Músicos y lesiones

Según las estadísticas un 75% de los músicos han tenido o tienen problemas relacionados con el tocar y existen diferentes factores que influyen el la aparición de estos problemas, algunos relacionados con el instrumento, con la sobre solicitación de la musculatura, con una técnica inapropiada, con el esfuerzo que implica tocar un instrumento, con la repetición del gesto y por ultimo también influyen las características individuales del músico. En realidad todas estas causas van a provocar una alteración de la biomecánica corporal que estará en la raíz de sobrecargas musculares, ligamentosas i articulares, aumento de tensión de los músculos, alteración del gesto y por último a la lesión.As the statistical a 75% of the musicians have had or have problems related to playing and exist different factors that influence the beginning of these problems, some related with the instrument, with the on solicitation of the musculature, with an inappropriate technique, with the effort that involves to play an instrument, with the repetition of the gesture and at last also influence the individual characteristics of the musician. All these causes are going to cause an alteration of the body biomechanics that will be in the root of muscular, ligaments and articulation overuse, increases of muscle’s tension, alteration of the gesture and finally the appareance of an injury.Peer Reviewe

Lesiones de partes blandas por fricción

La lesión por fricción es una lesión de partes blandas que dentro de su rareza se encuentra más frecuentemente en el contexto de los accidentes de tráfico. Las fuerzas tangenciales se transmiten des del asfalto, ruedas de los vehículos a tejido celular subcutáneo conduciendo a un gran deslizamiento del mismo sobre la fascia muscular. El movimiento anormal provoca la rotura de vasos linfáticos y vasculares conduciendo una colección serohemática. Las situaciones más frecuentemente encontrada son aquellas las cuales contienen masas musculares grandes. Normalmente es una lesión de larga evolución e infradiagnosticada en sus estados iniciales. Se presenta como una tumoración fría, dolorosa e incapacitante con piel adyacente intacta o con petequías. Se diagnostica con exploración física y pruebas complementarias, como ecografía. El tratamiento teniendo en cuenta diferentes ítems puede consistir en medida conservadoras o llegar a procedimientos quirúrgicos. En la literatura no se pone de manifiesto variabilidad en los resultados de diferentes procedimientos terapéuticos.Injury by friction is an injury of soft parts that although not frequent it is not unusual in the context of the traffic accidents. The tangential forces are transmitted from the asphalt and the wheels of the vehicles to the cellular subcutaneous fabric, producing a big sliding on the muscular fascia. The abnormal movement breaks the lymphatic and vascular glasses leading to a serohematic collection. The most usual situations are that ones which contain muscular big masses. Normally it is an injury of long evolution and infradiagnosticated in its initial conditions. The skin appears as a cold, painful tumor and disabling with adjacent skin intact or with petechiae. It is diagnosed by physical exploration and with additional tests, like ultrasound scan. The treatment, considering different items, can consist on conservative measures or even surgical procedures. In the literature variability is not revealed in the results of different therapeutic procedures.Peer ReviewedAward-winnin

Is magnetic resonance imaging a viable alternative to ultrasound as the primary imaging modality in the diagnosis of paediatric appendicitis? A systematic review

YesBackground: Appendicitis is the most common cause of acute abdominal pain requiring surgical intervention in paediatric patients. Ultrasound is generally the diagnostic imaging modality of choice, followed by CT, where paediatric appendicitis is suspected. However, high operator dependency and diagnostic restrictions related to anatomical and clinical presentation may limit consistency of application. This paper explores whether MRI is a viable alternative to ultrasound as the primary imaging modality. Method: A systematic review of the literature was undertaken. A search of Medline, Cinahl, PubMed Central and Google Scholar was undertaken supplemented by a review of reference lists, author searching and review of NICE evidence base for existing guidelines. Included studies were assessed for bias using the QUADAS-2 quality assessment tool and data were extracted systematically using a purposefully designed electronic data extraction proforma. Results: Seven studies were included in final review. The age range of participants extended from 0 to 19 years. Only one study with a patient age range of 0e14 used sedation. Sensitivity estimates from the included studies ranged from 92% to 100% while specificity ranged from 89% to 100%. A significant variation in the number and type of sequences was noted between the studies. Conclusion: MRI offers high sensitivity and specificity comparable to contrast enhanced CT and greater than ultrasound as reported in the literature. Where accessibility is not a restriction, MRI is a viable alternative to ultrasound in the assessment and diagnosis of paediatric appendicitis. Clinical practice recommendations have been provided to facilitate the translation of evidence into practice

Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments

The cancer microenvironment, which incorporates interactions with stromal cells, extracellular matrix (ECM), and other tumor cells in a 3-dimensional (3D) context, has been implicated in every stage of cancer development, including growth of the primary tumor, metastatic spread, and response to treatment. Our understanding of the tumor microenvironment and our ability to develop new therapies would greatly benefit from tools that allow us to systematically probe microenvironmental cues within a 3D context. Here, we leveraged recent advances in microfluidic technology to develop a platform for high-throughput fabrication of tunable cellular microniches (“microtissues”) that allow us to probe tumor cell response to a range of microenvironmental cues, including ECM, soluble factors, and stromal cells, all in 3D. We further combine this tunable microniche platform with rapid, flow-based population level analysis (n > 500), which permits analysis and sorting of microtissue populations both pre- and post-culture by a range of parameters, including proliferation and homotypic or heterotypic cell density. We used this platform to demonstrate differential responses of lung adenocarcinoma cells to a selection of ECM molecules and soluble factors. The cells exhibited enhanced or reduced proliferation when encapsulated in fibronectin- or collagen-1-containing microtissues, respectively, and they showed reduced proliferation in the presence of TGF-β, an effect that we did not observe in monolayer culture. We also measured tumor cell response to a panel of drug targets and found, in contrast to monolayer culture, specific sensitivity of tumor cells to TGFβR2 inhibitors, implying that TGF-β has an anti-proliferative affect that is unique to the 3D context and that this effect is mediated by TGFβR2. These findings highlight the importance of the microenvironmental context in therapeutic development and that the platform we present here allows the high-throughput study of tumor response to drugs as well as basic tumor biology in well-defined microenvironmental niches.American Association for Cancer Research (Stand Up to Cancer Charitable Initiative)National Institute for Biomedical Imaging and Bioengineering (U.S.) (National Research Service Award Fellowship)National Science Foundation (U.S.) (Graduate Research Fellowship Program Grant 1122374)Howard Hughes Medical Institut

Reference database of total retinal vessel surface area derived from volume-rendered optical coherence tomography angiography

Optical coherence tomography angiography (OCTA) enables three-dimensional, high-resolution, depth-resolved flow to be distinguished from non-vessel tissue signals in the retina. Thus, it enables the quantification of the 3D surface area of the retinal vessel signal. Despite the widespread use of OCTA, no representative spatially rendered reference vessel surface area data are published. In this study, the OCTA vessel surface areas in 203 eyes of 107 healthy participants were measured in the 3D domain. A Generalized Linear Model (GLM) model analysis was performed to investigate the effects of sex, age, spherical equivalent, axial length, and visual acuity on the OCTA vessel surface area. The mean overall vessel surface area was 54.53 mm2 (range from 27.03 to 88.7 mm2). OCTA vessel surface area was slightly negatively correlated with age. However, the GLM model analysis identified axial length as having the strongest effect on OCTA vessel surface area. No significant correlations were found for sex or between left and right eyes. This is the first study to characterize three-dimensional vascular parameters in a population based on OCTA with respect to the vessel surface area

A Novel, Low-Volume Method for Organ Culture of Embryonic Kidneys That Allows Development of Cortico-Medullary Anatomical Organization

Here, we present a novel method for culturing kidneys in low volumes of medium that offers more organotypic development compared to conventional methods. Organ culture is a powerful technique for studying renal development. It recapitulates many aspects of early development very well, but the established techniques have some disadvantages: in particular, they require relatively large volumes (1–3 mls) of culture medium, which can make high-throughput screens expensive, they require porous (filter) substrates which are difficult to modify chemically, and the organs produced do not achieve good cortico-medullary zonation. Here, we present a technique of growing kidney rudiments in very low volumes of medium–around 85 microliters–using silicone chambers. In this system, kidneys grow directly on glass, grow larger than in conventional culture and develop a clear anatomical cortico-medullary zonation with extended loops of Henle

Transport of organic anions and cations in murine embryonic kidney development and in serially-reaggregated engineered kidneys

Recent advances in renal tissue engineering have shown that dissociated, early renogenic tissue from the developing embryo can self-assemble into morphologically accurate kidney-like organs arranged around a central collecting duct tree. In order for such self-assembled kidneys to be useful therapeutically or as models for drug screening, it is necessary to demonstrate that they are functional. One of the main functional characteristics of mature kidneys is transport of organic anions and cations into and out of the proximal tubule. Here, we show that the transport function of embryonic kidneys allowed to develop in culture follows a developmental time-course that is comparable to embryonic kidney development in vivo. We also demonstrate that serially-reaggregated engineered kidneys can transport organic anions and cations through specific uptake and efflux channels. These results support the physiological relevance of kidneys grown in culture, a commonly used model for kidney development and research, and suggest that serially-reaggregated kidneys self-assembled from separated cells have some functional characteristics of intact kidneys

Músicos y lesiones

Según las estadísticas un 75% de los músicos han tenido o tienen problemas relacionados con el tocar y existen diferentes factores que influyen el la aparición de estos problemas, algunos relacionados con el instrumento, con la sobre solicitación de la musculatura, con una técnica inapropiada, con el esfuerzo que implica tocar un instrumento, con la repetición del gesto y por ultimo también influyen las características individuales del músico. En realidad todas estas causas van a provocar una alteración de la biomecánica corporal que estará en la raíz de sobrecargas musculares, ligamentosas i articulares, aumento de tensión de los músculos, alteración del gesto y por último a la lesión.As the statistical a 75% of the musicians have had or have problems related to playing and exist different factors that influence the beginning of these problems, some related with the instrument, with the on solicitation of the musculature, with an inappropriate technique, with the effort that involves to play an instrument, with the repetition of the gesture and at last also influence the individual characteristics of the musician. All these causes are going to cause an alteration of the body biomechanics that will be in the root of muscular, ligaments and articulation overuse, increases of muscle’s tension, alteration of the gesture and finally the appareance of an injury.Peer Reviewe

[Una apuesta a favor del placer (Barcelona.1995)]

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