Mind-mapping for interdisciplinary sustainable architecture

Teaching Sustainability is a complex and demanding task requiring a multidisciplinary approach as is clearly demonstrated by the world focus on the UN Sustainable Development Goals (and specially goal 11: Make cities inclusive, safe, resilient and sustainable). The flipped classroom methodology facilitates the necessary discussion for embedding different points of view on the learning process. In this way students can effectively receive out-of-class and in-class opportunities to promote personal learning. However, structuring the huge amount of information handled is a very difficult tasks for students. In order to develop students’ learner autonomy or develop high-level thinking skills to achieve the learning competencies embedded on an Interdisciplinary Sustainable Architecture (ISA) curriculum, the use of mind-mapping learning strategy is known an effective knowledge construction tool for helping students’ organizational thinking. Beyond this fact, many previous studies have considered peer assessment as an effective learning strategy to provide students with a teacher’s perspective view to think and evaluate knowledge acquisition. This research presents relevant results on the use of mind-maps with an online peer assessment approach. This tool is embedded as a key element for structuring Sustainability Assessment knowledge within a course based on the flipped teaching methodology. Moreover, an experiment has been conducted to evaluate the advantages and disadvantages of the proposed approach on students’ learning analytics such as time involvement and learning reflections. It is important that educators use an online peer assessment learning environment for learners and aim for the goals to help learners become more critical, independent, and autonomous in the development of any Sustainability curriculum

Mixed-matrix membranes

Article In Press title was: New directions for mixed-matrix membranes. Also published in German in Angewandte Chemie, 2017; 129(32):9420-9439.Research into extended porous materials such as metal-organic frameworks (MOFs) and porous organic frameworks (POFs), and their molecular analogues, metal-organic polyhedra (MOPs) and porous organic cages (POCs), has blossomed over the last decade. Given their chemical and structural mutability and notable porosity, MOFs have been proposed as novel adsorbents for industrial gas separations. In this context they have also been identified as promising filler components for high-performance mixed matrix membranes (MMMs). Research in this area has focused on enhancing the chemical compatibility between the MOF and polymer phase by judiciously functionalising the organic linkers of the MOF, modifying the MOF surface chemistry and, more recently, exploring how particle size, morphology and distribution enhance separation performance. Other filler materials, including POFs, MOPs and POCs, are also being explored as additives for MMMs and have shown, unexpectedly, remarkable anti-aging performance and excellent chemical compatibility for commercially available polymers. This review briefly outlines the state-of-the-art in MOF-MMM fabrication, and the more recent use of porous organic frameworks and molecular additives for MMMs.Janina Dechnik, Jorge Gascon, Christian J. Doonan, Christoph Janiak and Christopher J. Sumb

What is your diagnosis?

No abstract available.http://avmajournals.avma.org/loi/javmamn201

Surgical stabilization of shoulder luxation in a pot-bellied pig

CASE DESCRIPTION—A 4.6-month-old pot-bellied pig was evaluated because of non–weightbearing lameness (grade 5/5) in the right forelimb of 4 days’ duration. CLINICAL FINDINGS—Clinical and radiographic examination revealed a closed, lateral luxation of the right shoulder joint. TREATMENT AND OUTCOME—Initial attempts at closed reduction failed to provide adequate stability of the shoulder joint. Open reduction and internal fixation by placement of 2 lateral tension sutures with a system designed for canine cranial cruciate ligament repair provided adequate joint stability and a successful outcome. CONCLUSIONS AND CLINICAL RELEVANCE—Stabilization of the shoulder joint with lateral tension sutures after open reduction should be considered for management of lateral shoulder luxation in pot-bellied pigs.http://avmajournals.avma.org/loi/javmaam2013mn2013mn201

Advances for Treating in-Hospital Cardiac Arrest: Safety and Effectiveness of a New Automatic External Cardioverter-Defibrillator

