Como utilizar grãos de sorgo no preparo de produtos caseiros.

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Antibody response among portuguese healthcare workers prior to sars-cov-2 vaccine booster administration

Prioritizing healthcare workers (HCWs) for vaccination against the coronavirus disease 2019 (COVID-19) allowed to study the vaccine effectiveness in this professional group. The quantification of antibodies levels after vaccination among HCWs could give insights about SARS-CoV-2 protection. The aim of this study is to investigate SARS-CoV-2 immune response based on quantitation of antibodies against the spike receptor binding domain (RBD) of the S protein (anti-SRBD) and nucleocapside (anti-N) after the first vaccination stage in HCWs from the Local Health Unit of the Northeast of Portugal. Methods: Serum samples from 427 vaccinated HCW were tested for anti-SARS-CoV-2 immunoglobulin with chemiluminescent microparticle SARS-CoV-2 2 IgG I (anti-N) and IgG II (anti-SRBD) immunoassays detected by using ARCHITECT i1000SR (Abbot) equipment. Blood samples were collected between November and December of 2021, before the administration of 3rd vaccine dose. The chemiluminescent reaction anti-N immunoassay was expressed as an index classified as positive for values higher than 0.6. Anti-SRBD was quantified between 21.0 and 40,000.0 arbitrary units per ml (AU/mL) and values ≥ 50 AU/ml were considered positive. We obtained data about age, gender), infection with SARS-CoV-2 (PCR+), smoking habits and number of days between complete vaccination and blood sample collection Median, interquartile interval IIQ) and frequencies were obtained. Multivariate regression linear model was conducted to assess the factors affecting the values of anti-SRBD (logarithmized variable). Results: From all 427 HCW with median age 45.7 years [IIQ: 37.8-55.0], 89 (20.8%) were males, 89 (20.8%) had PCR+, 422 (98.8%) and 46 (21%) tested positive for IgG anti-SRBD and anti-N, respectively. The median of anti- SRBD was 737.3 (IIQ: 376.2-2270.1). According to the multivariate regression analysis, anti-SRBD values decrease as increase age (p = 0.004) and number of days since vaccination (p =0.004). Also, be a smoker decreases but a PCR+ increases anti-SRBD values. Conclusions/Recommendations: The SARS-CoV-2 antibody measurements suggested that quantitative anti-SRBD responses fall over the time (from days of complete immunization) and are lower among older vaccinated HCW.info:eu-repo/semantics/publishedVersio

Bacterial cellulose as a support for the growth of retinal pigment epithelium

The feasibility of bacterial cellulose (BC) as a novel substrate for retinal pigment epithelium (RPE) culture was evaluated. Thin (41.6 ± 2.2 m of average thickness) and heatdried BC substrates were surface modified via acetylation and polysaccharide adsorption, using chitosan and carboxymethyl cellulose. All substrates were characterized according to their surface chemistry, wettability, energy, topography and also regarding their permeability, dimensional stability, mechanical properties and endotoxin content. Then, their ability to promote RPE cell adhesion and proliferation in vitro was assessed. All surface-modified BC substrates presented similar permeation coefficients with solutes of up to 300 kDa. Acetylation of BC decreased its swelling and the amount of endotoxins. Surface modification of BC greatly enhanced the adhesion and proliferation of RPE cells. All samples showed similar stress-strain behavior; BC and acetylated BC showed the highest elastic modulus, but the latter exhibited a slightly smaller tensile strength and elongation at break as compared to pristine BC. Although similar proliferation rates were observed among the modified substrates, the acetylated ones showed higher initial cell adhesion. This difference may be mainly due to the moderately hydrophilic surface obtained after acetylation.The authors acknowledge the Portuguese Foundation for Science and Technology (FCT, Portugal) for the financial support provided by the Research Grants SERH/BD/63578/2009, SFRH/BD/64901/2009, SFRH/BPD/64958/2009, and SFRH/BPD/63148/2009 for S.G., J.P., J.P.S., and V.S., respectively. The authors also acknowledge the Projects PEst-OE/EQB/LA0004/2013, PEst-OE/EQB/LA0023/2013, PTDC/BBB-BQB/2450/2012, and RECI/BBB-EBI/0179/2012 (Number: FCOMP-01-0124-FEDER-027462), cofunded by QREN, FEDER

