The relationships between distances covered above generic andrelative speed thresholds by male soccer players in EnglishPremier League matches across two competitive seasons.The effects of positional demands and possession

The aims of this study were to: a) examine the relationships between high-intensity distances covered above generic and relative speed thresholds in English Premier League (EPL) matches across two consecutive seasons and b) analyze the effects of playing position and team possession. Sixteen elite male soccer players (seven defenders, six midfielders and three forwards) participated in this study (age 27.8 ± 3.5 years, height 183.7 ± 5.4 cm, body mass 83.9 ± 7.1 kg). An Optical Tracking System was used to collect the following variables: total distance covered; high-speed running distance (HSRD) (> 5.5 m/s); high-intensity running distance (HIRD) (5.5–7 m/s); sprint distance (> 7 m/s); total distance covered above Maximal Aerobic Speed (MAS); distance covered > 85% peak speed (PS); and distance > 30% Anaerobic Speed Reserve (ASR). All measures were analyzed as whole match totals and as distances covered in the periods of the team in possession (TIP), opponent team in possession (OTIP), and ball out of play (BOP). Analysis by position based on defenders, midfielders and forwards was also performed. Distance > 30% ASR was almost perfectly correlated with HSRD (r = 0.98), while distances > MAS were highly correlated with both HIRD (r = 0.91) and HSRD (r = 0.91), and distance > 85% PS were highly correlated with SD (r = 0.70). Although the generic and relative speed thresholds show almost perfect correlation, the differences between HSRD, HIRD and distance > MAS indicate that players may be exposed to more HIRD when using relative thresholds.info:eu-repo/semantics/publishedVersio

Outcomes and prognostic factors in parotid gland malignancies: A 10-year single center experience.

Objectives:To describe a 10-year single center experience with parotid gland malignancies and to determine factors affecting outcomes. Study Design:Retrospective review. Methods:The institutional cancer registry was used to identify patients treated surgically for malignancies of the parotid gland between January 2005 and December 2014. Clinical and pathologic data were collected retrospectively from patient charts and analyzed for their association with overall survival (OS) and disease-free survival (DFS). Results:Two hundred patients were identified. Mean age at surgery was 57.8 years, and mean follow-up time was 52 months. One hundred two patients underwent total parotidectomy, while 77 underwent superficial parotidectomy, and 21 underwent deep lobe resection. Seventy patients (35%) required facial nerve (FN) sacrifice. Acinic cell carcinoma was the most common histologic type (22%), followed by mucoepidermoid carcinoma (21.5%) and adenoid cystic carcinoma (12.5%). Twenty-nine patients (14.5%) experienced recurrences, with mean time to recurrence of 23.6 months (range: 1-82 months). Five- and 10-year OS were 81% and 73%, respectively. Five- and 10-year DFS were 80% and 73%, respectively. In univariate analyses, age > 60, histologic type, positive margins, high grade, T-stage, node positivity, perineural invasion, and FN involvement were predictors of OS and DFS. In the multivariate analysis, histology, positive margins, node positivity, and FN involvement were independent predictors of OS and DFS. Conclusions:Our single-center experience of 200 patients suggests that histology, positive margins, node positivity, and FN involvement are independently associated with outcomes in parotid malignancies. Level of Evidence:4

Piriformis syndrome: pain response outcomes following CT-guided injection and incremental value of botulinum toxin injection

PURPOSEPiriformis syndrome is a common pain condition affecting the buttock and posterior hip with or without radiation to the leg, and management of the condition involves many treatments. In this study, we hypothesize that a CT-guided injection with botulinum toxin is more effective in providing pain relief than a CT-guided injection without Botox.METHODSOverall, 97 consecutive patients with piriformis syndrome presented for a CT-guided injection of the piriformis muscle and perineural injection of the sciatic nerve. After the injection, the patients received a visual analog scale pain log to record their pain level until the follow-up appointment. P values of less than 0.2 were considered as confounder and adjusted by inverse probability of treatment weighting (IPTW) via propensity score. The effect of botulinum toxin on 48-hour response and duration of response was tested using weighted chi-square test and weighted Kaplan-Meier analysis.RESULTSThere was a total of 97 patients in the study, and 111 injections, as some patients had bilateral injections. Patients in the Botox group had more 48-hour response than patients in the non-botulinum toxin group (P < 0.001 with IPTW, P = 0.005 without IPTW). Median pain-free survival was 30 days for Botox group and 1 day for non-Botox group (P = 0.059 with IPTW, P = 0.10 without IPTW).CONCLUSIONCT-guided injections with botulinum toxin for patients with piriformis syndrome are more likely to lead to a positive response and a longer duration of response than patients who receive a CT-guided injection without botulinum toxin. We hope that this study facilitates future prospective randomized blind trials for patients with suspected piriformis syndrome

Seismic cycle and rheological effects on estimation of present-day slip rates for the Agua Blanca and San Miguel-Vallecitos faults, northern Baja California, Mexico

Geodesy can be used to infer long-term fault slip rates, assuming a model for crust and upper mantle rheology. We examine the sensitivity of fault slip rate estimates to assumed rheology for the Agua Blanca and San Miguel-Vallecitos faults in northern Baja California, Mexico, part of the Pacific–North America plate boundary zone. The Agua Blanca fault is seismically quiet, but offset alluvial fans indicate young activity. Current seismicity is confined to the nearby San Miguel-Vallecitos fault, a small offset fault better aligned with plate motion. GPS measurements between 1993 and 1998 suggest that both faults are active, with a combined slip rate of 4–8 mm yr. regardless of rheological model. However, slip rate estimates for the individual faults are sensitive to assumed rheology. Elastic half-space models yield 2–3 mm yr. for the Agua Blanca fault, and somewhat faster rates for the San Miguel-Vallecitos fault, 2–4 mm yr., with uncertainties of about 1 mm yr. Models incorporating viscoelastic rheology and seismic cycle effects suggest a faster slip rate for the Agua Blanca fault, 6 ± 1 mm yr, and a slower rate for the San Miguel-Vallecitos fault, 1 ± 1 mm yr, in better agreement with geological data, but these rates are sensitive to assumed rheology. Numerical simulations with a finite element model suggest that for similar rheological and friction conditions, slip on the San Miguel-Vallecitos fault should be favored due to better alignment with plate motion. Long-term faulting processes in the larger offset Agua Blanca fault may have lowered slip resistance, allowing accommodation of motion despite misalignment with plate motion

A novel method for metal–diamond composite coating deposition with cold spray and formation mechanism

This paper describes the application of cold spray to the deposition of a diamond grade pre-coated with Cu and Ni. This is the first time that pre-coated diamond powders are used as the sole feedstock without the addition of binders (ductile phases) in cold spraying. The experimental results showed that it was possible to manufacture thick metal–diamond composite coatings onto an Al alloy substrate with high diamond fraction in the coating and without phase change. Results from this paper also have demonstrated a new methodology for the deposition of metal–diamond/ceramic composite coating with the cold spray technique

Bioengineered lungs generated from human iPSCs‐derived epithelial cells on native extracellular matrix

The development of an alternative source for donor lungs would change the paradigm of lung transplantation. Recent studies have demonstrated the potential feasibility of using decellularized lungs as scaffolds for lung tissue regeneration and subsequent implantation. However, finding a reliable cell source and the ability to scale up for recellularization of the lung scaffold still remain significant challenges. To explore the possibility of regeneration of human lung tissue from stem cells in vitro, populations of lung progenitor cells were generated from human iPSCs. To explore the feasibility of producing engineered lungs from stem cells, we repopulated decellularized human lung and rat lungs with iPSC‐derived epithelial progenitor cells. The iPSCs‐derived epithelial progenitor cells lined the decellularized human lung and expressed most of the epithelial markers when were cultured in a lung bioreactor system. In decellularized rat lungs, these human‐derived cells attach and proliferate in a manner similar to what was observed in the decellularized human lung. Our results suggest that repopulation of lung matrix with iPSC‐derived lung epithelial cells may be a viable strategy for human lung regeneration and represents an important early step toward translation of this technology.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142929/1/term2589.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142929/2/term2589_am.pd

Melanopsin retinal ganglion cell loss in Alzheimer's disease

Objective Melanopsin retinal ganglion cells (mRGCs) are photoreceptors driving circadian photoentrainment, and circadian dysfunction characterizes Alzheimer disease (AD). We investigated mRGCs in AD, hypothesizing that they contribute to circadian dysfunction. Methods We assessed retinal nerve fiber layer (RNFL) thickness by optical coherence tomography (OCT) in 21 mild-moderate AD patients, and in a subgroup of 16 we evaluated rest-activity circadian rhythm by actigraphy. We studied postmortem mRGCs by immunohistochemistry in retinas, and axons in optic nerve cross-sections of 14 neuropathologically confirmed AD patients. We coimmunostained for retinal amyloid \u3b2 (A\u3b2) deposition and melanopsin to locate mRGCs. All AD cohorts were compared with age-matched controls. Results We demonstrated an age-related optic neuropathy in AD by OCT, with a significant reduction of RNFL thickness (p = 0.038), more evident in the superior quadrant (p = 0.006). Axonal loss was confirmed in postmortem AD optic nerves. Abnormal circadian function characterized only a subgroup of AD patients. Sleep efficiency was significantly reduced in AD patients (p = 0.001). We also found a significant loss of mRGCs in postmortem AD retinal specimens (p = 0.003) across all ages and abnormal mRGC dendritic morphology and size (p = 0.003). In flat-mounted AD retinas, A\u3b2 accumulation was remarkably evident inside and around mRGCs. Interpretation We show variable degrees of rest-activity circadian dysfunction in AD patients. We also demonstrate age-related loss of optic nerve axons and specifically mRGC loss and pathology in postmortem AD retinal specimens, associated with A\u3b2 deposition. These results all support the concept that mRGC degeneration is a contributor to circadian rhythm dysfunction in AD

Arboviral Etiologies of Acute Febrile Illnesses in Western South America, 2000–2007

Over recent decades, the variety and quantity of diseases caused by viruses transmitted to humans by mosquitoes and other arthropods (also known as arboviruses) have increased around the world. One difficulty in studying these diseases is the fact that the symptoms are often non-descript, with patients reporting such symptoms as low-grade fever and headache. Our goal in this study was to use laboratory tests to determine the causes of such non-descript illnesses in sites in four countries in South America, focusing on arboviruses. We established a surveillance network in 13 locations in Ecuador, Peru, Bolivia, and Paraguay, where patient samples were collected and then sent to a central laboratory for testing. Between May 2000 and December 2007, blood serum samples were collected from more than 20,000 participants with fever, and recent arbovirus infection was detected for nearly one third of them. The most common viruses were dengue viruses (genera Flavivirus). We also detected infection by viruses from other genera, including Alphavirus and Orthobunyavirus. This data is important for understanding how such viruses might emerge as significant human pathogens