In memoriam MIGUEL ÁNGEL MORÓN RÍOS

El Dr. Miguel Ángel Morón Ríos nació el 24 de octubre de 1952 en la Ciudad de México; realizó estudios de licenciatura, maestría y doctorado en la Facultad de Ciencias de la UNAM. Fue investigador Nacional SNI (1985-2017); Profesor- Investigador en la Facultad de Ciencias de la UNAM y Universidad Autónoma Metropolitana (1971-1981); Investigador Titular del Instituto de Ecología, A.C. (1981-2017); Curador general y fundador de la Colección Entomológica IEXA del Instituto de Ecología, A.C. (1985-2012). Realizó 31 estancias de investigación en instituciones de Inglaterra, Francia, Alemania, España, Holanda, Canadá, EUA, Colombia, Nicaragua y Costa Rica.El Dr. Miguel Ángel Morón Ríos nació el 24 de octubre de 1952 en la Ciudad de México; realizó estudios de licenciatura, maestría y doctorado en la Facultad de Ciencias de la UNAM. Fue investigador Nacional SNI (1985-2017); Profesor- Investigador en la Facultad de Ciencias de la UNAM y Universidad Autónoma Metropolitana (1971-1981); Investigador Titular del Instituto de Ecología, A.C. (1981-2017); Curador general y fundador de la Colección Entomológica IEXA del Instituto de Ecología, A.C. (1985-2012). Realizó 31 estancias de investigación en instituciones de Inglaterra, Francia, Alemania, España, Holanda, Canadá, EUA, Colombia, Nicaragua y Costa Rica

Ad Honorem, Miguel Ángel Morón Ríos (1952 – 2017)

Como homenaje Ad Honorem se presentan las múltiples y diversas actividades académicas que Miguel Ángel Morón realizó a lo largo de su productiva vida académica, haciendo un breve repaso de sus aportes científicos siguiendo un orden cronológico y temático.Como homenaje Ad Honorem se presentan las múltiples y diversas actividades académicas que Miguel Ángel Morón realizó a lo largo de su productiva vida académica, haciendo un breve repaso de sus aportes científicos siguiendo un orden cronológico y temático

Differences in the clinical and hormonal presentation of patients with familial and sporadic primary aldosteronism

Purpose: To compare the clinical and hormonal characteristics of patients with familial hyperaldosteronism (FH) and sporadic primary aldosteronism (PA). Methods: A systematic review of the literature was performed for the identification of FH patients. The SPAIN-ALDO registry cohort of patients with no suspicion of FH was chosen as the comparator group (sporadic group). Results: A total of 360 FH (246 FH type I, 73 type II, 29 type III, and 12 type IV) cases and 830 sporadic PA patients were included. Patients with FH-I were younger than sporadic cases, and women were more commonly affected (P = 0.003). In addition, the plasma aldosterone concentration (PAC) was lower, plasma renin activity (PRA) higher, and hypokalemia (P < 0.001) less frequent than in sporadic cases. Except for a younger age (P < 0.001) and higher diastolic blood pressure (P = 0.006), the clinical and hormonal profiles of FH-II and sporadic cases were similar. FH-III had a distinct phenotype, with higher PAC and higher frequency of hypokalemia (P < 0.001), and presented 45 years before sporadic cases. Nevertheless, the clinical and hormonal phenotypes of FH-IV and sporadic cases were similar, with the former being younger and having lower serum potassium levels. Conclusion: In addition to being younger and having a family history of PA, FH-I and III share other typical characteristics. In this regard, FH-I is characterized by a low prevalence of hypokalemia and FH-III by a severe aldosterone excess causing hypokalemia in more than 85% of patients. The clinical and hormonal phenotype of type II and IV is similar to the sporadic case

INNOVA Research Journal

La clase de matemáticas está en un proceso de evolución, las clases tradicionales centradas en el profesor van perdiendo vigencia en la educación ecuatoriana, dando paso a clases que priorizan al estudiante y sus aprendizajes. Tradicionalmente el docente de matemáticas ha tenido formación profesional en áreas técnicas y poca capacitación en aspectos pedagógicos que le den habilidades para llevar adelante una clase fundada en paradigmas constructivistas del aprendizaje, centrados en el estudiante y la calidad de sus aprendizajes. Una clase constructivista de matemáticas implica tener un estudiante con una visión diferente a su formación tradicional, debe estar motivado por alcanzar aprendizajes significativos, para esto debe ser capaz de investigar, analizar, reflexionar, plantear soluciones creativas, resolver situaciones del contexto, formado en valores y que aporta al crecimiento de la sociedad

Autonomous cortisol secretion in patients with primary aldosteronism: prevalence and implications on cardiometabolic profile and on surgical outcomes

Purpose: The aim of this study was to evaluate the prevalence of autonomous cortisol secretion (ACS) in patients with primary aldosteronism (PA) and its implications on cardiometabolic and surgical outcomes. Methods: This is a retrospective multicenter study of PA patients who underwent 1 mg dexamethasone-suppression test (DST) during diagnostic workup in 21 Spanish tertiary hospitals. ACS was defined as a cortisol post-DST >1.8 μg/dL (confirmed ACS if >5 μg/dL and possible ACS if 1.8–5 μg/dL) in the absence of spe cific clinical features of hypercortisolism. The cardiometabolic profile was compared with a control group with ACS without PA (ACS group) matched for age and DST levels. Results: The prevalence of ACS in the global cohort of patients with PA (n = 176) was 29% (ACS–PA; n = 51). Ten patients had confirmed ACS and 41 possible ACS. The cardiometabolic profile of ACS–PA and PA-only patients was simil ar, except for older age and larger tumor size of the adrenal lesion in the ACS–PA group. When comparing the ACS–PA group (n = 51) and the ACS group (n = 78), the prevalence of hypertension (OR 7.7 (2.64–22.32)) and cardiovascular events (OR 5.0 (2.29–11.07)) was higher in ACS–PA patients than in ACS patients. The coexistence of ACS in patien ts with PA did not affect the surgical outcomes, the proportion of biochemical cure and clinical cure being similar between ACS–PA and PA-only groups. Conclusion: Co-secretion of cortisol and aldosterone affects almost one-thi rd of patients with PA. Its occurrence is more frequent in patients with larger tumors and advanced age. However, the cardiometabolic and surgical outcomes of patients with ACS–PA and PA-only are similar

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

PKD2/polycystin-2 induces autophagy by forming a complex with BECN1

Macroautophagy/autophagy is an intracellular process involved in the breakdown of macromolecules and organelles. Recent studies have shown that PKD2/PC2/TRPP2 (polycystin 2, transient receptor potential cation channel), a nonselective cation channel permeable to Ca(2+)that belongs to the family of transient receptor potential channels, is required for autophagy in multiple cell types by a mechanism that remains unclear. Here, we report that PKD2 forms a protein complex with BECN1 (beclin 1), a key protein required for the formation of autophagic vacuoles, by acting as a scaffold that interacts with several co-modulators via its coiled-coil domain (CCD). Our data identified a physical and functional interaction between PKD2 and BECN1, which depends on one out of two CCD domains (CC1), located in the carboxy-terminal tail of PKD2. In addition, depletion of intracellular Ca(2+)with BAPTA-AM not only blunted starvation-induced autophagy but also disrupted the PKD2-BECN1 complex. Consistently, PKD2 overexpression triggered autophagy by increasing its interaction with BECN1, while overexpression of PKD2(D509V), a Ca(2+)channel activity-deficient mutant, did not induce autophagy and manifested diminished interaction with BECN1. Our findings show that the PKD2-BECN1 complex is required for the induction of autophagy, and its formation depends on the presence of the CC1 domain of PKD2 and on intracellular Ca(2+)mobilization by PKD2. These results provide new insights regarding the molecular mechanisms by which PKD2 controls autophagy.Comisión Nacional de Investigación y Desarrollo Tecnológico (CONICYT, Chile) Comisión Nacional de Investigación Científica y Tecnológica (CONICYT) CONICYT FONDECYT 1160820 1180495 1181361 1200490 1171075 Comisión Nacional de Investigación Científica y Tecnológica (CONICYT) ACT172066 FONDAP 15130011 CONICYT PhD fellowships 21140458 21140848 21140671 CONICYT International Investigation Project PII20150073 PEW Latin American Fellows Program in the Biomedical Science 00002991 United States Department of Health & Human Services National Institutes of Health (NIH) - USA HL-120732 HL-128215 HL-126012 HL-147933 U-inicia Program at Universidad de Chile UI024/19 Houston Methodist Research Institute International Centre for Genetic Engineering and Biotechnology, ICGEB CRP/CHL16-0

Differences in the presentation and evolution of primary aldosteronism in elderly (≥65 years) and young patients (<65 years).

To compare the presentation and evolution of primary aldosteronism (PA) in the elderly (≥65 years) and young patients ( A retrospective multicenter study was performed in 20 Spanish hospitals of PA patients in follow-up between 2018 and 2021. Three hundred fifty-two patients with PA Older patients with PA have a worse cardiometabolic profile than young patients with PA that it is related to a longer duration of hypertension. However, the results of the AVS, and adrenalectomy are similar in both groups. Therefore, the management of elderly patients with PA should be based not only on age, but rather on the overall medical, physical, social, and mental characteristics of the patients

Memorias IX Congreso Geológico Venezolano (2)

IX Congreso Geol&oacute;gico Venezolano (2