VNUML vs GNS3 en el desarrollo de laboratorios de redes virtuales

El aprendizaje práctico de redes de computadores es reconocido como un proceso crítico que permite a los estudiantes consolidar los conceptos introducidos en las lecciones teóricas. En este sentido, las tecnologías de virtualización están adquiriendo gran relevancia debido a que permiten desarrollar laboratorios de redes de computadores con un reducido coste de despliegue y gestión. Este artículo presenta un análisis comparativo entre GNS3 y VNUML, que son herramientas de virtualización open-source que han sido empleadas para el desarrollo de laboratorios de red virtuales para llevar a cabo el proceso de enseñanza-aprendizaje en las asignaturas Arquitectura de Redes y Arquitectura de Redes Avanzadas del Grado en Ingeniería Informática impartido en la Universidad de Murcia. El estudio presenta las principales ventajas y/o deficiencias de cada herramienta tanto para profesores como alumnos y se identifican los escenarios en los que parece más adecuada su utilización.SUMMARY -- The practical learning of computer networks is known to be a critical process in order to allow students to consolidate the concepts introduced in theoretical lessons. In this sense, virtualization technologies are becoming popular since they allow to set up a computer network laboratory with a reduced deployment and management cost. This paper presents a comparative analysis performed between GNS3 and VNUML, which are open-source tools for virtualization that have been used for developing virtual network laboratories that support the teaching-learning process in the Networks Architecture and Advanced Networks Architecture subjects of the Computer Engineering degree at the University of Murcia. The study presents the main advantages and/or deficiencies of each tool not only for professors but also for students and identifies the scenarios where the use of each tool seems to be more appropriate.Peer Reviewe

Achondroplasia with 47, xxy karyotype: a case report of the neonatal diagnosis of an extremely unusual association

Background: The association of achondroplasia and Klinefelter syndrome is extremely rare. To date, five cases have been previously reported, all of them diagnosed beyond the postnatal period, and only one was molecularly characterized. We describe the first case of this unusual association diagnosed in the neonatal period, the clinical findings and the molecular studies undertaken. Case presentation: The boy was born at term with clinical and radiological features indicating the diagnosis of achondroplasia or hypochondroplasia combined with the prenatal karyotype of Klinefelter syndrome (47,XXY). Neonatal FGFR3 mutation screening showed that the newborn was heterozygous for the classic achondroplasia G340R mutation. Microsatellite marker analysis showed that the sex chromosome aneuploidy had arisen from a non-disjunction error in paternal meiosis I, with a recombination event in the pseudoautosomal region 1 (PAR1). Conclusion: Specific mutation analysis is appropriate to confirm the clinical diagnosis of achondroplasia for appropriate diagnosis, prognosis, and genetic counseling, especially when the karyotype does not explain the abnormal prenatal sonographic findings. In the present case, a recombination event was observed in the PAR1 region, although recombinational events in paternally derived Klinefelter syndrome cases are much rarer than expected

PS-Dir: A Scalable Two-Level Directory Cache

As the number of cores increases in both incoming and future chip multiprocessors, coherence protocols must address novel hardware structures in order to scale in terms of performance, power, and area. It is well known that most blocks accessed by parallel applications are private (i.e., accessed by a single core). These blocks present different directory requirements and behavior than shared blocks. Based on this fact, this paper proposes a two-level directory cache that tracks shared blocks in a small and fast first-level cache and private blocks in a larger and slower second-level cache, namely Shared and Private caches, respectively. Speed and area reasons suggest the use of eDRAM technology much dense but slower than SRAM technology for the Private cache, which in turn brings energy savings. Experimental results for a 16-core system show improvements in performance by 11.1%, in area by 25.4%, and in energy consumption by 20.5% compared to a conventional directory cache.This work has been supported by the Spanish MICINN, as well as European Commission FEDER funds, under Grants CSD2006-00046 and TIN2009-14475-C04Valls, JJ.; Ros Bardisa, A.; Sahuquillo Borrás, J.; Gómez Requena, ME.; Duato Marín, JF. (2012). PS-Dir: A Scalable Two-Level Directory Cache. IEEE Computer Society. https://doi.org/10.1145/2370816.2370891

Grape Resveratrol Increases Serum Adiponectin and Downregulates Inflammatory Genes in Peripheral Blood Mononuclear Cells: A Triple-Blind, Placebo-Controlled, One-Year Clinical Trial in Patients with Stable Coronary Artery Disease

