La liberación inmediata de buques en procedimientos de medidas provisionales. ¿Nuevas tendencias y desafíos?

This article discusses the incidents and situations created when vessels are detained in foreign ports, and the measures that need to be undertaken to overcome these disputes, analyzing the United Nations Convention on the Law of the Sea; that not only provides a frame that all States (who have submitted) should constrain to, but also contributes to define the peaceful means for settlements intended to overcome such controversial situations. Apart from the consideration of all these regulations, jurisprudence and real precedents are explored. In first place, to perceive the way parties react towards these situations, and also to understand how the settlement of disputes be operationalized through the International Tribunal for the Law of the Sea. For this purpose, contemporary cases such as the Grand Prince, the ARA Libertad, and the Artic Sunrise are deepened.En el presente artículo se ven plasmados los incidentes que pueden presentarse cuando los buques y sus tripulaciones son detenidos en puertos extranjeros, y las distintas medidas a tomar ante estas controversias, analizando la Convención de las Naciones Unidas sobre el Derecho del Mar, que no solo provee una regulación marco a la que todos los Estados signatarios deben adecuarse, sino que también contribuye con la enunciación de las distintas formas de solución pacífica creadas para superar estas situaciones. Además de considerar estas regulaciones, es necesario analizar la jurisprudencia al respecto. En primer lugar, ya que ayuda a visualizar la forma en que los Estados actúan frente a estas situaciones y asimismo para comprender cómo el sistema de solución de controversias ha sido llevado a la práctica por el Tribunal de Hamburgo. Con esa finalidad profundizamos sobre algunos casos contemporáneos como el Grand Prince, el ARA Libertad y el Artic Sunrise

The freedom of navigation of warships in the territorial sea and its regulation from the 1982 United Nations Convention on the Law of the Sea

The following article explores the historical and legislative evolution regarding the navigation of foreign warships in the territorial sea, including the different lines of thought considered in the Conference of the United Nations on the Law of the Sea, so as to approach the current regime. In this context,we examine the legal situation of the previous authorization or notification regarding the innocent passage of warships, taking into consideration the legislative spirit of the United Nations Convention on the Law of the Sea of 1982 and without losing sight of the International Court of Justice contributions in the «Corfu Channel Case» analyzing its outstanding contributions, so as to finally highlight the actual practices in this field.El presente artículo explora la evolución histórica y normativa de la navegación de buques de guerra extranjeros en el mar territorial, incluyendo las distintas corrientes de pensamiento consideradas en las Conferencias de las Naciones Unidas sobre el Derecho del Mar para, luego, abordar el régimen actual. En este orden de ideas, examinamos la cuestión de la autorización o notificación previa respecto del paso inocente de buques extranjeros, observando el espíritu legislativo de la Convención de las Naciones Unidas sobre el Derecho del Mar de 1982 y sin perder de vista los aportes brindados por la Corte Internacional de Justicia en el asunto del Corfú Channel Case, exponiendo las consideraciones más relevantes para, finalmente, señalar las prácticas actuales en la materia

Pathogenetics of alveolar capillary dysplasia with misalignment of pulmonary veins.

Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a lethal lung developmental disorder caused by heterozygous point mutations or genomic deletion copy-number variants (CNVs) of FOXF1 or its upstream enhancer involving fetal lung-expressed long noncoding RNA genes LINC01081 and LINC01082. Using custom-designed array comparative genomic hybridization, Sanger sequencing, whole exome sequencing (WES), and bioinformatic analyses, we studied 22 new unrelated families (20 postnatal and two prenatal) with clinically diagnosed ACDMPV. We describe novel deletion CNVs at the FOXF1 locus in 13 unrelated ACDMPV patients. Together with the previously reported cases, all 31 genomic deletions in 16q24.1, pathogenic for ACDMPV, for which parental origin was determined, arose de novo with 30 of them occurring on the maternally inherited chromosome 16, strongly implicating genomic imprinting of the FOXF1 locus in human lungs. Surprisingly, we have also identified four ACDMPV families with the pathogenic variants in the FOXF1 locus that arose on paternal chromosome 16. Interestingly, a combination of the severe cardiac defects, including hypoplastic left heart, and single umbilical artery were observed only in children with deletion CNVs involving FOXF1 and its upstream enhancer. Our data demonstrate that genomic imprinting at 16q24.1 plays an important role in variable ACDMPV manifestation likely through long-range regulation of FOXF1 expression, and may be also responsible for key phenotypic features of maternal uniparental disomy 16. Moreover, in one family, WES revealed a de novo missense variant in ESRP1, potentially implicating FGF signaling in the etiology of ACDMPV

