Intelligent Municipal Heritage Management Service in a Smart City: Telecommunication Traffic Characterizationand Quality of Service

[EN] The monitoring of cultural heritage is becoming common in cities to provide heritage preservation and prevent vandalism. Using sensors and video cameras for this task implies the need to transmit information. In this paper, the teletraffic that cameras and sensors generate is characterized and the transmissions¿ influence on the municipal communications network is evaluated. Then, we propose models for telecommunication traffic sources in an intelligent municipal heritage management service inside a smart sustainable city. The sources were simulated in a smart city scenario to find the proper quality of service (QoS) parameters for the communication network, using Valencia City as background. Specific sensors for intelligent municipal heritage management were selected and four telecommunication traffic sources were modelled according to real-life requirements and sensors datasheet. Different simulations were performed to find the proper CIR (Committed Information Rate) and PIR (Peak Information Rate) values and to study the effects of limited bandwidth networks. Packet loss, throughput, delay, and jitter were used to evaluate the network¿s performance. Consequently, the result was the selection of the minimum values for PIR and CIR that ensured QoS and thus optimized the traffic telecommunication costs associated with an intelligent municipal heritage management service.This work was partially supported by Spanish Government Projects TIN2013-47272-C2-1-R and TEC2015-71932-REDTRodríguez-Hernández, MA.; Jiang, Z.; Gomez-Sacristan, Á.; Pla, V. (2019). Intelligent Municipal Heritage Management Service in a Smart City: Telecommunication Traffic Characterizationand Quality of Service. Wireless Communications and Mobile Computing (Online). 1-10. https://doi.org/10.1155/2019/8412542S11

Filtering Methods for Efficient Dynamic Access Control in 5G Massive Machine-Type Communication Scenarios

