H-Galois extensions with normal basis for weak Hopf algebras

Let H be a weak Hopf algebra and let A be an H-comodule algebra with subalgebra of coinvariants AH. In this paper we introduce the notion of H-Galois extension with normal basis and we prove that AH ,→ A is an H-Galois extension with normal basis if and only if AH ,→ A is an H-cleft extension which admits a convolution invertible total integral. As a consequence, if H is cocommutative and A commutative, we obtain a bijective correspondence between the second cohomology group H2 ϕAH (H, AH) and the set of isomorphism classes of H-Galois extensions with normal basis whose left action over AH is ϕAHThis work was supported by Ministerio de Economía y Competitividad and by Feder founds. Grant MTM2013-43687-P: Homología, homotopía e invariantes categóricos en grupos y álgebras no asociativasS

Advances and Perspectives in Dental Pulp Stem Cell Based Neuroregeneration Therapies

Human dental pulp stem cells (hDPSCs) are some of the most promising stem cell types for regenerative therapies given their ability to grow in the absence of serum and their realistic possibility to be used in autologous grafts. In this review, we describe the particular advantages of hDPSCs for neuroregenerative cell therapies. We thoroughly discuss the knowledge about their embryonic origin and characteristics of their postnatal niche, as well as the current status of cell culture protocols to maximize their multilineage differentiation potential, highlighting some common issues when assessing neuronal differentiation fates of hDPSCs. We also review the recent progress on neuroprotective and immunomodulatory capacity of hDPSCs and their secreted extracellular vesicles, as well as their combination with scaffold materials to improve their functional integration on the injured central nervous system (CNS) and peripheral nervous system (PNS). Finally, we offer some perspectives on the current and possible future applications of hDPSCs in neuroregenerative cell therapies.This research was supported by MICINN retos I+D+i (PID2019-104766RB-C21 and RYC-2013-13450, to J.R.P.) and UPV/EHU (GIU16/66 and PPGA20/22, to F.U., G.I.; and COLAB19/03 and IKERTU-2020.0155, to F.U., J.R.S.). Y.P. was funded by a Bikaintek PhD grant from the Basque Government (20-AF-W2-2018-00001)

Museo virtual de la neurociencia

Memoria ID-0154. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2015-2016

Human DenPulp Stem Cells Grown in Neurogenic Media Differentiate Into Endothelial Cells and Promote Neovasculogenesis in the Mouse Brain

Dental pulp stem cells (DPSCs) have the capacity to give rise to cells with neuronal-like phenotypes, suggesting their use in brain cell therapies. In the present work, we wanted to address the phenotypic fate of adult genetically unmodified human DPSCs cultured in Neurocult (TM) (Stem Cell Technologies), a cell culture medium without serum which can be alternatively supplemented for the expansion and/or differentiation of adult neural stem cells (NSCs). Our results show that non-genetically modified human adult DPSCs cultured with Neurocult NS-A proliferation supplement generated neurosphere-like dentospheres expressing the NSC markers Nestin and glial fibrillary acidic protein (GFAP), but also the vascular endothelial cell marker CD31. Remarkably, 1 month after intracranial graft into athymic nude mice, human CD31+/CD146+ and Nestin+ DPSC-derived cells were found tightly associated with both the endothelial and pericyte layers of brain vasculature, forming full blood vessels of human origin which showed an increased laminin staining. These results are the first demonstration that DPSC-derived cells contributed to the generation of neovasculature within brain tissue, and that Neurocult and other related serum-free cell culture media may constitute a fast and efficient way to obtain endothelial cells from human DPSCs.This work was funded by "Ramon y Cajal" program RYC-2013-13450 (JRP) and RYC 2012-11137 (JME); Spanish Ministry of Economy and Competitiveness SAF2015-70866-R; UPV/EHU (GIU16/66, UFI 11/44); and Basque Government (GV/EJ; IT831-13). JL and OP-A obtained a Ph.D. fellowship from the University of the Basque Country (UPV/EHU)

Guidelines to develop demonstration models on industry 4.0 for engineering training

[EN] Industrial digitization is currently a great challenge which involves continuous advances in tech-nologies such as automation, robotics, internet of things, cloud computing, big data, virtual and augmented reality or cybersecurity. Only those companies able to adapt and with qualified work-ers will be competitive. Therefore, it is necessary to design new environments to train students and workers in these enabling technologies. In this paper, a set of guidelines is proposed to develop a demonstration model on Industry 4.0. Following these guidelines, an existing manufacturing industrial system, based on an electro-pneumatic cell for classifying pieces, is updated to the Industry 4.0 paradigm. The result is an Industry 4.0 demonstration model where enabling tech-nologies are added in an integrated way. In this manner, students do not only train in each technology, but also understand the interactions between them. In the academic year 2020/21, this demonstration model has been used by engineering students in a subject of a master’s degree. Impressions and comments from students about the structure and management of the environ-ment, as well as the influence on their learning process are collected and discussed.SIThis work was supported by the Spanish State Research Agency, MCIN/AEI/10.13039/501100011033 under Grant PID2020-117890RB-I00. The work of José Ramón Rodríguez- Ossorio was supported by a grant of the Research Programme of the Universidad de León 2020. The work of Guzmán González-Mateos was supported by a grant of the Research Programme of the University of León 202

Evolución costera de la desembocadura del Guadalquivir en los últimos 6000 años (SW de España)

3 páginas, 2 figuras, 5 referencias.Since the last Holocene sea level rise, about 6,900 yr BP, a series of depositional littoral landforms has been generated at the outlet of the Guadalquivir river, with progradation along the predominant longshore drift (towards the east). The littoral spit systems mapped constitute fur progradation phases. The first is dated between the Flandrian maximum (6,900 yr BP) and 4,500 yr BP; the second between 4,200-3,900 yr BP and 2,700-2,600 yr BP; the third between 2,300 yr BP and 1,100 yr BP; and the fourth between 1,000 yr BP and the present. There were separations of successive erosional phases between 4,500-4,200 yr BP, 2,600-2,300 yr BP and, 1,100-1,000 yr BP. Thus, cycles of higher sedimentation are established, with a slight fall and then stability of sea level. Littoral barrier constructions dominate, with the genesis of extensive tidal flats that decrease the size of the estuaries. These sedimentary phases are interrupted by rapid rises in sea level lasting from 100 to 300 years, when the previously constructed littoral barriers are eroded. The cliffs retreat, causing migration inland of dunar constructions, with frequent overlapping layers. Marine influence within the estuaries in creases.Este trabajo ha sido subvencionado por los proyectos coordinados de la DGICYT PB91-0622-C03-0 1 y PB94-1090-C03-0l. Es una contribución al IGCP-367.Peer reviewe

Forage Yields and Structure of Moringa oleifera cv Nicaragua at Different Cutting Frequencies

The effect of the cutting frequency (45 and 60 days) on the morphological and productive behavior of Moringa oleifera Lam vc Nicaragua with irrigation and organic fertilization, on little differentiated fluvisols in Cauto Valley, in 2012. A randomized block design with four repetitions was applied. The cutting frequency affected the morphological variables (P≤ 0.001), but not DM from leaves, stems, and total yields (P≥ 0.05). The cutting times for both frequencies predisposed great variability between the first (February-March) and the third (June-July) cuts. The best plant height values were achieved in 60 days (P≤0.001), in comparison to 45 days, whereas the number and thickness of leaves per shoots varied (P≤ 0.001) at different cutting times based on innate plant features, not on the cutting frequency. Leaf proportion was higher (P≤0.001) in the 45-day frequency, and the DM yields ha-1 from leaves and DM ha-1 only differed in the first 45-day cut, in comparison to the other averages within the same cutting frequency, and the 60-day cut. The structure and productive behavior of Moringa were influenced by the cutting frequencies and times, whereas the cutting frequency alone just modified the structural variables

Effect of Ecotype and Cutting Frequency on Forage Yields of Moringa oleifera Lam in the Cauto Valley

The study took place at the Experimental Station of Pastures and Forages to evaluate the effect of the cut frequency (45 and 60 days) on forage yields of Moringa oleifera ecotypes Nicaragua and Criolla, with irrigation and organic fertilization, on fluvisol, in the Cauto Valley. A randomized block design with 2x2 factorial design and four replicas was used. The plants were cut 10 cm high from the ground, and variables plant height, shoot amount and thickness, number of leaves, leaf/stem ratio, total dry matter (DM) yields, and dry leaves and stems, were determined. Except for the number of shoots, all the variables were significant for the cutting frequency (P < 0.001). The number of leaves was the only variable with a difference for the ecotype factor (P < 0.05). The highest yields in total dry matter were achieved at 60 days (3.8 t.ha-1). However, the experiment only lasted 180 days with gradual reduction in production, caused by the competition between M. oleifera and invading graminaceae. The study concluded that the cutting frequency of 60 days produced increased yields of DM. However, the cutting height favored the presence of invading plants, with decreasing yields and sustainability of forage production