Cell cycle and DNA content of mitotic cells in brain ganglia of drosophila larvae

The programmes of replication of hetero- and euchromatin regions, mitotic cell cycle and the DNA content in metaphases in brain ganglia from late third instar larvae of Drosophila melanogaster (wild type and a tumour bearing mutant, 1(2)gl, strain) and of Drosophila nasuta were examined by autoradiography of [3H]thymidine labelled (continuous or pulse) cells and by cytophotometry, respectively. Brain ganglia labelled continuously with [3H]thymidine for 24 h in vitro showed a significantly high proportion of cells with incorporation of radioactivity restricted to heterochromatin only. Pulse labelling of brain ganglia from larvae of Drosophila melanogaster and Drosophila nasuta followed by chase for different time intervals showed that (i) the frequency of labelled metaphases was more than 50% within 15 to 30 min of chase and remained higher than 50% in nearly all the chase samples till 24 h, (ii) euchromatin labelled metaphases appeared with a low frequency within 1 to 4 h chase period but the heterochromatin labelled metaphases continued to be more common in the later chase samples also, (iii) single chromatid labelled second cycle metaphases were seen within 1 to 4 h after the pulse, but their frequency did not increase in the later samples. Cytophotometry of feulgen-DNA and Hoechst 33258 stained metaphases in late third instar larval brain ganglia revealed a greater variation in the DNA content of individual metaphases, although the means were close to the expected 4 C content. It appears that in relation to the known asymmetric cell divisions of neuroblast and other neural cells, the mitotically active cells in brain ganglia comprise a heterogenous population with widely varying lengths of the different phases of cell cycle; some of them may not cycle regularly and may possibly have a discontinuous S-phase

AngularGrad: A New Optimization Technique for Angular Convergence of Convolutional Neural Networks

Convolutional neural networks (CNNs) are trained using stochastic gradient descent (SGD)-based optimizers. Recently, the adaptive moment estimation (Adam) optimizer has become very popular due to its adaptive momentum, which tackles the dying gradient problem of SGD. Nevertheless, existing optimizers are still unable to exploit the optimization curvature information efficiently. This paper proposes a new AngularGrad optimizer that considers the behavior of the direction/angle of consecutive gradients. This is the first attempt in the literature to exploit the gradient angular information apart from its magnitude. The proposed AngularGrad generates a score to control the step size based on the gradient angular information of previous iterations. Thus, the optimization steps become smoother as a more accurate step size of immediate past gradients is captured through the angular information. Two variants of AngularGrad are developed based on the use of Tangent or Cosine functions for computing the gradient angular information. Theoretically, AngularGrad exhibits the same regret bound as Adam for convergence purposes. Nevertheless, extensive experiments conducted on benchmark data sets against state-of-the-art methods reveal a superior performance of AngularGrad. The source code will be made publicly available at: https://github.com/mhaut/AngularGrad

Local randomness in Hardy's correlations: Implications from information causality principle

Study of nonlocal correlations in term of Hardy's argument has been quite popular in quantum mechanics. Recently Hardy's argument of non-locality has been studied in the context of generalized non-signaling theory as well as theory respecting information causality. Information causality condition significantly reduces the success probability for Hardy's argument when compared to the result based on non-signaling condition. Here motivated by the fact that maximally entangled state in quantum mechanics does not exhibit Hardy's non-local correlation, we do a qualitative study of the property of local randomness of measured observable on each side reproducing Hardy's non-locality correlation,in the context of information causality condition. On applying the necessary condition for respecting the principle of information causality, we find that there are severe restrictions on the local randomness of measured observable in contrast to results obtained from no-signaling condition.Still, there are some restrictions imposed by quantum mechanics that are not obtained from information causality condition.Comment: 6 pages, 2 tables, new references adde

Realization of Optimal Disentanglement by Teleportation via Separable Channel

We discuss here the best disentanglement processes of states of two two-level systems which belong to (i) the universal set, (ii) the set in which the states of one party lie on a single great circle of the Bloch sphere, and (iii) the set in which the states of one party commute with each other, by teleporting the states of one party (on which the disentangling machine is acting) through three particular type of separable channels, each of which is a mixture of Bell states. In the general scenario, by teleporting one party's state of an arbitrary entangled state of two two-level parties through some mixture of Bell states, we have shown that this entangled state can be made separable by using a physically realizable map $\tilde{V}$, acting on one party's states, if $\tilde{V} (I) = I, \tilde{V} ({\sigma}_j) = {\lambda}_j {\sigma}_j$, where ${\lambda}_j \ge 0$ (for $j = 1, 2, 3$), and ${\lambda}_1 + {\lambda}_2 + {\lambda}_3 \le 1$.Comment: 20 pages Late

Solvation Enhances the Distinction Between Carboxylated Armchair and Zigzag Single-Wall Carbon Nanotubes (SWNT-COOH)

