Avaliação de variáveis associadas à permeabilidade de fístulas arteriovenosas criadas por um nefrologista para fins de hemodiálise

Introduction: Arteriovenous fistula (AVF) is considered the gold standard vascular access for chronic hemodialysis, and its failure predicts higher morbidity and mor-tality rates. Objective: 1) To evaluate the success rate of AVF created by a nephrolo-gist and 2) to identify clinical, laboratory, and demographic variables that influence AVF patency. Methods: A retrospective cohort study of 101 patients with chronic kidney disease for a total of 159 AVF cre-ated by a nephrologist between June 2010 and June 2013. Results: Of the AVFs cre-ated, 124 (78%) displayed immediate pa-tency and 110 (62.9%) displayed late pa-tency. Hemoglobin (10-12 g/dL) was the only variable related to late AVF patency (p = 0.05). An elevated blood pressure at time of surgery was associated with a low-er number of procedures per patient (p = 0.001). Proximal AVF occurred more fre-quently in patients with dual access (p = 0.03). The AVF success rate was similar to those previously reported in the literature. Conclusion: Hemoglobin level in the rec-ommended range has a favorable impact on late AVF patency and elevated blood pressure during surgery on the lower number of vascular accesses per patient. The high success rate indicates that it can be placed by trained nephrologistsIntrodução: A fístula arteriovenosa (FAV) é considerada o acesso vascular padrão ouro para hemodiálise crônica, e sua falha pre-diz taxas mais altas de morbimortalidade. Objetivos: 1) Avaliar a taxa de sucesso da FAV criada por um nefrologista e 2) identi-ficar variáveis clínicas, laboratoriais e demo-gráficas que influenciam a patência da FAV. Métodos: Estudo de coorte retrospectivo de 101 pacientes com doença renal crônica, totalizando 159 FAVs criados por um ne-frologista entre junho de 2010 e junho de 2013. Resultados: Das FAVs criadas, 124 (78%) apresentaram patência imediata e 110 (62,9%) apresentaram patência tardia. A he-moglobina (10-12 g/dL) foi a única variável relacionada à patência tardia da FAV (p = 0,05). A pressão arterial elevada no momento da cirurgia foi associada a um menor número de procedimentos por paciente (p = 0,001). A FAV proximal ocorreu com maior frequência em pacientes com dois acessos confecciona-dos (p = 0,03). A taxa de sucesso da FAV foi semelhante à relatada anteriormente na lite-ratura. Conclusão: O nível de hemoglobina no intervalo recomendado tem um impacto favorável na perviedade tardia da FAV e pres-são arterial elevada durante a cirurgia no me-nor número de acessos vasculares por pacien-te. A alta taxa de sucesso indica que ela pode ser feita por nefrologistas treinados

Ressonância de plasmon de superfície localizado e aplicação em biossensores e células solares

Lolalized surface plasmon ressonance applied to biosensors and solar cells. Within the last decades, the research on nanoparticles presenting localized surface plasmon resonance has increased constantly. In these materials, the interaction between electrons and incident light results in charge separation, enhancement of the electromagnetic field on the nanoparticles surface and in unique optical properties. Although many metals such as gold, silver, copper and aluminum present localized surface plasmon resonance within the visible range, gold and silver are the most commonly studied metals, due to the chemical inertia of gold and intense plasmon resonance from silver. In this review, we provide a description of the origin of localized surface plasmon resonance through the works developed by Mie, Maxwell and Maxwell-Garnett and a description of many examples of application of plasmonic nanoparticles on biosensors and solar cells, detailing the contribution of these plasmonic nanoparticles on the performance of these devices

AVALIAÇÃO DA UTILIZAÇÃO DE RECURSOS DE ENSINO ON-LINE RELACIONADOS A DIFERENTES ESTILOS DE APRENDIZAGEM

O presente trabalho apresenta os resultados de uma pesquisa que objetivou a criação de recursos on-line para apoio ao ensino de uma disciplina presencial de cursos de engenharia, com foco na criação de objetos de aprendizagem que pudessem atender aos diferentes estilos de aprendizagem dos estudantes. A partir da identificação dos estilos de aprendizagem de cada aluno, realizou-se a avaliação do seu comportamento com relação aos diferentes objetos. Mais do que avaliar o comportamento dos estudantes, o principal foco do trabalho foi desenvolver recursos de ensino que pudessem responder aos diferentes perfis de aprendizagem, de modo a contribuir para a melhoria do processo de ensino-aprendizagem

Arginase 1 deficiency presenting as complicated hereditary spastic paraplegia

INTRODUCTION: Argininemia or arginase deficiency is a metabolic disorder caused by pathogenic variants in ARG1 and consists of a variable association of progressive spastic paraplegia, intellectual disability, and seizures. Hereditary spastic paraplegia (HSP) is a group of inherited diseases whose main feature is a progressive gait disorder characterized by lower limb spasticity. This study presents 7 patients with arginase 1 deficiency from 6 different families, all with an initial diagnosis of complicated HSP. METHODS: We evaluated the clinical data of 7 patients belonging to six independent families who were diagnosed with hyperargininemia in a neurogenetics outpatient clinic. RESULTS: All patients had lower limb spasticity and six had global developmental delay. Five individuals had intellectual disability and two had epilepsy. Psychiatric abnormalities were seen in two patients. In two participants of this study, MRI disclosed thinning of the corpus callosum. Molecular diagnosis was made by whole exome sequencing. All variants were present in homozygosis; we identified two novel missense variants, one novel frameshift variant, and one previously published missense variant. DISCUSSION: Clinical diagnosis of early onset complicated hereditary spastic paraplegia was made in all patients. Two patients were initially suspected of having SPG11 due to thinning of the corpus callosum. As argininemia may present with a highly penetrant phenotype of spastic paraplegia associated with additional symptoms, this disease may represent a specific entity amongst the complicated HSPs

Comparison of methods to estimate lake-surface-water temperature using Landsat 7 ETM+ and MODIS imagery : case study of a large shallow subtropical lake in southern Brazil

Water temperature regulates many processes in lakes; therefore, evaluating it is essential to understand its ecological status and functioning, and to comprehend the impact of climate change. Although few studies assessed the accuracy of individual sensors in estimating lake-surface-water temperature (LSWT), comparative analysis considering different sensors is still needed. This study evaluated the performance of two thermal sensors, MODIS and Landsat 7 ETM+, and used Landsat methods to estimate the SWT of a large subtropical lake. MODIS products MOD11 LST and MOD28 SST were used for comparison. For the Landsat images, the radiative transfer equation (RTE), using NASA’s Atmospheric Correction Parameter Calculator (AtmCorr) parameters, was compared with the single-channel algorithm in different approaches. Our results showed that MOD11 obtained the highest accuracy (RMSE of 1.05 C), and is the recommended product for LSWT studies. For Landsat-derived SWT, AtmCorr obtained the highest accuracy (RMSE of 1.07 C) and is the recommended method for small lakes. Sensitivity analysis showed that Landsat-derived LSWT using the RTE is very sensitive to atmospheric parameters and emissivity. A discussion of the main error sources was conducted. We recommend that similar tests be applied for Landsat imagery on different lakes, further studies on algorithms to correct the cool-skin effect in inland waters, and tests of different emissivity values to verify if it can compensate for this effect, in an effort to improve the accuracy of these estimates

Crude protein of pastures of grass napier submitted organic fertilization and mineral

Todos os textos, informa??es e resultados apresentados s?o de inteira responsabilidade dos autores.Parte da inicia??o cient?fica do primeiro autor, financiada pelo Programa Institucional de Bolsas de Inicia??o Cient?fica, em Desenvolvimento Tecnol?gico e Inova??o - PIBICTI/IF Sudeste MG.Bruno Grossi Costa Homem, publicado no artigo como segundo autor: Bruno Gossi Costa Homem.Objetivou-se com este trabalho avaliar os teores de prote?na bruta (PB) do capim-Napier, manejado como pastejo, sob dois n?veis de aduba??o mineral e dois n?veis de aduba??o org?nica. O delineamento experimental adotado foi em blocos, com quatro repeti??es. Os tratamentos foram compostos por duas doses de aduba??o mineral (133 e 200 Kg de N ha-1), duas de aduba??o org?nica (133 e 200 Kg de N ha-1) e mais uma testemunha. As aduba??es foram parceladas em quatro aplica??es posteriormente ao corte de desbastamento e ao corte realizado de acordo com altura de manejo de pastejo da cultivar Napier (1 m de entrada e 0,5 m de sa?da). A aduba??o org?nica foi realizada com cama sobreposta de su?no e para a aduba??o qu?mica foi usada ureia. As quantidades de cloreto de pot?ssio e superfosfato triplo nas aduba??es minerais foram determinadas de acordo com o n?vel de pot?ssio e f?sforo na cama sobreposta de su?no. As amostras foram secadas em estufa de ventila??o for?ada a 65 ?C, mo?das em moinho tipo Willey com peneira de 1 mm e, posteriormente, as amostras foram submetidas an?lises de PB pelo m?todo Kjeldahl. Foi observado que os dois n?veis de aduba??o mineral apresentaram maior valor de PB (P>0,05), entretanto os dois n?veis de aduba??o org?nica na forma de cama sobreposta de su?no apresentaram maior teor de PB que a testemunha, mostrando que a cama sobreposta tem potencial para ser utilizada na aduba??o de pastagens de capim-Napier. Os dois n?veis de aduba??o mineral promoveram maiores teores de PB em rela??o ?s aduba??es org?nica com cama sobreposta de suinocultura.The objective of this study was to evaluate the crude protein (CP) of Napier grass, as managed grazing under two levels of mineral fertilizer and two levels of organic fertilization. The experimental design was in blocks with four replications. The treatments consisted of two doses of mineral fertilizer (133 and 200 kg N ha-1), two organic fertilization (133 and 200 kg N ha-1) and another witness. Fertilization was divided in four applications later cutting chopping and cutting carried out according to height and grazing management cultivar Napier (1 m and 0.5 m input output). The organic fertilization was performed with superimposed pig bed and the chemical fertilizer was used urea. The quantities of potassium chloride and triple super phosphate in the mineral fertilizers have been determined according to the level of potassium and phosphorus in the overlapping porcine bed. The samples were dried in a forced ventilation oven at 65 ? C, ground in a Wiley mill with a 1 mm sieve and subsequently the samples were subjected to analysis by the Kjeldahl method PB. It was observed that the two levels of mineral fertilizer showed higher value of CP (P> 0.05), however the two levels of organic fertilizer in the form of superimposed pig bed had higher content of CP that the witness, showing that the bunk bed It has the potential to be used in the fertilization of Napier grass pastures. The two levels of mineral fertilization promoted higher crude protein content in relation to organic fertilization with superimposed swine bed

Dry mass production in pastures of grass napier undergoing organic fertilizations and mineral

Todos os textos, informa??es e resultados apresentados s?o de inteira responsabilidade dos autores.Parte da inicia??o cient?fica do primeiro autor, financiada pelo Programa de Bolsas de Inicia??o Cient?fica, Tecnol?gica e Inova??o (PIBICTI/IF Sudeste MG).Objetivou-se com este trabalho avaliar a produ??o de massa seca (MS) do capim-Napier, manejado como pastejo, sob dois n?veis de aduba??o mineral e dois n?veis de aduba??o org?nica. O delineamento experimental adotado foi em blocos, com quatro repeti??es. Os tratamentos foram compostos por duas doses de aduba??o mineral (133 e 200 Kg de N ha-1), duas de aduba??o org?nica (133 e 200 Kg de N ha-1) e mais uma testemunha. As aduba??es foram parceladas em quatro aplica??es posteriormente ao corte de desbastamento e ao corte realizado de acordo com altura de manejo de pastejo da cultivar Napier (1 m de entrada e 0,5 m de sa?da). A aduba??o org?nica foi realizada com cama sobreposta de su?no e para a aduba??o qu?mica foi usada ureia. As quantidades de cloreto de pot?ssio e super fosfato triplo nas aduba??es minerais foram determinadas de acordo com o n?vel de pot?ssio e f?sforo na cama sobreposta de su?no. As amostras foram secadas em estufa de ventila??o for?ada a 65 ?C para a avalia??o da massa seca. N?o foi observado efeito (P>0,05) entre os diferentes tratamentos na produ??o de mat?ria seca. Para a avalia??o dos cortes foi observado um incremento na produ??o de MS do primeiro corte para o quarto, sendo que o 3? e 4? cortes tiveram uma maior produ??o e o 1? menor produ??o. N?o houve diferen?a na produ??o de mat?ria seca entre os n?veis de aduba??o mineral e org?nica na forma de cama sobreposta de su?no. Entre os corte foi observado maior produ??o de mat?ria seca nos 3? e 4? cortes.The objective of this study was to evaluate the dry matter production of Napier grass, as managed grazing under two levels of mineral fertilizer and two levels of organic fertilization. The experimental design was in blocks with four replications. The treatments consisted of two doses of mineral fertilizer (133 and 200 kg N ha-1), two organic fertilization (133 and 200 kg N ha-1) and another witness. Fertilization was subsequently divided in four applications to the cutting chopping and cutting performed in accordance with pasture management height cultivating Napier (1 m 0.5 m input and output). The organic fertilization was performed with superimposed pig bed and the chemical fertilizer was used urea. The quantities of potassium chloride and triple superphosphate in mineral fertilizers were determined in accordance with the phosphorus and potassium levels in the overlapping porcine bed. The samples were dried in a forced ventilation oven at 65 ? C for the evaluation of the dry mass. For the evaluation of the cuts was observed an increase in dry matter production of first cut to the room, and the 3? and 4? cuts had a higher production and lower production 1?. No differences in dry matter production between the levels of mineral and organic fertilizer in the form of superimposed pig bed. Among the court there was a higher dry matter yield in the 3rd and 4th cuts

Níveis séricos da IL-13 na esclerose sistêmica: uma revisão sistemática com meta-análise / Serum levels of IL-13 in systemic sclerosis: a systematic review with meta-analysis

A interleucina-13 (IL-13) sérica foi investigada na esclerose sistêmica (ES) por meio de uma meta-análise para avaliar a possível diferença nos níveis em pacientes com a doença e pessoas saudáveis. As buscas foram realizadas nas bases de dados Pubmed, ScienceDirect, Cochrane Library, LILACS e Scopus para estudos do tipo caso-controle pertinentes utilizando os descritores. Os níveis séricos dos pacientes com ES em relação aos controles saudáveis foram plotados usando o software Review Manager 5.3. A avaliação da qualidade de cada estudo elegível foi conduzida na Escala de Newcastle-Ottawa (NOS). Quatro estudos de caso-controle foram selecionados para esta meta-análise e continham um total de 120 pacientes com ES e 84 controles saudáveis. Nossos resultados demonstram níveis séricos elevados da IL-13 em pacientes com ES, com um agrupamento médio de 0,70 ng/ml (p=0,00001) (IC 95%: -0,42 a -0,99, p=0,6). A IL-13 está aumentada no soro de pacientes com ES em comparação com os controles saudáveis e pode ser útil como possível biomarcador da doença. 

Imaging of adult leukodystrophies

Leukodystrophies are genetically determined white matter disorders. Even though leukodystrophies essentially affect children in early infancy and childhood, these disorders may affect adults. In adults, leukodystrophies may present a distinct clinical and imaging presentation other than those found in childhood. Clinical awareness of late-onset leukodystrophies should be increased as new therapies emerge. MRI is a useful tool to evaluate white matter disorders and some characteristics findings can help the diagnosis of leukodystrophies. This review article briefly describes the imaging characteristics of the most common adult leukodystrophies