Phenotypic divergence in two sibling species of shorebird: Common Snipe and Wilson’s Snipe (Charadriiformes: Scolopacidae)

Natural and social selection are among the main shapers of biological diversity but their relative importance in divergence remains understudied. Additionally, although neutral evolutionary processes may promote phenotypic divergence, their potential contribution in speciation is often overlooked in studies of comparative morphology. In this study, we investigated phenotypic differentiation in two allopatric shorebirds: the Palaearctic Common Snipe Gallinago gallinago and the Nearctic Wilson’s Snipe Gallinago delicata. Specimens of Common Snipe (n = 355 skins, n = 163 skeletons) and Wilson’s Snipe (n = 403 skins, n = 141 skeletons) in natural history collections were examined to quantify differences in skeletal and external measurements, and measures of wing and tail plumage variables. The species do not differ in skeletal variables except for the relatively larger sternum of the Common Snipe. The two species do not differ in multivariate wing size or shape (pointedness). Previously known plumage differences between these species were confirmed: the Common Snipe has fewer rectrices, longer and wider outermost rectrices, more extensive white on tips of the secondary feathers, and more white in the axillaries. Between-species variance in skeleton, primary length and plumage variables was greater than expected if drift was mainly responsible for phenotypic divergence, suggesting a role of selective processes. However, drift could not be rejected after adjusting for multiple comparisons. Differences in plumage traits were greater than in skeletal or external measurements. Because snipe use plumage traits in signalling, the results suggest a more rapid divergence in socially selected traits between these species than in traits related to resource use

Processo de cuidados à pessoa com delírio de Cotard: Uma reflexão sobre a ação.

No processo de cuidados à pessoa com doença mental, no contexto do Estágio V – Enfermagem de Saúde Mental e Psiquiatria, prestamos cuidados à pessoa com delírio de Cotard, o que despoletou o nosso interesse no aprofundar desta temática. Cotard diz-nos que “as pessoas que demonstram este tipo de delírios apresentam a recusa dos próprios órgãos e sangue, além de acreditarem que todas as suas partes corpóreas, incluindo a alma, estão mortas” (citado por Olmi, Rossa & Furlanetto, 2016, pp.96-97). A intervenção do enfermeiro perante a pessoa que apresenta delírios, deve ser em primeiro lugar, zelar pela segurança do doente e depois procurar controlar os delírios, muitas vezes em articulação com a psicofarmacologia (Stuart e Laraia, 2006). Objetivos: Explicitar o papel do enfermeiro junto da pessoa com delírio de Cotard; Apresentar a reflexão sobre a tomada de decisão no processo de cuidados à pessoa com delírio de Cotard. Materiais e métodos: Atendendo à importância que a reflexão assume no processo de aprendizagem, considera-se pertinente o recurso à reflexão sobre a ação tendo por base o ciclo reflexivo de Gibbs (Santos e Fernandes, 2004). Resultados: A reflexão sobre a situação da prática de cuidados à pessoa com delírio de Cotard, no decorrer do processo de ensino-aprendizagem, facilitou nos estudantes o desenvolvimento do sentido critico indo ao encontro do que defende Madeira (2014, p.30) quando afirma que a exploração de situações da prática permite “a apreensão concreta de uma situação para a representação abstrata e conceptual”. Conclusões A oportunidade de prestar cuidados à pessoa com delírio de Cotard e a reflexão sobre a ação permitiram integrar os principais conceitos que suportam a intervenção do enfermeiro à pessoa com atividade delirante. Relevância para a Enfermagem e/ou Saúde: A reflexão sobre a ação contribui para a tomada de decisão responsável sendo por isso fundamental no processo de formação do enfermeiro. 2 Referências Bibliográficas Madeira, A.C.S.C.M.(2014). O Estudante de Enfermagem no Processo de Cuidados em Contexto de Ensino Clínico. Tese de Candidatura ao grau de Doutor em Ciências de Enfermagem. Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto, Portugal. Disponível em: https://repositorio-aberto.up.pt/bitstream/10216/78973/2/35058.pdf Olmi, M. P.; Rossa, O. R.; & Furlanetto, K. (Janeiro de 2016). Sindrome de Cotard: A busca pela vida num delírio de morte, pp. 96-100. Santos, E.; Fernandes, A. (2004). Prática Reflexiva: Guia para a Reflexão Estruturada. Revista Referência, (11), 59-62. Disponível em: https://rr.esenfc.pt/rr/index.php?module=rr&target=publicationDetails&pesquisa=&id_artigo=20 64&id_revista=5&id_edicao=10 Stuart, Gail; Laraia, Michele - Enfermagem Psiquiátrica - Princípios e Prática. 6ª ed. Porto Alegre: Artmed Editora, 2001. 958p. ISBN 9788573077131N/

