Instellar grains within interstellar grains

The discovery of crystals of titanium carbide in an interstellar graphite spherule is reported. The new species is particularly interesting in that it came in a protective wrapping (the graphite spherule) which eliminated the possibility of chemical alteration during its residence in the interstellar medium and in the meteorite in which it was discovered

Metacognition of First Year Occupational Therapy Students: A Comparison of Entry-Level Degrees

The purpose of this study was to compare the metacognitive awareness among first year students in entry-level occupational therapy programs. The study investigated the similarities and differences in awareness of cognition and strategies used to regulate cognition in occupational therapy assistant (OTA), Master of Occupational Therapy (MOT), and Occupational Therapy Doctorate (OTD) programs to inform teaching practices for the different educational demands and expected outcomes of each program. Thirty occupational therapy students (11 OTA, 10 MOT, and 9 OTD) completed the Metacognitive Awareness Inventory (MAI) during their first semester of occupational therapy courses at two universities. Overall, the results indicated the student reported use of metacognitive strategies was more similar than dissimilar among the three entry-level programs. Additionally, MAI responses were not predictive of course grades. Instructors can design educational experiences to tap into the metacognition of the student, promoting effective and efficient learning to meet the high educational standards required for our profession. Students who are effective and efficient learners will be more prepared to meet the demands of a complex healthcare environment in their respective practitioner roles

Activated polyhydroxyalkanoate meshes prevent bacterial adhesion and biofilm development in regenerative medicine applications

Regenerative medicine has become an extremely valuable tool offering an alternative to conventional therapies for the repair and regeneration of tissues. The re-establishment of tissue and organ functions can be carried out by tissue engineering strategies or by using medical devices such as implants. However, with any material being implanted inside the human body, one of the conundrums that remains is the ease with which these materials can get contaminated by bacteria. Bacterial adhesion leads to the formation of mature, alive and complex three-dimensional biofilm structures, further infection of surrounding tissues and consequent development of complicated chronic infections. Hence, novel tissue engineering strategies delivering biofilm-targeted therapies, while at the same time allowing tissue formation are highly relevant. In this study our aim was to develop surface modified polyhydroxyalkanoate-based fiber meshes with enhanced bacterial anti-adhesive and juvenile biofilm disrupting properties for tissue regeneration purposes. Using reactive and amphiphilic star-shaped macromolecules as an additive to a polyhydroxyalkanoate spinning solution, a synthetic antimicrobial peptide, Amhelin, with strong bactericidal and anti-biofilm properties, and Dispersin B, an enzyme promoting the disruption of exopolysaccharides found in the biofilm matrix, were covalently conjugated to the fibers by addition to the solution before the spinning process. Staphylococcus epidermidis is one of the most problematic pathogens responsible for tissue-related infections. The initial antibacterial screening showed that Amhelin proved to be strongly bactericidal at 12 μg/ml and caused >50% reductions of biofilm formation at 6 μg/ml, while Dispersin B was found to disperse >70% of pre-formed biofilms at 3 μg/ml. Regarding the cytotoxicity of the agents toward L929 murine fibroblasts, a CC50 of 140 and 115 μg/ml was measured for Amhelin and Dispersin B, respectively. Optimization of the electrospinning process resulted in aligned fibers. Surface activated fibers with Amhelin and Dispersin B resulted in 83% reduction of adhered bacteria on the surface of the fibers. Additionally, the materials developed were found to be cytocompatible toward L929 murine fibroblasts. The strategy reported in this preliminary study suggests an alternative approach to prevent bacterial adhesion and, in turn biofilm formation, in materials used in regenerative medicine applications such as tissue engineering

Presolar SIC Grains of Type Y: Origin from Low-Metallicity Asymptotic Giant Branch Stars

