18 research outputs found
Dispositivo para la determinación del volumen aparente
Desde el punto de vista tecnológico el volumen aparente y la porosidad de un polvo revisten un especial significado en la correcta dosificación en volumen de formas farmacéuticas, y desde el biogalénico en las tasas de disolución y absorción. Para la determinación del volumen aparente, se ha ideado un procedimiento de descenso volumétrico que cumple con las exigencias de las normas AFNOR y D IN. Se describe y aplica, con buen resultado, al estudio de polvos de diversos barbitúricos y con los valores obtenidos se calcula su porosidad
Airborne Cupressaceae Pollen and Its Major Allergen, Cup a 1, in Urban Green Areas of Southern Iberian Peninsula
Cupressaceae pollen is responsible for winter respiratory allergies in the Mediterranean
area. Pollen grains of this diverse family share the same characteristics under light microscopy.
Consequently, the partial contribution of each Cupressaceae species to the airborne pollen spectrum
cannot be determined with conventional aerobiological methods. Studies on major aeroallergens offer
better information on the allergic sensitization and appearance of symptoms in patients sensitized to
airborne pollen and spores. Our aim was to determine if airborne Cupressaceae pollen concentrations
correspond to aerodynamics of the major allergen of Cupressus (Cup a 1), as well as the aeroallergen
correlation with different-sized particles. The air was sampled in two cities of Southern Spain
(Granada and Córdoba) using the Hirst-type volumetric sampler for airborne pollen detection
during 2006 to 2008 and the Andersen Cascade Impactor for aeroallergen detection during the
main pollination period of Cupressaceae in the same period. The samples were analyzed by the
methodology proposed by the Spanish Aerobiology Network (REA), the minimum requirements of
the European Aeroallergen Society (EAS) for pollen, and by ELISA immunoassay to detect airborne
Cup a 1. The distribution patterns of airborne Cupressaceae pollen and Cup a 1 were observed
throughout the sampling period, although with some irregular oscillations. Cupressaceae pollen and
Cup a 1 showed positive and significant correlation during the period of maximum concentrations
(January to March). However, the results of this study showed that the period of exposure of
aeroallergens depends on the Cupressus species and their abundance in cities. According to the
allergy potential obtained, species like C. arizonica could release more allergens than other species
like C. sempervirens.Ministry of Science and Technology I + D + I of Spain
CGL2006-1648-CO3-02Andalusian Government
RNM 011
The photosynthetic cytochrome c550 from the diatom Phaeodactylum tricornutum
The photosynthetic cytochrome c550 from the marine diatom Phaeodactylum tricornutum has been purified and characterized. Cytochrome c550 is mostly obtained from the soluble cell extract in relatively large amounts. In addition, the protein appeared to be truncated in the last hydrophobic residues of the C-terminus, both in the soluble cytochrome c550 and in the protein extracted from the membrane fraction, as deduced by mass spectrometry analysis and the comparison with the gene sequence. Interestingly, it has been described that the C-terminus of cytochrome c550 forms a hydrophobic finger involved in the interaction with photosystem II in cyanobacteria. Cytochrome c550 was almost absent in solubilized photosystem II complex samples, in contrast with the PsbO and Psb31 extrinsic subunits, thus suggesting a lower affinity of cytochrome c550 for the photosystem II complex. Under iron-limiting conditions the amount of cytochrome c550 decreases up to about 45% as compared to iron-replete cells, pointing to an iron-regulated synthesis. Oxidized cytochrome c550 has been characterized using continuous wave EPR and pulse techniques, including HYSCORE, and the obtained results have been interpreted in terms of the electrostatic charge distribution in the surroundings of the heme centre.España, MINECO BIO2012-35271, BIO2015-64169-P, MAT2011-23861 and CTQ2015-64486-
Revisiting the epidemiology of bloodstream infections and healthcare-associated episodes: results from a multicentre prospective cohort in Spain (PRO-BAC Study)
PROBAC REIPI/GEIH-SEIMC/SAEI Group.The epidemiology of bloodstream infections (BSIs) is dynamic as it depends on microbiological, host and healthcare system factors. The aim of this study was to update the information regarding the epidemiology of BSIs in Spain considering the type of acquisition. An observational, prospective cohort study in 26 Spanish hospitals from October 2016 through March 2017 including all episodes of BSI in adults was performed. Bivariate analyses stratified by type of acquisition were performed. Multivariate analyses were performed by logistic regression. Overall, 6345 BSI episodes were included; 2510 (39.8%) were community-acquired (CA), 1661 (26.3%) were healthcare-associated (HCA) and 2056 (32.6%) hospital-acquired (HA). The 30-day mortality rates were 11.6%, 19.5% and 22.0%, respectively. The median age of patients was 71 years (interquartile range 60–81 years) and 3656 (58.3%; 95% confidence interval 57.1–59.6%) occurred in males. The proportions according to patient sex varied according to age strata. Escherichia coli (43.8%), Klebsiella spp. (8.9%), Staphylococcus aureus (8.9%) and coagulase-negative staphylococci (7.4%) were the most frequent pathogens. Multivariate analyses confirmed important differences between CA and HCA episodes, but also between HCA and HA episodes, in demographics, underlying conditions and aetiology. In conclusion, we have updated the epidemiological information regarding patients’ profiles, underlying conditions, frequency of acquisition types and aetiological agents of BSI in Spain. HCA is confirmed as a distinct type of acquisition.This work was financed by grants from Plan Nacional de I+D+i 2013–2016, Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades [PI16/01432] and the Spanish Network for Research in Infectious Diseases (REIPI) [RD16/0016/0001; RD16/0016/0008], co‐financed by the European Development Regional Fund ‘A way to achieve Europe’, Operative program Intelligent Growth 2014–2020
Risk Factors and Predictive Score for Bacteremic Biliary Tract Infections Due to Enterococcus faecalis and Enterococcus faecium: a Multicenter Cohort Study from the PROBAC Project
Biliary-tract bloodstream infections (BT-BSI) caused by Enterococcus faecalis and E. faecium are associated with inappropriate empirical treatment and worse outcomes compared to other etiologies. The objective of this study was to investigate the risk factors for enterococcal BT-BSI. Patients with BT-BSI from the PROBAC cohort, including consecutive patients with BSI in 26 Spanish hospitals between October 2016 and March 2017, were selected; episodes caused by E. faecalis or E. faecium and other causes were compared. Independent predictors for enterococci were identified by logistic regression, and a predictive score was developed. Eight hundred fifty episodes of BT-BSI were included; 73 (8.5%) were due to target Enterococcus spp. (48 [66%] were E. faecium and 25 [34%] E. faecalis). By multivariate analysis, the variables independently associated with Enterococcus spp. were (OR; 95% confidence interval): cholangiocarcinoma (4.48;1.32 to 15.25), hospital acquisition (3.58;2.11 to 6.07), use of carbapenems in the previous month (3.35;1.45 to 7.78), biliary prosthesis (2.19;1.24 to 3.90), and moderate or severe chronic kidney disease (1.55;1.07 to 2.26). The AUC of the model was 0.74 [95% CI0.67 to 0.80]. A score was developed, with 7, 6, 5, 4, and 2 points for these variables, respectively, with a negative predictive value of 95% for a score # 6. A model, including cholangiocarcinoma, biliary prosthesis, hospital acquisition, previous carbapenems, and chronic kidney disease showed moderate prediction ability for enterococcal BT-BSI. Although the score will need to be validated, this information may be useful for deciding empirical therapy in biliary tract infections when bacteremia is suspected. IMPORTANCE Biliary tract infections are frequent, and a significant cause of morbidity and mortality. Bacteremia is common in these infections, particularly in the elderly and patients with cancer. Inappropriate empirical treatment has been associated with increased risk of mortality in bacteremic cholangitis, and the probability of receiving inactive empirical treatment is higher in episodes caused by enterococci. This is because many of the antimicrobial agents recommended in guidelines for biliary tract infections lack activity against these organisms. To the best of our knowledge, this is the first study analyzing the predictive factors for enterococcal BT-BSI and deriving a predictive score.8 página
Las redes como dispositivos para la gestión educativa en Iberoamérica
La presente aportación se focaliza en cómo el trabajo en red puede ayudar a mejorar la organización y gestión de los centros educativos. Presenta referentes normativos pero también identifica redes centradas en la gestión y pone ejemplos de alguna de ellas. Recoge las aportaciones de 36 especialistas, que han elaborado los informes de 11 países iberoamericanos
#EllasSomosTodas
El trabajo obtuvo un premio de la Modalidad B de los Premios Tomás García Verdejo a las buenas prácticas educativas de la Comunidad Autónoma de Extremadura para el curso académico 2014/2015Se describe un proyecto llevado a cabo en el IES Al-Qazares (Cáceres), en concreto en el Ciclo Formativo de Grado Superior de Integración Social, orientado a la sensibilización contra la violencia de género en la sociedad y en el centro. Entre los objetivos de la experiencia destacan: animar al alumnado a ser partícipe de sus propios aprendizajes fomentando una metodología basada en la investigación-acción, utilizar las tecnologías de la información y comunicación, desarrollar habilidades de trabajo en equipo y gestión de conflictos, fomentar la igualdad entre hombres y mujeres y aplicar la perspectiva de género en el desarrollo del trabajo diarioExtremaduraES
Ukelelex : historia de una jota hawaiana
Convocatoria proyectos de innovación de Extremadura 2020/2021Se presenta un proyecto colaborativo de los centros IESO Sierra la Mesta de Santa Amalia (Badajoz) y el IES Maestro Gonzalo Korrea de Jaraíz de la Vera (Cáceres) que tenía la intención de crear una orquesta de ukeleles en Extremadura y abordar de manera interdisciplinar la historia de este intrumento y todas las derivaciones culturales e históricas en relación a Portugal (por ser ese instrumento una herencia de este país) y a los viajes de finales del siglo XIX al cotinente americano. Los objetivos principales de la propuesta fueron: motivar al alumnado con un nuevo instrumento; dar a conocer el ukelele y su historia, de tradición portuguesa; aprender a tocar un instrumento de manera individual y grupal; propiciar encuentros virtuales y presenciales con el fin de crear una orquesta de ukeleles estable en el tiempo e incentivar la cooperación e implicación de toda la comunidad educativa en el desarrollo del proyectoExtremaduraES
Artificial Intelligence Tools for Teaching and Learning in Communication: Challenges, Possibilities, Netiquette
El proyecto de innovación docente titulado Herramientas de Inteligencia Artificial para la docencia y el aprendizaje en Comunicación: retos, posibilidades, netetiquetas, aborda las herramientas de IA para conocer y explotar sus posibilidades en estudios de Comunicación, desde una perspectiva ética, deontológica, creativa y de empoderamiento para la docencia y el aprendizaje en las aulas. ChatGPT ha actualizado y avivado los retos y problemas que la Inteligencia Artificial puede llevar a las aulas. Como modelo de lenguaje avanzado, basado en inteligencia artificial, el chat Generative Pre-trained Transformer es una herramienta muy útil para la generación de textos. Sin embargo, los docentes advierten sus contradicciones y peligros: al ser un modelo generativo, puede generar textos aleatorios o irrelevantes; los estudiantes pueden utilizarlo para hacer trabajos sin apenas esfuerzo, mermando sus capacidades de lectura, redacción y autoaprendizaje; y el fraude, no detectable por los tradicionales programas de antiplagio, hace que sea casi indetectable. No obstante, este proyecto quiere analizar esos problemas para educar a profesorado y alumnado en la búsqueda de las herramientas positivas que la IA y ChatGPT, entre otras inteligencias artificiales, pueden brindarnos. Para ello, se analizará la famosa herramienta (en su recién estrenada versión 4.0 al cierre de esta solicitud) y otras herramientas de IA que son útiles para la docencia, aprendizaje y preparación profesional de estudiantes de Comunicación (Lumen5, Hugging Face, Canva, CopyAI, Prismas, Jasper, Artssy, Runway, Fliki, Resemble, Capcut, Gradescope, Scribble Diffusion, Midjourney, Wombo, Crayon, Grammarly, Deepl entre otras). Todas ellas conforman el proceso creativo completo de creación de textos y contenidos de comunicación, con todos los posibles ingredientes: texto, imagen, vídeo, voz, avatares, ilustraciones, dibujos, interacciones. No se pretende que la máquina trabaje por el comunicador, sino que la máquina inspire, guíe y corrija un contenido humano y humanizado.The teaching innovation project entitled Artificial Intelligence Tools for teaching and learning in Communication: challenges, possibilities, netiquette, addresses AI tools in order to learn about and exploit their possibilities in Communication studies, from an ethical, deontological, creative and empowering perspective for teaching and learning in the classroom. ChatGPT has updated and enlivened the challenges and problems that Artificial Intelligence can bring to the classroom. As an advanced, AI-based language model, the chat Generative Pre-trained Transformer is a very useful tool for text generation. However, teachers warn of its contradictions and dangers: being a generative model, it can generate random or irrelevant texts; students can use it to do work with little effort, undermining their reading, writing and self-learning skills; and fraud, undetectable by traditional anti-plagiarism programmes, makes it almost undetectable. However, this project aims to analyse these problems in order to educate teachers and students in the search for the positive tools that AI and ChatGPT, among other artificial intelligences, can provide us with. To do so, we will analyse the famous tool (in its recently released version 4.0 at the closing of this application) and other AI tools that are useful for teaching, learning and professional preparation of Communication students (Lumen5, Hugging Face, Canva, CopyAI, Prismas, Jasper, Artssy, Runway, Fliki, Resemble, Capcut, Gradescope, Scribble Diffusion, Midjourney, Wombo, Crayon, Grammarly, Deepl among others). All of them make up the complete creative process of creating texts and communication content, with all the possible ingredients: text, image, video, voice, avatars, illustrations, drawings, interactions. The aim is not for the machine to work for the communicator, but for the machine to inspire, guide and correct human and humanised content.Oficina para la Calidad UCMDepto. de Periodismo y Nuevos MediosFac. de Ciencias de la InformaciónFALSEsubmitte
Pseudomonas aeruginosa Community-Onset Bloodstream Infections: Characterization, Diagnostic Predictors, and Predictive Score Development—Results from the PRO-BAC Cohort
Community-onset bloodstream infections (CO-BSI) caused by gram-negative bacilli are common and associated with significant mortality; those caused by Pseudomonas aeruginosa are associated with worse prognosis and higher rates of inadequateempirical antibiotic treatment. The aims of this study were to describe the characteristics of patients with CO-BSI caused by P. aeruginosa, to identify predictors, and to develop a predictive score for P. aeruginosa CO-BSI. Materials/methods: PROBAC is a prospective cohort including patients >14 years with BSI from 26 Spanish hospitals between October 2016 and May 2017. Patients with monomicrobial P. aeruginosa CO-BSI and monomicrobial Enterobacterales CO-BSI were included. Variables of interest were collected. Independent predictors of Pseudomonas aeruginosa CO-BSI were identified by logistic regression and a prediction score was developed. Results: A total of 78patients with P. aeruginosa CO-BSI and 2572 with Enterobacterales CO-BSI were included. Patients with P. aeruginosa had a median age of 70 years (IQR 60–79), 68.8% were male, median Charlson score was 5 (IQR 3–7), and 30-daymortality was 18.5%. Multivariate analysis identified the following predictors of CO-BSI-PA [adjusted OR (95% CI)]: male gender [1.89 (1.14–3.12)], haematological malignancy [2.45 (1.20–4.99)], obstructive uropathy [2.86 (1.13–3.02)], source of infection other than urinary tract, biliary tract or intra-abdominal [6.69 (4.10–10.92)] and healthcare-associated BSI [1.85 (1.13–3.02)]. Anindex predictive of CO-BSI-PA was developed; scores ≥ 3.5 showed a negative predictive value of 89% and an area under the receiver operator curve (ROC) of 0.66. Conclusions: We did not find a good predictive score of P. aeruginosa CO-BSI due to its relatively low incidence in the overall population. Our model includes variables that are easy to collect in real clinical practice and could be useful to detect patients with very low risk of P. aeruginosa CO-BSI