Cenicero Electrónico Inteligente con Recompensas (CEIR) : Otro concepto de cenicero electrónico inteligente con recompensas para espacios urbanos

Este trabajo se enfoca en la construcción de un diseño tecnológico para el desarrollo de un artefacto de recolección de residuos específicos de colilla de cigarrillos en áreas urbanas. Su propósito es, al mismo tiempo, utilitario y funcional ya que está orientado a facilitar la implementación de políticas de conductas de responsabilidad ciudadana basadas en recompensas. Para este objetivo se creó una prueba de concepto que involucra un diseño de software, una arquitectura, componentes electro-mecánicos embebidos y una aplicación informática para su gestión integral y conexión digital con sistemas municipales. La articulación de estos componentes se denominará Cenicero Electrónico Inteligente con Recompensas (CEIR), su diseño y construcción permiten diferentes tipos de adaptaciones para propósitos similares al cuidado del medio ambiente e innovaciones públicas.Sociedad Argentina de Informática e Investigación Operativ

Receptor Electrónico de Residuos (RER): una infraestructura conceptual de recompensas directa de hábitos ciudadanos

Este trabajo propone un diseño tecnológico para el desarrollo de un artefacto de recolección de residuos urbanos. Su propósito es facilitar la instrumentación de políticas de conductas de responsabilidad ciudadana basadas en recompensas. Para este propósito se creó una prueba de concepto que involucra un diseño de software, una arquitectura, componentes electromecánicos embebidos y una aplicación informática de gestión integral y conexión digital con sistemas de gestión municipales. La articulación de estos componentes se denominará Receptor Electrónico de Residuos (RER), su diseño y construcción permiten diferentes tipos de adaptaciones para propósitos similares al cuidado del medio ambiente e innovaciones en tecnologías en ciudades digital públicas.XI Workshop Innovación en Sistemas de Software.Red de Universidades con Carreras en Informátic

Receptor Electrónico de Residuos (RER): una infraestructura conceptual de recompensas directa de hábitos ciudadanos

Este trabajo propone un diseño tecnológico para el desarrollo de un artefacto de recolección de residuos urbanos. Su propósito es facilitar la instrumentación de políticas de conductas de responsabilidad ciudadana basadas en recompensas. Para este propósito se creó una prueba de concepto que involucra un diseño de software, una arquitectura, componentes electromecánicos embebidos y una aplicación informática de gestión integral y conexión digital con sistemas de gestión municipales. La articulación de estos componentes se denominará Receptor Electrónico de Residuos (RER), su diseño y construcción permiten diferentes tipos de adaptaciones para propósitos similares al cuidado del medio ambiente e innovaciones en tecnologías en ciudades digital públicas.XI Workshop Innovación en Sistemas de Software.Red de Universidades con Carreras en Informátic

Receptor Electrónico de Residuos (RER): una infraestructura conceptual de recompensas directa de hábitos ciudadanos

Este trabajo propone un diseño tecnológico para el desarrollo de un artefacto de recolección de residuos urbanos. Su propósito es facilitar la instrumentación de políticas de conductas de responsabilidad ciudadana basadas en recompensas. Para este propósito se creó una prueba de concepto que involucra un diseño de software, una arquitectura, componentes electromecánicos embebidos y una aplicación informática de gestión integral y conexión digital con sistemas de gestión municipales. La articulación de estos componentes se denominará Receptor Electrónico de Residuos (RER), su diseño y construcción permiten diferentes tipos de adaptaciones para propósitos similares al cuidado del medio ambiente e innovaciones en tecnologías en ciudades digital públicas.XI Workshop Innovación en Sistemas de Software.Red de Universidades con Carreras en Informátic

Cenicero Electrónico Inteligente con Recompensas (CEIR) : Otro concepto de cenicero electrónico inteligente con recompensas para espacios urbanos

Este trabajo se enfoca en la construcción de un diseño tecnológico para el desarrollo de un artefacto de recolección de residuos específicos de colilla de cigarrillos en áreas urbanas. Su propósito es, al mismo tiempo, utilitario y funcional ya que está orientado a facilitar la implementación de políticas de conductas de responsabilidad ciudadana basadas en recompensas. Para este objetivo se creó una prueba de concepto que involucra un diseño de software, una arquitectura, componentes electro-mecánicos embebidos y una aplicación informática para su gestión integral y conexión digital con sistemas municipales. La articulación de estos componentes se denominará Cenicero Electrónico Inteligente con Recompensas (CEIR), su diseño y construcción permiten diferentes tipos de adaptaciones para propósitos similares al cuidado del medio ambiente e innovaciones públicas.Sociedad Argentina de Informática e Investigación Operativ

Identification of TRPC6 as a possible candidate target gene within an amplicon at 11q21-q22.2 for migratory capacity in head and neck squamous cell carcinomas

Abstract: Background: Cytogenetic and gene expression analyses in head and neck squamous cell carcinomas (HNSCC) have allowed identification of genomic aberrations that may contribute to cancer pathophysiology. Nevertheless, the molecular consequences of numerous genetic alterations still remain unclear. Methods: To identify novel genes implicated in HNSCC pathogenesis, we analyzed the genomic alterations present in five HNSCC-derived cell lines by array CGH, and compared high level focal gene amplifications with gene expression levels to identify genes whose expression is directly impacted by these genetic events. Next, we knocked down TRPC6, one of the most highly amplified and over-expressed genes, to characterize the biological roles of TRPC6 in carcinogenesis. Finally, real time PCR was performed to determine TRPC6 gene dosage and mRNA levels in normal mucosa and human HNSCC tissues. Results: The data showed that the HNSCC-derived cell lines carry most of the recurrent genomic abnormalities previously described in primary tumors. High-level genomic amplifications were found at four chromosomal sites (11q21-q22.2, 18p11.31-p11.21, 19p13.2-p13.13, and 21q11) with associated gene expression changes in selective candidate genes suggesting that they may play an important role in the malignant behavior of HNSCC. One of the most dramatic alterations of gene transcription involved the TRPC6 gene (located at 11q21-q22.2) which has been recently implicated in tumour invasiveness. siRNA-induced knockdown of TRPC6 expression in HNSCC-derived cells dramatically inhibited HNSCC-cell invasion but did not significantly alter cell proliferation. Importantly, amplification and concomitant overexpression of TRPC6 was also found in HNSCC tumour samples. Conclusions: Altogether, these data show that TRPC6 is likely to be a target for 11q21-22.2 amplification that confers enhanced invasive behavior to HNSCC cells. Therefore, TRPC6 may be a promising therapeutic target in the treatment of HNSCC.This work was supported by Instituto de Salud Carlos III-Fondo de Investigacion Sanitaria [FIS PI11/929 to M.-D.C and C. S.]; Red Tematica de Investigacion Cooperativa en Cancer [RD12/0036/0015] Instituto de Salud Carlos III (ISCIII), Spanish Ministry of Economy and Competitiveness & European Regional Development Fund (ERDF); and Obra Social CajAstur-Instituto Universitario de Oncologia del Principado de Asturias.Bernaldo De Quirós, S.; Merlo, A.; Secades, P.; Zambrano, I.; Saenz De Santa María, I.; Ugidos, N.; Jantus Lewintre, E.... (2013). Identification of TRPC6 as a possible candidate target gene within an amplicon at 11q21-q22.2 for migratory capacity in head and neck squamous cell carcinomas. 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Desenvolvimento neuromotor, crescimento físico e ontogenia comportamental em cricetídeos (Mesocricetus auratus e Phodopus sungorus)

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas.O desenvolvimento dos filhotes em roedores é modulado pelos mais diversos fatores tais como temperatura, meio social e variáveis ecológicas. Esta pesquisa foi desenvolvida com o objetivo de comparar alguns aspectos do desenvolvimento sensorial, neuromotor, físico e comportamental em duas espécies de roedores da família Cricetidae (M. auratus e P. sungorus). Para realizar tais comparações foram criadas duas situações distintas. 1) Situação ecológica: os sujeitos permaneceram na caixa-viveiro, tiveram acesso a alimento, água e palha para o ninho; o ambiente social incluía a presença da mãe e dos irmãos. Como variável dependente foram registrados as seguintes categorias de comportamento: tempo despendido em contato físico mãe-filhote, filhote-filhote, permanência no ninho, manipulação do material do ninho, brincadeira, comportamento ingestivo (comer e beber), locomoção no ninho e locomoção fora do ninho. As sessões de observação tiveram duração de 20 minutos por dia e foram realizadas todos os dias do 5° ao 25°dia de idade dos filhotes (dia do nascimento = Dia 0). 2) Situação teste: os animais eram retirados da caixa-viveiro para execução dos testes de "surface righting", geotaxia negativa e para sessões de observação do comportamento de 6 min., as quais eram realizadas em uma pequena caixa sem comida, água, palha ou congêneres. Nestas sessões foi registrado o tempo despendido em movimentos lentos, locomoção e erguer-se, do 1° ao 25° dia após o nascimento dos filhotes, em dias alternados (dia do nascimento = dia 0). Nas duas situações registramos a auto-limpeza e o dia de abertura dos olhos. As mensurações da massa corporal dos sujeitos foram realizadas de 5 em 5 dias. Através da análise estatística encontrou-se diferenças significativas entre as espécies na habilidade para geotaxia negativa, no crescimento físico (abertura de olhos e peso) e em várias categorias de comportamento: contato-físico filhote-filhote, brincadeira, movimentos lentos, auto-limpeza, erguer-se e locomoção na situação teste. Com base nos resultados obtidos na presente pesquisa podemos classificar o desenvolvimento de hasmter dourado (M. auratus) e hamster siberiano (P. sungorus) em 4 fases: 1) desenvolvimento neuromotor e do sistema vestibular (do 1° ao 3° dia); 2) das habilidades locomotoras, exploratórias e manipulatórias (do 8° ao 14° dia); 3) das habilidades sociais específicas (do 15° ao 19° dia) e; 4) amadurecimento integrado (do 20° ao 25°dia). Embora possamos incluir ambas espécies nestas fases, existem particularidades que diferenciam o desenvolvimento nas mesmas. De uma maneira em geral, o crescimento físico em M. auratus é mais lento que em P. sungorus, mas após a formação integrada dos vários sistemas sensorio-motores, as interações sociais entre os filhotes durante o período juvenil parece mais intenso em M. auratus, embora esta espécies seja considerada solitária

Efficient Implementation of Application-Aware Spinlock Control in MPSoCs

Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G × E), however, so far, thorough replication of findings is rare and G × E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G × E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G × E in schizophrenia. While such investigations are now well underway, new challenges emerge for G × E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotyp