The Midwifery Unit Network: creating a community of practice to enhance maternity services

The Midwifery Unit Network (MUNet) is a community of practice which aims to promote and support the implementation and improvement of midwifery units (MUs) in the UK and internationally. It was launched in April 2016 and has been growing fast since its inception. In this article the co-leads of the MUNet describe how they established the network, and the challenges that they had to overcome. The aim of this article is to inspire more midwives and parent advocates to consider establishing a community of practice, and to offer some guidance on the key aspects involved

Assessing skewness in financial markets

It is common knowledge that investors like large gains and dislike large losses. This translates into a preference for right-skewed return distributions, with right tails heavier than left tails. Skewness is thus interesting not only as a way to describe the shape of a distribution, but also for risk measurement. We review the statistical literature on skewness and provide a comprehensive framework for its assessment. We present a new measure of skewness, based on a relative comparison between above average and below average returns. We show that this measure represents a valid complement to the state of the art

Assessing skewness in financial markets

It is a matter of common observation that investors value substantial gains but are averse to heavy losses. Obvious as it may sound, this translates into an interesting preference for right-skewed return distributions, whose right tails are heavier than their left tails. Skewness is thus not only a way to describe the shape of a distribution, but also a tool for risk measurement. We review the statistical literature on skewness and provide a comprehensive framework for its assessment. Then, we present a new measure of skewness, based on the decomposition of variance in its upward and downward components. We argue that this measure fills a gap in the literature and show in a simulation study that it strikes a good balance between robustness and sensitivity

Recovery of Interdependent Networks

Recent network research has focused on the cascading failures in a system of interdependent networks and the necessary preconditions for system collapse. An important question that has not been addressed is how to repair a failing system before it suffers total breakdown. Here we introduce a recovery strategy of nodes and develop an analytic and numerical framework for studying the concurrent failure and recovery of a system of interdependent networks based on an efficient and practically reasonable strategy. Our strategy consists of repairing a fraction of failed nodes, with probability of recovery $\gamma$, that are neighbors of the largest connected component of each constituent network. We find that, for a given initial failure of a fraction $1-p$ of nodes, there is a critical probability of recovery above which the cascade is halted and the system fully restores to its initial state and below which the system abruptly collapses. As a consequence we find in the plane $\gamma-p$ of the phase diagram three distinct phases. A phase in which the system never collapses without being restored, another phase in which the recovery strategy avoids the breakdown, and a phase in which even the repairing process cannot avoid the system collapse

Role of anisotropy in the F\"orster energy transfer from a semiconductor quantum well to an organic crystalline overlayer

We consider the non-radiative resonant energy transfer from a two-dimensional Wannier exciton (donor) to a Frenkel exciton of a molecular crystal overlayer (acceptor). We characterize the effect of the optical anisotropy of the organic subsystem on this process. Using realistic values of material parameters, we show that it is possible to change the transfer rate within typically a factor of two depending on the orientation of the crystalline overlayer. The resonant matching of donor and acceptor energies is also partly tunable via the organic crystal orientation.Comment: 6 pages, 8 figure

Severe New Limits on the Host Galaxies of Gamma Ray Bursts

The nature of Gamma Ray Bursts (GRBs) remains a complete mystery, despite the recent breakthrough discovery of low energy counterparts, although it is now generally believed that at least most GRBs are at cosmological distances. Virtually all proposed cosmological models require bursters to reside in ordinary galaxies. This can be tested by looking inside the smallest GRB error boxes to see if ordinary galaxies appear at the expected brightness levels. This letter reports on an analysis of the contents of 26 of the smallest regions, many from the brightest bursts. These events will have $z < 0.4$ and small uncertainties about luminosity functions, K corrections and galaxy evolutions; whereas the recent events with optical transients are much fainter and hence have high redshifts and grave difficulties in interpretation. This analysis strongly rejects the many models with peak luminosities of $10^{57} photons \cdot s^{-1}$ as deduced from the $LogN-LogP$ curve with no evolution. Indeed, the lower limit on acceptable luminosities is $6 \times 10^{58} photons \cdot s^{-1}$. The only possible solution is to either place GRBs at unexpectedly large distances (with $z > 5.9$ for the faint BATSE bursts) or to require bursters to be far outside any normal host galaxy.Comment: 17 pages, to be published by ApJ