We report isotopic data for 27 presolar SiC grains of the rare subtype Y in an acid-resistant residue of the Murchison (CM2) meteorite. Presolar SiC grains of type Y constitute only ~1% of Murchison SiC grains larger than ~2 μm and are defined as having 12C/13C > 100 (solar = 89) and 14N/15N > 272 (solar). In a Si 3-isotope plot, their Si isotopic compositions plot to the right of the correlation line defined by the majority of presolar SiC grains (the mainstream population), whose isotopic compositions indicate an origin in C-rich asymptotic giant branch (AGB) stars of near-solar metallicity. Because of their low abundance, the new Y grains were identified by automatic isotopic imaging of the 12C/13C ratio in the ion microprobe. We report C, N, and Si isotopic ratios of all 27 grains, inferred initial 26Al/27Al ratios of 18, and Ti isotopic ratios of 20 grains. Whereas 14N/15N and 26Al/27Al ratios exhibit the same range as mainstream grains, the C, Si, and Ti isotopic ratios are distinct. Carbon-12/carbon-13 ratios range up to 295 and 30Si/28Si excesses up to 183‰ relative to solar. The average 29Si/28Si ratio of Y grains is by 59‰ smaller than that of mainstream grains. Ti isotopic ratios relative to 48Ti are somewhat similar to those of mainstream grains, but extend to more extreme anomalous compositions. One grain has 46Ti/48Ti, 49Ti/48Ti, and 50Ti/48Ti excesses of 183‰, 365‰, and 990‰, respectively, relative to solar. These features exhibited by Y grains point to an origin in AGB stars of somewhat lower than solar metallicity. In the envelope of such stars the proportion of 12C and s-processed material dredged up from deep zones that experienced partial He burning and was mixed with original material is higher than in stars of solar metallicity. Their envelopes are therefore expected to have larger 12C/13C, 30Si/28Si, and 49Ti/48Ti and 50Ti/48Ti ratios than mainstream grains. We compare the C, Si, and Ti isotopic compositions of Y grains with the results of theoretical models of AGB stars with 1.5, 3, and 5 M☉ and Z = 0.006, 0.01, and 0.02. While solar-metallicity (Z = 0.02) AGB models cannot account for the Y grain data, the models with Z = 0.01 can reproduce the measured isotopic compositions reasonably well. A range of stellar masses (from 1.5 M☉ possibly up to 5 M☉) is indicated by the grain data. The present study together with additional data on SiC grains of type Z furthermore indicate that the rate of change of the ratios of the secondary Si isotopes (29Si and 30Si) relative to 28Si prior to solar system formation was lower than has been generally assumed, implying larger contributions of 28Si from Type Ia supernovae compared to those from Type II supernovae. The Si isotopic ratios of Galactic cosmic rays also suggest such an evolution

Constraints on stellar grain formation from presolar graphite in the murchison meteorite

We report the results of isotopic, chemical, structural, and crystallographic microanalyses of graphitic spherules (0.3-9 μm) extracted from the Murchison meteorite. The spherules have 12C/13C ratios ranging over 3 orders of magnitude (from 0.02 to 80 times solar), clearly establishing their presolar origin as stellar condensates. These and other isotopic constraints point to a variety of stellar types as sources of the carbon, including low-mass asymptotic giant branch (AGB) stars and supernovae. Transmission electron microscopy (TEM) of ultrathin sections of the spherules revealed that many have a composite structure consisting of a core of nanocrystalline carbon surrounded by a mantle of well-graphitized carbon. The nanocrystalline cores are compact masses consisting of randomly oriented graphene sheets, from PAH-sized units up to sheets 3-4 nm in diameter, with little graphitic layering order. These sheets probably condensed as isolated particles that subsequently coalesced to form the cores, after which the surrounding graphitic mantles were added by vapor deposition. We also detected internal crystals of metal carbides in one-third of the spherules. These crystals (5-200 nm) have compositions ranging from nearly pure TiC to nearly pure Zr-Mo carbide. Some of these carbides occur at the centers of the spherules and are surrounded by well-graphitized carbon, having evidently served as heterogeneous nucleation centers for condensation of carbon. Others were entrained by carbon as the spherules grew. The chemical and textural evidence indicates that these carbides formed prior to carbon condensation, which indicates that the C/O ratios in the stellar sources were very close to unity. Only one of the 67 spherules studied in the TEM contained SiC, from which we infer that carbon condensation nearly always preceded SiC formation. This observation places stringent limits on the possible delay of graphite formation and is consistent with the predictions of equilibrium thermodynamics in the inferred range of pressure and C/O ratios. We model the formation of the observed refractory carbides under equilibrium conditions, both with and without s-process enrichment of Zr and Mo, and show that the chemical variation among internal crystals is consistent with the predicted equilibrium condensation sequence. The compositions of most of the Zr-Mo-Ti carbides require an s-process enrichment of both Zr and Mo to at least 30 times their solar abundances relative to Ti. However, to account for crystals in which Mo is also enriched relative to Zr, it is necessary to suppose that Zr is removed by separation of the earliest formed ZrC crystals from their parent gas. We also explore the formation constraints imposed by kinetics, equilibrium thermodynamics, and the observation of clusters of carbide crystals in some spherules, and conclude that relatively high formation pressures (≳ 0.1 dynes cm-2), and/or condensable carbon number densities (≳108 cm-3) are required. The graphite spherules with 12C/13C ratios less than the solar value may have originated in AGB stellar winds. However, in the spherically symmetric AGB atmospheres customarily assumed in models of stellar grain formation, pressures are much too low (by factors of ≳102) to produce carbide crystals or graphite spherules of the sizes observed within plausible timescales. If some of the graphite spherules formed in the winds from such stars, it thus appears necessary to assume that the regions of grain formation are density concentrations with length scales less than a stellar radius. Some of the spherules with both12C/13C ratios greater than the solar value and 28Si excesses probably grew in the ejecta of super-novae. The isotopic compositions and growth constraints imply that they must have formed at high densities (e.g., with p≳10-12 g cm-3) from mixtures of inner-shell material with material from the C-rich outer zones

