472 research outputs found
Spitzer IRAC Low Surface Brightness Observations of the Virgo Cluster
We present 3.6 and 4.5 micron Spitzer IRAC imaging over 0.77 square degrees
at the Virgo cluster core for the purpose of understanding the formation
mechanisms of the low surface brightness intracluster light features.
Instrumental and astrophysical backgrounds that are hundreds of times higher
than the signal were carefully characterized and removed. We examine both
intracluster light plumes as well as the outer halo of the giant elliptical
M87. For two intracluster light plumes, we use optical colors to constrain
their ages to be greater than 3 & 5 Gyr, respectively. Upper limits on the IRAC
fluxes constrain the upper limits to the masses, and optical detections
constrain the lower limits to the masses. In this first measurement of mass of
intracluster light plumes we find masses in the range of 5.5 x 10^8 - 4.5 x
10^9 and 2.1 x 10^8 - 1.5 x 10^9 solar masses for the two plumes for which we
have coverage. Given their expected short lifetimes, and a constant production
rate for these types of streams, integrated over Virgo's lifetime, they can
account for the total ICL content of the cluster implying that we do not need
to invoke ICL formation mechanisms other than gravitational mechanisms leading
to bright plumes. We also examined the outer halo of the giant elliptical M87.
The color profile from the inner to outer halo of M87 (160 Kpc) is consistent
with either a flat or optically blue gradient, where a blue gradient could be
due to younger or lower metallicity stars at larger radii. The similarity of
the age predicted by both the infrared and optical colors (> few Gyr) indicates
that the optical measurements are not strongly affected by dust extinction.Comment: 16 pages including appendix, 9 figures, ApJ accepte
The outer halos of elliptical galaxies
Recent progress is summarized on the determination of the density
distributions of stars and dark matter, stellar kinematics, and stellar
population properties, in the extended, low surface brightness halo regions of
elliptical galaxies. With integral field absorption spectroscopy and with
planetary nebulae as tracers, velocity dispersion and rotation profiles have
been followed to ~4 and ~5-8 effective radii, respectively, and in M87 to the
outer edge at ~150 kpc. The results are generally consistent with the known
dichotomy of elliptical galaxy types, but some galaxies show more complex
rotation profiles in their halos and there is a higher incidence of
misalignments, indicating triaxiality. Dynamical models have shown a range of
slopes for the total mass profiles, and that the inner dark matter densities in
ellipticals are higher than in spiral galaxies, indicating earlier assembly
redshifts. Analysis of the hot X-ray emitting gas in X-ray bright ellipticals
and comparison with dynamical mass determinations indicates that non-thermal
components to the pressure may be important in the inner ~10 kpc, and that the
properties of these systems are closely related to their group environments.
First results on the outer halo stellar population properties do not yet give a
clear picture. In the halo of one bright galaxy, lower [alpha/Fe] abundances
indicate longer star formation histories pointing towards late accretion of the
halo. This is consistent with independent evidence for on-going accretion, and
suggests a connection to the observed size evolution of elliptical galaxies
with redshift.Comment: 8 pages. Invited review to appear in the proceedings of "Galaxies and
their Masks" eds. Block, D.L., Freeman, K.C. & Puerari, I., 2010, Springer
(New York
The merger history, AGN and dwarf galaxies of Hickson Compact Group 59
Compact group galaxies often appear unaffected by their unusually dense
environment. Closer examination can, however, reveal the subtle, cumulative
effects of multiple galaxy interactions. Hickson Compact Group (HCG) 59 is an
excellent example of this situation. We present a photometric study of this
group in the optical (HST), infrared (Spitzer) and X-ray (Chandra) regimes
aimed at characterizing the star formation and nuclear activity in its
constituent galaxies and intra-group medium. We associate five dwarf galaxies
with the group and update the velocity dispersion, leading to an increase in
the dynamical mass of the group of up to a factor of 10 (to 2.8e13 Msun), and a
subsequent revision of its evolutionary stage. Star formation is proceeding at
a level consistent with the morphological types of the four main galaxies, of
which two are star-forming and the other two quiescent. Unlike in some other
compact groups, star-forming complexes across HCG 59 closely follow mass-radius
scaling relations typical of nearby galaxies. In contrast, the ancient globular
cluster populations in galaxies HCG 59A and B show intriguing irregularities,
and two extragalactic HII regions are found just west of B. We age-date a faint
stellar stream in the intra-group medium at ~1 Gyr to examine recent
interactions. We detect a likely low-luminosity AGN in HCG 59A by its ~10e40
erg/s X-ray emission; the active nucleus rather than star formation can account
for the UV+IR SED. We discuss the implications of our findings in the context
of galaxy evolution in dense environments.Comment: 38 pages, 17 figures. Please visit "http://tinyurl.com/isk-hcg59" for
a full-resolution PDF. Accepted for publication in the Astrophysical Journa
Excessive Biologic Response to IFNβ Is Associated with Poor Treatment Response in Patients with Multiple Sclerosis
Interferon-beta (IFNβ) is used to inhibit disease activity in multiple sclerosis (MS), but its mechanisms of action are incompletely understood, individual treatment response varies, and biological markers predicting response to treatment have yet to be identified.he relationship between the molecular response to IFNβ and treatment response was determined in 85 patients using a longitudinal design in which treatment effect was categorized by brain magnetic resonance imaging as good (n = 70) or poor response (n = 15). Molecular response was quantified using a customized cDNA macroarray assay for 166 IFN-regulated genes (IRGs).The molecular response to IFNβ differed significantly between patients in the pattern and number of regulated genes. The molecular response was strikingly stable for individuals for as long as 24 months, however, suggesting an individual ‘IFN response fingerprint’. Unexpectedly, patients with poor response showed an exaggerated molecular response. IRG induction ratios demonstrated an exaggerated molecular response at both the first and 6-month IFNβ injections.MS patients exhibit individually unique but temporally stable biological responses to IFNβ. Poor treatment response is not explained by the duration of biological effects or the specific genes induced. Rather, individuals with poor treatment response have a generally exaggerated biological response to type 1 IFN injections. We hypothesize that the molecular response to type I IFN identifies a pathogenetically distinct subset of MS patients whose disease is driven in part by innate immunity. The findings suggest a strategy for biologically based, rational use of IFNβ for individual MS patients
Acute pancreatitis following medical abortion: Case report
BACKGROUND: Acute pancreatitis rarely complicates pregnancy. Although most pregnant women with acute pancreatitis have associated gallstones, less common causes such as drugs have been reported. CASE PRESENTATION: We report the case of a 34-year-old woman who underwent medical abortion with mifepristone and gemeprost and received codeine as pain-relief during the induction of abortion. She developed a severe acute necrotizing pancreatitis which required 14 days of intensive care. Other possible etiological factors, i.e. gallstone, alcohol intake and hyperlipidemia, were excluded. CONCLUSIONS: The reported case of acute pancreatitis was most likely drug-induced
Industrial methodology for process verification in research (IMPROVER): toward systems biology verification
Motivation: Analyses and algorithmic predictions based on high-throughput data are essential for the success of systems biology in academic and industrial settings. Organizations, such as companies and academic consortia, conduct large multi-year scientific studies that entail the collection and analysis of thousands of individual experiments, often over many physical sites and with internal and outsourced components. To extract maximum value, the interested parties need to verify the accuracy and reproducibility of data and methods before the initiation of such large multi-year studies. However, systematic and well-established verification procedures do not exist for automated collection and analysis workflows in systems biology which could lead to inaccurate conclusions
Switching Multiple Sclerosis Patients with Breakthrough Disease to Second-Line Therapy
BACKGROUND: Multiple sclerosis (MS) patients with breakthrough disease on immunomodulatory drugs are frequently offered to switch to natalizumab or immunosuppressants. The effect of natalizumab monotherapy in patients with breakthrough disease is unknown. METHODS: This is an open-label retrospective cohort study of 993 patients seen at least four times at the University of California San Francisco MS Center, 95 had breakthrough disease on first-line therapy (60 patients switched to natalizumab, 22 to immunosuppressants and 13 declined the switch [non-switchers]). We used Poisson regression adjusted for potential confounders to compare the relapse rate within and across groups before and after the switch. RESULTS: In the within-group analyses, the relapse rate decreased by 70% (95% CI 50,82%; p<0.001) in switchers to natalizumab and by 77% (95% CI 59,87%; p<0.001) in switchers to immunosuppressants; relapse rate in non-switchers did not decrease (6%, p = 0.87). Relative to the reduction among non-switchers, the relapse rate was reduced by 68% among natalizumab switchers (95% CI 19,87%; p = 0.017) and by 76% among the immunosuppressant switchers (95% CI 36,91%; p = 0.004). CONCLUSIONS: Switching to natalizumab or immunosuppressants in patients with breakthrough disease is effective in reducing clinical activity of relapsing MS. The magnitude of the effect and the risk-benefit ratio should be evaluated in randomized clinical trials and prospective cohort studies
Cost of managing an episode of relapse in multiple sclerosis in the United States
BACKGROUND: The purpose of this study was to determine the direct medical US cost of managing multiple sclerosis relapses. METHODS: Direct data analysis and cost modeling were employed to derive typical resource use profiles and costs in 2002 US dollars, from the perspective of a third-party payer responsible for comprehensive health-care. The location and scope of health care services provided over a 90-day period were used to define three levels of relapse management. Hospitalization and resulting subsequent care was defined as high intensity management. A medium level of intervention was defined as either use of the emergency room, an observational unit, or administration of acute treatments, such as intravenous methylprednisolone in an outpatient or home setting. The lowest intensity of care comprised physician office visits and symptom-related medications. Data were obtained from many sources including all payer inpatient, ambulatory and emergency room databases from several states, fee schedules, government reports, and literature. All charges were adjusted using cost-to-charge ratios. RESULTS: Average cost per person for high management level was 1,847 and mild episode $243. CONCLUSIONS: Management strategies leading to a reduction in the frequency and severity of a relapse, less reliance on inpatient care, or increased access to steroid infusions in the home, would have a substantial impact on the economic consequences of managing relapses
Metal enrichment processes
There are many processes that can transport gas from the galaxies to their
environment and enrich the environment in this way with metals. These metal
enrichment processes have a large influence on the evolution of both the
galaxies and their environment. Various processes can contribute to the gas
transfer: ram-pressure stripping, galactic winds, AGN outflows, galaxy-galaxy
interactions and others. We review their observational evidence, corresponding
simulations, their efficiencies, and their time scales as far as they are known
to date. It seems that all processes can contribute to the enrichment. There is
not a single process that always dominates the enrichment, because the
efficiencies of the processes vary strongly with galaxy and environmental
properties.Comment: 18 pages, 8 figures, accepted for publication in Space Science
Reviews, special issue "Clusters of galaxies: beyond the thermal view",
Editor J.S. Kaastra, Chapter 17; work done by an international team at the
International Space Science Institute (ISSI), Bern, organised by J.S.
Kaastra, A.M. Bykov, S. Schindler & J.A.M. Bleeke
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