Sustained reentry in a 3d regionally ischemic human heart. A simulation study

In this work, we have studied the vulnerable window and propagation patterns in a human heart during acute ischemia. A 3-D biventricular model of a human heart with realistic heterogeneity and fiber orientations has been considered. The ischemic region was located in the anterior left ventricular wall mimicking the occlusion of the circumflex artery. The electrical activity of the tissue was modeled with the monodomain model along with a modified version of the ten Tusscher 2006 ionic model. The model predicts the generation of sustained re-entrant activity in the form of a rotor around the ischemic zone. Patterns in the form of figure-of-eight were also observed within the vulnerable window. The re-entrant activity originates in the endocardial surface and propagates transmurally towards the epicardium

Reintervenciones quirúrgicas en pacientes contraumatismo torácico, abdominal o ambos

A descriptive, longitudinal, retrospective and prospective study was carried out at the University Hospital "Dr. Carlos J. Finlay "from Havana, Cuba; To determine the behavior of surgical reinterventions after thoracic, abdominal or both trauma during the period from September 2010 to August 2015.Of 1558 patients operated by thoracic, abdominal, or both trauma, 68 surgical reinterventions were performed in 44 patients, representing an incidence of 2.8%. The reinterventions of patients initially operated ondue to abdominal trauma were the main causes of postoperative bleeding and collection in those operated by this type of trauma, while pleural empyema and pneumothorax were the most frequent variants in those operated on for chest trauma . The inadvertent lesions to the initial operative act were the predominant causes of the reinterventions, a fact that was related to the deaths due to this cause versus the group of reintervened patients without evidence of these injuries.Mortality predominated in the patients reintervened in 4 or more opportunities, with hypovolemic and septic shock being the main causes. From the analysis Aand discussion of the results we conclude that mortality in patients with chest trauma, abdomen or both is associated with the presence of inadvertent injuries and the frequency of reinterventions due to postoperative complications.Se realizó un estudio descriptivo, longitudinal, retrospectivo y prospectivo en el Hospital Universitario “Dr. Carlos J. Finlay” de La Habana, Cuba; para determinar el comportamiento de las reintervenciones quirúrgicas después de un traumatismo torácico, abdominal o ambos durante el período comprendido entre septiembre del 2010 hasta agosto del 2015. De 1558 pacientes operados por traumatismo torácico, abdominal o de ambos se realizaron 68 reintervenciones quirúrgicas en 44 pacientes, lo que representa una incidencia de un 2.8%. Predominaron las reintervenciones de enfermos operados inicialmente por trauma abdominal, resaltando como causas principales la colección y el sangrado postoperatorio en los operados por esta modalidad de trauma, mientras que el empiema pleural y el neumotórax resultaron las variantes más frecuentes en los operados por traumas de tórax. Las lesiones inadvertidas al acto operatorio inicial resultaron las causales predominantes de las reintervenciones, dato que se relacionó con respecto a los fallecidos por esta causa versus el grupo de enfermos reintervenidos sin evidencia de estas lesiones. La mortalidad predominó en los enfermos reintervenidos en 4 ó más oportunidades, deviniendo como principales causas el shock hipovolémico y el séptico. Del análisis y la discusión de los resultados concluimos que la mortalidad en pacientes con traumas de tórax, abdomen o ambos está asociada a la presencia de lesiones inadvertidas y ala frecuencia de reintervenciones por complicaciones postoperatoria

Vulnerability to Reentry in a 3D Regionally Ischemic Ventricular Slab Preparation, a Simulation Study

Ventricular tachycardia and ventricular fibrillation are known to be two types of cardiac arrhythmias that usually take place during acute ischemia and frequently lead to sudden death. In this work, we have studied the different patterns of activation displayed in a virtual ventricular slab preparation after premature stimulation during acute ischemia. Furthermore, we also have analyzed the vulnerable window (VW) under such conditions. Influence of the tissue structure and morphology of the ischemic zone have also been considered. For a centered ischemic zone, eight shaped reentry was originated at the mid plane of the slab and the VW was found to be almost the same as for the 2D simulations. Eight shaped reentry were formed in the epicardial surface as the morphology of the ischemic zone changed (the centre of the ischemic zone was moved toward the epicardial surface). These changes also caused a reduction in the VW of a 24% as compared with the centered ischemic zone

Síndrome del túnel radial: Epicondilitis resistente

Desde 1996 al 2003, fueron intervenidos 25 pacientes (26 extremidades) de síndrome del túnel radial. Todos los procedimientos fueron realizados por el mismo cirujano y en el mismo hospital con un abordaje postero-externo del túnel radial. Se realizó un seguimiento de todos los pacientes en el tiempo después de la cirugía de 4 meses a 6 años y 4 meses (tiempo medio de 22 meses). Los resultados fueron evaluados según los criterios de Roles y Mausdley; 12 pacientes tuvieron resultados excelentes (46.15%), 9 pacientes buenos (34.61%) y 5 pacientes regulares (19.23%). Once pacientes fueron tratados previamente de epicondilitis lateral (entesitis). La mayoría de los pacientes están satisfechos con la cirugía refiriendo un alivio de la sintomatología y una mejora de la funcionalidad tras la cirugía.Between 1996 and 2003, 25 patients (26 extremities) underwent decompression of the radial tunnel. All procedures were performed at the same surgeon and the same institution using posterior approach. The total 25 patients were available for follow-up evaluation alter surgery (range 4 months - 6 years and 4 months) with average of 22 months. The outcomes was determined using the original criteria of Roles and Mausdley, 12 patients were rated as excellent (46.15%), 9 patients has good results (34.61%) and 5 patients had fair results. Eleven patients were treated previously of tennis elbow. Most of the patients were satisfied and felt subjectively improved by the surgery. They obtained pain relief and better functional status after surgery

Reintervenciones quirúrgicas en pacientes contraumatismo torácico, abdominal o ambos

A descriptive, longitudinal, retrospective and prospective study was carried out at the University Hospital "Dr. Carlos J. Finlay "from Havana, Cuba; To determine the behavior of surgical reinterventions after thoracic, abdominal or both trauma during the period from September 2010 to August 2015.Of 1558 patients operated by thoracic, abdominal, or both trauma, 68 surgical reinterventions were performed in 44 patients, representing an incidence of 2.8%. The reinterventions of patients initially operated ondue to abdominal trauma were the main causes of postoperative bleeding and collection in those operated by this type of trauma, while pleural empyema and pneumothorax were the most frequent variants in those operated on for chest trauma . The inadvertent lesions to the initial operative act were the predominant causes of the reinterventions, a fact that was related to the deaths due to this cause versus the group of reintervened patients without evidence of these injuries.Mortality predominated in the patients reintervened in 4 or more opportunities, with hypovolemic and septic shock being the main causes. From the analysis Aand discussion of the results we conclude that mortality in patients with chest trauma, abdomen or both is associated with the presence of inadvertent injuries and the frequency of reinterventions due to postoperative complications.Se realizó un estudio descriptivo, longitudinal, retrospectivo y prospectivo en el Hospital Universitario “Dr. Carlos J. Finlay” de La Habana, Cuba; para determinar el comportamiento de las reintervenciones quirúrgicas después de un traumatismo torácico, abdominal o ambos durante el período comprendido entre septiembre del 2010 hasta agosto del 2015. De 1558 pacientes operados por traumatismo torácico, abdominal o de ambos se realizaron 68 reintervenciones quirúrgicas en 44 pacientes, lo que representa una incidencia de un 2.8%. Predominaron las reintervenciones de enfermos operados inicialmente por trauma abdominal, resaltando como causas principales la colección y el sangrado postoperatorio en los operados por esta modalidad de trauma, mientras que el empiema pleural y el neumotórax resultaron las variantes más frecuentes en los operados por traumas de tórax. Las lesiones inadvertidas al acto operatorio inicial resultaron las causales predominantes de las reintervenciones, dato que se relacionó con respecto a los fallecidos por esta causa versus el grupo de enfermos reintervenidos sin evidencia de estas lesiones. La mortalidad predominó en los enfermos reintervenidos en 4 ó más oportunidades, deviniendo como principales causas el shock hipovolémico y el séptico. Del análisis y la discusión de los resultados concluimos que la mortalidad en pacientes con traumas de tórax, abdomen o ambos está asociada a la presencia de lesiones inadvertidas y ala frecuencia de reintervenciones por complicaciones postoperatoria

Realización de vídeo de enseñanza online y presencial para prácticas por internet y presenciales de la radiografía de muñeca como método para valorar el desarrollo óseo

Se ha realizado un video en el que el alumno visualiza los diferentes estadios de desarrollo que tienen lugar en la osificación de la muñeca y puede aprender cómo utilizar la radiografía de muñeca para determinar el momento de desarrollo del paciente

Biological behavior of familial papillary thyroid microcarcinoma: Spanish multicenter study

Purpose Familial papillary thyroid microcarcinoma (FPTMC) can present a more aggressive behavior than the sporadic microcarcinoma. However, few studies have analyzed this situation. The objective is to analyze the recurrence rate of FPTMC and the prognostic factors which determine that recurrence in Spain. Methods Spanish multicenter longitudinal analytical observational study was conducted. Patients with FPTMC received treatment with curative intent and presented cure criteria 6 months after treatment. Recurrence rate and disease-free survival (DFS) were analyzed. Two groups were analyzed: group A (no tumor recurrence) vs. group B (tumor recurrence). Results Ninety-four patients were analyzed. During a mean follow-up of 73.3 +/- 59.3 months, 13 recurrences of FPTMC (13.83%) were detected and mean DFS was 207.9 +/- 11.5 months. There were multifocality in 56%, bilateral thyroid involvement in 30%, and vascular invasion in 7.5%; that is to say, they are tumors with histological factors of poor prognosis in a high percentage of cases. The main risk factors for recurrence obtained in the multivariate analysis were the tumor size (OR: 2.574, 95% CI 1.210-5.473; p = 0.014) and the assessment of the risk of recurrence of the American Thyroid Association (ATA), both intermediate risk versus low risk (OR: 125, 95% CI 10.638-1000; p < 0.001) and high risk versus low risk (OR: 45.454, 95% CI 5.405-333.333; p < 0.001). Conclusion FPTMC has a recurrence rate higher than sporadic cases. Poor prognosis is mainly associated with the tumor size and the risk of recurrence of the ATA

ALMA observations of Elias 2–24: a protoplanetary disk with multiple gaps in the Ophiuchus molecular cloud

We present ALMA 1.3 mm continuum observations at 0. 2 (25 au) resolution of Elias 2–24, one of the largest and brightest protoplanetary disks in the Ophiuchus Molecular Cloud, and we report the presence of three partially resolved concentric gaps located at ∼20, 52, and 87 au from the star. We perform radiative transfer modeling of the disk to constrain its surface density and temperature radial profile and place the disk structure in the context of mechanisms capable of forming narrow gaps such as condensation fronts and dynamical clearing by actively forming planets. In particular, we estimate the disk temperature at the locations of the gaps to be 23, 15, and 12 K (at 20, 52, and 87 au, respectively), very close to the expected snowlines of CO (23–28 K) and N2 (12–15 K). Similarly, by assuming that the widths of the gaps correspond to 4–8× the Hill radii of forming planets (as suggested by numerical simulations), we estimate planet masses in the range of 0.2 1.5 – MJup, 1.0 8.0 – MJup, and 0.02 0.15 – MJup for the inner, middle, and outer gap, respectively. Given the surface density profile of the disk, the amount of “missing mass” at the location of each one of these gaps (between 4 and 20 MJup) is more than sufficient to account for the formation of such planets.Fil: Cieza, Lucas A.. Universidad Diego Portales; ChileFil: Casassus, Simon. Universidad de Chile; ChileFil: Pérez, Sebastian. Universidad de Chile; ChileFil: Hales, Antonio. Alma Observatory; ChileFil: Cárcamo, Miguel. Universidad de Chile; ChileFil: Ansdell, Megan. University of California at Berkeley; Estados UnidosFil: Avenhaus, Henning. Universitat Zurich; SuizaFil: Bayo, Amelia. Universidad de Valparaiso; ChileFil: Bertrang, Gesa H.-M.. Universidad Diego Portales; ChileFil: Cánovas, Hector. Agencia Espacial Europea; EspañaFil: Christiaens, Valentin. Universidad de Chile; ChileFil: Dent, William. Alma Observatory; ChileFil: Ferrero, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Gamen, Roberto Claudio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Olofsson, Johan. Universidad de Valparaiso; ChileFil: Orcajo, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Osses, Axel. Universidad de Chile; ChileFil: Peña Ramirez, Karla. Universidad de Antofagasta; ChileFil: Principe, David. Massachusetts Institute of Technology; Estados UnidosFil: Ruíz Rodríguez, Dary. Rochester Institute Of Technology; Estados UnidosFil: Schreiber, Matthias R.. Universidad de Valparaiso; ChileFil: Plas, Gerrit van der. Univ. Grenoble Alpes; SuizaFil: Williams, Jonathan P.. Institute For Astronomy, University Of Hawaii; Estados UnidosFil: Zurlo, Alice. Universidad Diego Portales; Chil

ON/OFF metal-triggered molecular tweezers for fullerene recognition

Producción CientíficaHerein, we report molecular tweezers for fullerene recognition based on 2,2′-bipyridine-bearing corannulene motifs. The syn or anti confirmation can be selected simply by Cu(I) coordination/decoordination, thus controlling the fullerene recognition capability of the system on demand and leading to the formation of effective metal-triggered ON/OFF molecular tweezers.We thank the Spanish Ministry of Science, Innovation and Universities (MCIU) for funding (project numbers PGC2018096880-A-I00, MCIU/AEI/FEDER, UE, PGC2018-099470-B-I00, and MCIU/AEI/FEDER, UE). R. G.-R. acknowledges the Spanish MINECO/AEI and the European Union (ESF) for a Ramón y Cajal contract (RYC-2015-19035). H. B. acknowledges the Alfonso Martín Escudero Foundation for a postdoctoral fellowshi