6 research outputs found
Procalcitonin and C-Reactive Protein for invasive bacterial pneumonia diagnosis among children in Mozambique, a malaria-endemic area
- Author
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Background: Pneumonia is the major cause of mortality and morbidity in children worldwide. Procalcitonin (PCT) and C-reactive protein (CRP) are used in developed countries to differentiate between viral and bacterial causes of pneumonia. Validity of these markers needs to be further explored in Africa. Methodology and Principal Findings: We assessed the utility of PCT and CRP to differentiate viral from invasive bacterial pneumonia in children <5 years hospitalized with clinical severe pneumonia (CSP) in rural Mozambique, a malaria-endemic area with high HIV prevalence. Prognostic capacity of these markers was also evaluated. Out of 835 children with CSP, 87 fulfilled definition of viral pneumonia and 89 of invasive bacterial pneumonia. In absence of malaria parasites, levels of PCT and CRP were lower in the viral group when compared to the invasive bacterial one (PCT: median = 0.21 versus 8.31 ng/ml, p<0.001; CRP: 18.3 vs. 185.35 mg/l, p<0.001). However, in presence of malaria parasites distribution between clinical groups overlapped (PCT: median = 23.1 vs. 21.75 ng/ml, p = 0.825; CRP: median = 96.8 vs. 217.4 mg/l, p = 0.052). None of the two markers could predict mortality. Conclusions: Presence of malaria parasites should be taken into consideration, either for clinical or epidemiological purposes, if using PCT or CRP to differentiate viral from invasive bacterial pneumonia in malaria-endemic areas
Procalcitonin and C-Reactive Protein for invasive bacterial pneumonia diagnosis among children in Mozambique, a malaria-endemic area
- Author
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Background: Pneumonia is the major cause of mortality and morbidity in children worldwide. Procalcitonin (PCT) and C-reactive protein (CRP) are used in developed countries to differentiate between viral and bacterial causes of pneumonia. Validity of these markers needs to be further explored in Africa. Methodology and Principal Findings: We assessed the utility of PCT and CRP to differentiate viral from invasive bacterial pneumonia in children <5 years hospitalized with clinical severe pneumonia (CSP) in rural Mozambique, a malaria-endemic area with high HIV prevalence. Prognostic capacity of these markers was also evaluated. Out of 835 children with CSP, 87 fulfilled definition of viral pneumonia and 89 of invasive bacterial pneumonia. In absence of malaria parasites, levels of PCT and CRP were lower in the viral group when compared to the invasive bacterial one (PCT: median = 0.21 versus 8.31 ng/ml, p<0.001; CRP: 18.3 vs. 185.35 mg/l, p<0.001). However, in presence of malaria parasites distribution between clinical groups overlapped (PCT: median = 23.1 vs. 21.75 ng/ml, p = 0.825; CRP: median = 96.8 vs. 217.4 mg/l, p = 0.052). None of the two markers could predict mortality. Conclusions: Presence of malaria parasites should be taken into consideration, either for clinical or epidemiological purposes, if using PCT or CRP to differentiate viral from invasive bacterial pneumonia in malaria-endemic areas
Impacts of Use and Abuse of Nature in Catalonia with Proposals for Sustainable Management
- Author
- Aparicio Enric
- ArĂșs i Gorina Pere
- Basnou Corina
- Blanché i Vergés CÚsar
- Bonada i CaparrĂłs NĂșria
- Canals PurificaciĂł
- Capodiferro Marco
- Carceller Roqué Xavier
- Casademunt Ălex
- Casals Missio Joan
- Casals Pere
- Casañas F. (Francesc)
- CatalĂĄn i AguilĂ Jordi
- Checa Joan
- Cordero Pedro J.
- Corominas Joaquim
- Espelta Morral Josep Maria
- Estrada i Miyares Marta
- Folch Ramon
- Franquesa Teresa
- Garcia-Lozano Carla
- GarĂ MercĂš
- Geli Anna M.