OBJECTIVES: The purpose of this study was to prospectively analyze the performance and safety of a new programmable, fully automatic external cardioverter-defibrillator (AECD) in a European multicenter trial. BACKGROUND Although, the response time to cardiac arrest (CA) is a major determinant of mortality and morbidity, in-hospital strategies have not significantly changed during the last 30 years. METHODS: Patients (n = 117) at risk of CA in monitored wards (n = 51) and patients undergoing electrophysiologic testing or implantable cardioverter-defibrillator (ICD) implantation (n = 66) were enrolled. The accuracy of the automatic response of the device to any change of rhythm (lasting >1 s and >4 beats) was confirmed by reviewing the simultaneously recorded Holter data and the programmed parameters. RESULTS: During 1,240 h, 1,988 episodes of rhythm changes were documented. A total of 115 episodes lasted > or =10 s or needed treatment (pacing, n = 32; ICD, n = 51; AECD, n = 35) for termination. The device detected ventricular tachyarrhythmias with a sensitivity of 100% and specificity of 97.6% (true negatives, n = 1,454; true positives, n = 499; false positives, n = 35; false negatives, n = 0). The false positives were all caused by T-wave oversensing during ventricular pacing. There were no complications or adverse events. The mean response time was 14.4 s for those episodes needing a full charge of the capacitor. CONCLUSIONS: This new AECD is safe and effective in detecting, monitoring, and treating spontaneous arrhythmias. This fully automatic device shortens the response time to treatment, and it is likely that it will significantly improve the outcome of patients with in-hospital CA

p53 Aberrations do not predict individual response to fludarabine in patients with B-cell chronic lymphocytic leukaemia in advanced stages Rai III/IV

Abnormalities of p53 have been associated with short survival and non-response to therapy in chronic lymphocytic leukaemia (CLL). We have evaluated the rate of response to fludarabine as first-line therapy in 54 patients with advanced stage CLL, analysing the cytogenetic profile, aberrations in p53, including the methylation status of its promoter, and the immunoglobulin heavy-chain variable-region (IGVH) mutation status. According to the advanced stage of the disease in this series, 75% of patients presented genetic aberrations associated with poor prognosis: del(17p) and/or del(11q), and no-mutated IGVH genes. Ten patients (18.5%) had methylation in the promoter region of p53. Eighty-three per cent of patients treated achieved a response, with a high rate of complete remission (47.6%). Although we found a significant correlation between failures and the presence of p53 aberrations (P = 0.0065), either with methylation (P = 0.018) or deletion (P = 0.015), 64% of the patients with aberrations in this gene responded to treatment (11/17), suggesting that fludarabine induces high remission rates, even in these patients. This is the first time that the significance of p53 promoter methylation status is described in this pathology, and our data support that this epigenetic phenomenon could be involved in the pathogenesis and clinical evolution of CLL

Acute Effects of Work Rest Interval Duration of 3 HIIT Protocols on Cycling Power in Trained Young Adults

High-Intensity Interval Training (HIIT) is described as a succession of short duration and maximum or near-maximum intensity efforts, alternated by recovery periods during which exercise continues at a lower intensity (active recovery) or is interrupted (passive recovery). Our objective was to evaluate the acute responses of three HIIT protocols of different work/rest interval times over the total time of the session, with self-selectable load and up to exhaustion, “all out”.The sample was composed of 22 male participants (n = 22) between 19 and 24 years old. The HIIT protocol consisted of one of the three HIIT protocols, of 30, 60 and 90 s density ratio 1:1 and with passive rest, with a total exercise duration of 10 min. The test was performed in a cycloergometer set in workload mode independent of the pedaling frequency. The comparison of the three HIIT protocols shows that the duration of the work/rest intervals, starting from 30 s of work, in the cycloergometer, there are no significant differences in the levels of lactate concentration in the blood, nor in the heart rate, since a similar amount is obtained in the three protocols. The percentage of maximum power developed reached in each HIIT protocol is related to the duration of the working intervals

Integrative Oncogenomic Analysis of Microarray Data in Hematologic Malignancies

During the last decade, gene expression microarrays and array-based comparative genomic hybridization (array-CGH) have unraveled the complexity of human tumor genomes more precisely and comprehensively than ever before. More recently, the simultaneous assessment of global changes in messenger RNA (mRNA) expression and in DNA copy number through "integrative oncogenomic" analyses has allowed researchers the access to results uncovered through the analysis of one-dimensional data sets, thus accelerating cancer gene discovery. In this chapter, we discuss the major contributions of DNA microarrays to the study of hematological malignancies, focusing on the integrative oncogenomic approaches that correlate genomic and transcriptomic data. We also present the basic aspects of these methodologies and their present and future application in clinical oncology