Improving Visual Field Examination of the Macula Using Structural Information

Purpose: To investigate a novel approach for structure-function modeling in glaucoma to improve visual field testing in the macula. Methods: We acquired data from the macular region in 20 healthy eyes and 31 with central glaucomatous damage. Optical coherence tomography (OCT) scans were used to estimate the local macular ganglion cell density. Perimetry was performed with a fundus-tracking device using a 10-2 grid. OCT scans were matched to the retinal image from the fundus perimeter to accurately map the tested locations onto the structural damage. Binary responses from the subjects to all presented stimuli were used to calculate the structure-function model used to generate prior distributions for a ZEST (Zippy Estimation by Sequential Testing) Bayesian strategy. We used simulations based on structural and functional data acquired from an independent dataset of 20 glaucoma patients to compare the performance of this new strategy, structural macular ZEST (MacS-ZEST), with a standard ZEST. Results: Compared to the standard ZEST, MacS-ZEST reduced the number of presentations by 13% in reliable simulated subjects and 14% with higher rates (≥20%) of false positive or false negative errors. Reduction in mean absolute error was not present for reliable subjects but was gradually more important with unreliable responses (≥10% at 30% error rate). Conclusions: Binary responses can be modeled to incorporate detailed structural information from macular OCT into visual field testing, improving overall speed and accuracy in poor responders. Translational Relevance: Structural information can improve speed and reliability for macular testing in glaucoma practice

Two years of monitoring Supergiant Fast X-ray Transients with Swift

We present two years of intense Swift monitoring of three SFXTs, IGR J16479-4514, XTE J1739-302, and IGR J17544-2619 (since October 2007). Out-of-outburst intensity-based X-ray (0.3-10keV) spectroscopy yields absorbed power laws with by hard photon indices (G~1-2). Their outburst broad-band (0.3-150 keV) spectra can be fit well with models typically used to describe the X-ray emission from accreting NSs in HMXBs. We assess how long each source spends in each state using a systematic monitoring with a sensitive instrument. These sources spend 3-5% of the total in bright outbursts. The most probable flux is 1-2E-11 erg cm^{-2} s^{-1} (2-10 keV, unabsorbed), corresponding to luminosities in the order of a few 10^{33} to 10^{34} erg s^{-1} (two orders of magnitude lower than the bright outbursts). The duty-cycle of inactivity is 19, 39, 55%, for IGR J16479-4514, XTE J1739-302, and IGR J17544-2619, respectively. We present a complete list of BAT on-board detections further confirming the continued activity of these sources. This demonstrates that true quiescence is a rare state, and that these transients accrete matter throughout their life at different rates. X-ray variability is observed at all timescales and intensities we can probe. Superimposed on the day-to-day variability is intra-day flaring which involves variations up to one order of magnitude that can occur down to timescales as short as ~1ks, and whichcan be explained by the accretion of single clumps composing the donor wind with masses M_cl~0.3-2x10^{19} g. (Abridged)Comment: Accepted for publication in MNRAS. 17 pages, 11 figures, 8 table

Effect of Ferric Sodium EDTA administration, in combination with vitamin C, folic acid, copper gluconate, zinc gluconate and selenomethionine, on cardiovascular risk evaluation: exploration of the HRV frequency domain

