Wireless RF camera monitoring for underwater cooperative robotic archaeological applications

The increasing demand for underwater robotic intervention systems around the world in several application domains requires of more versatile and inexpensive systems. One example of such applications is the archaeology, where experimented divers study and reconstruct the history, recovering key objects in order to classify and preserve them properly. Moreover, this task is especially dangerous at deeps below 50 meters, where the archaeologist needs more sophisticated diving equipment and degree of experience due to high risk to which it is exposed caused by possible decompression situations. The use of supervised semi-autonomous robots can help to this task. To achieve this goal, a wireless communication system can provide freedom of movements to the robot and, at the same time, will allow the operator to get camera feedback and supervise the intervention.Peer Reviewe

Underwater Wireless Vision System Using Progressive Image Compression and Region of Interest

[ES] La creciente demanda en todo el mundo de sistemas de intervención submarina en diversos dominios de aplicación requiere sistemas más versátiles y económicos. Empleando un sistema de comunicación inalámbrica, los robots semiautónomos supervisados disponen de libertad de movimientos y, al mismo tiempo, permiten al operador obtener información visual y supervisar la intervención. Por otro lado, la velocidad de transmisión de datos típica de los canales inalámbricos submarinos es, en general, muy limitada, siendo necesaria la aplicación de técnicas de compresión avanzadas. En este artículo se presenta principalmente el algoritmo DEBT (Depth Embedded Block Tree) para la compresión progresiva de imágenes con región de interés (ROI). Los resultados demuestran ventajas con respecto a otros algoritmos de compresión, y la posibilidad de ejecución del algoritmo en tiempo real en ordenadores embebidos de bajo consumo basados en ARM.[EN] The increasing demand for underwater robotic intervention systems around the world in several application domains requires more versatile and inexpensive systems. By using a wireless communication system, supervised semi-autonomous robots have freedom of movement and, at the same time, allows the operator to get camera feedback and supervise the intervention. On the otherhand, the typical data rate of the wireless submarine channels is generally very limited, requiring the application of advanced compression techniques. In this paper we present the DEBT (Depth Embedded Block Tree) algorithm for the progressive compressionof images with region of interest (ROI). The results demonstrate advantages with other compression algorithms, and the possibilityof executing the algorithm in real time on ARM-based embedded low-power computers.Este trabajo ha sido parcialmente financiado por el Ministerio de Economía y competitividad, código de proyecto DPI2014-57746-C3 (proyecto MERBOTS), por la Generalitat Valenciana GVA, con el código de proyecto PROMETEO/2016/066 y por la Universidad Jaume I, proyecto MASUMIA (P1-1B2015-68), becas PREDOC/2012/47, PREDOC/2013/46, y por el CNPq del Brasil.Rubino, EM.; Centelles, D.; Sales, J.; Martí, JV.; Marín, R.; Alvares, AJ.; Sanz, PJ. (2017). Sistema de Visión Subacuático Inalámbrico Usando un Algoritmo de Compresión Progresivo con Región de Interés. Revista Iberoamericana de Automática e Informática industrial. 15(1):46-57. https://doi.org/10.4995/riai.2017.8953OJS4657151Adams, M., Kossentini, F., Sept 2000. Jasper: a software-based JPEG-2000 codec implementation. In: Image Processing, 2000. 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Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Funder: Funder: Fundación bancaria ‘La Caixa’ Number: LCF/PR/PR16/51110003 Funder: Grifols SA Number: LCF/PR/PR16/51110003 Funder: European Union/EFPIA Innovative Medicines Initiative Joint Number: 115975 Funder: JPco-fuND FP-829-029 Number: 733051061Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues