Gliomatose leptomeningea primária difusa

Universidade Federal de São Paulo (UNIFESP) Department of Neurology and NeurosurgeryUniversidade Federal de São Paulo (UNIFESP) Department of RadiologyUniversidade Federal de São Paulo (UNIFESP) Department of PathologyUniversidade Federal de São Paulo (UNIFESP) Paediatric Oncology Institute Department of PaediatricsUNIFESP, Department of Neurology and NeurosurgeryUNIFESP, Department of RadiologyUNIFESP, Department of PathologyUNIFESP, Paediatric Oncology Institute Department of PaediatricsSciEL

The COVID-19 pandemic and professional nursing practice in the context of hospitals

The COVID-19 pandemic has imposed challenges to health systems and institutions, which had to quickly create conditions to meet the growing health needs of the population. Thus, this study aimed to assess the impact of COVID-19 on professional nursing practice environments and to identify the variables that affected their quality. Quantitative, observational study, conducted in 16 Portuguese hospitals, with 1575 nurses. Data were collected using a questionnaire and participants responded to two different moments in time: the pre-pandemic period and after the fourth critical period of COVID-19. The pandemic had a positive impact on the Structure and Outcome components, and a negative trend in the Process component. The variables associated with the qualification of the components and their dimensions were predominantly: work context, the exercise of functions in areas of assistance to COVID-19 patients, length of professional experience and length of experience in the service. The investment in professional practice environments impacted the improvement of organizational factors, supporting the development of nurses’ work towards the quality of care. However, it is necessary to invest in nurses’ participation, involvement and professional qualifications, which are aspects strongly dependent on the institutions’ management strategies.info:eu-repo/semantics/publishedVersio

The therapeutic approach of the May-Thurner Syndrome without Deep Venous Thrombosis: a systematic review

May-Thurner Syndrome is a clinical condition which causes a variety of vascular symptoms, resulting from pelvic and lower extremity venous flow obstruction caused by the compression of the iliac vein by overlying iliac artery. Treatment paradigms have changed as experience with endovascular modalities has evolved, making traditional surgical treatment strategies essentially obsolete and a endovascular treatment with angioplasty and stenting along selective thrombolysis has become the standard for symptomatic the syndrome. The objective of this present study is to show the therapeutic approach in treatment when there’s no presence of Deep Venous Thrombosis (DVT) symptoms. To accomplish this purpose, a systematic review of articles about May-Thurner Syndrome and its management therapies, published from January 1, 2005 to September 20, 2015, on PubMED and SCOPUS databases, was carried out. Search terms were “may-thurner syndrome” (medical subject headings [MeSH term]), “iliocaval compression syndrome” (MeSH), “cockett syndrome” (MeSH), “peripheral vascular diseases” (MeSH), and “treatment” (keyword). Of the 89 retrieved studies, 14 met the elegibility criteria. Retrieved studies covered that without correction of this syndrome, patients are at continued risk for recurrent deep vein thrombosis and post-thrombotic syndrome. Considering the therapy, systemic anticoagulation is the first component, and endovascular treatment appears to be superior to conventional surgical treatment. It should be the first line of therapy. Furthermore, there has been multiple advences in the recent years for chronic arterial occlusions using techniques such as blunt micro dissection, radiofrequency energy and laser. In the absence of deep venous trombosis, conservative treatments are preferred. To conclude, based on the review of the literature, a combination of conservative and endovascular therapy usually provides the best treatment in most cases. Thus, further researches must be done to advance in the matter of therapeutic of the non-DVT form of May-Thurner Syndrome.   Keywords: May-Thurner Syndrome, Iliocaval Compression Syndrome, Cockett Syndrome, Peripheral Vascular Disease, Treatment

The COVID-19 Pandemic and Professional Nursing Practice in the Context of Hospitals