Elective Recurrent Inguinal Hernia Repair : Value of an Abdominal Wall Surgery Unit

The aim of this study was to analyze the impact of an abdominal wall surgery unit on postoperative complications (within 90 days postoperatively), hernia recurrence and chronic postoperative inguinal pain after elective recurrent inguinal hernia repair. We conducted a retrospective cohort study of all adult patients who underwent elective recurrent inguinal hernia repair between January 2010 and October 2021. Short- and long-term outcomes were compared between the group of patients operated on in the abdominal wall surgery unit and the group of patients operated on by other units not specialized in abdominal wall surgery. A logistic regression model was performed for hernia recurrence. A total of 250 patients underwent elective surgery for recurrent inguinal hernia during the study period. The patients in the abdominal wall surgery group were younger (P ≤ 0.001) and had fewer comorbidities (P ≤ 0.001). There were no differences between the groups in terms of complications. The patients in the abdominal wall surgery group presented fewer recurrences (15% vs. 3%; P = 0.001). Surgery performed by the abdominal wall surgery unit was related to fewer recurrences in the multivariate analysis (HR = 0.123; 95% CI = 0.21-0.725; P = 0.021). Specialization in abdominal wall surgery seems to have a positive impact in terms of recurrence in recurrent inguinal hernia repair. The influence of comorbidities or type of surgery (i.e., outpatient surgery) require further study

Variabilidade genética e seleção para caracteres de crescimento da seringueira.

O presente estudo objetivou estimar parâmetros e valores genéticos para os caracteres altura e diâmetro de progênies de seringueira, pelo método de modelos mistos (procedimento REML/BLUP). Progênies de meio-irmãos foram estabelecidas em área do município de Dois Irmãos do Buriti (MS), sob delineamento de blocos ao acaso, com 28 tratamentos (progênies), cinco repetições e dez plantas por parcela. A coleta dos dados foi realizada em março de 2004. Aos 12 meses de idade foram avaliados os caracteres altura e diâmetro. Nas herdabilidades individuais no sentido restrito para altura (0,1877) e diâmetro (0,1809), bem como nas herdabilidades médias no sentido restrito de progênies para altura (0,3385) e diâmetro (0,4124) observaram-se boas magnitudes. Ganhos genéticos preditos na ordem de 14,04% a 16,54% foram obtidos para o caráter altura e 25,76% a 91,78% para o caráter diâmetro. Os resultados estimulam a continuidade do programa de melhoramento genético, com a possibilidade de maximização dos ganhos nas gerações seguintes

Synthesis of novel Glycoconjugates derived from Alkynyl heterocycles through a click approach

Accepted author version posted online: 05 Jun 2012The synthesis of a series of novel 1,4-disubstituted 1,2,3-triazole compounds bearing a D-glucose derivative and an heteroaromatic system is described. Alkylation of isatin, 3-methyl-carbazole and one tetrahydro-gamma-carboline with propargyl bromide gave their N-propargyl derivatives in good yields. These compounds further reacted with acetylated D-glucose with the azide group in position 1, to give three final products and with peracetylated 6-azido-6-deoxy-alpha-D-methylglucoside giving the corresponding derivative of tetrahydro-gamma-carboline.FCT (Fundação para a Ciência e Tecnologia) and FEDE