This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.[Purpose] The grape and wine polyphenol resveratrol exerts cardiovascular benefits but evidence from randomized human clinical trials is very limited. We investigated dose-depending effects of a resveratrol-containing grape supplement on stable patients with coronary artery disease (CAD) treated according to currently accepted guidelines for secondary prevention of cardiovascular disease.[Methods] In a triple-blind, randomized, placebo-controlled, one-year follow-up, 3-arm pilot clinical trial, 75 stable-CAD patients received 350 mg/day of placebo, resveratrol-containing grape extract (grape phenolics plus 8 mg resveratrol) or conventional grape extract lacking resveratrol during 6 months, and a double dose for the following 6 months. Changes in circulating inflammatory and fibrinolytic biomarkers were analyzed. Moreover, the transcriptional profiling of inflammatory genes in peripheral blood mononuclear cells (PBMCs) was explored using microarrays and functional gene expression analysis.[Results] After 1 year, in contrast to the placebo and conventional grape extract groups, the resveratrol-containing grape extract group showed an increase of the anti-inflammatory serum adiponectin (9.6 %, p = 0.01) and a decrease of the thrombogenic plasminogen activator inhibitor type 1 (PAI-1) (−18.6 %, p = 0.05). In addition, 6 key inflammation-related transcription factors were predicted to be significantly activated or inhibited, with 27 extracellular-space acting genes involved in inflammation, cell migration and T-cell interaction signals presenting downregulation (p < 0.05) in PBMCs. No adverse effects were detected in relation to the study products.[Conclusions] Chronic daily consumption of a resveratrol-containing grape nutraceutical could exert cardiovascular benefits in stable-CAD patients treated according to current evidence-based standards, by increasing serum adiponectin, preventing PAI-1 increase and inhibiting atherothrombotic signals in PBMCs.This study was supported by public funds: Projects CICYT-BFU2007-60576 and Consolider-Ingenio 2010 (CSD2007-00063, Fun-C-Food) from the Spanish Ministry of Science and Innovation (MICINN) and GERM-06-04486 (Fundación Séneca, Murcia, Spain). Dr. Tomé-Carneiro received a FPI grant from MICINN and Dr. Larrosa received a JAE-DOC contract from the Consejo Superior de Investigaciones Científicas (CSIC, Spain).Peer reviewe

Effects of hamstring-emphasized neuromuscular training on strength and sprinting mechanics in football players

The objective of this study was to examine the effects of a neuromuscular training program combining eccentric hamstring muscle strength, plyometrics, and free/resisted sprinting exercises on knee extensor/flexor muscle strength, sprinting performance, and horizontal mechanical properties of sprint running in football (soccer) players. Sixty footballers were randomly assigned to an experimental group (EG) or a control group (CG). Twenty‐seven players completed the EG and 24 players the CG. Both groups performed regular football training while the EG performed also a neuromuscular training during a 7‐week period. The EG showed a small increases in concentric quadriceps strength (ES = 0.38/0.58), a moderate to large increase in concentric (ES = 0.70/0.74) and eccentric (ES = 0.66/0.87) hamstring strength, and a small improvement in 5‐m sprint performance (ES = 0.32). By contrast, the CG presented lower magnitude changes in quadriceps (ES = 0.04/0.29) and hamstring (ES = 0.27/0.34) concentric muscle strength and no changes in hamstring eccentric muscle strength (ES = −0.02/0.11). Thus, in contrast to the CG (ES = −0.27/0.14), the EG showed an almost certain increase in the hamstring/quadriceps strength functional ratio (ES = 0.32/0.75). Moreover, the CG showed small magnitude impairments in sprinting performance (ES = −0.35/−0.11). Horizontal mechanical properties of sprint running remained typically unchanged in both groups. These results indicate that a neuromuscular training program can induce positive hamstring strength and maintain sprinting performance, which might help in preventing hamstring strains in football players.Actividad Física y Deport

Ethics Guidelines for the Creation and Use of Registries for Biomedical Research Purposes

La información clínica almacenada en registros de diverso tipo constituye una herramienta fundamental para la investigación biomédica. Hasta hace pocos años la creación y uso de registros epidemiológicos, o la utilización de información procedente de registros pre-existentes con fines de investigación, apenas tenía limitaciones. Esta situación ha cambiado de modo sustancial debido básicamente a la creciente importancia que las leyes actuales conceden a la protección de la intimidad, la privacidad y la confidencialidad de los datos de carácter personal. Aunque el marco legal es ya muy explícito, hay un cierto espacio para la deliberación ética y el consejo prudente, al objeto de realizar con dicha información una investigación válida y útil y que, al mismo tiempo, respete los derechos de los sujetos y la legalidad vigente. En las presentes directrices se abordan aquellos aspectos que se han considerado relevantes desde un punto de vista ético en el manejo de registros con fines de investigación, incluyendo no sólo el uso sino la creación misma del registro. Se proporcionan 24 recomendaciones agrupadas en 10 apartados: justificación de la creación de un registro, organización y definición de responsabilidades, validez científica del proyecto de investigación, requisitos éticos de las colecciones de datos anónimos y de los registros anonimizados, requisitos éticos de los registros que contienen datos de carácter personal, usos de la historia clínica con fines de investigación, uso de registros históricos y de personas fallecidas, contacto con los sujetos de investigación, comunicación de resultados y revisión por un Comité de Ética de la Investigación.The clinical information stored in registries and records of different types is a fundamental tool for biomedical research. Up until just a few years ago, hardly any limitations existed on the creation and use of epidemiological registries or the use of information from pre-existing records for research purposes. This situation has changed substantially due mainly to the growing importance current laws place upon the safeguarding of the privacy and confidentiality of personal data. Although the legal framework is already quite explicit, a certain degree of leeway exists for ethical debate and prudence advice for the purpose of conducting valid, useful research with this information which will also respect the rights of the subjects and the laws in force. These guidelines deal with those aspects which have been considered relevant from an ethical standpoint in the handling of records and registries for research-related purposes, including not only the use but also the creation proper of the registries. A total of twenty-four recommendations are provided, grouped into ten sections: warranting of the creation of registry, organization and definition of responsibilities, scientific validity of the research project, ethical requirements of the collections of anonymous and anonymized data, ethical requirements of the registries including personal data, uses of medical records for research purposes, use of historical records of deceased individuals, contact with the research subjects, notification of results and review by a Research Ethics Committee