The COVID-19 pandemic has imposed challenges to health systems and institutions, which had to quickly create conditions to meet the growing health needs of the population. Thus, this study aimed to assess the impact of COVID-19 on professional nursing practice environments and to identify the variables that affected their quality. Quantitative, observational study, conducted in 16 Portuguese hospitals, with 1575 nurses. Data were collected using a questionnaire and participants responded to two different moments in time: the pre-pandemic period and after the fourth critical period of COVID-19. The pandemic had a positive impact on the Structure and Outcome components, and a negative trend in the Process component. The variables associated with the qualification of the components and their dimensions were predominantly: work context, the exercise of functions in areas of assistance to COVID-19 patients, length of professional experience and length of experience in the service. The investment in professional practice environments impacted the improvement of organizational factors, supporting the development of nurses’ work towards the quality of care. However, it is necessary to invest in nurses’ participation, involvement and professional qualifications, which are aspects strongly dependent on the institutions’ management strategiesinfo:eu-repo/semantics/publishedVersio

The role of eletrical synapses in epileptic seizures

INTRODUÇÃO: No sistema nervoso central a comunicação entre neurônios se realiza através de estruturas denominadas sinapses: elétricas ou químicas. As sinapses elétricas são formadas pela aproximação das membranas plasmáticas de dois neurônios formando estruturas chamadas junções comunicantes (gap junctions, do inglês). As junções comunicantes são compostas por seis subunidades da proteína conexina de cada membrana, formando poros que comunicam o citoplasma de células adjacentes e permitem a passagem de íons e pequenas moléculas. OBJETIVOS: A presente revisão pretende descrever e discutir os principais resultados que apontam para uma importante relação entre junções comunicantes e sincronia neuronal durante crises epilépticas. RESULTADOS E CONCLUSÃO: Quando um neurônio é despolarizado, este tipo de comunicação permite a rápida transferência iônica entre as células, promovendo alta sincronia neuronal. Recentemente, o papel das junções comunicantes na geração e propagação de descargas epilépticas tem sido estudado através do uso de diferentes modelos experimentais in vivo, in vitro e in silico (modelos computacionais).INTRODUCTION: In the central nervous system, neuronal communication is accomplished by structures called synapses: electrical or chemical. Electrical synapses are formed by the apposition of plasmatic membranes at gap junctions and the interaction of connexin subunits from two neurons. At this site, connexin complexes create intercellular pores that communicate the cytoplasm of adjacent neurons and allow free flow of ions and small molecules. OBJECTIVE: In this review, we will present and discuss recent results showing the possible involvement of electrical synapses in the neuronal hypersynchronization during epileptic seizures. RESULTS AND CONCLUSION: When a neuron is depolarized, ions flow very rapidly from one cell to the other promoting high neuronal synchrony. More recently, the role of gap junctions in the generation and propagation of epileptic discharges has been investigated using combined approaches of in vivo, in vitro and in silico (computational) models

Incidental fishing of Epinephelus itajara (Lichtenstein, 1822) : the vulnerability of a critically endangered species of the Brazilian coast

Epinephelus itajara, popularly known as grouper, has a wide distribution and is considered the largest fish in the Atlantic Ocean. Behavioral characteristics allied to overfishing and degradation of marine habitats caused declines in E. itajara populations throughout the entire geographic distribution area. The goliath grouper is currently ranked on the IUCN RedList as Vulnerable in Global Status and Critically Endangered in the Gulf of Mexico. In Brazil, even with a fishing moratorium that has protected it since 2002, the species is categorized as critically endangered in the Red Book of the Instituto Chico Mendes de Conservação da Biodiversidade. Taking into account these factors and the information gap on the goliath grouper, this study addresses an account of an occasional “post mortem” encounter with a specimen on the edge of Pajuçara beach, Maceió - Alagoas. It was an adult individual, whose size was estimated at 1.6 m and 70 kg of body mass. This study also presents discussions about the conservation status of the species and the efficiency in the management of marine protected areas, revealing that even with many marine protection areas, incidental captures and port records are still recurrent on the Brazilian coast. This record highlights the need to reinforce inspections, in addition to suggesting that the management of these areas be more efficient, ensuring the reestablishment of grouper populations in the region.info:eu-repo/semantics/publishedVersio

CORREÇÃO DO SOLO E ADUBAÇÃO DA CANA-DE-AÇÚCAR

Introdução: O maior desenvolvimento do sistema radicular de uma planta irá refletir inicialmente em maior resistência à seca, maior absorção de nutrientes e consequentemente maior produtividade. Assim, fatores como o manejo de correção do solo e a adubação na cultura da cana-de-açúcar mantém a alta produtividade. Objetivo: fazer uma breve revisão sobre correção do solo e educação da cana-de-açúcar. Metodologia: revisão de literatura. A adubação da cana-de-açúcar inicia-se com a amostragem de solo, continua com a aplicação de calcário e termina com a utilização do fertilizante, sendo o objetivo evidenciar a importância do domínio dessas técnicas no campo. Considerações: Na agricultura atual, se faz necessário o desenvolvimento de novos manejos para alavancar a produção de alimentos. A cultura de cana-de-açúcar se faz necessário manter longevidade e produtividade, com aplicação de manejo de adubação e correção do solo em cana soca restabelecer o sistema radicular. As maiores profundidades exploradas pelos sistemas radiculares dessas cultura são responsáveis por maiores produtividades alcançadas, portanto, deve constituir objetivo, no manejo das culturas, o maior aprofundamento do sistema radicular, com o intuito de promover consequentemente maior resistência à seca e maior produtividade, e no caso da cana, maior longevidade da cultura. Além disso, é fundamental promover planejamento da adubação é saber quais elementos são necessários para o fornecimento via adubação para a cana-de-açúcar e qual o período será realizado essa aplicação. Sendo assim podemos observar que a gestão de informações técnicas com respaldo dos dados de campo pode promover maior sustentabilidade e promoção da produtividade em termos sociais, ambientais e econômicos

Manifestações clínicas da coinfecção entre covid-19 e dengue em adultos: revisão integrativa

Objective: to identify the evidence available in the scientific literature on the clinical manifestations of co-infection between Covid-19 and Dengue in adults. Method: integrative review, carried out in the MEDLINE/PUBMED, LILACS, IBECS, WoS and EMBASE databases, in June 2021. The descriptors "adult", "Coronavirus infections" and "dengue" with their synonyms were crossed by means of operators Booleans AND and OR. Results: 23 studies were included, with a predominance of 19 case studies (82.6%). The main clinical manifestations identified from the studies were: fever, headache, dyspnea, cough, myalgia, retro orbital pain, and skin rash. In addition to laboratory findings such as: thrombocytopenia, lymphopenia, and leukopenia. Conclusion: covid-19 and Dengue coinfection was identified and the need for an immediate search for a differential diagnosis is pointed out, in order to prevent clinical problems and reduce unexpected outcomes.Objetivo: identificar as evidências disponíveis na literatura científica sobre as manifestações clínicas da coinfecção entre COVID-19 e Dengue em adultos. Método: revisão integrativa, realizadas nas bases MEDLINE/PUBMED, LILACS, IBECS, WoS e EMBASE, em junho de 2021. Os descritores “adulto”, “Infecções por Coronavírus” e “dengue” junto aos seus sinônimos, foram cruzados por meio de operadores booleanos “AND” e “OR”. Resultados: Foram incluídos 23 estudos, predominando estudos de caso 19 (82,6%). As principais manifestações clínicas identificadas a partir dos estudos foram: febre, cefaleia, dispneia, tosse, mialgia, dor retro orbital e rash cutâneo. Além de achados laboratoriais como: trombocitopenia, linfopenia e leucopenia. Conclusão: a coinfecção COVID-19 e Dengue foi identificada e aponta-se a necessidade da busca imediata do diagnóstico diferencial, para prevenir os agravos clínicos e diminuir os desfechos inesperados