Impact of the International Nosocomial Infection Control Consortium (INICC) Multidimensional Hand Hygiene Approach During 3 Years in 6 Hospitals in 3 Mexican Cities

To evaluate the impact of the International Nosocomial Infection Control Consortium (INICC) multidimensional hand hygiene (HH) approach in Mexico, and analyze predictors of poor HH compliance. From June 2002 to April 2006, we conducted a prospective, observational, before-and-after study in 8 intensive care units (ICUs) from 6 hospitals in 3 cities of Mexico. The approach included administrative support, availability of supplies, education and training, reminders in the workplace, process surveillance, and performance feedback. A total of 13,201 observations for HH opportunities were done in each ICU, during randomly selected 30-minute periods. Overall, HH compliance increased from 45% to 79% (95% confidence interval [CI], 69.1-86.5; P = 0.01). Univariate and multivariate analyses showed that several variables were significantly associated with poor HH compliance: males versus females (61% versus 66%; 95% CI, 0.91-0.96; P = 0.0001), physicians versus nurses (62% versus 67%; 95% CI, 0.91-0.97; P = 0.0001), and adult versus neonatal ICUs (67% versus 54%; 95% CI, 0.79-0.84; P = 0.0001), among others. Hand hygiene programs should focus on variables found to be predictors of poor HH compliance

A spatio-temporal econometric model of regional growth in Spain

Regional growth, Panel data, Spatial dependence, Spillovers, Spain, C31, C33, J24, O18, R11,

Early rhythm-control therapy in patients with atrial fibrillation

BACKGROUND Despite improvements in the management of atrial fibrillation, patients with this condition remain at increased risk for cardiovascular complications. It is unclear whether early rhythm-control therapy can reduce this risk. METHODS In this international, investigator-initiated, parallel-group, open, blinded-outcome-assessment trial, we randomly assigned patients who had early atrial fibrillation (diagnosed ≤1 year before enrollment) and cardiovascular conditions to receive either early rhythm control or usual care. Early rhythm control included treatment with antiarrhythmic drugs or atrial fibrillation ablation after randomization. Usual care limited rhythm control to the management of atrial fibrillation–related symptoms. The first primary outcome was a composite of death from cardiovascular causes, stroke, or hospitalization with worsening of heart failure or acute coronary syndrome; the second primary outcome was the number of nights spent in the hospital per year. The primary safety outcome was a composite of death, stroke, or serious adverse events related to rhythm-control therapy. Secondary outcomes, including symptoms and left ventricular function, were also evaluated. RESULTS In 135 centers, 2789 patients with early atrial fibrillation (median time since diagnosis, 36 days) underwent randomization. The trial was stopped for efficacy at the third interim analysis after a median of 5.1 years of follow-up per patient. A first-primary-outcome event occurred in 249 of the patients assigned to early rhythm control (3.9 per 100 person-years) and in 316 patients assigned to usual care (5.0 per 100 person-years) (hazard ratio, 0.79; 96% confidence interval, 0.66 to 0.94; P=0.005). The mean (±SD) number of nights spent in the hospital did not differ significantly between the groups (5.8±21.9 and 5.1±15.5 days per year, respectively; P=0.23). The percentage of patients with a primary safety outcome event did not differ significantly between the groups; serious adverse events related to rhythm-control therapy occurred in 4.9% of the patients assigned to early rhythm control and 1.4% of the patients assigned to usual care. Symptoms and left ventricular function at 2 years did not differ significantly between the groups. CONCLUSIONS Early rhythm-control therapy was associated with a lower risk of adverse cardiovascular outcomes than usual care among patients with early atrial fibrillation and cardiovascular conditions