511 research outputs found
Histogram comparison as a powerful tool for the search of new physics at LHC. Application to CMSSM
We propose a rigorous and effective way to compare experimental and
theoretical histograms, incorporating the different sources of statistical and
systematic uncertainties. This is a useful tool to extract as much information
as possible from the comparison between experimental data with theoretical
simulations, optimizing the chances of identifying New Physics at the LHC. We
illustrate this by showing how a search in the CMSSM parameter space, using
Bayesian techniques, can effectively find the correct values of the CMSSM
parameters by comparing histograms of events with multijets + missing
transverse momentum displayed in the effective-mass variable. The procedure is
in fact very efficient to identify the true supersymmetric model, in the case
supersymmetry is really there and accessible to the LHC
Bayesian approach and Naturalness in MSSM analyses for the LHC
The start of LHC has motivated an effort to determine the relative
probability of the different regions of the MSSM parameter space, taking into
account the present, theoretical and experimental, wisdom about the model.
Since the present experimental data are not powerful enough to select a small
region of the MSSM parameter space, the choice of a judicious prior probability
for the parameters becomes most relevant. Previous studies have proposed
theoretical priors that incorporate some (conventional) measure of the
fine-tuning, to penalize unnatural possibilities. However, we show that such
penalization arises from the Bayesian analysis itself (with no ad hoc
assumptions), upon the marginalization of the mu-parameter. Furthermore the
resulting effective prior contains precisely the Barbieri-Giudice measure,
which is very satisfactory. On the other hand we carry on a rigorous treatment
of the Yukawa couplings, showing in particular that the usual practice of
taking the Yukawas "as required", approximately corresponds to taking
logarithmically flat priors in the Yukawa couplings. Finally, we use an
efficient set of variables to scan the MSSM parameter space, trading in
particular B by tan beta, giving the effective prior in the new parameters.
Beside the numerical results, we give accurate analytic expressions for the
effective priors in all cases. Whatever experimental information one may use in
the future, it is to be weighted by the Bayesian factors worked out here.Comment: LaTeX, 19 pages, 3 figure
Cotilos impactados vs. roscados no cementados: estudio radiológico post-operatorio comparativo
Se han valorado radiografías AP de pelvis obtenidas tras colocación de 102 pró-
tesis no cementadas en 97 pacientes: 51 eran del tipo cótilo roscado (CR), y 51 del tipo cótilo
impactado (CI). Se ha medido el ángulo de inclinación, la posición del cotilo, el grado de centraje,
el grado de protrusión/extrusión, y la superficie de contacto entre cótilo y la cavidad acetabular.
Globahnente los CR quedan implantados más verticalmente que los CI (p=0,006), así como
más lateralizados (p=0,02). El porcentaje de cótilos bien centrados en relación al acetábulo es
mayor entre los CI que entre los CR (p=0,002). Un 19% de los CR quedaron parcialmente extraídos,
no llegando a contactar con el fondo de la cavidad acetabular, mientras que en ningún
caso de los CI se apreció este problema. En conclusión, a pesar de la teórica ventaja de poseer
una estabilidad inicial mayor, la orientación de los CR no resulta tan óptima como la obtenida
con los CI, lo que asegura una estabilidad mejor a largo plazo y una menor usura del polietileno.—Post-operative anteroposterior radiographs of the pelvis in 102 patients receiving
a cementless total hip arthroplasty were analyzed. In a group, a screwed spherical socket
(SCR) was applied, while in other a press-fit impacted socket (IMP) was used. The following parameters
were studied: inclination angle, location and centering of the acetabular component,
degree of protrusion-extrusion, and porcentage of contact surface between the socket and the
acetabulum. SCR sockets appeared to be placed more vertically (p=0.006), and laterally
(p=0.02) than IMP prostheses. The percent of properly centered sockets was higher among
IMP than among SCR implants (p=0.002). SCR prostheses were found to be partly extruded in
19% of cases while none of the IMP prostheses had this problem. In conclussion, despite the
theoretical advantage of the SCR implants having a better initial fixation than the IMP implants,
the latter tend to be implanted in a more optimal position, thus ensuring a better longterm
stability and therefore less wear problems can be expected
Fair scans of the seesaw. Consequences for predictions on LFV processes
Usual analyses based on scans of the seesaw parameter-space can be biassed
since they do not cover in a fair way the complete parameter-space. More
precisely, we show that in the common "R-parametrization", many acceptable
R-matrices, compatible with the perturbativity of Yukawa couplings, are
normally disregarded from the beginning, which produces biasses in the results.
