Green urine from propofol

"A 65-year-old female, with past medical history of hypertension and chronic hypoxemic respiratory failure due to chronic obstructive pulmonary disease (COPD), was admitted after endoscopic resection of colonic polyps and a large rectal mass. For this procedure, general anesthesia with intravenous Propofol was utilized. Due to technical difficulty of the procedure, the total anesthesia time was 7 hours and 48 minutes with a total use of 2,951.06 mg of Propofol. On post-procedure day #1, the patient's urine was noted to be green (Figure 1). The patient denied dysuria, frequency, urgency, and foul smell. Additionally, liver function tests, renal function tests, complete blood count, and urinalysis were all within normal limits."Cole T. Bredehoeft (1), Rebecca T. Rist (2), Christian A. Rojas-Moreno (2,3); 1. School of Medicine, University of Missouri. 2. Department of Medicine, University of Missouri. 3. Division of Infectious Diseases, Department of Medicine, University of Missouri.Includes bibliographical reference

Predicting the growth of lettuce from soil infrared reflectance spectra: the potential for crop management

How well could one predict the growth of a leafy crop from reflectance spectra from the soil and how might a grower manage the crop in the light of those predictions? Two fields in the Cambridgeshire Fens in eastern England where farmers grow lettuce commercially were studied. Topsoil was sampled and analysed for various nutrients, particle-size distribution, and organic carbon concentration. Crop measurements (lettuce diameter) were derived by photogrammetry. Reflectance spectra were obtained in the laboratory from the soil in the near- and mid-infrared ranges, and these were used to predict crop performance by partial least squares regression (PLSR). Individual soil properties were also predicted from the spectra by PLSR. These estimated soil properties were used to predict lettuce diameter with a linear model (LM) and a linear mixed model (LMM): considering differences between lettuce varieties and the spatial correlation between data points. The PLSR predictions of the soil properties and lettuce diameter were close to observed values, with the latter showing a mean squared error (MSE) of 3.90 cm2 for Field 1 and 6.87 cm2 for Field 2. Prediction of lettuce diameter from the estimated soil properties with the LMs gave somewhat poorer results than those that used the soil spectra as predictor variables (difference in MSE for Field 1: 0.69 cm2 and Field 2: 2.12 cm2). Predictions from LMMs were more precise than those from the raw spectra (by PLSR alone) with a difference in mean squared error (MSE) of 2.12 cm2 for Field 1 and of 5.10 cm2 for Field 2. All model predictions improved when the effects of variety were taken into account. Predictions from the reflectance spectra, via the estimation of soil properties, can enable growers to decide what treatments to apply to grow lettuce and how to vary their treatments within their fields to maximize the net profit from the crop

Degassing at Sabancaya volcano measured by UV cameras and the NOVAC network

We used low-cost Raspberry Pi ultraviolet (UV) cameras to measure sulphur dioxide (SO2) fluxes from Sabancaya volcano, Peru, during eruptive activity on 27 April 2018. Light dilution corrections were made by operating instruments at two distances simultaneously. Estimated SO2 fluxes of 27.1 kgs-1 are higher than previously reported, likely due to the current eruptive episode (ongoing since November 2016). Each eruptive event included frequent (2–3 per minute), ash-rich emissions, forming gas pulses with masses of 3.0–8.2 tonnes SO2. Sustained degassing and lack of overpressure suggest open-vent activity. Mean fluxes are consistent with those measured by a permanent NOVAC station (25.9 kgs-1) located under the plume, with remaining differences likely due to windspeed estimates and sampling rate. Our work highlights the importance of accurate light dilution and windspeed modelling in SO2 retrievals and suggests that co-location of UV cameras with permanent scanning spectrometers may be valuable in providing accurate windspeeds

Influence of irrigation type in the prevalence of bovine fasciolosis, Cajamarca-Peru

La fasciolosis es una enfermedad zoonótica relevante en los Andes peruanos, causa considerables pérdidas económicas al reducir la productividad del ganado y actualmente se reporta resistencia a los antihelmínticos, por lo que es necesario encontrar nuevas formas de control integral de esta parasitosis; por ello, el objetivo de este estudio fue demostrar la influencia del tipo de riego en la prevalencia de la fasciolosis bovina (Bos taurus) en unidades de producción lechera en la provincia de San Marcos, región Cajamarca, Perú. Un total de 20 bovinos lecheros fueron introducidos en dos predios con diferentes sistemas de riego: tradicional o por inundación (n = 10) y tecnificado o por aspersión (n = 10). A partir de marzo y durante diez meses consecutivos fueron alimentados con las raciones cultivadas en los predios y se monitoreó la prevalencia de fasciolosis mediante la técnica coproparasitológica de sedimentación natural. La excreción de huevos comenzó en agosto en la unidad ganadera que utilizaba el riego por inundación, con una prevalencia final del 60%; mientras que en la unidad ganadera que utilizaba el riego por aspersión, los primeros casos se detectaron en septiembre, con una prevalencia final de 20%. A los resultados, la prueba de Fischer determinó que no había asociación entre la prevalencia del parásito y el tipo de riego (p=0,1698). El estudio sugiere que la prevalencia de la fasciolosis en los bovinos alimentados con pasto rye-grass (Lolium perenne) más trébol (Trifolium repens) cultivados con riego por inundación fue mayor que la del riego por aspersión; sin embargo, se recomienda investigar con un mayor número de muestras y utilizar métodos de diagnóstico más específicos.Fasciolosis is a relevant zoonotic disease in the Peruvian Andes, it causes considerable economic losses by reducing cattle productivity and currently, resistance to anthelmintics is reported, so it is necessary to find new ways to comprehensively control this parasitosis. In this context, the objective of this study was to demonstrate the influence of the type of irrigation on the prevalence of bovine (Bos taurus) fasciolosis in dairy production units in the province of San Marcos, Cajamarca region, Peru. A total of 20 dairy cattle were introduced in two farms with different irrigation systems: traditional or flood irrigation (n = 10) and technified or sprinkler irrigation (n = 10). Starting in March and for ten consecutive months they were fed the rations produced on the farms and the prevalence of fasciolosis was monitored using the coproparasitological technique of natural sedimentation. In the livestock unit using flood irrigation, eggs excretion began in August, with a final prevalence of 60%; while in the livestock unit using sprinkler irrigation, the first cases were detected in September and the final prevalence was 20%. To the results, Fischer’s test determined that there was no association between the prevalence of the parasite and the type of irrigation (p=0.1698). The study suggests that the prevalence of fasciolosis in cattle fed rye-grass (Lolium perenne) / clover (Trifolium repens) grown with flood irrigation was higher than that of sprinkler irrigation; however, it is recommended to investigate with a larger number of samples and use more specific diagnostic methods

