Influence of digital technologies of distance education on the mental health of a child in the conditions of wartime realities

Russian aggression against Ukraine has caused considerable damage not only to the Ukrainian economy and infrastructure but also to the mental health of the nation. The highest risk group includes schoolchildren who have experienced traumatic experiences and, in some cases, physical injuries. The purpose of the article is to analyze the impact of digital technologies of distance education on the mental health of children in the conditions of military operations. Methods of analysis, synthesis, structural-functional, prognostic were used. In the results, the general problems of children's mental health formation in Ukraine were determined, peculiarities of the implementation of the recommendations of the World Health Organization regarding the observance of mental health were traced, and the effects of an aggressive digital environment, which were intensified by military actions, were determined. Special attention is paid to the recommendations to teachers regarding the continued use of digital technologies and distance education in wartime conditions. In the conclusions, it was noted that military challenges impose additional obligations on teachers and parents, because in the conditions of martial law, protecting children's psyche from additional stress is extremely important. For this, a system of methodological recommendations has been developed, which will be relevant for this process

Phytoremediation combined with biorefinery on the example of two agricultural crops grown on Ni soil and degraded by P. chrysosporium

During the last few decades, phytoremediation process has attracted much attention because of the growing concerns about the deteriorating quality of soil caused by anthropogenic activities. Here, a tandem phytoremediation/biorefinery process was proposed as a way to turn phytoremediation into a viable commercial method by producing valuable chemicals in addition to cleaned soil. Two agricultural plants (Sinapis alba and Helianthus annuus) were grown in moderately contaminated soil with ca. 100 ppm of Ni and further degraded by a fungal lignin degrader - Phanerochaete chrysosporium. Several parameters have been studied: the viability of plants, biomass yield and their accumulating and remediating potentials. Further down-stream processing showed that up to 80% of Ni can be easily extracted from contaminated biomass by aqueous extraction at mild conditions. Finally, it was demonstrated that the grown onto contaminated soil plants can be degraded by Phanerochaete chrysosporium and the effect of nickel and biomass pre-treatment on the solid state fermentation was studied. The proposed and studied in this work methodology can pave the way to successful commercialization of the phytoremediation process in the near futur

A basin-wide Black Sea Mnemiopsis leidyi database

A specific marine biological data management tool, the Black Sea Mnemiopsis leidyi database system was created within the European Commission 6th framework Black Sea SCENE project for the Black Sea region and is now being supported by the Permanent Secretariat of the Black Sea Commission. The core team of scientists studying M. leidyi in the Black Sea was brought together and all their available M. leidyi data and metadata were loaded into the common database. This works on the Internet and has a simple user interface. It gives Black Sea scientists the option to load all their corresponding data on the database and to use it as an effective tool to work both with M. leidyi and, in future, with other gelatinous organisms’ data, including another invasive ctenophore Beroe ovata. All loaded metadata and historical data are available to the entire scientific community. More recent data are available to the team members and with some restrictions to other scientists.JRC.H.5-Land Resources Managemen

Photovaractor performance for optically controlled microwave circuits, Journal of Telecommunications and Information Technology, 2002, nr 1

The photovaractor for optically controlled microwave circuits was designed and studied. The photovaractor module was fabricated as a planar p-i-n photodiode chip placed in a fibre optic matching receptacles. Study of C-V characteristics in the light illumination mode has shown that capacitance characteristics are strongly dependent on the light illumination power. These variations of the photovaractor diode capacitance are large enough to be used in optically controlled circuits such as oscillators, mixers and switchers

Mutations in KEOPS-Complex Genes Cause Nephrotic Syndrome with Primary Microcephaly

Galloway-Mowat syndrome (GAMOS) is an autosomal-recessive disease characterized by the combination of early-onset nephrotic syndrome (SRNS) and microcephaly with brain anomalies. Here we identified recessive mutations in OSGEP, TP53RK, TPRKB, and LAGE3, genes encoding the four subunits of the KEOPS complex, in 37 individuals from 32 families with GAMOS. CRISPR-Cas9 knockout in zebrafish and mice recapitulated the human phenotype of primary microcephaly and resulted in early lethality. Knockdown of OSGEP, TP53RK, or TPRKB inhibited cell proliferation, which human mutations did not rescue. Furthermore, knockdown of these genes impaired protein translation, caused endoplasmic reticulum stress, activated DNA-damage-response signaling, and ultimately induced apoptosis. Knockdown of OSGEP or TP53RK induced defects in the actin cytoskeleton and decreased the migration rate of human podocytes, an established intermediate phenotype of SRNS. We thus identified four new monogenic causes of GAMOS, describe a link between KEOPS function and human disease, and delineate potential pathogenic mechanisms

Peculiarities of the active component formation in alumina-supported copper molybdate catalysts for soot combustion

Peculiarities of the formation of the phase composition of alumina-supported copper molybdate catalysts and their reactivity in the soot oxidation model reaction have been studied. Catalysts have been prepared by incipient wetness impregnation with aqueous solutions of precursors of the supported components, while varying the order of introduction of the components and their molar ratio and content. The catalysts have been studied by XRD, UV-vis DR spectroscopy, and H2-TPR. It has been shown that the phase composition of the supported samples and, as a consequence, their catalytic activity are significantly affected by the order of introduction of the supported components due to their interaction with the support

Denosumab induction and Zoledronic acid maintenance therapy for recurrent unresectable giant cell tumour of the distal tibia: A case report with sustained tumour control after drug withdrawal

A 31-year-old woman was diagnosed with a recurrent and rapidly growing giant cell tumour of distal tibia with skin ulceration after intralesional curettage. The patient started on Denosumab 120 mg subcutaneously, once per month with additional loading doses on Days 8 and 15 attempting to avoid below-knee amputation. Twelve doses of Denosumab were administered in 9 months, resulting in resolution of pain, reduction of tumour size and calcification. Hence, the local surgical treatment was delayed and bisphosphonate maintenance therapy was initiated as skin healing was incomplete. The patient was given Zoledronic acid infusions at a dose of 4 mg. After the third infusion, the skin healed. As tumour remained stable, it was decided to continue maintenance. Overall, six doses of Zoledronic acid at 6 months intervals were administrated over 3 years. At the end of the maintenance, the patient experienced no pain and satisfied with her limb function. Since the lesion remained stable over 3 years after Denosumab discontinuation, it was suggested to stop further medical treatment and proceed to active surveillance. The patient’s disease is still stable clinical remission with no serious adverse events 41 months after Denosumab cessation and 10 months after the last bisphosphonate infusion. The present case confirmed the high effectiveness of denosumab as induction therapy in advanced recurrent giant cell tumour. We speculate that following the Denosumab-induced tumour ossification, high Zoledronic acid uptake in lesion may prevent tumour reactivation due to its improved pharmacodynamics with an assumed irreversible anti-tumoral effect on residual mutated cells. This hypothesis requires confirmation in future studies

THE STUDY OF CADMIUM UPTAKE BY WATER HYACINTH (EICHHORNIA CRASSIPES) USING A NATURAL MODELLING APPROACH

The results of the investigation on the accumulation of cadmium by water hyacinth, depending on the conditions of pollutant exposure and the presence of various additives are discussed. The main specialty of this study is that all the experiments were carried out in natural conditions using the approach based on the application of the capacities called minicosms. It allowed estimating hit consequences of pollutant on ecosystem most really having made experiment in the conditions as much as possible close to the natural. In this article a very important problem of an accuracy and reliability of the results of trace elements determination in plants is also debated. As a result of carried investigations it was shown that the degree of cadmium extraction by hyacinth from contaminated natural water while maintaining the viability of the plants depends on the way of pollutant introducing into the reservoir and the maximum (about 79%) value is observed in the case of it’s gradual entry

Photovaractor performance for optically controlled microwavecircuits

The photovaractor for optically controlled microwave circuits was designed and studied. The photovaractor module was fabricated as a planar p-i-n photodiode chip placed in a fibre optic matching receptacles. Study of C-V characteristics in the light illumination mode has shown that capacitance characteristics are strongly dependent on the light illumination power. These variations of the photovaractor diode capacitance are large enough to be used in optically controlled circuits such as oscillators, mixers and switchers