Desarrollo y evaluación de la competencia gestión de la información en titulaciones técnicas: estudio de casos

[SPA]Hoy en día ya no es suficiente contar con las habilidades básicas de alfabetización que teníamos antes, como saber leer o escribir. Hoy incluso no basta con saber utilizar el ordenador, el teléfono u otros medios de comunicación. Se hace necesario estar alfabetizado informacionalmente (ALFIN). Esto implica no solo saber que la información existe, sino saber como encontrarla, como utilizarla, como manipularla, como sacar provecho de ella. Así se manifestaba en 2003 Horton especialista en derecho al acceso a la información pública. Un estudiante o un profesor son alfabetos informacionales porque saben cuando y porqué necesitan información, dónde encontrarla y como valorarla, utilizarla y comunicarla de manera ética. En este trabajo se presenta el estudio de tres casos llevados a cabo con estudiantes de diversas escuelas de ingeniería en la Universidad Politécnica de Cartagena. En ellos se muestra un procedimiento sencillo para incluir en la metodología docente de cualquier área de conocimiento la formación en gestión de la información, esto es, en el acceso, recuperación, análisis, evaluación y uso de la información. Asimismo se presenta una rúbrica que permite evaluar los logros adquiridos por los estudiantes que no son sino una forma de evaluar dicha habilidad. [ENG]Nowadays, the ability to read or write is not considered anymore as a basic standard for literacy. Neither the capability to use a computer, a telephone or any other communication device is enough in a professional context. Conversely, the informational literacy has become a professional skill of utmost importance. This means that the graduate must know not only that a certain information exists, but also it's necessary to know how to find it, use it, manipulate it and get benefit from it. A student or a lecturer are skilled on informational literacy when they identify why they do need the information, and they can find it, value, use and communicate it in an ethical manner. In this work, tree different classroom methodologies employed in several Departments and Technical University of Cartagena (UPCT) are presented. The activities to develop the information literacy of the students are thoroughly explained. A rubric for the evaluation of this competency is presented.Campus Mare Nostrum, Universidad Politécnica de Cartagena, Universidad de Murcia, Región de Murci

Detection system of magnetic nanoparticles in biological tissues by Magnetoencephalography

Magnetic nanoparticles are useful for a wide range of applications from data storage to medical imaging. Their unique features (controllable size in the nanoscale range, possibility to be coated with biological molecules, response to the application of a magnetic field...) make the development of a variety of medical applications possible, both for diagnosis and therapy [1-3]. On the other hand, Magnetoencephalography (MEG) is a non-invasive functional imaging technique that enables the description of the temporal and spatial patterns of brain activity in resting conditions or related to different basic cognitive processes, by detecting the weak magnetic fields generated by currents in the neurons [4,5]. The detection of the weak magnetic fields depends on gradiometer detection coils coupled to a superconducting quantum interference device (SQUID). However, MEG systems are not currently being used for the detection of MNPs in biological tissues. A system to newly detect Magnetic Nanoparticles (MNPs) in the brain and in biological tissues will be described. The method uses a commercial Magnetoencephalograph (MEG) and opens new possibilities to extend the use of MEG systems to new applications for both diagnosis and therapy of medical diseases, different from its common use in neurological diagnosis. To test the validity of the system, in this work, we will show its ability to detect MNPs in biological tissues and their possible use in diagnosis of cerebral brain microinjurie

Strategies for penicillin V dendronization with cationic carbosilane dendrons and study of antibacterial properties.

Strategies to synthesize a cationic carbosilane dendron containing the antibiotic penicillin V potassium salt (PenVK) at the focal point are discussed. The preparation of such a compound requires the use of systems with no donor atoms such as N or S in their framework, because their presence favours the rupture of the penicillin beta-lactam ring. The antibacterial activity of the new dendron containing ammonium groups, at the periphery, and the PenV moiety, at the focal point, against gram-positive Staphylococcus aureus strains was evaluated. These results were compared with those obtained for free PenVK, a related cationic dendron without a penicillin moiety at the focal point, and also compared with an equimolar mixture of this last dendron with free PenV. The data obtained indicate that, on one hand, the conjugation or interaction of PenV with cationic dendrons reduces its activity in comparison with free PenVK. On the other hand, the penicillin dendron is able to release the antibiotic in the presence of esterease, due to the breaking of the ester bond in this derivative.Ministerio de Economía y Empres