[EN] One of the three main use cases of the fifth generation of mobile networks (5G) is massive machine-type communications (mMTC). The latter refers to the highly synchronized accesses to the cellular base stations from a great number of wireless devices, as a product of the automated exchange of small amounts of data. Clearly, an efficient mMTC is required to support the Internet-of-Things (IoT). Nevertheless, the method to change from idle to connected mode, known as the random access procedure (RAP), of 4G has been directly inherited by 5G, at least, until the first phase of standardization. Research has demonstrated the RAP is inefficient to support mMTC, hence, access control schemes are needed to obtain an adequate performance. In this paper, we compare the benefits of using different filtering methods to configure an access control scheme included in the 5G standards: the access class barring (ACB), according to the intensity of access requests. These filtering methods are a key component of our proposed ACB configuration scheme, which can lead to more than a three-fold increase in the probability of successfully completing the random access procedure under the most typical network configuration and mMTC scenario.This research has been supported in part by the Ministry of Economy and Competitiveness of Spain under Grant TIN2013-47272-C2-1-R and Grant TEC2015-71932-REDT. The research of I. Leyva-Mayorga was partially funded by grant 383936 CONACYT-GEM 2014.Leyva-Mayorga, I.; Rodríguez-Hernández, MA.; Pla, V.; Martínez Bauset, J. (2019). Filtering Methods for Efficient Dynamic Access Control in 5G Massive Machine-Type Communication Scenarios. Electronics. 8(1):1-18. https://doi.org/10.3390/electronics8010027S11881Laya, A., Alonso, L., & Alonso-Zarate, J. (2014). Is the Random Access Channel of LTE and LTE-A Suitable for M2M Communications? A Survey of Alternatives. IEEE Communications Surveys & Tutorials, 16(1), 4-16. doi:10.1109/surv.2013.111313.00244Biral, A., Centenaro, M., Zanella, A., Vangelista, L., & Zorzi, M. (2015). The challenges of M2M massive access in wireless cellular networks. Digital Communications and Networks, 1(1), 1-19. doi:10.1016/j.dcan.2015.02.001Tello-Oquendo, L., Leyva-Mayorga, I., Pla, V., Martinez-Bauset, J., Vidal, J.-R., Casares-Giner, V., & Guijarro, L. (2018). Performance Analysis and Optimal Access Class Barring Parameter Configuration in LTE-A Networks With Massive M2M Traffic. IEEE Transactions on Vehicular Technology, 67(4), 3505-3520. doi:10.1109/tvt.2017.2776868Tavana, M., Rahmati, A., & Shah-Mansouri, V. (2018). Congestion control with adaptive access class barring for LTE M2M overload using Kalman filters. Computer Networks, 141, 222-233. doi:10.1016/j.comnet.2018.01.044Lin, T.-M., Lee, C.-H., Cheng, J.-P., & Chen, W.-T. (2014). PRADA: Prioritized Random Access With Dynamic Access Barring for MTC in 3GPP LTE-A Networks. IEEE Transactions on Vehicular Technology, 63(5), 2467-2472. doi:10.1109/tvt.2013.2290128De Andrade, T. P. C., Astudillo, C. A., Sekijima, L. R., & Da Fonseca, N. L. S. (2017). The Random Access Procedure in Long Term Evolution Networks for the Internet of Things. IEEE Communications Magazine, 55(3), 124-131. doi:10.1109/mcom.2017.1600555cmWang, Z., & Wong, V. W. S. (2015). Optimal Access Class Barring for Stationary Machine Type Communication Devices With Timing Advance Information. IEEE Transactions on Wireless Communications, 14(10), 5374-5387. doi:10.1109/twc.2015.2437872Tello-Oquendo, L., Pacheco-Paramo, D., Pla, V., & Martinez-Bauset, J. (2018). Reinforcement Learning-Based ACB in LTE-A Networks for Handling Massive M2M and H2H Communications. 2018 IEEE International Conference on Communications (ICC). doi:10.1109/icc.2018.8422167Leyva-Mayorga, I., Rodriguez-Hernandez, M. A., Pla, V., Martinez-Bauset, J., & Tello-Oquendo, L. (2019). Adaptive access class barring for efficient mMTC. Computer Networks, 149, 252-264. doi:10.1016/j.comnet.2018.12.003Kalalas, C., & Alonso-Zarate, J. (2017). Reliability analysis of the random access channel of LTE with access class barring for smart grid monitoring traffic. 2017 IEEE International Conference on Communications Workshops (ICC Workshops). doi:10.1109/iccw.2017.7962744Leyva-Mayorga, I., Tello-Oquendo, L., Pla, V., Martinez-Bauset, J., & Casares-Giner, V. (2016). Performance analysis of access class barring for handling massive M2M traffic in LTE-A networks. 2016 IEEE International Conference on Communications (ICC). doi:10.1109/icc.2016.7510814Arouk, O., & Ksentini, A. (2016). General Model for RACH Procedure Performance Analysis. IEEE Communications Letters, 20(2), 372-375. doi:10.1109/lcomm.2015.2505280Zhang, Z., Chao, H., Wang, W., & Li, X. (2014). Performance Analysis and UE-Side Improvement of Extended Access Barring for Machine Type Communications in LTE. 2014 IEEE 79th Vehicular Technology Conference (VTC Spring). doi:10.1109/vtcspring.2014.7023042Cheng, R.-G., Chen, J., Chen, D.-W., & Wei, C.-H. (2015). Modeling and Analysis of an Extended Access Barring Algorithm for Machine-Type Communications in LTE-A Networks. IEEE Transactions on Wireless Communications, 14(6), 2956-2968. doi:10.1109/twc.2015.2398858Widrow, B., Glover, J. R., McCool, J. M., Kaunitz, J., Williams, C. S., Hearn, R. H., … Goodlin, R. C. (1975). Adaptive noise cancelling: Principles and applications. Proceedings of the IEEE, 63(12), 1692-1716. doi:10.1109/proc.1975.1003

Estudio preliminar de asignación individual de cerdos ibéricos usando marcadores genéticos de ADN

