Effect of wild ungulate density on invertebrates in a Mediterranean ecosystem

Efecto de la densidad de ungulados silvestres sobre los invertebrados en un ecosistema Mediterráneo En las últimas décadas, la abundancia y distribución de determinadas especies de caza mayor, especialmente el ciervo rojo (Cervus elaphus) y el jabalí (Sus scrofa), han aumentado en la zona centromeridional de España como resultado de las estrategias de gestión cinegética. La alta densidad de estas especies de ungulados puede afectar a la abundancia de los invertebrados epigeos. Estudiamos la relación entre la abundancia de las especies de caza mayor y la biodiversidad, la riqueza de taxones, la biomasa de invertebrados y su frecuencia en nueve fincas de caza, y se comparó con las zonas de exclusión de ungulados. De por sí, la exclusión de ungulados afectó a la riqueza de invertebrados, ya que se encontraron valores más bajos en las parcelas abiertas, mientras que las mayores diferencias en la diversidad de invertebrados entre parcelas abiertas y cercadas se encontraron en zonas con una alta densidad de jabalíes. Donde la densidad de jabalíes era alta, el número de invertebrados disminuyó, mientras que donde era baja, el ciervo rojo tuvo un efecto positivo en la abundancia de invertebrados. Así, las parcelas cercadas parecían ofrecer refugio a los invertebrados, sobre todo donde los jabalíes eran abundantes. Este estudio apoya la idea de que las poblaciones con una alta densidad de ungulados perjudican a la estructura de las comunidades faunísticas, probablemente debido a la disminución de la disponibilidad de alimentos como consecuencia del sobrepastoreo, la modificación de las condiciones de los micronichos ecológicos y la depredación directa. Sin embargo, los efectos dependieron del grupo de invertebrados, ya que las especies saprofitas podrían beneficiarse de la alta abundancia de ungulados. Nuestros resultados reflejan la necesidad de controlar la densidad de las poblaciones de ungulados en condiciones mediterráneas en el suroeste de Europa y de establecer parcelas de exclusión de ungulados.In recent decades, the abundance and distribution of certain big game species, particularly red deer (Cervus elaphus) and wild boar (Sus scrofa), have increased in south central Spain as a result of hunting management strategies. The high density of these ungulate species may affect the abundance of epigeous invertebrates. We tested the relationships between big game abundance and biodiversity, taxon richness, the biomass of invertebrates and their frequency on nine hunting estates and in comparison to ungulate exclusion areas. Ungulate exclusion itself affected invertebrate richness, since lower values were found in the open plots, whereas the highest differences in invertebrate diversity between fenced and open plots was found in areas with high wild boar density. Where wild boar densities were high, the number of invertebrates decreased, while where they were low, red deer had a positive effect on invertebrate abundance. Fenced plots thus seemed to provide refuge for invertebrates, particularly where wild boar were abundant. This study supports the idea that the structure of fauna communities is damaged by high density populations of ungulates, probably due to decreased food availability owing to overgrazing, modified conditions of ecological microniches and direct predation. However, the effects depended on the group of invertebrates, since saprophytic species could benefit from high ungulate abundance. Our findings reflect the need to control ungulate population density under Mediterranean conditions in south–western Europe and to implement ungulate exclusion plots.Efecto de la densidad de ungulados silvestres sobre los invertebrados en un ecosistema Mediterráneo En las últimas décadas, la abundancia y distribución de determinadas especies de caza mayor, especialmente el ciervo rojo (Cervus elaphus) y el jabalí (Sus scrofa), han aumentado en la zona centromeridional de España como resultado de las estrategias de gestión cinegética. La alta densidad de estas especies de ungulados puede afectar a la abundancia de los invertebrados epigeos. Estudiamos la relación entre la abundancia de las especies de caza mayor y la biodiversidad, la riqueza de taxones, la biomasa de invertebrados y su frecuencia en nueve fincas de caza, y se comparó con las zonas de exclusión de ungulados. De por sí, la exclusión de ungulados afectó a la riqueza de invertebrados, ya que se encontraron valores más bajos en las parcelas abiertas, mientras que las mayores diferencias en la diversidad de invertebrados entre parcelas abiertas y cercadas se encontraron en zonas con una alta densidad de jabalíes. Donde la densidad de jabalíes era alta, el número de invertebrados disminuyó, mientras que donde era baja, el ciervo rojo tuvo un efecto positivo en la abundancia de invertebrados. Así, las parcelas cercadas parecían ofrecer refugio a los invertebrados, sobre todo donde los jabalíes eran abundantes. Este estudio apoya la idea de que las poblaciones con una alta densidad de ungulados perjudican a la estructura de las comunidades faunísticas, probablemente debido a la disminución de la disponibilidad de alimentos como consecuencia del sobrepastoreo, la modificación de las condiciones de los micronichos ecológicos y la depredación directa. Sin embargo, los efectos dependieron del grupo de invertebrados, ya que las especies saprofitas podrían beneficiarse de la alta abundancia de ungulados. Nuestros resultados reflejan la necesidad de controlar la densidad de las poblaciones de ungulados en condiciones mediterráneas en el suroeste de Europa y de establecer parcelas de exclusión de ungulados

High rabbit abundance proves detrimental to the population growth rate in European rabbit (Oryctolagus cuniculus L.) extensive breeding enclosures