All-particle cosmic ray energy spectrum measured by the HAWC experiment from 10 to 500 TeV

We report on the measurement of the all-particle cosmic ray energy spectrum with the High Altitude Water Cherenkov (HAWC) Observatory in the energy range 10 to 500 TeV. HAWC is a ground based air-shower array deployed on the slopes of Volcan Sierra Negra in the state of Puebla, Mexico, and is sensitive to gamma rays and cosmic rays at TeV energies. The data used in this work were taken from 234 days between June 2016 to February 2017. The primary cosmic-ray energy is determined with a maximum likelihood approach using the particle density as a function of distance to the shower core. Introducing quality cuts to isolate events with shower cores landing on the array, the reconstructed energy distribution is unfolded iteratively. The measured all-particle spectrum is consistent with a broken power law with an index of $-2.49\pm0.01$ prior to a break at $(45.7\pm0.1$) TeV, followed by an index of $-2.71\pm0.01$. The spectrum also respresents a single measurement that spans the energy range between direct detection and ground based experiments. As a verification of the detector response, the energy scale and angular resolution are validated by observation of the cosmic ray Moon shadow's dependence on energy.Comment: 16 pages, 11 figures, 4 tables, submission to Physical Review

Search for very-high-energy emission from Gamma-ray Bursts using the first 18 months of data from the HAWC Gamma-ray Observatory

The High Altitude Water Cherenkov (HAWC) Gamma-ray Observatory is an extensive air shower detector operating in central Mexico, which has recently completed its first two years of full operations. If for a burst like GRB 130427A at a redshift of 0.34 and a high-energy component following a power law with index -1.66, the high-energy component is extended to higher energies with no cut-off other than from extragalactic background light attenuation, HAWC would observe gamma rays with a peak energy of $\sim$300 GeV. This paper reports the results of HAWC observations of 64 gamma-ray bursts (GRBs) detected by $\mathit{Swift}$ and $\mathit{Fermi}$, including three GRBs that were also detected by the Large Area Telescope ($\mathit{Fermi}$-LAT). An ON/OFF analysis method is employed, searching on the time scale given by the observed light curve at keV-MeV energies and also on extended time scales. For all GRBs and time scales, no statistically significant excess of counts is found and upper limits on the number of gamma rays and the gamma-ray flux are calculated. GRB 170206A, the third brightest short GRB detected by the Gamma-ray Burst Monitor on board the $\mathit{Fermi}$ satellite ($\mathit{Fermi}$-GBM) and also detected by the LAT, occurred very close to zenith. The LAT measurements can neither exclude the presence of a synchrotron self-Compton (SSC) component nor constrain its spectrum. Instead, the HAWC upper limits constrain the expected cut-off in an additional high-energy component to be less than $100~\rm{GeV}$ for reasonable assumptions about the energetics and redshift of the burst.Comment: 19 pages, 6 figures, published in Ap

Immunohistochemical assessment of Pax8 expression during pancreatic islet development and in human neuroendocrine tumors

The paired box transcription factor Pax8 is critical for development of the eye, thyroid gland as well as the urinary and reproductive organs. In adult, Pax8 overexpression is associated with kidney, ovarian and thyroid tumors and has emerged as a specific marker for these cancers. Recently, Pax8 expression was also reported in human pancreatic islets and in neuroendocrine tumors, identifying Pax8 as a novel member of the Pax family expressed in the pancreas. Herein, we sought to provide a comprehensive analysis of Pax8 expression during pancreogenesis and in adult islets. Immunohistochemical analysis using the most employed Pax8 polyclonal antibody revealed strong nuclear staining in the developing mouse pancreas and in mature human and mouse islets. Astonishingly, Pax8 mRNA in mouse islets was undetectable while human islets exhibited low levels. These discrepancies raised the possibility of antibody cross-reactivity. This premise was confirmed by demonstrating that the polyclonal Pax8 antibody also recognized the islet-enriched Pax6 protein both by Western blotting and immunohistochemistry. Thus, in islets polyclonal Pax8 staining corresponds mainly to Pax6. In order to circumvent this caveat, a novel Pax8 monoclonal antibody was used to re-evaluate whether Pax8 was indeed expressed in islets. Surprisingly, Pax8 was not detected in neither the developing pancreas or in mature islets. Reappraisal of pancreatic neuroendocrine tumors using this Pax8 monoclonal antibody exhibited no immunostaining as compared to the Pax8 polyclonal antibody. In conclusion, Pax8 is not expressed in the pancreas and cast doubts on the value of Pax8 as a pancreatic neuroendocrine tumor marker