-wheat/paddy-paddy cropping system). Among the horticultural-based cropping systems, citrus with high management has better SOC restoration compared to mango orchard. Cotton-based cropping system either as intercropping or sequential cropping registered least improvement of SOC storage. In Vertisols, the percentage of water stable aggregates and concentration of carbon in WSA was higher than Alfisols. Water stable aggregates, carbon concentration increased with decrease in size class. By and large, the maximum concentration of SOC in the water stable aggregates was observed in <0.1 mm size aggregates. In 0-30 cm soil depth, passive fraction of HA-C was relatively higher than FA-C in surface whereas FA-C increased with soil depth. The percent variations in passive fractions among different cropping systems were not pronounced as compared to active and slow pool of C

The functional, social and economic impact of acute encephalitis syndrome in Nepal--a longitudinal follow-up study.

notes: PMCID: PMC3772013Open Access JournalOver 133,000 children present to hospitals with Acute Encephalitis Syndrome (AES) annually in Asia. Japanese encephalitis (JE) accounts for approximately one-quarter of cases; in most cases no pathogen is identified and management is supportive. Although JE is known to result in neurological impairment, few studies have examined the wider impact of JE and AES on patients and their families.Wellcome TrustUniversity of Liverpool Clinical Fellowshi

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN