46 research outputs found
High-Temperature Short-Time and Holder Pasteurization of Donor Milk: Impact on Milk Composition
Holder pasteurization (HoP; 62.5 °C, 30 min) is commonly used to ensure the microbiological safety of donor human milk (DHM) but diminishes its nutritional properties. A high-temperature short-time (HTST) system was designed as an alternative for human milk banks. The objective of this study was to evaluate the effect of this HTST system on different nutrients and the bile salt stimulated lipase (BSSL) activity of DHM. DHM was processed in the HTST system and by standard HoP. Macronutrients were measured with a mid-infrared analyzer. Lactose, glucose, myo-inositol, vitamins and lipids were assayed using chromatographic techniques. BSSL activity was determined using a kit. The duration of HTST treatment had a greater influence on the nutrient composition of DHM than did the tested temperature. The lactose concentration and the percentage of phospholipids and PUFAs were higher in HTST-treated than in raw DHM, while the fat concentration and the percentage of monoacylglycerides and SFAs were lower. Other nutrients did not change after HTST processing. The retained BSSL activity was higher after short HTST treatment than that following HoP. Overall, HTST treatment resulted in better preservation of the nutritional quality of DHM than HoP because relevant thermosensitive components (phospholipids, PUFAs, and BSSL) were less affected.This research was funded by grants from the Spanish Research Projects in Health funded
by ISCIII-the state plan for scientific and technical research and innovation and European Regional
Development Fund (ERDF) (ref. PI12/02128 and PI15/00995) and by ALG2016-75476-R project
from the Ministerio de Economía, Industria y Competitividad (Spain). Moreover, this work has
received a grant from the Hero Institute for Infant Nutrition (Alcantarilla, Murcia, España; 2012).
Additionally, this study was supported by RETICS “Maternal and Child Health and Development
Network” (SAMID Network), funded by the PN I+D+i 2008-2011 (Spain), ISCIII-Sub-Directorate
General for Research Assessment and Promotion and the ERDF (ref. RD12/0026)
Level of blood pressure control in a hypertensive population when measurements are performed outside the clinical setting
Background: To determine whether the number of optimally controlled hypertensive patients
is higher using self-measurement of blood pressure at home and ambulatory monitoring,
compared to using conventional blood pressure measurements at the doctor’s office.
Method: An observational, cross-sectional, multicentre, descriptive study of a random sample
of 237 primary health care patients, known to be hypertensive, from Badajoz (Spain). Blood
pressure was measured at the doctor’s office and by self-measurement at home. Those patients
showing good control by self-measurement were subjected to 24-hour ambulatory monitoring.
Optimal control was understood as blood pressure < 140/90 mm Hg when measured at the
doctor’s office, and < 135/85 mm Hg when self-measured at home and by daytime ambulatory
monitoring.
Results: Mean systolic/diastolic measurements at the doctor’s office and by self-measurement
were 145.6/83.9 and 134.0/78.7 mm Hg, respectively (p < 0.000). In the population optimally
controlled by self-measurement and who subsequently received ambulatory monitoring, the
mean blood pressure was 121.8/73.4 and 125.6/76.2 mm Hg, respectively (p = 0.002; p < 0.000).
When measured at the doctor’s office blood pressure was controlled in about 29.5% (95% CI
23.7-35.3%) of patients, in 38% when self-measured (95% CI 31.4-44.2%; p < 0.000), and
in 24.5% when it was confirmed through ambulatory monitoring (95% CI 15.4-33.6%).
Sensitivity and positive predictive values of the office measurements for the detection of patients
who were well-controlled by self-measurement were 50% and 64.3%, respectively, and
53.4% and 73.8% as regards ambulatory monitoring. Conclusions: A higher level of control is achieved with self-measurement at home not confirmed
by ambulatory monitoring. Therefore, the white coat effect does not seem to influence
the percentage of well-controlled patients detected at the doctor’s office. Office blood pressure
does not appear to be useful in distinguishing which individual patients are optimally controlled
Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection
Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) play a key role in the defense against viral infections, for instance plasmacytoid DCs (pDCs), have the capacity to produce vast amounts of interferon-alpha (IFN-α). In COVID-19 there is a deficit in DC numbers and IFN-α production, which has been associated with disease severity. In this work, we described that in addition to the DC deficiency, several DC activation and homing markers were altered in acute COVID-19 patients, which were associated with multiple inflammatory markers. Remarkably, previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+ myeloid DCs and pDCs seven months after SARS-CoV-2 infection. Moreover, the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients, while no restoration of integrin β7 and indoleamine 2,3-dyoxigenase (IDO) levels were observed. These findings contribute to a better understanding of the immunological sequelae of COVID-19
INFORME CIENTÍFICO – TÉCNICO de la Campaña SUBVENT1
Memoria del Informe Cintífico-Técnico de la campaña oceanográfica SUBVENT-1.Anexos de operatividad y de las distintas técnicas utilizados a lo largo de la misma.La campaña SUBVENT1-0913 se ha realizado a lo largo del talud inferior del margen continental de las Islas Canarias, área que también es conocida en la literatura como Cuenca Canaria. Esta zona se caracteriza por la presencia de una serie de estructuras geológicas recientes, así se encuentran la parte distal de los depósitos de debris procedentes de las avalanchas volcánicas generadas desde las Islas Canarias, a favor de la pendiente y probablemente en relación con episodios eruptivos. En la parte meridional se encuentra además un conjunto de montes submarinos, de diversa entidad, de origen volcánico y, en general, aparece todo un conjunto de montículos con desniveles comprendidos entre 30 y 300 m que han constituido el principal objetivo de esta campaña. Así mismo, en este sector existen numerosos escarpes lineales de orientación subparalela a la del propio talud a los que se encuentran asociados en ocasiones los citados montículos.
La adquisición de nuevos datos geofísicos y el muestreo llevado a cabo durante la campaña permitirá conocer mejor el origen de estos montículos y el proceso de emisión que los ha generado. Por otro lado, el conocimiento de las relaciones entre los sedimentos de debris y hemipelágicos junto con los asociados a las posibles emisiones de la zona permitirá conocer no sólo la evolución sedimentaria de este margen, sino establecer los episodios de emisión que generaron los montículos y conocer sus patrones de crecimiento. Así mismo, se podrá evaluar la tasa de sedimentación de la zona y el papel de la masa de agua de fondo antártica (AABW) en esta evolución.The SUBVENT1-0913 cruise has been carried out along the lower slope of the continental margin of the Canary Islands. This area is characterized by the presence of several recent geological structures. Among these are the distal parts of the volcano-clastics debris deposits originated by volcanic avalanches of the Canary Islands, transported by gravity along the slope and probably related in origin to eruptive episodes. In the southern part, numerous and different reliefs (seamounts, hills or mounds) of volcanic origin occur. The most frequents features display heights between 30 and 300 m and they have constituted one of the main aims of this survey. Moreover, in this sector there are several subparallel linear scarps with similar directions to the slope trend that could be associated with the aforementioned mounds.
The acquisition of new geophysical data and samples during this campaign will allow a better understanding of the origin of these mounds and the emission processes that have generated them. On the other hand, the knowledge of the relationships between debris and hemipelagic sediments together with those associated with possible venting processes in the area, will reveal not only the sedimentary evolution of this margin, but also to establish emission episodes generating mounds and to know their growth patterns. Furthermore, it would be possible to evaluate the sedimentation rate in the area and the role played by the Antarctic Bottom Water (AABW) mass on this process.Plan Nacional de I+D, Ministerio de Economía y Competitividad. Investigación fundamental no Orientada. Proyecto de Investigación Coordinado SUBVENT “Emisiones submarinas de fluidos en los márgenes continentales de las Islas Canarias y del Golfo de Cádiz: Análisis comparativo de las construcciones asociadas” (CGL2012‐39524‐C02). Acción Complementaria EXARCAN “Trabajos científico-técnicos para la preparación, presentación y defensa de las propuestas de España ante Naciones Unidas para la Extensión de la Plataforma Continental de las Islas Canarias y Galicia” (CTM2010-09496-E)
POR UNA CULTURA DE PAZ: UNA MIRADA DESDE LAS CIENCIAS DE LA CONDUCTA
En
virtud
de
lo
anterior,
los
estudiosos
de
las
ciencias
de
la
conducta
de
la
Universidad
Autónoma
del
Estado
de
México,
ante
la
persistencia
y
proliferación
de
estos
hechos
en
diversas
partes
del
Mundo
y
de
nuestro
país
en
particular, se
convocó
a
los
estudiosos
interesados
y
a
la
sociedad
en
general
a
presentar
trabajos
para
analizar,
debatir
y
proponer
estrategias
de
acción
y
dirección,
que
fortalezcan
una
convivencia y bienestar con sentido humanista para una cultura de paz.
El
presente
texto
es
producto
de
esta convocatoria
que
recoge
los
trabajos
de
los
interesados
en
la
temática,
de
diferentes
países
(España,
Argentina,
Cuba,
Brasil,
Costa
Rica
y
México)
retomando
con
ello
sus
experiencias
relativas
al
estudio,
análisis,
comprensión
e
instrumentación
de
la
cultura
de
paz
en
los
distintos
ámbitos
institucionales
en
los
que
participan:
educativo,
salud,
penitenciario,
social,
laboral,
familia,
alimentario,
psicológico,
por
mencionar
algunos.
El
presente
libro,
propicia
un
espacio
de
reflexión,
diálogo
y
posicionamiento
de
las
ciencias
de
la
conducta
para
la
apropiación,
análisis,
debate
y
propuestas
que
fortalezcan
una
cultura
de
paz
a
través
de
la
convivencia
y
el
bienestar
social
con
sentido
humanista.
El
sistema
económico
neoliberal
y
el
proceso
de
globalización
han
contribuido
al
logro
de
avances
significativos
en
la
ciencia
y
la
tecnología,
pero
también
han
propiciado
la
polarización
de
las
sociedades
lo
que
ha
impactado
de
manera
negativa
a
la
sociedad
en
su
conjunto,
pero
en
mayor
medida
a
los grupos
vulnerables. Dicha
polarización
ha
traído
consigo
un
desarrollo
desigual
del
mundo
que
se
expresa
de
diferentes
maneras
tanto
en
países
desarrollados
como
en
los
llamados
del
tercer
mundo,
en
donde
no
están
satisfechas
las
necesidades
humanas
elementales
de
todos
los
sectores
de
la
población,
siempre
falta
algo.
Si
a
esto
le
sumamos
los
conflictos
internacionales por
diferentes
motivos
que
enfrentan
algunas
naciones,
una
insuficiente
cobertura
educativa
y
de
salud,
desempleo
y
pobreza
extrema,
entre
otras
cosas;
estamos
frente
a
retos
de
gran
envergadura
para
los
gobiernos,
para
los
estudiosos
y
para
la
sociedad
civil
en
general. Uno
de
los
intentos
para
frenar
y prevenir
la
agudización
de
estas
problemáticas
es
la
cultura
de
paz,
cuyo
estudio
y propuestas
han
ido
avanzando
en
diferentes
sentidos
y
de
manera
favorable,
el
tema
está
presente
en
diferentes
Organismos
Internacionales
como
la
ONU,
la
UNESCO,
la
OCDE,
El
Banco
Mundial,
entre
otros.
Pero
falta
mucho
por
hacer.Universidad Autónoma del Estado de Méxic
Obstáculos que enfrentan las víctimas de delito sexual en las etapas del proceso penal
Financiado por el Programa de Justicia de la Union Europea (2014-2020): “RE-TREAT: Reshaping treatment approaches towards victims of sexual crimes within criminal proceedings
Anti-Spike antibodies 3 months after SARS-CoV-2 mRNA vaccine booster dose in patients on hemodialysis: the prospective SENCOVAC study
Background: Patients on hemodialysis are at high-risk for complications derived from coronavirus disease 2019 (COVID-19). The present analysis evaluated the impact of a booster vaccine dose and breakthrough severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on humoral immunity 3 months after the booster dose. Methods: This is a multicentric and prospective study assessing immunoglobulin G anti-Spike antibodies 6 and 9 months after initial SARS-CoV-2 vaccination in patients on hemodialysis that had also received a booster dose before the 6-month assessment (early booster) or between the 6- and 9-month assessments (late booster). The impact of breakthrough infections, type of vaccine, time from the booster and clinical variables were assessed. Results: A total of 711 patients [67% male, median age (range) 67 (20-89) years] were included. Of these, 545 (77%) received an early booster and the rest a late booster. At 6 months, 64 (9%) patients had negative anti-Spike antibody titers (3% of early booster and 29% of late booster patients, P =. 001). At 9 months, 91% of patients with 6-month negative response had seroconverted and there were no differences in residual prevalence of negative humoral response between early and late booster patients (0.9% vs 0.6%, P =. 693). During follow-up, 35 patients (5%) developed breakthrough SARS-CoV-2 infection. Antibody titers at 9 months were independently associated with mRNA-1273 booster (P =. 001), lower time from booster (P =. 043) and past breakthrough SARS-CoV-2 infection (P <. 001). Conclusions: In hemodialysis patients, higher titers of anti-Spike antibodies at 9 months were associated with mRNA-1273 booster, lower time from booster and past breakthrough SARS-CoV-2 infectionThe present project has been supported by Fresenius Medical Care, Diaverum, Vifor Pharma, Vircell, Fundación Renal Iñigo Álvarez de Toledo and ISCIII FEDER funds RICORS2040 (RD21/0005
una mirada desde las Ciencias de la Conducta
Este libro es el resultado de los trabajos presentados en el 1er Congreso Internacional "Convivencia y bienestar con sentido humanista para una cultura de paz"
Reformulando el tratamiento procesal de las víctimas de violencia sexual en procesos penales
Esta obra presenta las investigaciones desarrolladas a lo largo del proyecto europeo de
investigación, financiado por el Programa de Justicia de la Union Europea (2014-2020):
“RE-TREAT: Reshaping treatment approaches towards victims of sexual crimes within criminal proceedings”. Los objetivos perseguidos por este proyecto de investigación son, entre otros, el análisis de las barreras, recursos y prácticas nocivas en el tratamiento de las víctimas de delitos sexuales a lo largo de las diversas fases del proceso penal, identificación de mejores prácticas en este ámbito que pueden ser aplicadas por los operadores jurídicos, o bien, la sensibilización de los actores que abordan este fenómeno.
Se presentan en el primer Capítulo los obstáculos que enfrentan las víctimas de delitos sexuales en las diversas etapas del proceso penal español, se describen los estándares prácticos para profesionales del sistema de justicia que trabajan con víctimas de violencia sexual en el Capítulo II de la obra. En el Capítulo III se incluyen recomendaciones políticas que permiten garantizar un mejor tratamiento hacia las víctimas de violencia sexual por parte del sistema de justicia en España y en el Capítulo IV el informe comparativo de la situación con Grecia e Italia.Esta obra presenta las investigaciones desarrolladas a lo largo del proyecto europeo de
investigación, financiado por el Programa de Justicia de la Union Europea (2014-2020):
“RE-TREAT: Reshaping treatment approaches towards victims of sexual crimes within criminal proceedings”Financed by The European Union Justice Program (2014-2020). RE-TREAT: Reshaping treatment approaches towards victims of sexual violence within criminal proceedings. JUST-JACC-AG-2019 - 878566 - RETREATObstáculos que enfrentan las víctimas de delito sexual en las etapas del proceso penal / Helena Soleto, Sabela Oubiña Barbolla, Jessica Jullien de Asís, Aurea Grané Chávez, Margarita Diges Junco, Candela Galán González, Nieves Pérez-Mata, Anna Fiodorova, Federico González Barrera, Iván Navarro Papic, Rosa Gómez de Liaño, Raquel López Jiménez, Daniel Rodríguez Horcajo, Soledad Torrecuadrada García Lozano, Ignacio de Torres Guajardo, Belén Hernández Moura, Emiliano Carretero Morales, Irene de Lamo Velado, Rocío Zafra Espinosa de los Monteros, Cristina Ruiz López, Miriam Peláez Devesa (pp. 7-92). -- Guía para profesionales de la justicia que trabajan con mujeres víctimas de violencia sexual / Monique Anderson, Evelien Claes (pp. 93-116). -- Recomendaciones políticas / Monique Anderson, Evelien Claes, Anna Fiodorova, Helena Soleto (p. 117-165). -- Estudio comparativo sobre tratamiento procesal a víctimas de violencia sexual en España, Grecia e Italia / Sabela Oubiña Barbolla, Helena Soleto Muñoz, Nieves Pérez-Mata, Daniel Rodríguez Horcajo, Margarita Diges Junco, Miriam Peláez Devesa, Jessica Jullien de Asís, Aurea Grané, Candela Galán González, Manuel Cancio Meliá, Jose Alberto Revilla González (pp. 166-229
Integrative epigenomics in Sjögren´s syndrome reveals novel pathways and a strong interaction between the HLA, autoantibodies and the interferon signature
Primary Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by lymphocytic infiltration and damage of exocrine salivary and lacrimal glands. The etiology of SS is complex with environmental triggers and genetic factors involved. By conducting an integrated multi-omics study, we confirmed a vast coordinated hypomethylation and overexpression effects in IFN-related genes, what is known as the IFN signature. Stratified and conditional analyses suggest a strong interaction between SS-associated HLA genetic variation and the presence of Anti-Ro/SSA autoantibodies in driving the IFN epigenetic signature and determining SS. We report a novel epigenetic signature characterized by increased DNA methylation levels in a large number of genes enriched in pathways such as collagen metabolism and extracellular matrix organization. We identified potential new genetic variants associated with SS that might mediate their risk by altering DNA methylation or gene expression patterns, as well as disease-interacting genetic variants that exhibit regulatory function only in the SS population. Our study sheds new light on the interaction between genetics, autoantibody profiles, DNA methylation and gene expression in SS, and contributes to elucidate the genetic architecture of gene regulation in an autoimmune population