Design of a Flipped Classroom experience and ICT in the classroom

La metodología “Flipped Classroom” elimina el enfoque tradicional y lo reemplazan con tareas activas en clase y trabajo previo y posterior a la clase. A pesar de la popularidad de estos enfoques en los medios de comunicación y cursos impartidos a docentes relacionados con esta metodología, hay muy poca evidencia de la efectividad o consistencia en la comprensión de lo que en realidad sucede en las aulas. Este trabajo pretende analizar si el uso combinado de los recursos disponibles, webs temáticas y la edición de vídeos por parte del profesorado mediante el enfoque “Flipped Classroom” mejora el aprendizaje del alumno. Asímismo, se pretende evaluar si dicha innovación metodológica presenta un impacto diferencial en la evaluación final cuando se compara el método tradicional con dicha innovación docente, mediante el uso de análisis estadístico. Los resultados de la experiencia no han arrojado diferencias significativas, pero han sido positivos debido a que la metodologúa Flipped Classroom mejora el feedback que el profesorado recibe del alumnado en tiempo real, permitiendo adaptarse al ritmo de aprendizaje del alumnado. Sin embargo, el propio alumnado reconoce que no puede entenderse como una estrategia de sustitución del profesor. En este sentido, la implementación práctica del engfoque “Flipped Classroom” requiere necesariamente de una plasmación tácita en la guía docente para tener el poder vinculante necesario para que el estudiante haga el esfuerzo de revisar en casa el soporte audiovisual temático y los materiales de apoyo.The "Flipped Classroom" methodology eliminates the traditional approach and replaces it with active tasks in class and study before and after class. Despite the popularity of these approaches in the media and courses given to teachers related to this methodology, there is very little evidence of the effectiveness or consistency in understanding what actually happens in the classroom. This paper aims to analyze whether the combined use of available resources, thematic websites and the video editing by teachers through the "Flipped Classroom" approach improves student learning. Likewise, it is intended to evaluate if such methodological innovation presents a differential impact in the final evaluation when this teaching innovation is compared with the traditional method through the use of statistical analysis. The results of the experience have not shown significant differences, but they have been positive because the Flipped Classroom methodology improves the feedback that the teachers receive from the students in real time, allowing them to adapt to the student's learning rhythm. However, the students themselves recognize that it can not be understood as a teacher substitution strategy. In this sense, the practical implementation of the "Flipped Classroom" approach necessarily requires its tacit inclusion in the teaching guide in order to have the necessary binding power for the student to make the effort to review the thematic audiovisual and additional support materials at home

Influencia del factor de crecimieneto fibroblástico y la hidroxiapatita en la regeneración ósea tras resección crítica del cúbito del conejo

Peer Reviewe

Effects of Multifunctional Margins Implementation on Biodiversity in Annual Crop

The most suitable land for agricultural use has been gradually occupied by crops around the world. Large, uninterrupted croplands have been created, while disproportionate amounts of fertilizers, insecticides, fungicides and herbicides are applied on them. As a result, agricultural activity has a negative impact on biodiversity the ecological intensification of cultivated lands has become necessary. Multifunctional Margins (MFM), the establishment of native flora margins adjacent to croplands, provide a semi-natural habitat for food and wildlife refuge. Three different species mixtures sown in MFM were studied in this paper. The large capacity of six species used in MFM (Borago officinalis, Glebionis coronaria, Coriandrum sativum, Sinapis alba, Trifolium resupinatum and Vicia sativa) was determined. Reductions of up to 65% in the appearance of weeds and increases of 36% in pollinator biodiversity in sown MFM with respect to the MFM of spontaneous flora were observed. The biodiversity of the epigeal fauna increased by 15% in the MFM of spontaneous flora and by 32% in sown MFM, with respect to annual crops

Evaluation of the presence of HLB in Rutaceae in nature reserves in Misiones, Argentina

The disease Huanglongbing (HLB) is currently the most serious threat for Argentina’s Citrus industry. Early diagnosis of affected tissues requires conventional molecular methods, polymerase chain reaction (PCR) or quantitative real time PCR (qPCR), due to the inability to grow any of the bacteria involved in the disease etiology: Candidatus Liberibacter asiaticus (CLas), africanus (CLaf), and americanus (CLam). Because HLB is incipient in Argentina eradication of all infected plants is recommended, however the presence of HLB in wild plants cannot be ruled out or has not been locally studied.EEA Bella VistaFil: Gochez, Alberto Martín. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bella Vista; ArgentinaFil: Aranda, M. Paula. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bella Vista; ArgentinaFil: Velozo, Lucía. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bella Vista; ArgentinaFil: Buemo, Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Grupo de Investigación en Genética Aplicada; ArgentinaFil: Rodríguez, Manuela. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales; ArgentinaFil: Agostini, Juan Pedro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Montecarlo; ArgentinaFil: Talavera, Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Grupo de Investigación en Genética Aplicada; ArgentinaFil: Alayon Luaces, Paula. Universidad Nacional del Nordeste. Facultad de Ciencias Agrarias; ArgentinaFil: Gaiad, Emilio. Universidad Nacional del Nordeste. Facultad de Ciencias Agrarias; ArgentinaFil: Argüelles, Carina F. Consejo Nacional de Investigaciones Científicas y Técnicas. Grupo de Investigación en Genética Aplicada; ArgentinaFil: Miretti, Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Grupo de Investigación en Genética Aplicada; Argentin

Diseño de un modelo SIGC en el marco del programa AUDIT para la Facultad de Ciencias Económicas y Empresariales

El presente proyecto pone de manifiesto el compromiso de la Facultad de Ciencias Económicas y Empresariales de la Universidad Complutense de Madrid con la mejora continua de la calidad en el marco del programa AUDIT. Se pretenden establecer los criterios de calidad, hacer el seguimiento de los procesos definidos para lograrlos y establecer estrategias de mejora continua, así como responder al compromiso de satisfacción de las necesidades y respuesta a las expectativas de los diferentes grupos de interés, y facilitar el seguimiento de las titulaciones implantadas

Diseño de un modelo SIGC en el marco del programa AUDIT para la Facultad de Ciencias Económicas y Empresariales

El presente proyecto pone de manifiesto el compromiso de la Facultad de Ciencias Económicas y Empresariales de la Universidad Complutense de Madrid con la mejora continua de la calidad en el marco del programa AUDIT. Se pretenden establecer los criterios de calidad, hacer el seguimiento de los procesos definidos para lograrlos y establecer estrategias de mejora continua, así como responder al compromiso de satisfacción de las necesidades y respuesta a las expectativas de los diferentes grupos de interés, y facilitar el seguimiento de las titulaciones implantadas

Polymorphisms in genes related to the complement system and antibody-mediated cardiac allograft rejection

[Abstract] Background. Heart transplantation (HT) is a life-saving treatment for patients with end-stage heart failure. One of the main problems after HT is the humoral response termed antibody-mediated rejection (AMR). Complement activation plays a key role in AMR contributing to graft damage. The aim of this study was to analyze genetic variants in genes related to the complement pathways that could be associated with the development of AMR. Methods. Analysis of 51 genes related to the complement pathway was performed by next-generation sequencing in 46 HT recipients, 23 with and 23 without AMR. Statistical analysis was performed with SNPstats and R. Results. We identified 2 single nucleotide polymorphisms, 1 in the mannose-binding lectin 2 gene (p.Gly54Asp-MBL2) and 1 in the complement factor properdin gene (p.Asn428(p=)-CFP), that showed significant association with the absence and development of AMR, respectively. Moreover, the presence of the rare allele in p.Gly54Asp-MBL2 control patients correlated with an immunodeficiency of mannose-binding lectin (6.24 ng/ml vs 207.50 ng/ml, p < 0.01), whereas the presence of the rare allele p.Asn428(p=)-CFP in patients with AMR correlated with higher levels of properdin protein (14.65 μg/ml vs 10.77 μg/ml, p < 0.05). Conclusions. AMR is a complex phenotype affected by many recipient factors. Variants in p.Gly54Asp-MBL2 and p.Asn428(p=)-CFP genes, encoding mannose-binding lectin 2 and properdin, may influence the risk of AMR.Instituto de Salud Carlos III; PI13/0217

Study of the break-up channel in 11Li+208Pb collisions at energies around the Coulomb barrier

We present a study of 11Li+208 Pb collisions at energies around the Coulomb barrier (Elab = 24.3 and 29.8 MeV), measured at the post-accelerated beam facility, ISAC II, at TRIUMF (Vancouver, Canada). A remarkably large yield of 9Li has been observed, a result that is attributed to the weak binding of the 11Li nucleus. The angular distribution of this 9Li yield, relative to the elastic one, has been analysed in terms of first-order semiclassical calculations as well as four-body and three-body Continuum-Discretized Coupled-Channels (CDCC) calculations, based on a three-body and di-neutron model of the 11Li nucleus, respectively. The calculations reproduce well the trend of the data and support the existence of a large concentration of B (E1) strength at very low excitation energies. The connection of this large B (E1) with a possible low-lying dipole resonance is discussed

Analysis of variants in the HCN4 gene and in three single nucleotide polymorphisms of the CYP3A4 gene for association with ivabradine reduction in heart rate: a preliminary report

[Abstract] Background: Ivabradine, a selective bradycardic drug, inhibits the If. In patients with heart failure (HF), ivabradine reduces the risk of rehospitalization and mortality. The average heart rate (HR) reduction is 8–10 beats, although clinical trials reveal interindividual variability. The aim of the study is to identify variants associated with HR reduction produced by ivabradine in genes involved in the drug metabolism (CYP3A4) or related to the drug target (HCN4). Methods: In an exploratory cohort (n = 11), patients started on ivabradine were genotyped and the HR reduction was studied. Results: The mean HR reduction after the treatment was 18.10 ± 12.26 bpm. The HR reduction was ≥ 15 bpm in 3 patients and > 5 and < 15 bpm in 7 patients. Four synonymous variants, L12L, L520L, P852P, and P1200P, were detected in the HCN4 gene (frequency = 0.045, 0.045, and 0.681, respectively). Moreover, the CYP3A4*1F and CYP3A4*1B were found in one patient each and CYP3A4*1G was presented in 3 patients. Conclusions: This is the first study using an exploratory pharmacogenetic approach that attempts to explain interindividual variability in ivabradine HR reduction. However, more research must be undertaken in order to determine the role of variants in HCN4 and CYP3A4 genes in response to ivabradine.Instituto de Salud Carlos III; RD12/004

Simultaneous analysis of the elastic scattering and breakup channel for the reaction 11 Li + 208 Pb at energies near the Coulomb barrier

We present a detailed analysis of the elastic scattering and breakup channel for the reaction of Li11 on Pb208 at incident laboratory energies of 24.3 and 29.8 MeV, measured at the radioactive ion beam facility of TRIUMF, in Vancouver, Canada. A large yield of Li9 fragments was detected by four charged particle telescopes in a wide angular range. The experimental angular and energy distributions of these Li9 fragments have been compared to coupled-reaction-channel and continuum-discretized coupled-channel calculations. The large production of Li9 fragments at small angles can be explained by considering a direct breakup mechanism, while at medium-large angles a competition between direct breakup and neutron transfer to the continuum of the Pb208 target was observed.Proyecto Nacional (España) PA2009-08848 PA2009-07387 PA2010-22131-C02-01 FPA2009-07653 FPA2012-32443Programa Consolider-Ingenio 2010 (España) CSD2007-0004