[EN] The European rabbit (Oryctolagus cuniculus L.) is a key prey species in Mediterranean ecosystems that has declined in its natural ranges as a result of diseases and loss of habitat. This situation has led to the production of wild rabbits in enclosures in which they can acclimate and breed. The efficiency of these enclosures as extensive breeding systems is defined by their population growth rate (PGR). The aim of this study is to analyse the effect of rabbit abundance on the PGR. This has been done by creating general linear models to explain autumn and spring PGR with the use of rabbit abundance estimates, enclosure size, aerial predation and previous PGR as possible explanatory variables. Rabbit abundance and enclosure size negatively affected the autumn PGR, while only rabbit abundance affected the spring PGR in the best-fit models. It is suggested that maintaining rabbit densities at fewer than 30 rabbits per hectare might help to optimise the efficiency inside enclosures.L.R.A. was supported by a grant from the University of Córdoba. Our English was reviewed by Sally Newton. This work is funded by the Andalusia Autonomous Environmental Government through a project for the conservation of the Cinereous Vulture in Córdoba province.Ruiz-Aizpurua, L.; Guerrero-Casado, J.; Carpio, AJ.; Tortosa, FS. (2014). High rabbit abundance proves detrimental to the population growth rate in European rabbit (Oryctolagus cuniculus L.) extensive breeding enclosures. World Rabbit Science. 22(3):179-186. doi:10.4995/wrs.2014.1668.SWORD179186223Branco, M., Ferrand, N., & Monnerot, M. (2000). Phylogeography of the European rabbit (Oryctolagus cuniculus) in the Iberian Peninsula inferred from RFLP analysis of the cytochrome b gene. Heredity, 85(4), 307-317. doi:10.1046/j.1365-2540.2000.00756.xBurnham K.P., Anderson D.R. 2002. Model Selection and Multimodel Inference: A Practical Information-Theoretic Approach. 2nd ed. Springer, New York, USA, 488.Junta de Andalucía. 2003. Dehesas de Sierra Morena. Reserva de la Biosfera. Consejería de Medio Ambiente, Junta de Andalucía. Sevilla.Mulero-Mendigorri A. 2013. El paisaje forestal-cinegético en Sierra Morena. Cuadernos Geográficos, 52: 108-128.Redpath S.M., Thirgood S.J. 1997. Birds of prey and red grouse. Stationery Office. London, UK

International longitudinal registry of patients with atrial fibrillation and treated with rivaroxaban: RIVaroxaban Evaluation in Real life setting (RIVER)

Background Real-world data on non-vitamin K oral anticoagulants (NOACs) are essential in determining whether evidence from randomised controlled clinical trials translate into meaningful clinical benefits for patients in everyday practice. RIVER (RIVaroxaban Evaluation in Real life setting) is an ongoing international, prospective registry of patients with newly diagnosed non-valvular atrial fibrillation (NVAF) and at least one investigator-determined risk factor for stroke who received rivaroxaban as an initial treatment for the prevention of thromboembolic stroke. The aim of this paper is to describe the design of the RIVER registry and baseline characteristics of patients with newly diagnosed NVAF who received rivaroxaban as an initial treatment. Methods and results Between January 2014 and June 2017, RIVER investigators recruited 5072 patients at 309 centres in 17 countries. The aim was to enroll consecutive patients at sites where rivaroxaban was already routinely prescribed for stroke prevention. Each patient is being followed up prospectively for a minimum of 2-years. The registry will capture data on the rate and nature of all thromboembolic events (stroke / systemic embolism), bleeding complications, all-cause mortality and other major cardiovascular events as they occur. Data quality is assured through a combination of remote electronic monitoring and onsite monitoring (including source data verification in 10% of cases). Patients were mostly enrolled by cardiologists (n = 3776, 74.6%), by internal medicine specialists 14.2% (n = 718) and by primary care/general practice physicians 8.2% (n = 417). The mean (SD) age of the population was 69.5 (11.0) years, 44.3% were women. Mean (SD) CHADS2 score was 1.9 (1.2) and CHA2DS2-VASc scores was 3.2 (1.6). Almost all patients (98.5%) were prescribed with once daily dose of rivaroxaban, most commonly 20 mg (76.5%) and 15 mg (20.0%) as their initial treatment; 17.9% of patients received concomitant antiplatelet therapy. Most patients enrolled in RIVER met the recommended threshold for AC therapy (86.6% for 2012 ESC Guidelines, and 79.8% of patients according to 2016 ESC Guidelines). Conclusions The RIVER prospective registry will expand our knowledge of how rivaroxaban is prescribed in everyday practice and whether evidence from clinical trials can be translated to the broader cross-section of patients in the real world

EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI) : Study protocol for a multicentre, observational trial

More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369

Effect of wild ungulate density on invertebrates in a Mediterranean ecosystem

In recent decades, the abundance and distribution of certain big game species, particularly red deer (Cervus elaphus) and wild boar (Sus scrofa), have increased in south central Spain as a result of hunting management strategies. The high density of these ungulate species may affect the abundance of epigeous invertebrates. We tested the relationships between big game abundance and biodiversity, taxon richness, the biomass of invertebrates and their frequency on nine hunting estates and in comparison to ungulate exclusion areas. Ungulate exclusion itself affected invertebrate richness, since lower values were found in the open plots, whereas the highest differences in invertebrate diversity between fenced and open plots was found in areas with high wild boar density. Where wild boar densities were high, the number of invertebrates decreased, while where they were low, red deer had a positive effect on invertebrate abundance. Fenced plots thus seemed to provide refuge for invertebrates, particularly where wild boar were abundant. This study supports the idea that the structure of fauna communities is damaged by high density populations of ungulates, probably due to decreased food availability owing to overgrazing, modified conditions of ecological microniches and direct predation. However, the effects depended on the group of invertebrates, since saprophytic species could benefit from high ungulate abundance. Our findings reflect the need to control ungulate population density under Mediterranean conditions in south–western Europe and to implement ungulate exclusion plots

EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI): Study protocol for a multicentre, observational trial

Introduction More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. Methods and analysis EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. Ethics and dissemination EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369.