We give a straightforward procedure to scan the space of complex R-matrices in
a complete way, giving a very simple rule to incorporate the perturbativity
requirement as a condition for the entries of the R-matrix, something not
considered before. As a relevant application of this, we show that the extended
believe that BR(mu --> e, gamma) in supersymmetric seesaw models depends
strongly on the value of theta_13 is an "optical effect" produced by such
biassed scans, and does not hold after a careful analytical and numerical
study. When the complete scan is done, BR(mu --> e, gamma) gets very
insensitive to theta_13. Moreover, the values of the branching ratio are
typically larger than those quoted in the literature, due to the large number
of acceptable points in the parameter-space which were not considered before.
Including (unflavoured) leptogenesis does not introduce any further dependence
on theta_13, although decreases the typical value of BR(mu --> e, gamma).Comment: 22 pages, 5 figure
Scavenging Behaviour of Red Deer Cervus elaphus Linnaeus, 1758 (Artiodactyla: Cervidae) in Eastern Spain
A male red deer was repeatedly observed scavenging in eastern Spain. This is the first time this behaviour of the red deer being recorded by means of camera traps. Scavenging behaviour of herbivores may have implications for wildlife biologists and managers
Flat Tree-level Inflationary Potentials in Light of CMB and LSS Data
We use cosmic microwave background and large scale structure data to test a
broad and physically well-motivated class of inflationary models: those with
flat tree-level potentials (typical in supersymmetry). The non-trivial features
of the potential arise from radiative corrections which give a simple
logarithmic dependence on the inflaton field, making the models very
predictive. We also consider a modified scenario with new physics beyond a
certain high-energy cut-off showing up as non-renormalizable operators (NRO) in
the inflaton field. We find that both kinds of models fit remarkably well CMB
and LSS data, with very few free parameters. Besides, a large part of these
models naturally predict a reasonable number of e-folds. A robust feature of
these scenarios is the smallness of tensor perturbations (r < 10^{-3}). The NRO
case can give a sizeable running of the spectral index while achieving a
sufficient number of e-folds. We use Bayesian model comparison tools to assess
the relative performance of the models. We believe that these scenarios can be
considered as a standard physical class of inflationary models, on a similar
footing with monomial potentials.Comment: 42 LaTeX pages, 8 figure
Age and Chronodisruption in Mouse Heart: Effect of the NLRP3 Inflammasome and Melatonin Therapy
Age and age-dependent inflammation are two main risk factors for cardiovascular diseases.
Aging can also affect clock gene-related impairments such as chronodisruption and has been linked
to a decline in melatonin synthesis and aggravation of the NF- B/NLRP3 innate immune response
known as inflammaging. The molecular drivers of these mechanisms remain unknown. This study
investigated the impact of aging and NLRP3 expression on the cardiac circadian system, and the
actions of melatonin as a potential therapy to restore daily rhythms by mitigating inflammaging. We
analyzed the circadian expression and rhythmicity of clock genes in heart tissue of wild-type and
NLRP3-knockout mice at 3, 12, and 24 months of age, with and without melatonin treatment. Our
results support that aging, NLRP3 inflammasome, and melatonin affected the cardiac clock genes
expression, except for Rev-erba, which was not influenced by genotype. Aging caused small phase
changes in Clock, loss of rhythmicity in Per2 and Rora, and mesor dampening of Clock, Bmal1, and
Per2. NLRP3 inflammasome influenced the acrophase of Clock, Per2, and Rora. Melatonin restored the
acrophase and the rhythm of clock genes affected by age or NLRP3 activation. The administration of
melatonin re-established murine cardiac homeostasis by reversing age-associated chronodisruption.
Altogether, these results highlight new findings about the effects aging and NLRP3 inflammasome
have on clock genes in cardiac tissue, pointing to continuous melatonin as a promising therapy to
placate inflammaging and restore circadian rhythm in heart muscle. Additionally, light microscopy
analysis showed age-related morphological impairments in cardiomyocytes, which were less severe
in mice lacking NLRP3. Melatonin supplementation preserved the structure of cardiac muscle fibers
in all experimental groups.Instituto de Salud Carlos III (Ministerio de Economia y Competitividad, Spain) (European Regional Development Fund/European Social Fund "Investing in your future") PI13-981
PI16-00519
PI19-01372
CB16-10-00238
CB16/10/00239Junta de Andalucia CTS-101Spanish Governmen
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