diseases. Using the Heart Rate Variability (HRV) analysis is possible to provide an evaluation of the safety and the effectiveness of intervention. Objective: To evaluate the efficacy and safety of Ferric Sodium EDTA in combination with vitamin C, folic acid, copper gluconate, zinc gluconate and selenomethionine (Ferachel forte®) 2 tabs/day for 24 days in elderly patients with secondary anaemia, by exploring the HRV frequency domain. Methods: In 45 elderly patients with secondary anaemia and/or low-moderate kidney failure, laboratory values after administration of Ferric Sodium EDTA, 2 tabs a day, in combination with vitamin C, folic acid, copper gluconate, zinc gluconate and selenomethionine (Ferachel forte®) for 24 days (N=16 patients) or ferrous gluconate 63 mg/day added to saline solution, administered using intravenous access during the hospitalization period of 15 ± 5 days (N=29 patients) were evaluated. Also, ECG signals and bioelectrical impedance (BIA) were measured. Results: Oral iron supplementation with Ferric Sodium EDTA, in combination with vitamin C, folic acid, copper gluconate, zinc gluconate and selenomethionine (Ferachel forte®) confirmed to be effective and safe about the cardiovascular risk in old patients. This study showed the real superiority of the oral administration about the cardiovascular risk in elderly patients in comparison with intravenous administration of ferrous gluconate. Conclusion: This study confirms that Ferric Sodium EDTA combination (Ferachel forte®) can be a valid alternative to ferrous gluconate intravenous therapy (gold standard) in the treatment of secondary anaemia in elderly patients. In fact, during the treatment, efficacy results have been maintained without statistically significant variations about cardiovascular risk, evaluated by exploring the HRV frequency domain

C ion-implanted TiO2 thin film for photocatalytic applications

Third-generation TiO2 photocatalysts were prepared by implantation of C+ ions into 110 nm thick TiO2 films. An accurate structural investigation was performed by Rutherford backscattering spectrometry, secondary ion mass spectrometry, X-ray diffraction, Raman-luminescence spectroscopy, and UV/VIS optical characterization. The C doping locally modified the TiO2 pure films, lowering the band-gap energy from 3.3 eV to a value of 1.8 eV, making the material sensitive to visible light. The synthesized materials are photocatalytically active in the degradation of organic compounds in water under both UV and visible light irradiation, without the help of any additional thermal treatment. These results increase the understanding of the C-doped titanium dioxide, helpful for future environmental applications. (C) 2015 AIP Publishing LLC

Polar cap absorption events of November 2001 at Terra Nova Bay, Antarctica

Polar cap absorption (PCA) events recorded during November 2001 are investigated by observations of ionospheric absorption of a 30MHz riometer installed at Terra Nova Bay (Antarctica), and of solar proton flux, monitored by the NOAA-GOES8 satellite in geo-synchronous orbit. During this period three solar proton events (SPE) on 4, 19 and 23 November occurred. Two of these are among the dozen most intense events since 1954 and during the current solar cycle (23rd), the event of 4 November shows the greatest proton flux at energies >10MeV. Many factors contribute to the peak intensity of the two SPE biggest events, one is the Coronal Mass Ejection (CME) speed, other factors are the ambient population of SPE and the shock front due to the CME. During these events absorption peaks of several dB (~20dB) are observed at Terra Nova Bay, tens of minutes after the impact of fast halo CMEs on the geomagnetic field. </p><p style="line-height: 20px;"> Results of a cross-correlation analysis show that the first hour of absorption is mainly produced by 84–500MeV protons in the case of the 4 November event and by 15–44MeV protons for the event of 23 November, whereas in the entire event the contribution to the absorption is due chiefly to 4.2–82MeV (4 November) and by 4.2–14.5MeV (23 November). Good agreement is generally obtained between observed and calculated absorption by the empirical flux-absorption relationship for threshold energy <i>E<sub>0</sub></i>=10MeV. From the residuals one can argue that other factors (e.g. X-ray increases and geomagnetic disturbances) can contribute to the ionospheric absorption.<br><br><b>Key words.</b> Ionosphere (Polar Ionosphere, Particle precipitation) – Solar physics (Flares and mass ejections

XMM-Newton and Swift observations of XTE J1743-363

XTEJ1743-363 is a poorly known hard X-ray transient, that displays short and intense flares similar to those observed from Supergiant Fast X-ray Transients. The probable optical counterpart shows spectral properties similar to those of an M8 III giant, thus suggesting that XTEJ1743-363 belongs to the class of the Symbiotic X-ray Binaries. In this paper we report on the first dedicated monitoring campaign of the source in the soft X-ray range with XMM-Newton and Swift/XRT. T hese observations confirmed the association of XTEJ1743-363 with the previously suggested M8 III giant and the classification of the source as a member of the Symbiotic X-ray binaries. In the soft X-ray domain, XTEJ1743-363 displays a high absorption (~6x10^22 cm^-2 ) and variability on time scales of hundreds to few thousand seconds, typical of wind accreting systems. A relatively faint flare (peak X-ray flux 3x10^-11 erg/cm^2/s) lasting ~4 ks is recorded during the XMM-Newton observation and interpreted in terms of the wind accretion scenario.Comment: Accepted for publication on A&

