Aromatase inhibitors in men: effects and therapeutic options

Aromatase inhibitors effectively delay epiphysial maturation in boys and improve testosterone levels in adult men Therefore, aromatase inhibitors may be used to increase adult height in boys with gonadotropin-independent precocious puberty, idiopathic short stature and constitutional delay of puberty. Long-term efficacy and safety of the use of aromatase inhibitors has not yet been established in males, however, and their routine use is therefore not yet recommended

Modality, Potentiality and Contradiction in Quantum Mechanics

In [11], Newton da Costa together with the author of this paper argued in favor of the possibility to consider quantum superpositions in terms of a paraconsistent approach. We claimed that, even though most interpretations of quantum mechanics (QM) attempt to escape contradictions, there are many hints that indicate it could be worth while to engage in a research of this kind. Recently, Arenhart and Krause [1, 2, 3] have raised several arguments against this approach and claimed that, taking into account the square of opposition, quantum superpositions are better understood in terms of contrariety propositions rather than contradictory propositions. In [17] we defended the Paraconsistent Approach to Quantum Superpositions (PAQS) and provided arguments in favor of its development. In the present paper we attempt to analyze the meanings of modality, potentiality and contradiction in QM, and provide further arguments of why the PAQS is better suited, than the Contrariety Approach to Quantum Superpositions (CAQS) proposed by Arenhart and Krause, to face the interpretational questions that quantum technology is forcing us to consider.Comment: Published in: New Directions in Paraconsistent Logic, J-Y B\'eziau M. Chakraborty & S. Dutta (Eds.), Springer, in press. arXiv admin note: text overlap with arXiv:1404.518

Non-local signatures of the chiral magnetic effect in Dirac semimetal Bi0.97_{0.97}Sb0.03_{0.03}

The field of topological materials science has recently been focussing on three-dimensional Dirac semimetals, which exhibit robust Dirac phases in the bulk. However, the absence of characteristic surface states in accidental Dirac semimetals (DSM) makes it difficult to experimentally verify claims about the topological nature using commonly used surface-sensitive techniques. The chiral magnetic effect (CME), which originates from the Weyl nodes, causes an $\textbf{E}\cdot\textbf{B}$-dependent chiral charge polarization, which manifests itself as negative magnetoresistance. We exploit the extended lifetime of the chirally polarized charge and study the CME through both local and non-local measurements in Hall bar structures fabricated from single crystalline flakes of the DSM Bi$_{0.97}$Sb$_{0.03}$. From the non-local measurement results we find a chiral charge relaxation time which is over one order of magnitude larger than the Drude transport lifetime, underlining the topological nature of Bi$_{0.97}$Sb$_{0.03}$.Comment: 6 pages, 6 figures + 7 pages of supplemental materia

Many worlds and modality in the interpretation of quantum mechanics: an algebraic approach

Many worlds interpretations (MWI) of quantum mechanics avoid the measurement problem by considering every term in the quantum superposition as actual. A seemingly opposed solution is proposed by modal interpretations (MI) which state that quantum mechanics does not provide an account of what `actually is the case', but rather deals with what `might be the case', i.e. with possibilities. In this paper we provide an algebraic framework which allows us to analyze in depth the modal aspects of MWI. Within our general formal scheme we also provide a formal comparison between MWI and MI, in particular, we provide a formal understanding of why --even though both interpretations share the same formal structure-- MI fall pray of Kochen-Specker (KS) type contradictions while MWI escape them.Comment: submitted to the Journal of Mathematical Physic

Fatigue analysis-based numerical design of stamping tools made of cast iron

This work concerns stress and fatigue analysis of stamping tools made of cast iron with an essentially pearlitic matrix and containing foundry defects. Our approach consists at first, in coupling the stamping numerical processing simulations and structure analysis in order to improve the tool stiffness geometry for minimizing the stress state and optimizing their fatigue lifetime. The method consists in simulating the stamping process by considering the tool as a perfect rigid body. The estimated contact pressure is then used as boundary condition for FEM structure loading analysis of the tool. The result of this analysis is compared with the critical stress limit depending on the automotive model. The acceptance of this test allows calculating the fatigue lifetime of the critical zone by using the S–N curve of corresponding load ratio. If the prescribed tool life requirements are not satisfied, then the critical region of the tool is redesigned and the whole simulation procedures are reactivated. This method is applied for a cast iron EN-GJS-600-3. The stress-failure (S–N) curves for this material is determined at room temperature under push pull loading with different load ratios R0σmin/σmax0−2, R0−1 and R00.1. The effects of the foundry defects are determined by SEM observations of crack initiation sites. Their presence in tested specimens is associated with a reduction of fatigue lifetime by a factor of 2. However, the effect of the load ratio is more important