Assignment tests and related methods combined with the use of microsatellite markers enable the determination of cross-breeding among populations. The best classification of the Iberian Pig seems to be in three main varieties, and several local varieties, with different impacts on the genetic structure of the population. In this study 26 microsatellites were analysed in eight varieties of Iberian Pig and screened for betweenbreed and within-breed specificity. In Spain a terminal cross between Iberian females and Duroc boars is permitted for the production of typical Iberian meat products. Although the use of these hybrids are not recommended for further breeding, it is necessary to evaluate the possible influence of the Duroc pig in the Iberian pig, because the influence of this exotic breed (and others) began even before the establishment of the breed book. Molecular and statistical tools seem to be the best choice for that evaluation to complement detection based on morphological traits.Pruebas de asignación y métodos similares combinados con el uso de marcadores microsatélites permiten la determinación de cruces entre razas y la homogeneidad intrarraza. La mejor clasificación del cerdo Ibérico parece ser en tres grandes variedades acompañadas por un gran número de ecotipos locales con influencia diferente en la estructura genética de la raza. En este estudio se han analizado 26 microsatélites en ocho variedades de cerdo Ibérico para describir la posible especificidad intra e inter-raza. Está permitido cruzar madres Ibéricas con sementales Duroc para obtener una primera generación de individuos destinados a la producción de los clásicos derivados cárnicos Ibéricos. Aunque el empleo de estos híbridos no se recomienda para la reproducción, es necesario evaluar la posible influencia de la raza Duroc en el cerdo Ibérico, ya que el uso de esta raza y de otras empezó incluso antes de que estuviera establecido el libro genealógico. Las herramientas moleculares y estadísticas parecen ser la mejor elección para esta evaluación como complemento de la detección basada en caracteres morfológicos

Modelling driving behaviour and its impact on the energy management problem in hybrid electric vehicles

Perfect knowledge of future driving conditions can be rarely assumed on real applications when optimally splitting power demands among different energy sources in a hybrid electric vehicle. Since performance of a control strategy in terms of fuel economy and pollutant emissions is strongly affected by vehicle power requirements, accurate predictions of future driving conditions are needed. This paper proposes different methods to model driving patterns with a stochastic approach. All the addressed methods are based on the statistical analysis of previous driving patterns to predict future driving conditions, some of them employing standard vehicle sensors, while others require non-conventional sensors (for instance, global positioning system or inertial reference system). The different modelling techniques to estimate future driving conditions are evaluated with real driving data and optimal control methods, trading off model complexity with performance.Guardiola García, C.; Plá Moreno, B.; Blanco Rodriguez, D.; Reig Bernad, A. (2014). Modelling driving behaviour and its impact on the energy management problem in hybrid electric vehicles. International Journal of Computer Mathematics. 91(1):147-156. doi:10.1080/00207160.2013.829567S147156911Ericsson, E. (2001). Independent driving pattern factors and their influence on fuel-use and exhaust emission factors. Transportation Research Part D: Transport and Environment, 6(5), 325-345. doi:10.1016/s1361-9209(01)00003-7Q. Gong, P. Tulpule, V. Marano, S. Midlam-Mohler, and G. Rizzoni,The role of ITS in PHEV performance improvement, 2011 American Control Conference, June–July, San Francisco, CA, 2011, pp. 2119–2124.C. Guardiola, B. Pla, S. Onori, and G. Rizzoni,A new approach to optimally tune the control strategy for hybrid vehicles applications, IFAC Workshop on Engine and Powertrain Control, Simulation and Modeling E-COSM’12, October, Rueil-Malmaison, France, 2012.Johannesson, L., Asbogard, M., & Egardt, B. (2007). Assessing the Potential of Predictive Control for Hybrid Vehicle Powertrains Using Stochastic Dynamic Programming. IEEE Transactions on Intelligent Transportation Systems, 8(1), 71-83. doi:10.1109/tits.2006.884887Liu, S., & Yao, B. (2008). Coordinate Control of Energy Saving Programmable Valves. IEEE Transactions on Control Systems Technology, 16(1), 34-45. doi:10.1109/tcst.2007.903073Paganelli, G. (2001). General supervisory control policy for the energy optimization of charge-sustaining hybrid electric vehicles. JSAE Review, 22(4), 511-518. doi:10.1016/s0389-4304(01)00138-2Rizzoni, G., Guzzella, L., & Baumann, B. M. (1999). Unified modeling of hybrid electric vehicle drivetrains. IEEE/ASME Transactions on Mechatronics, 4(3), 246-257. doi:10.1109/3516.789683Control of hybrid electric vehicles. (2007). IEEE Control Systems, 27(2), 60-70. doi:10.1109/mcs.2007.338280L. Serrao, S. Onori, and G. Rizzoni,ECMS as realization of Pontryagin's minimum principle for HEV control, 2009 American Control Conference, June, Saint Louis, MO, 2009, pp. 3964–3969.Serrao, L., Onori, S., & Rizzoni, G. (2011). A Comparative Analysis of Energy Management Strategies for Hybrid Electric Vehicles. Journal of Dynamic Systems, Measurement, and Control, 133(3). doi:10.1115/1.4003267Stockar, S., Marano, V., Canova, M., Rizzoni, G., & Guzzella, L. (2011). Energy-Optimal Control of Plug-in Hybrid Electric Vehicles for Real-World Driving Cycles. IEEE Transactions on Vehicular Technology, 60(7), 2949-2962. doi:10.1109/tvt.2011.2158565Sundström, O., Ambühl, D., & Guzzella, L. (2009). On Implementation of Dynamic Programming for Optimal Control Problems with Final State Constraints. Oil & Gas Science and Technology – Revue de l’Institut Français du Pétrole, 65(1), 91-102. doi:10.2516/ogst/2009020O. Sundström and L. Guzzella,A generic dynamic programming Matlab function, 18th IEEE International Conference on Control Applications Part of 2009 IEEE Multi-conference on Systems and Control, July, Saint Petersburg, 2009, pp. 1625–1630.R. Wang and S.M. Lukic,Review of driving conditions prediction and driving style recognition based control algorithms for hybrid electric vehicles, Vehicle Power and Propulsion Conference (VPPC), 2011 IEEE, September 6–9, Raleigh, NC, 2011, pp. 1–7

Program of genetic management of the hispano-arabe horse breed

The Hispano-Arabe horse breed could be considered as a synthetic breed formed in Spain at least two centuries ago, because the farmer intention of create a breed for working and sport according the necessities of the epoch. Today the breed is officially recognized as autochthons breed of especial protection, due to their few effectives. In this communication we are presenting the program for the genetic management of the breed in development in an interdisciplinary and inter-institutional manner. The program has the following parts: Design and initiation of a program of improvement and conservation; Creation of a germplasm bank for the principal reproducers; Study of the genetic structure of the breed using DNA microsatellite markers; Technical formation and divulgation of the breed. The program and the work developed by the moment are described.El caballo Hispano-Árabe puede considerarse una raza sintética formada en España desde hace más de dos siglos por la intención de los ganaderos de contar con una raza de trabajo y deporte adecuada a las necesidades de la época. Hoy en día está reconocido oficialmente como una raza autóctona de protección especial, debido a sus escasos efectivos. En esta comunicación se presenta el programa de gestión genética de la raza, el cual se está desarrollando de manera interdisciplinar e inter-institucional. Consta de los siguientes apartados: Diseño y puesta en marcha de un programa de mejora y de conservación; Creación de un banco de germoplasma de los reproductores destacados; Estudio de la estructura genética de la raza utilizando marcadores microsatélites del ADN; Formación técnica y divulgación de la raza. Se describen el programa y las actuaciones desarrolladas hasta el momento

Adaptive access class barring for efficient mMTC

[EN] In massive machine-type communications (mMTC), an immense number of wireless devices communicate autonomously to provide users with ubiquitous access to information and services. The current 4G LTE-A cellular system and its Internet of Things (IoT) implementation, the narrowband IoT (NB-IoT), present appealing options for the interconnection of these wireless devices. However, severe congestion may arise whenever a massive number of highly-synchronized access requests occur. Consequently, access control schemes, such as the access class barring (ACB), have become a major research topic. In the latter, the precise selection of the barring parameters in a real-time fashion is needed to maximize performance, but is hindered by numerous characteristics and limitations of the current cellular systems. In this paper, we present a novel ACB configuration (ACBC) scheme that can be directly implemented at the cellular base stations. In our ACBC scheme, we calculate the ratio of idle to total available resources, which then serves as the input to an adaptive filtering algorithm. The main objective of the latter is to enhance the selection of the barring parameters by reducing the effect of the inherent randomness of the system. Results show that our ACBC scheme greatly enhances the performance of the system during periods of high congestion. In addition, the increase in the access delay during periods of light traffic load is minimal.This research has been supported in part by the Ministry of Economy and Competitiveness of Spain under Grant TIN2013-47272-C2-1-R and Grant TEC2015-71932-REDT. The research of I. Leyva-Mayorga was partially funded by grant 383936 CONACYT-GEM 2014.Leyva-Mayorga, I.; Rodríguez-Hernández, MA.; Pla, V.; Martínez Bauset, J.; Tello-Oquendo, L. (2019). Adaptive access class barring for efficient mMTC. Computer Networks. 149:252-264. https://doi.org/10.1016/j.comnet.2018.12.003S25226414

Boundless multiobjective models for cash management

"This is an Accepted Manuscript of an article published by Taylor & Francis in Engineering Economist on 31-05-2018, available online: https://doi.org/10.1080/0013791X.2018.1456596"[EN] Cash management models are usually based on a set of bounds that complicate the selection of the optimal policies due to nonlinearity. We here propose to linearize cash management models to guarantee optimality through linear-quadratic multiobjective compromise programming models. We illustrate our approach through a reformulation of the suboptimal state-of-the-art Gormley-Meade¿s model to achieve optimality. Furthermore, we introduce a much simpler formulation that we call the boundless model that also provides optimal solutions without using bounds. Results from a sensitivity analysis using real data sets from 54 different companies show that our boundless model is highly robust to cash flow prediction errors.Generalitat de Catalunya [2014 SGR 118]; Ministerio de Economia y Competitividad [Collectiveware TIN2015-66863-C2-1-R].Salas-Molina, F.; Rodriguez-Aguilar, JA.; Pla Santamaría, D. (2018). Boundless multiobjective models for cash management. Engineering Economist (Online). 63(4):363-381. https://doi.org/10.1080/0013791X.2018.1456596S363381634Artzner, P., Delbaen, F., Eber, J.-M., & Heath, D. (1999). Coherent Measures of Risk. Mathematical Finance, 9(3), 203-228. doi:10.1111/1467-9965.00068Baccarin, S. (2009). Optimal impulse control for a multidimensional cash management system with generalized cost functions. European Journal of Operational Research, 196(1), 198-206. doi:10.1016/j.ejor.2008.02.040Ballestero, E., & Romero, C. (1998). Multiple Criteria Decision Making and its Applications to Economic Problems. doi:10.1007/978-1-4757-2827-9Bar-Ilan, A., Perry, D., & Stadje, W. (2004). A generalized impulse control model of cash management. Journal of Economic Dynamics and Control, 28(6), 1013-1033. doi:10.1016/s0165-1889(03)00064-2Baumol, W. J. (1952). The Transactions Demand for Cash: An Inventory Theoretic Approach. The Quarterly Journal of Economics, 66(4), 545. doi:10.2307/1882104Bemporad, A., & Morari, M. (1999). Control of systems integrating logic, dynamics, and constraints. Automatica, 35(3), 407-427. doi:10.1016/s0005-1098(98)00178-2Ben-Tal, A., El Ghaoui, L., & Nemirovski, A. (2009). Robust Optimization. doi:10.1515/9781400831050Branke, J., Deb, K., Miettinen, K., & Słowiński, R. (Eds.). (2008). Multiobjective Optimization. Lecture Notes in Computer Science. doi:10.1007/978-3-540-88908-3Chelouah, R., & Siarry, P. (2000). Journal of Heuristics, 6(2), 191-213. doi:10.1023/a:1009626110229Chen, X., & Simchi-Levi, D. (2009). A NEW APPROACH FOR THE STOCHASTIC CASH BALANCE PROBLEM WITH FIXED COSTS. Probability in the Engineering and Informational Sciences, 23(4), 545-562. doi:10.1017/s0269964809000242Constantinides, G. M., & Richard, S. F. (1978). Existence of Optimal Simple Policies for Discounted-Cost Inventory and Cash Management in Continuous Time. Operations Research, 26(4), 620-636. doi:10.1287/opre.26.4.620Moraes, M. B. da C., & Nagano, M. S. (2014). Evolutionary models in cash management policies with multiple assets. Economic Modelling, 39, 1-7. doi:10.1016/j.econmod.2014.02.010Da Costa Moraes, M. B., Nagano, M. S., & Sobreiro, V. A. (2015). Stochastic Cash Flow Management Models: A Literature Review Since the 1980s. Decision Engineering, 11-28. doi:10.1007/978-3-319-11949-6_2De Avila Pacheco, J. V., & Morabito, R. (2011). Application of network flow models for the cash management of an agribusiness company. Computers & Industrial Engineering, 61(3), 848-857. doi:10.1016/j.cie.2011.05.018Girgis, N. M. (1968). Optimal Cash Balance Levels. Management Science, 15(3), 130-140. doi:10.1287/mnsc.15.3.130Golden, B., Liberatore, M., & Lieberman, C. (1979). Models and solution techniques for cash flow management. Computers & Operations Research, 6(1), 13-20. doi:10.1016/0305-0548(79)90010-8Gormley, F. M., & Meade, N. (2007). The utility of cash flow forecasts in the management of corporate cash balances. European Journal of Operational Research, 182(2), 923-935. doi:10.1016/j.ejor.2006.07.041Gregory, G. (1976). Cash flow models: A review. Omega, 4(6), 643-656. doi:10.1016/0305-0483(76)90092-xGurobi Optimization, Inc (2017) Gurobi optimizer reference manual, Houston.Keown, A. J., & Martin, J. D. (1977). A Chance Constrained Goal Programming Model for Working Capital Management. The Engineering Economist, 22(3), 153-174. doi:10.1080/00137917708965174Miller, M. H., & Orr, D. (1966). A Model of the Demand for Money by Firms. The Quarterly Journal of Economics, 80(3), 413. doi:10.2307/1880728Neave, E. H. (1970). The Stochastic Cash Balance Problem with Fixed Costs for Increases and Decreases. Management Science, 16(7), 472-490. doi:10.1287/mnsc.16.7.472PARK, C. S., & HERATH, H. S. B. (2000). EXPLOITING UNCERTAINTY—INVESTMENT OPPORTUNITIES AS REAL OPTIONS: A NEW WAY OF THINKING IN ENGINEERING ECONOMICS. The Engineering Economist, 45(1), 1-36. doi:10.1080/00137910008967534Penttinen, M. J. (1991). Myopic and stationary solutions for stochastic cash balance problems. European Journal of Operational Research, 52(2), 155-166. doi:10.1016/0377-2217(91)90077-9Rockafellar, R. T., & Uryasev, S. (2002). Conditional value-at-risk for general loss distributions. Journal of Banking & Finance, 26(7), 1443-1471. doi:10.1016/s0378-4266(02)00271-6Salas-Molina, F., Martin, F. J., Rodríguez-Aguilar, J. A., Serrà, J., & Arcos, J. L. (2017). Empowering cash managers to achieve cost savings by improving predictive accuracy. International Journal of Forecasting, 33(2), 403-415. doi:10.1016/j.ijforecast.2016.11.002Salas-Molina, F., Pla-Santamaria, D., & Rodriguez-Aguilar, J. A. (2016). A multi-objective approach to the cash management problem. Annals of Operations Research, 267(1-2), 515-529. doi:10.1007/s10479-016-2359-1Srinivasan, V., & Kim, Y. H. (1986). Deterministic cash flow management: State of the art and research directions. Omega, 14(2), 145-166. doi:10.1016/0305-0483(86)90017-4Stone, B. K. (1972). The Use of Forecasts and Smoothing in Control-Limit Models for Cash Management. Financial Management, 1(1), 72. doi:10.2307/3664955Stone, B. K., & Miller, T. W. (1987). Daily Cash Forecasting with Multiplicative Models of Cash Flow Patterns. Financial Management, 16(4), 45. doi:10.2307/3666108Xu, X., & Birge, J. R. (2008). Operational Decisions, Capital Structure, and Managerial Compensation: A News Vendor Perspective. The Engineering Economist, 53(3), 173-196. doi:10.1080/00137910802262887Yu, P.-L. (1985). Multiple-Criteria Decision Making. doi:10.1007/978-1-4684-8395-

Dagestan blunt-nosed viper, Macrovipera lebetina obtusa (Dwigubsky, 1832), venom. Venomics, antivenomics, and neutralization assays of the lethal and toxic venom activities by anti-Macrovipera lebetina turanica and anti-Vipera berus berus antivenoms

10 páginas 2 figuras, 3 tablasWe have applied a combination of venomics, in vivo neutralization assays, and in vitro third-generation antivenomics analysis to assess the preclinical efficacy of the monospecific anti-Macrovipera lebetina turanica (anti-Mlt) antivenom manufactured by Uzbiopharm® (Uzbekistan) and the monospecific anti-Vipera berus berus antivenom from Microgen® (Russia) against the venom of Dagestan blunt-nosed viper, Macrovipera lebetina obtusa (Mlo). Despite their low content of homologous (anti-Mlt, 5-10%) or para-specific (anti-Vbb, 4-9%) F(ab')2 antibody fragments against M. l. obtusa venom toxins, both antivenoms efficiently recognized most components of the complex venom proteome's arsenal, which is made up of toxins derived from 11 different gene families and neutralized, albeit at different doses, key toxic effects of M. l. obtusa venom, i.e., in vivo lethal and hemorrhagic effects in a murine model, and in vitro phospholipase A2, proteolytic and coagulant activities. The calculated lethality neutralization potencies for Uzbiopharm® anti-Mlt and anti-Vbb Microgen® antivenoms were 1.46 and 1.77 mg/mL, indicating that 1 mL of Uzbiopharm® and Microgen® antivenoms may protect mice from 41 to 50 LD50s of Mlo venom, respectively. The remarkable degree of conservation of immunogenic determinants between species of the clades of European and Oriental viper, which evolved geographically segregated since the early Miocene, suggests an eventual window of opportunity for the treatment of envenomings by Eurasian snakes. Clearly, the rational use of heterologous antivenoms requires establishing their para-specificity landscapes. This paper illustrates the analytical power of combining in vitro and in vivo preclinical quantitative assays toward this goalThis research was partly funded by grant BFU2017-89103-P (Ministerio de Ciencia, Innovación y Universidades, Madrid, Spain), by Vicerrectoría de Investigación, Universidad de Costa Rica (741-A0-804), and by LLC “Innova plus” (Saint-Petersburg, Russia).Peer reviewe

Vertebral fracture risk in glucocorticoid-induced osteoporosis: the role of hypogonadism and corticosteroid boluses

Objective: The aim of this study was to identify the risk factors associated with fragility fracture (FF) development in glucocorticoid (GC)-treated patients. Methods: 127 patients (aged 62±18 years, 63% women) on GC-treatment (mean dose 14.5±14.1 mg/day and duration 47.7±69 months) were included. The clinical data collected included bone metabolism study (including gonadal axis), GC-treatment, disease activity, dual-energy X-ray absorptiometry analysis (evaluating densitometric osteoporosis (OP) and trabecular bone score (TBS) degraded microarchitecture values (DMA)), X-ray (assessing vertebral fractures (VF)), FRAX risk (GC-adjusted) and previous FF. Results: 17% of the patients had VF, 28% FF (VF and/or non-VF), 29% OP and 52% DMA. Patients with VF received more GC boluses (57.1% vs 29.5%, p=0.03), were older (68±13 vs 60±19 years, p=0.02), postmenopausal (100% vs 67%, p=0.02), had low testosterone levels (57% vs 11%, p=0.02), lower TBS values (1.119±0.03 vs 1.237±0.013, p100, p=0.01) and having received GC boluses (OR 3.45; 95% CI 1.04 to 12.15, p=0.01) were the main factors related to VF. Hypogonadism (OR 7.03; 95% CI 1.47 to 38.37, p=0.01) and FRAX >20 (OR 7.08; 95% CI 1.28 to 53.71, p=0.02) were factors related to FF. Conclusion: Hypogonadism is the principal risk factor for developing fractures in GC-treated men and women, whereas receiving GC boluses is a major factor for VF. These results indicate the importance of evaluating the gonadal axis in these patients

Miniatures from domestic contexts in Iron age Iberia

This article reviews a set of miniatures from domestic contexts in Iron Age eastern Iberia, and interprets them in terms of their role in forging social personae. After an introduction to the historical case under consideration, the miniatures are described in terms of their typology and their contexts of provenance are outlined. Though not abundant, they tend to occur in central places in the landscape; specifically, they are often found in houses of the powerful. The vast majority are miniatures of pottery and tools, though some miniature weapons are recorded. We contend that these objects were used as a means of enculturation and for the learning of values and norms. It is no coincidence that they emerge in the archaeological record of Iron Age Iberia at the same time as the rise of a social structure based on hereditary power