Comparison of the Toxicological Effects of Pesticides in Non-Tumorigenic MCF-12A and Tumorigenic MCF-7 Human Breast Cells

Humans are exposed to residues of organophosphate and neonicotinoid pesticides, commonly used in agriculture. Children are particularly vulnerable and, among possible adverse outcomes, the increased incidence of premature mammary gland development (thelarche) has raised concern. We evaluated the toxicological effects of chlorpyrifos (CPF), imidacloprid (IMI) and glyphosate (GLY) at exposure concentrations occurring in children on the tumorigenic MCF-7 and non-tumorigenic MCF-12A breast cell lines, as representative of the target organ model, assessing cytotoxicity, apoptosis, necrosis, intracellular reactive oxygen species (ROS) and ATP levels, 17β-estradiol secretion and gene expression of nuclear receptors involved in mammary gland development. The pesticides decreased cell vitality in MCF-7 and cell proliferation in MCF-12A cells. ATP levels were decreased in MCF-7 cells by pesticides and apoptosis was increased in MCF-12A cells only by GLY (2.3 nM). ROS production was decreased by pesticides in both cell lines, except IMI (1.6 nM) in MCF-7 cells. Endocrine disrupting activity was highlighted by induction of 17β-estradiol secretion and modulation of the gene expression of estrogen alpha and beta, progesterone, androgen, and aryl hydrocarbon receptors in both cell lines. The use of MCF-7 and MCF-12A cells highlighted dissimilar modes of action of each pesticide at low human relevant concentrations

Exposure to Endocrine Disruptors and Nuclear Receptors Gene Expression in Infertile and Fertile Men from Italian Areas with Different Environmental Features

Internal levels of selected endocrine disruptors (EDs) (i.e., perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), di-2-ethylhexyl-phthalate (DEHP), mono-(2-ethylhexyl)-phthalate (MEHP), and bisphenol A (BPA)) were analyzed in blood/serum of infertile and fertile men from metropolitan, urban and rural Italian areas. PFOS and PFOA levels were also evaluated in seminal plasma. In peripheral blood mononuclear cells (PBMCs) of same subjects, gene expression levels of a panel of nuclear receptors (NRs), namely estrogen receptor α (ERα) estrogen receptor β (ERβ), androgen receptor (AR), aryl hydrocarbon receptor (AhR), peroxisome proliferator-activated receptor γ (PPARγ) and pregnane X receptor (PXR) were also assessed. Infertile men from the metropolitan area had significantly higher levels of BPA and gene expression of all NRs, except PPARγ, compared to subjects from other areas. Subjects from urban areas had significantly higher levels of MEHP, whereas subjects from rural area had higher levels of PFOA in both blood and seminal plasma. Interestingly, ERα, ERβ, AR, PXR and AhR expression is directly correlated with BPA and inversely correlated with PFOA serum levels. Our study indicates the relevance of the living environment when investigating the exposure to specific EDs. Moreover, the NRs panel in PBMCs demonstrated to be a potential biomarker of effect to assess the EDs impact on reproductive health

The Role of Trauma in Early Onset Borderline Personality Disorder: A Biopsychosocial Perspective

The role of childhood trauma in the development of borderline personality disorder (BPD) in young age has long been studied. The most accurate theoretical models are multifactorial, taking into account a range of factors, including early trauma, to explain evolutionary pathways of BPD. We reviewed studies published on PubMed in the last 20 years to evaluate whether different types of childhood trauma, like sexual and physical abuse and neglect, increase the risk and shape the clinical picture of BPD. BPD as a sequela of childhood traumas often occurs with multiple comorbidities (e.g. mood, anxiety, obsessive-compulsive, eating, dissociative, addictive, psychotic, and somatoform disorders). In such cases it tends to have a prolonged course, to be severe, and treatment-refractory. In comparison with subjects who suffer from other personality disorders, patients with BPD experience childhood abuse more frequently. Adverse childhood experiences affect different biological systems (HPA axis, neurotransmission mechanisms, endogenous opioid systems, gray matter volume, white matter connectivity), with changes persisting into adulthood. A growing body of evidence is emerging about interaction between genes (e.g. FKBP5 polymorphisms and CRHR2 variants) and environment (physical and sexual abuse, emotional neglect)