Exploring the reactivity of 2-trichloromethylbenzoxazoles for access to substituted benzoxazoles

The reactivity of 2-trichloromethylbenzoxazoles towards various nucleophiles, under metal free or iron-catalyzed conditions, for the synthesis of substituted benzoxazoles is described. These methods allow for selective substitution at either the 2- or 2’- position of the benzoxazoles using the same starting materials / reagents. This approach allows for the controlled synthesis of a variety of key derivatives from a single 2-trichloromethylbenzoxazole starting material

Incidence and drug treatment of emotional distress after cancer diagnosis : a matched primary care case-control study

Notes This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License.Peer reviewedPublisher PD

Aberrant behaviours of reaction diffusion self-organisation models on growing domains in the presence of gene expression time delays

Turing’s pattern formation mechanism exhibits sensitivity to the details of the initial conditions suggesting that, in isolation, it cannot robustly generate pattern within noisy biological environments. Nonetheless, secondary aspects of developmental self-organisation, such as a growing domain, have been shown to ameliorate this aberrant model behaviour. Furthermore, while in-situ hybridisation reveals the presence of gene expression in developmental processes, the influence of such dynamics on Turing’s model has received limited attention. Here, we novelly focus on the Gierer–Meinhardt reaction diffusion system considering delays due the time taken for gene expression, while incorporating a number of different domain growth profiles to further explore the influence and interplay of domain growth and gene expression on Turing’s mechanism. We find extensive pathological model behaviour, exhibiting one or more of the following: temporal oscillations with no spatial structure, a failure of the Turing instability and an extreme sensitivity to the initial conditions, the growth profile and the duration of gene expression. This deviant behaviour is even more severe than observed in previous studies of Schnakenberg kinetics on exponentially growing domains in the presence of gene expression (Gaffney and Monk in Bull. Math. Biol. 68:99–130, 2006). Our results emphasise that gene expression dynamics induce unrealistic behaviour in Turing’s model for multiple choices of kinetics and thus such aberrant modelling predictions are likely to be generic. They also highlight that domain growth can no longer ameliorate the excessive sensitivity of Turing’s mechanism in the presence of gene expression time delays. The above, extensive, pathologies suggest that, in the presence of gene expression, Turing’s mechanism would generally require a novel and extensive secondary mechanism to control reaction diffusion patterning

Braneworld Tensor Anisotropies in the CMB

Cosmic microwave background (CMB) observations provide in principle a high-precision test of models which are motivated by M theory. We set out the framework of a program to compute the tensor anisotropies in the CMB that are generated in braneworld models. In the simplest approximation, we show the braneworld imprint as a correction to the power spectra for standard temperature and polarization anisotropies.Comment: Minor corrections and references added. Accepted for publication in Phys. Rev.