Hida Scan in The Follow-Up of Biliary-Enteric Anastomoses

In order to assess the patency and function of biliary-enteric anastomoses performed in our Department of Surgery, 21 patients entered the following study, provided an informed consent was obtained. All the patients were affected by benign biliary tract diseases and underwent either Roux-en-Y hepaticojejunostomy (11 cases), or side-to-side choledochoduodenostomy (10 cases). The 21 patients were evaluated with Tc-99m-HIDA scanning at intervals of 20 days–36 months after the surgical procedure (mean 14 months). The images were obtained after intravenous injection of the radioactive medium (5 mCi) and the scans were taken at 1 min (1 frame/s), 3 min (1 frame/10 s), and 56 min (1 frame/2 min). The data were analyzed by a Digital PDP 11/34 Computer System. This method allowed us to assess each individual patient for the patency of the anastomosis and, by computer analysis, to build up a profile of the timing of the passage of the radioactive medium through the anastomosis; a delayed passage across the anastomosis was always pathological

Green Root Collective Action for Conservation of Agri-Bio Diversity: a Case Study in Tuscany

The literature on environmental policy shows that institutional arrangements are key in designing effective environmental policies. Besides regulation and market (Coasian) solutions, grass root collective action has been advocated as a possible solution for the provision of agro-environmental public goods. We gauge that the same institutional arrangement can be found in many territorially integrated food chains that aims at re-embedding food production in the local society. Building on this literature, we present a case study - a short supply chain for bread production from ancient local wheat landraces in Tuscany – emphasizing the role played by collective action in maintaining high quality production in a context of severe information asymmetries

Validation of driving behaviour as a step towards the investigation of Connected and Automated Vehicles by means of driving simulators

Connected and Automated Vehicles (CAVs) are likely to become an integral part of the traffic stream within the next few years. Their presence is expected to greatly modify mobility behaviours, travel demands and habits, traffic flow characteristics, traffic safety and related external impacts. Tools and methodologies are needed to evaluate the effects of CAVs on traffic streams, as well as the impact on traffic externalities. This is particularly relevant under mixed traffic conditions, where human-driven vehicles and CAVs will interact. Understanding technological aspects (e.g. communication protocols, control algorithms, etc.) is crucial for analysing the impact of CAVs, but the modification induced in human driving behaviours by the presence of CAVs is also of paramount importance. For this reason, the definition of appropriate CAV investigations methods and tools represents a key (and open) issue. One of the most promising approaches for assessing the impact of CAVs is operator in the loop simulators, since having a real driver involved in the simulation represents an advantageous approach. However, the behaviour of the driver in the simulator must be validated and this paper discusses the results of some experiments concerning car-following behaviour. These experiments have included both driving simulators and an instrumented vehicle, and have observed the behaviours of a large sample of drivers, in similar conditions, in different experimental environments. Similarities and differences in driver behaviour will be presented and discussed with respect to the observation of one important quantity of car-following, the maintained spacing

Spin relaxation rates in quasi-one-dimensional coupled quantum dots

We study theoretically the spin relaxation rate in quasi-one-dimensional coupled double semiconductor quantum dots. We consider InSb and GaAs-based systems in the presence of the Rashba spin-orbit interaction, which causes mixing of opposite-spin states, and allows phonon-mediated transitions between energy eigenstates. Contributions from all phonon modes and coupling mechanisms in zincblende semiconductors are taken into account. The spin relaxation rate is shown to display a sharp, cusp-like maximum as function of the interdot-barrier width, at a value of the width which can be controlled by an external magnetic field. This remarkable behavior is associated with the symmetric-antisymmetric level splitting in the structure.Comment: 4 figures, Submitted to Applied Physics Letter