The effect of various solvents on the structures and properties of carboxylated SWNTs has been explored using the Same Level Different Basis Set approach (SLDB), where B3LYP functional of density functional theory (DFT) was applied. Armchair (4,4) and zigzag (8,0) and (9,0) tubes were considered as the test bed. In order to simulate varying concentration of –COOH groups, one to five acids groups were placed at one end of these tubes. These samples were placed in different solvents (namely, CS2, THF and water) with varying polarity and results were compared with gas-phase properties. Similar to the gas-phase, zigzag tubes also exhibit both regular (r-COOH, v(C=O) above 1700 cm-1) and low-frequency (lf-COOH, v(C=O) below 1700 cm-1) acid groups. Characteristics of r-COOH group are not affected much in solvents, but lf-COOH of the zigzag tube is the one that makes these tubes distinguishable from its armchair cousin. Stability and charge distribution of SWNT-COOH strongly depend on the number of acid groups in different solvents which may help controlling further functionalization. Vibrational analyses reveal certain features in the 1400-1600 cm-1 range that are characteristic of lf-COOH in different solvents, which may help in the assignment of experimental spectra of oxidized SWNT in solvents

Probing liquid surface waves, liquid properties and liquid films with light diffraction

Surface waves on liquids act as a dynamical phase grating for incident light. In this article, we revisit the classical method of probing such waves (wavelengths of the order of mm) as well as inherent properties of liquids and liquid films on liquids, using optical diffraction. A combination of simulation and experiment is proposed to trace out the surface wave profiles in various situations (\emph{eg.} for one or more vertical, slightly immersed, electrically driven exciters). Subsequently, the surface tension and the spatial damping coefficient (related to viscosity) of a variety of liquids are measured carefully in order to gauge the efficiency of measuring liquid properties using this optical probe. The final set of results deal with liquid films where dispersion relations, surface and interface modes, interfacial tension and related issues are investigated in some detail, both theoretically and experimentally. On the whole, our observations and analyses seem to support the claim that this simple, low--cost apparatus is capable of providing a wealth of information on liquids and liquid surface waves in a non--destructive way.Comment: 25 pages, 12 figures, to appear in Measurement Science and Technology (IOP

Distinguishability of the Bell states

More than two multipartite orthogonal states cannot always be discriminated (with certainty) if only local operations and classical communication (LOCC) are allowed. Using an existing inequality among the measures of entanglement, we show that any three Bell states cannot be discriminated by LOCC. Exploiting the inequality, we calculate the distillable entanglement of a certain class of (4\otimes 4) mixed states.Comment: 3 Pages Latex, references added, minor change

Mahanine exerts in vitro and in vivo antileishmanial activity by modulation of redox homeostasis

Earlier we have established a carbazole alkaloid (mahanine) isolated from an Indian edible medicinal plant as an anticancer agent with minimal effect on normal cells. Here we report for the first time that mahanine-treated drug resistant and sensitive virulent Leishmania donovani promastigotes underwent apoptosis through phosphatidylserine externalization, DNA fragmentation and cell cycle arrest. An early induction of reactive oxygen species (ROS) suggests that the mahanine-induced apoptosis was mediated by oxidative stress. Additionally, mahanine-treated Leishmania-infected macrophages exhibited anti-amastigote activity by nitric oxide (NO)/ROS generation along with suppression of uncoupling protein 2 and Th1-biased cytokines response through modulating STAT pathway. Moreover, we have demonstrated the interaction of a few antioxidant enzymes present in parasite with mahanine through molecular modeling. Reduced genetic and protein level expression of one such enzyme namely ascorbate peroxidase was also observed in mahanine-treated promastigotes. Furthermore, oral administration of mahanine in acute murine model exhibited almost complete reduction of parasite burden, upregulation of NO/iNOS/ROS/IL-12 and T cell proliferation. Taken together, we have established a new function of mahanine as a potent antileishmanial molecule, capable of inducing ROS and exploit antioxidant enzymes in parasite along with modulation of host’s immune response which could be developed as an inexpensive and nontoxic therapeutics either alone or in combination

On local indistinguishability of orthogonal pure states by using a bound on distillable entanglement

We show that the four states a|00>+b|11>, b^*|00>-a^*|11>, c|01>+d|10> and d^*|01>-c^*|10> cannot be discriminated with certainty if only local operations and classical communication (LOCC) are allowed and if only a single copy is provided, except in the case when they are simply |00>, |11>, |01> and |10> (in which case they are trivially distinguishable with LOCC). We go on to show that there exists a continuous range of values of a, b, c and d such that even three states among the above four are not locally distinguishable, if only a single copy is provided. The proof follows from the fact that logarithmic negativity is an upper bound of distillable entanglement.Comment: 6 pages latex, no figure

Search for the Higgs boson in events with missing transverse energy and b quark jets produced in proton-antiproton collisions at s**(1/2)=1.96 TeV

We search for the standard model Higgs boson produced in association with an electroweak vector boson in events with no identified charged leptons, large imbalance in transverse momentum, and two jets where at least one contains a secondary vertex consistent with the decay of b hadrons. We use ~1 fb-1 integrated luminosity of proton-antiproton collisions at s**(1/2)=1.96 TeV recorded by the CDF II experiment at the Tevatron. We find 268 (16) single (double) b-tagged candidate events, where 248 +/- 43 (14.4 +/- 2.7) are expected from standard model background processes. We place 95% confidence level upper limits on the Higgs boson production cross section for several Higgs boson masses ranging from 110 GeV/c2 to 140 GeV/c2. For a mass of 115 GeV/c2 the observed (expected) limit is 20.4 (14.2) times the standard model prediction.Comment: 8 pages, 2 figures, submitted to Phys. Rev. Let