Little-studied arc-backarc system in the spotlight

A research cruise has documented changes in rift tectonics, volcanism, and hydrothermalism along the least studied and most enigmatic sector of a crustal complex in the southwest Pacific Ocean. Results from the longitudinal transect are expected to provide insight into processes involving the Kermadec arc-Havre backarc (KAHB) system, a continuum from oceanic spreading to continental rifting at a convergent plate boundary KAHB forms the central sector of an active, 2000-km arc-backarc complex between Tonga and New Zealand (Figure 1). The expedition also engaged in the first comprehensive survey of submarine vents in the Taupo Volcanic Zone (TVZ) at the south end of the KAHB system. Identified in the off-shore segment of TVZ were three major hydrothermal vent areas associated with late Quaternary fault structures. Data from the expedition and from other recent research in the same area addressed questions concerning the type of hydrothermal venting, magmatic heterogeneity along and across KAHB, the style of backarc rifting, and tectonic and magmatic consequences of anomalous terranes colliding with the subduction margin

Carnot cycle for an oscillator

Carnot established in 1824 that the efficiency of cyclic engines operating between a hot bath at absolute temperature $T_{hot}$ and a bath at a lower temperature $T_{cold}$ cannot exceed $1-T_{cold}/T_{hot}$. We show that linear oscillators alternately in contact with hot and cold baths obey this principle in the quantum as well as in the classical regime. The expression of the work performed is derived from a simple prescription. Reversible and non-reversible cycles are illustrated. The paper begins with historical considerations and is essentially self-contained.Comment: 19 pages, 3 figures, sumitted to European Journal of Physics Changed content: Fluctuations are considere

Dreaming of drams: Authenticity in Scottish whisky tourism as an expression of unresolved Habermasian rationalities

In this paper, the production of whisky tourism at both independently owned and corporately owned distilleries in Scotland is explored by focusing on four examples (Arran, Glengoyne, Glenturret and Bruichladdich). In particular, claims of authenticity and Scottishness of Scottish whiskies through commercial materials, case studies, website-forum discussions and 'independent' writing about such whisky are analysed. It is argued that the globalisation and commodification of whisky and whisky tourism, and the communicative backlash to these trends typified by the search for authenticity, is representative of a Habermasian struggle between two irreconcilable rationalities. This paper will demonstrate that the meaning and purpose of leisure can be understood through such explorations of the tension between the instrumentality of commodification and the freedom of individuals to locate their own leisure lives in the lifeworld that remains. © 2011 Taylor & Francis

The Results of CHD7 Analysis in Clinically Well-Characterized Patients with Kallmann Syndrome

Item does not contain fulltextCONTEXT: Kallmann syndrome (KS) and CHARGE syndrome are rare heritable disorders in which anosmia and hypogonadotropic hypogonadism co-occur. KS is genetically heterogeneous, and there are at least eight genes involved in its pathogenesis, whereas CHARGE syndrome is caused by autosomal dominant mutations in only one gene, the CHD7 gene. Two independent studies showed that CHD7 mutations can also be found in a minority of KS patients. OBJECTIVE: We aimed to investigate whether CHD7 mutations can give rise to isolated KS or whether additional features of CHARGE syndrome always occur. DESIGN: We performed CHD7 analysis in a cohort of 36 clinically well-characterized Dutch patients with KS but without mutations in KAL1 and with known status for the KS genes with incomplete penetrance, FGFR1, PROK2, PROKR2, and FGF8. RESULTS: We identified three heterozygous CHD7 mutations. The CHD7-positive patients were carefully reexamined and were all found to have additional features of CHARGE syndrome. CONCLUSION: The yield of CHD7 analysis in patients with isolated KS seems very low but increases when additional CHARGE features are present. Therefore, we recommend performing CHD7 analysis in KS patients who have at least two additional CHARGE features or semicircular canal anomalies. Identifying a CHD7 mutation has important clinical implications for the surveillance and genetic counseling of patients