Estimation of muscular forces from SSA smoothed sEMG signals calibrated by inverse dynamics-based physiological static optimization

The estimation of muscular forces is useful in several areas such as biomedical or rehabilitation engineering. As muscular forces cannot be measured in vivo non-invasively they must be estimated by using indirect measurements such as surface electromyography (sEMG) signals or by means of inverse dynamic (ID) analyses. This paper proposes an approach to estimate muscular forces based on both of them. The main idea is to tune a gain matrix so as to compute muscular forces from sEMG signals. To do so, a curve fitting process based on least-squares is carried out. The input is the sEMG signal filtered using singular spectrum analysis technique. The output corresponds to the muscular force estimated by the ID analysis of the recorded task, a dumbbell weightlifting. Once the model parameters are tuned, it is possible to obtain an estimation of muscular forces based on sEMG signal. This procedure might be used to predict muscular forces in vivo outside the space limitations of the gait analysis laboratory.Postprint (published version

Metabolic risk score indexes validation in overweight healthy people

The constellation of adverse cardiovascular disease (CVD) and metabolic risk factors, including elevated abdominal obesity, blood pressure (BP), glucose, and triglycerides (TG) and lowered high-density lipoprotein-cholesterol (HDL-C), has been termed the metabolic syndrome (MetSyn) [1]. A number of different definitions have been developed by the World Health Organization (WHO) [2], the National Cholesterol Education Program Adult Treatment Panel III (ATP III) [3], the European Group for the Study of Insulin Resistance (EGIR) [4] and, most recently, the International Diabetes Federation (IDF) [5]. Since there is no universal definition of the Metabolic Syndrome, several authors have derived different risk scores to represent the clustering of its components [6-11]

A lepto-hadronic model for the high energy emission from the jets of FR I radiogalaxies

We present a lepto-hadronic model for the VHE emission from the relativistic jets of FR I radiogalaxies. We assume that protons and electrons are accelerated in a compact region near the base of the jet, and they cool emitting multiwavelength radiation as they propagate along the jet. The particle distributions are obtained using an inhomogeneous steady-state transport equation that accounts for the cooling processes as well as the convection of particles in the jet. The dominant processes that contribute to the photon SED are electron and proton synchrotron radiation, inverse Compton interactions, and the inelastic collisions pp and pã. The accompanying neutrino output is obtained and the possibility of detection with Km3Net and IceCube is discussed for the cases of Cen A and M87.Fil: Reynoso, Matias Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Físicas de Mar del Plata. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Físicas de Mar del Plata; ArgentinaFil: Medina, Maria C.. L'Institut de recherche sur les lois fondamentales de l'Univers; FranciaFil: Romero, Gustavo Esteban. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; ArgentinaInternational Astronomical Union SymposiumReino UnidoInstituto Argentino de Radioastronomí

Fast quantitative analysis of n-alkanes, PAHs and alkenones in sediments

Altres ajuts: acord transformatiu CRUE-CSICUnidad de excelencia María de Maeztu CEX2019-000940-MThe study of different organic biomarker classes is essential to elucidate global Earth dynamics since different biogeochemical processes play a role in regulating environmental and climatic conditions. However, multiproxy analysis generally consists of labor-intensive and time-consuming methodologies, which hamper the study of a large number of samples. Here, we develop and validate a fast analytical method to quantify different classes of organic biomarkers (PAHs, n-alkanes and alkenones) in sediments. This new method sequentally extracts and fractionates the target compounds using a pressure liquid extraction (PLE) system, which allows us to selectively obtain the analytes by reducing the time of analysis, sample handling and solvent usage. We show that our method provides reproducible results and high recoveries (>70%), and can be applied to a wide range of sedimentary environments, such as oceanic basins, continental slope and shelf, and lakes. Moreover, the method provides reproducible estimates of paleoclimatic indices, such as the carbon preference index (CPI), the average chain length (ACL) and the U37K'-derived sea-surface temperature (SST). Therefore, this new method enables fast quantitative multiproxy analysis of oceanic, coastal and lake sediments

El Plan Estratégico y el Desarrollo Económico Local de la Ciudad de Córdoba, Argentinade

The Strategic Plan of Córdoba (PEC) is one of the few strategic urban development plans in Latin America which has actually been implemented in the majority of its components. The PEC was conceived as a collective and global project of the city as a whole without excessive protagonism or special ownership by a few. The PEC integrated a policy of public works – oriented at the “social debt” which existed in the city – with a work on urbanistic norms and directions and economic development. The PEC as a space for articulation achieved to organise a great number of representatives from civil society organisations, achieving legitimacy and representation in the work of the PEC

Dataset of above and below ground traits assessed in Durum wheat cultivars grown under Mediterranean environments differing in water and temperature conditions

Ideotypic characteristics of durum wheat associated with higher yield under different water and temperature regimes were studied under Mediterranean conditions. The focus of this paper is to provide raw and supplemental data from the research article entitled "Durum wheat ideotypes in Mediterranean environments differing in water and temperature conditions" [1], which aims to define specific durum wheat ideotypes according to their responses to different agronomic conditions. In this context, six modern (i.e. post green revolution) genotypes with contrasting yield performance (i.e. high vs low yield) were grown during two consecutive years under different treatments: (i) winter planting under support-irrigation conditions, (ii) winter planting under rainfed conditions, (iii) late planting under support-irrigation. Trials were conducted at the INIA station of Colmenar de Oreja (Madrid). Different traits were assessed to inform about water status (canopy temperature at anthesis and stable carbon isotope composition (delta C-13) of the flag leaf and mature grains), root performance (root traits and the oxygen isotope composition (delta O-18) in the stem base water), phenology (days from sowing to heading), nitrogen status/photosynthetic capacity (nitrogen content and stable isotope composition (delta N-15) of the flag leaf and mature grain together with the pigment contents and the nitrogen balance index (NBI) of the flag leaf), crop growth (plant height (PH) and the normalized difference vegetation index (NDVI) at anthesis), grain yield and agronomic yield components. For most of the parameters assessed, data analysis demonstrated significant differences among genotypes within each treatment. The level of significance was determined using the Tukey-b test on independent samples, and ideotypes were modelled from the results of principle component analysis. The present data shed light on traits that help to define specific ideotype characteristics that confer genotypic adaptation to a wide range of agronomic conditions produced by variations in planting date, water conditions and seasonThis study was supported by the Spanish projects PID2019-106650RB-C21 and PCIN-2017-063, from the Ministerio de Ciencia e Innovacion, Spain. FZR is a recipient of a research grant (FI-AGAUR) sponsored by the Agency for Management of University and Research Grants (AGAUR) in collaboration with the University of Barcelona (UB) . We thank the personnel from the exper-imental station of INIA at Colmenar de Oreja (Aranjuez) for their continued support of our re-search. We thank the members of the Integrative Crop Ecophysiology Group for their assistance during the data assessment of the study. We extend our thanks to The Water Research Institute (IdRA) for their financial support to cover laboratory analyses. JLA acknowledges support from ICREA Academia, Generalitat de Catalunya, Spain. We thank Dr. J.Voltas from the University of Lleida, Spain, for his support with the delta 18O water analyses

Identification of β2 microglobulin, the product of B2M gene, as a Host Factor for Vaccinia Virus Infection by Genome-Wide CRISPR genetic screens

Genome-wide genetic screens are powerful tools to identify genes that act as host factors of viruses. We have applied this technique to analyze the infection of HeLa cells by Vaccinia virus, in an attempt to find genes necessary for infection. Infection of cell populations harboring single gene inactivations resulted in no surviving cells, suggesting that no single gene knock-out was able to provide complete resistance to Vaccinia virus and thus allow cells to survive infection. In the absence of an absolute infection blockage, we explored if some gene inactivations could provide partial protection leading to a reduced probability of infection. Multiple experiments using modified screening procedures involving replication restricted viruses led to the identification of multiple genes whose inactivation potentially increase resistance to infection and therefore cell survival. As expected, significant gene hits were related to proteins known to act in virus entry, such as ITGB1 and AXL as well as genes belonging to their downstream related pathways. Additionally, we consistently found β2-microglobulin, encoded by the B2M gene, among the screening top hits, a novel finding that was further explored. Inactivation of B2M resulted in 54% and 91% reduced VV infection efficiency in HeLa and HAP1 cell lines respectively. In the absence of B2M, while virus binding to the cells was unaffected, virus internalization and early gene expression were significantly diminished. These results point to β2-microglobulin as a relevant factor in the Vaccinia virus entry process.This work was supported by grants ERTA2014-00006, RTA2017-0066 and PID2021-128466OR-I00 funded by Ministerio de Ciencia e Innovación MCIN/AEI/10.13039/501100011033 as part of the Plan Estatal de Investigación Científica, Desarrollo e Innovación (https://www.ciencia.gob.es) to R.B. A.M. was recipient of a predoctoral contract from Subprograma Estatal de Formación, Programa Estatal de Promoción del Talento y su Empleabilidad en I+D+I, Spain from the Ministerio de Ciencia e Innovación, grant number PRE2018-085415. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.S

Enfoques para promover la participación infantil y adolescente.

La participación constituye un fin en sí mismo que redunda en la autonomía individual y empoderamiento colectivo, a la vez que es también un medio que fortalece la calidad democrática de nuestras sociedades. Reconocida como derecho universal humano (1948), el derecho a participar queda protegido para la ciudadanía infantil en la legislación internacional de mediados y último tercio del siglo XX que asume la infancia como sujeto de derechos. Los estudios acerca de la participación de este colectivo se apoyan en dicho reconocimiento jurídico para aproximarse a la realidad desde un enfoque de derechos donde niños, niñas y adolescentes constituyen actores sociales. Este artículo se propuso realizar un ejercicio de análisis teórico acerca de la participación en general y de la participación infantil y adolescente en particular, a la luz de otros enfoques que consideramos complementarios al enfoque de derechos, pero escasamente explotados: el enfoque de capacidades, el enfoque feminista y el enfoque intercultural desde una lectura socio-crítica. Los resultados del análisis teórico-conceptual permitieron vincular el concepto de participación con los de agencia y autonomía, así como evidenciar las inercias y barreras sociales, culturales e institucionales que limitan los procesos participativos en la ciudadanía, con especial incidencia en las experiencias y vivencias de la infancia y la adolescencia. Se concluye que la participación de niños, niñas y adolescentes hace referencia a una capacidad individual, colectiva y territorial, expuesta y limitada por estereotipos binarios o patriarcales y adultocéntricos. Los tres enfoques planteados nos invitan, en definitiva, a repensar la participación infantil y adolescente desde los valores de autonomía, responsabilidad, igualdad y diversidad

Impacto socio económico de la explotación de banano tipo exportación en la Vereda De Guachaca

El estudio del impacto socioeconómico de la explotación de Banano tipo exportación en la vereda de Guachaca, nos permite determinar los cambios que se han operado en la vereda al implantarse empresas altamente capitalistas como lo es la industria bananera. La zona de Guachaca, como característica generalizada del sector rural colombiano, presentaba como actividad principal la economía campesina o de subsistencia basada en los productos de pan coger, dándose la subutilización de las mejores tierras en una ganadería extensiva que mantenía a la población en un estadio de estancamiento económico y social, al no contar con fuentes de empleo que les permitiera una estabilidad en sus ingresos mejorando así sus condiciones de vida. Con el inicio de la industria bananera la zona ha sufrido fluctuaciones económicas y sociales, que se han hecho evidentes con la vinculación de gran parte de la población a dicha actividad. Lo cual ha generado un mejoramiento en los niveles de vida de la población, al contar con unos ingresos estables que garanticen una mayor satisfacción de sus necesidades básicas, lo que se convierte en factor de atracción para inmigrantes que encuentran un aspecto propicio para vivir