- Germain i Otzet Josep
- GonzĂĄlez-Guerrero Ăscar
- Gordillo Javier
- GosĂ lbez i Noguera Joaquim
- Grimalt Obrador Joan
- GuĂ rdia Anna
- Isern RosĂł
- Jordana i Vidal Jordi
- Junqué Eva
- Lascurain i Golferichs Josep
- Lleonart Jordi
- Llorente Gustavo A.
- Lloret Romañach Josep
- Lloret Francisco
- Mallarach Josep Maria
- MartĂn Vide Javier
- Medir i Huerta Rosa M.
- Melero Cavero Yolanda
- Montasell i Dorda Josep
- Montori Albert
- Munné Antoni (Munné i Torras)
- Nel·lo Oriol
- PalazĂłn Santiago
- Palmero Marina
- Parés Margarida
- Peñuelas Josep
- Pino i Vilalta Joan
- PintĂł i Fusalba Josep
- Planagumà Llorenç
- Pons Xavier
- Prat i Fornells NarcĂs
- Puig i Civera Carme
- Puig Ventosa Ignasi
- PuigdomĂšnech Pere
- Pujol BuxĂł Eudald
- Roca Pascual NĂșria
- Rodrigo Jofre
- RodrĂguez Teijeiro JosĂ© Domingo
- Roig i Munar Francesc Xavier
- RomanyĂ i SocorĂł Joan
- Rovira Pere
- Sauras Yera Teresa
- Serrat David
- SimĂł Joan
- Soler Insa Jordi
- Sostoa FernĂĄndez Adolfo de
- Sà ez Llorenç
- Terradas Jaume
- Vallejo V. RamĂłn (Victoriano RamĂłn)
- Vicente Paloma
- Vilaplana Joan Manuel
- Vinyoles CartanyĂ Dolors
- Ălvarez DomĂnguez Enrique
- Publication venue
- 'MDPI AG'
- Publication date
- Field of study
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
- Author
- Aawsaj Y
- Abadia M
- AbadâGurumeta A
- AbadâMotos A
- Abassy J
- Abate E
- Abbasov A
- Abbott D
- Abbott Tom EF
- Abdalla M
- Abdeldayem H
- Abdelkabir M
- Abdelkader Salama I
- Abdelkarim M
- Abdelsamed A
- Abdulfattah F
- Abdulwahed E
- AbdurâRahman LO
- Abel MK
- Abelevich A
- Abiyere H
- Aboelkassem Ibrahim A
- Aboharp Hasan Z
- Abou Chaar MK
- Abreu da Silva A
- Abubakar A
- Abukhalaf SA
- Abukhalaf Sadi
- Acebes GarcĂa F
- Achalandabaso Boira M
- Acher A
- Acosta MĂ©rida MA
- Acrich E
- Adam Essa Adam ME
- Adamina M
- Adamina Michel
- Adamina Michel
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Aderombi A
- Adeyeye A
- Adeyeye A
- Adi H
- Adiamah A
- Adisa Adewale
- Afzal MF
- Agapov M
- Agarwal Arnav
- Aggarwal M
- Aghayeva A
- Agilinko J
- Agnes A
- Agostini C
- Agrawal A
- Agrawal N
- Agresta F
- Aguado LĂłpez H
- Aguiar JĂșnior S
- Aguilar Gonzalez M
- Ahmed A
- Ahmed A
- Ahmed K
- Ahmed ME
- Ahmed Z
- Ahmeidat A
- Ahn JH
- Aiken T
- Aimé A
- Akalin M
- Akaydin E
- Akbas A
- Akhtar MA
- Akhtar N
- Akhter Rahman MM
- Akin E
- Akkulak Murat
- Akrivou D
- Al Abdallah M
- Al ahmad F
- Al Asadi T
- Al Awwad S
- Al Ayed A
- Al Habes H
- Al Riyami S
- AL Sayed M
- Alaa S
- AlAamer O
- Aladeojebi A
- Alagoa Joao A
- Alakaloko Felix
- Alam F
- Alameer Ehab
- Alamri Alex
- Alanazi F
- Alawneh F
- Albaqami F
- Albertsmeier M
- Albertsmeier Markus
- Alcaide Matas F
- Alconchel F
- AlcĂĄzar JA
- Alderson Derek
- Aldokali N
- AleksiÄ L
- Alemanno G
- Alfaifi J
- Alfieri S
- Alfonso Garcia M
- Algallai M
- Alghamdi M
- Alghuliga A
- Alhamed A
- Alharthi M
- Alhassan N
- Ali karar AA
- Ali Sani S
- Ali AA
- Ali M
- Ali S
- Alishi Y
- Aliyeva Z
- Aljiffry M
- Alkadiki Ghadah Z
- Alkhateb S
- Allue M
- Almaadany Faraj S
- Almassaudi A
- Almeida AC
- Almeida JI
- AlmeidaâReis R
- Almezghwi H
- Almgla N
- Almond Max
- Alnumani T
- Alobaysi S
- Alobeed O
- Alonso de la Fuente N
- Alonso Poza A
- AlonsoâLamberti L
- Alqahtani D
- Alqannas M
- Alrahawy M
- Alsayadi M
- Alsayadi R
- Alselaim N
- Alser Osaid
- Alshaar Muhammad
- Alshahrani A
- Alshahrani M
- Alshammari S
- Alshareea E
- Alshareef K
- Alsharif F
- Alshryda Sattar
- Alsoufi A
- Alsowaina K
- Altinel Y
- Altintoprak F
- Altom R
- Altomare DF
- Altomi I
- Alurralde C
- Alvarez E
- Alvarez MR
- Alvi A
- Alwarfly S
- Alyami M
- Alzaede S
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- Alzeerelhouseini H I. A.
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- AlâMohammad A
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- AlâNajjar H
- AlâShehari M
- AlâSlaibi I
- Amaral MJ
- Amira G
- Amorim E
- Amrani L
- Anania G
- Anastasi A
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- Angamuthu N
- Angelou D
- Angenete E
- AngosoâClavijo M
- Annamalai S
- Annessi V
- Annicchiarico A
- Anscomb N
- Antic A
- Antonakis P
- Antonopoulou MI
- Anula R
- AparicioâLĂłpez D
- Aprile A
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- AriasâAmĂ©zquita F
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- BaiĂŁo JM
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- Fahey BA
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- FernĂĄndez Pablos FJ
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- Ferraz I
- Ferreira Pinto AP
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- Figueiredo de Barros I
- Findlay L
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- Fiore Marco
- Fiore Marco
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- Fitzgerald J Edward
- Flamey N
- Fleming CA
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- Flindall I
- Flores Clotet R
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- Ford Samuel
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- Freyschlag Christian
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- Fujiwara Keiichi
- Fuks D
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- GalvĂŁo D
- Gani J
- Ganly Ian
- Garba S
- Garcia Egea J
- Garcia Santos EP
- Garcia J
- GarciaâSancho Tellez L
- GarcĂa Alonso M
- GarcĂa DomĂnguez M
- GarcĂa PĂ©rez JM
- GarcĂa Septiem J
- GarcĂa JS
- GarcĂaâConde M
- GarcĂaâPlaza AGP
- GarcĂaâQuijada J
- Garfinkle R
- Garg PK
- Garino M
- Garmanova T
- Garmanova Tatiana
- Garrett WV
- Garrido R
- Gascon Ferrer I
- Gash K
- Gass M
- Gata V
- Gattolin A
- Gaunt A
- Gauri N
- Gaziants V
- GegĂșndez SimĂłn A
- Gelarda E
- Gemmell C
- Gemmill E
- Gennari S
- Gentilli S
- George G
- Gerns N
- Geroukalis A
- Ghaly G
- Ghamgh R
- Ghanbari A
- Ghannam A
- Ghebre Rahel
- Ghitulescu G
- Ghosh Dhruva
- Ghosh Dhruva
- Giacometti M
- Giaglaras A
- Gialamas E
- Gianardi D
- Gil CatalĂĄn A
- Gil MartĂnez J
- Gill R
- Gilliland J
- Gillis AE
- Gimenez Maurel T
- Giménez Francés C
- Ginghina O
- Giraudo G
- Giuffrida M
- Giuffrida MC
- Giunta A
- Gklavas A
- Glasbey James C
- Glasbey James C
- Glasbey James C
- Glasbey James C
- Glass N
- Gleeson E
- Glehen O
- Goksoy B
- Golda T
- GoldâDeutch R
- Gomes GMA
- Gomes Gustavo Mendonça AtaĂde
- Gomes J
- Gomez Fernandez L
- Gomez Ruiz M
- GomezâMayorga JL
- GomezâRosado J
- Gonzalez J
- Gonzalez R
- GonzalezâGonzalez E
- GonzalezâMuñoz JI
- GonzĂĄlez Argente FX
- GonzĂĄlez de Miguel M
- GonzĂĄlezâNicolĂĄs TrĂ©bol MT
- Goodrum S
- Goran M
- Gori A
- GortĂĄzar de las Casas S
- Gossedge G
- Gourbault L
- Gouvas N
- GraciaâRoche C
- Grainger C
- Grama F
- Grasset E
- Grasso M
- GrauâTalens EJ
- Grechenig M
- Grechi A
- Grecinos Gustavo
- Green L
- Green S
- Gregoric P
- Gribnev P
- Grieco C
- Griffiths Ewen A
- Griffiths Ewen A
- Griffiths O
- Grilo JV
- Grimley E
- Gronchi Alessandro
- Groot G
- Grossi U
- Grotenhuis BA
- Grove T
- GrubaÄ Ćœ
- Gruber R
- Gruendl Magdalena
- Guadagni S
- Guaglio M
- Guariglia CA
- Guerci C
- Guerra GR
- Guevara O
- GuevaraâMartĂnez J
- Guglielmetti L
- Guglielmi A
- Guidi G
- Guillamot Ruano P
- Gujjuri Rohan R
- Gultekin FA
- Gundara J
- Guner A
- Gupta A
- Gupta S
- Gutelkin Murat
- Gutierrez Samaniego M
- Gutiérrez Fernåndez AI
- Guven O
- GuĂ rdia N
- GĂłmez DĂaz CJ
- GĂłmez Sanz T
- GönĂŒllĂŒ E
- GĂŒler SA
- GĂŒreĆin A
- Hacım NA
- Hagger R
- Hainsworth A
- Haji A
- Hakami I
- Halkias C
- Halkias Constantine
- Hall J
- Hamdan KH
- Hamdy R
- Hammed A
- Hammed S
- Hammer C
- Hamza HM
- Hamzaoglu I
- Handa S
- Hanly A
- Hanna M
- Hanson A
- Haq A
- Haque PD
- Harald M
- Harbjerg JL
- Hardie CM
- Hardy NP
- Harries R
- Harris Benjamin
- Harris Benjamin
- Harris G
- Harrison Ewen M
- Hart C
- Hartveld L
- Hassan E
- Hawkin P
- Hawkins AT
- Hayati F
- Haynes AB
- Heer B
- Heinius G
- Helminen O
- Heneghan H
- Henriques P
- Henriques S
- Heras Aznar J
- Heritage Emily
- Herman A
- Hernandez Bartolome MA
- Hernandez Gutierrez J
- Hernandez P
- Hernandez R
- HernĂĄndezâGarcĂa M
- Herrera Mora DR
- Herrero Lopez M
- Herrod P
- Herzberg J
- Hill C
- Hirji S
- Hisham Intisar
- Hmedat A
- Ho D
- Ho MF
- Ho Michael
- Hoffmann PV
- Hogan A
- Hompes R
- Hon S
- Honarpisheh H
- Horn C
- Houlden C
- Hraishawi I
- Huhta H
- Humes D
- Humphreys L
- Hunt A
- Hunt L
- Hussain AH
- Hutchinson Peter
- Hutchinson Peter J
- Huynh KT
- Hwang Shelley
- I Sharara M
- Iannone I
- Ibrahim AF
- Ibrahim B
- Ibrahim S
- IbåñezâAguirre FJ
- IflazoÄlu N
- Ijichi TR
- Ikram H
- Illingworth B
- Impellizzeri H
- Inama M
- Incollingo P
- Inzunza M
- Ioannidis O
- Iordache N
- Iosifescu RV
- Ip M
- Ipponi P
- Isaac John
- Isik Arda
- Islam AA
- Ismail O
- Isolani SM
- Isoton JC
- Ivancevic N
- Iversen LH
- Izbicki J
- Izzo F
- Jackman J
- Jain A
- Jain D
- Jain M
- Jaloun H
- Jamal A
- James A
- Jang S
- Janik M
- Jayarajah U
- Jayasankar B
- Jayasilan J
- Jayasinghe JD
- Jeftic N
- Jelenkovic J
- Jenkinson Michael D
- Jenkinson Michael D
- Jenny HE
- Jeri S
- Jesudason MR
- Jeyaraj P
- Jeyarajan E
- Jezieniecki C
- Jha M
- Jia F
- Jimenez Higuera E
- Jimenez MiramĂłn J
- Jimenez Ramirez LJ
- Jimenez Toscano M
- Jimenez V
- Jiménez A
- Jobran F
- Jocson R
- Johnstone J
- Jones Conor S
- Jonescheit J
- Jonker Pascal
- Jordan P
- Jordan S
- Jouffret L
- Jover JM
- Jovine E
- JW Wilkin Richard
- JĂĄcome F
- JĂ€ger T
- Kaafarani H
- Kaafarani Haytham MA
- Kacem MJ
- Kakotkin V
- Kalayarasan R
- Kalfountzos C
- Kam da Silva Andrade A
- Kamal M
- Kamal N
- Kamalov A
- Kamarajah Sivesh K
- Kamarajah Sivesh K
- KamburoÄlu MB
- Kamel F
- Kamera BS
- Kamoka E
- Kamphues C
- Kanemitsu Y
- Kannummal Veetil S
- Kanthasamy S
- Kapoor S
- Kappenberger A
- Kara H
- Kara Y
- Karahasanoglu T
- Karaitianos IG
- Karamarkovic A
- Karandikar S
- Karim A
- Karimuddin A
- KarloviÄ D
- Kashif M
- Kasivisvanathan Veeru
- Kassir R
- Katory M
- Kattakayam A
- Katusic Z
- Kaul S
- Kauppila JH
- Kauppila JH
- Kaushal M
- Kavanagh D
- Kaya T
- Kayyal MY
- Kazachenko E
- Keatley James M
- Kebabçı E
- KecmanoviÄ D
- Keeler BD
- Keller Debby
- Keller Debby
- Kembuan G
- Kenic M
- Kennelly R
- Kent A
- Kerawala AA
- Khajuria A
- Khan A
- Khan AH
- Khan F
- Khan J
- Khan K
- Khan S
- Khan Tabassum
- Khatri Chetan
- Khaw Rachel A
- Khokhar MI
- Kiconco H
- Kilani AI
- Kilinc Tuncer G
- Killeen S
- Kim NJ
- Kirmizi Y
- Kjaer DW
- Klaristenfeld D
- Klatte Tobias
- Kleeff J
- Kler A
- Klimopoulos S
- Kloppers C
- KmeziÄ S
- Knezevic D
- Knight Andrew
- Knights E
- Knowles C
- Knowles J
- Kocatas A
- Koh A
- Kokkinos G
- Kokobelyan AK
- Kokoropoulos P
- Koleva Radica M
- Kolias Angelos
- Kolias Angelos
- Kolla C
- Kollengode VV
- Kolli VS
- Konney Thomas
- Konstadoulakis M
- Konstantinou C
- Konsten J
- Kontovounisios C
- Kornblith LZ
- Kottayasamy Seenivasagam R
- Koukoulis G
- Kourdouli A
- Kovacevic B
- Kowalewski P
- Krarup P
- Krdzic I
- Kredan A
- Kretzmer L
- Krishnan E
- Kristensen HĂ
- Krivokapic Z
- Kroon HM
- Kruijff Schelto
- KrĆĄul D
- Kubiliute E
- Kubyshkin V
- Kucuk GO
- Kudchadkar S
- Kuiper S
- Kulkarni N
- Kulkarni R
- Kulle CB
- Kumar A
- Kumar L
- Kumar S
- Kumar V
- KutkeviÄius J
- Kuttanchettiyar KG
- KwanâFeinberg R
- Kwiatkowski A
- Kyriacou H
- KÀlviÀinen H
- Königsrainer A
- KĂŒĂ§ĂŒk IF
- La Regina D
- La Torre F
- Labib PL
- Lacy AM
- Ladd MR
- Laface L
- Laforest A
- Laharwal A
- Lakkis Z
- Lala AK
- Lalou L
- Lamb Benjamin
- Landaluceâolavarria A
- Lapolla P
- Laporte G
- Larentzakis A
- Larkin J
- Laskar N
- Lasses MartĂnez B
- LatinÄiÄ S
- Lauretta A
- Lauscher J
- Lavy R
- Law J
- Lawani Ismail
- Lawday S
- Lawday Samuel
- Lawday Samuel
- Layton Georgia R
- Le Roy B
- Lecolle K
- Lederhuber Hans
- Lederhuber Hans
- Ledesma FS
- Lee M
- Lee N
- Leede E
- Lenzi E
- Leon R
- Leung Elaine YL
- Leventoglu Sezai
- Leventoglu Sezai
- LewisâLloyd C
- Li Elizabeth
- Li Elizabeth
- Li M
- Li Z
- Liakakos T
- Liao CCL
- Lieske B
- Lim M
- Lim RZM
- Lima Buarque I
- Lima da Cruz L
- Lima da Silva C
- Lima MJ
- Linari C
- Lippa Laura
- Lira dos Santos Leite A
- Litta F
- Litvin A
- Litvin Andrey
- Litvina Y
- Liu J
- Liu T
- Lizzi V
- Locatelli A
- Loch FN
- Loehrer A
- Loehrer Andrew
- Loncar Z
- Long C
- Longhi M
- Longhini A
- Longstaff L
- Lopes L
- Lopez Abad A
- LoraâCumplido P
- Lorena Maria Aguilera
- Lorenzon L
- Losada M
- Lott N
- Loubani M
- Loutzidou L
- Lowery A
- Lozano Lominchar P
- Lucchini SM
- Luglio G
- Lule H
- Lun EWY
- Lunevicius R
- Lunghi EG
- Lynch N
- Lyons A
- LĂĄzaro A
- López Antoñanzas L
- Löffler Markus W
- Löffler MW
- Löfgren N
- M. elghazaly S
- Maa Albared S
- Maccabe TA
- MacDonald L
- Machado D
- Machado N
- Macina S
- Madani Kia T
- Madani R
- Madonini M
- Maffioli A
- Magee C
- Maghrebi H
- Magowan D
- Mahajan A
- Mahendran V
- Mahmood M
- Mahmoud Ali F
- Mahvi D
- Maida P
- Maiga A
- Maimbo Mayaba
- Majbar AM
- Majkowska A
- Major P
- Major Piotr
- Majrashi S
- Majumdar KS
- Mak TWC
- Malapati H
- Malcolm FL
- Malgras B
- Malibary N
- Mall JW
- Maltinti G
- Manatakis DK
- Manfredelli S
- Manku B
- Mann Harvinder S
- Manrique E
- Manso I
- Manson J
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- Manu N
- Maqueda GonzĂĄlez R
- Marafante C
- Marano A
- Marchbank Adrian
- MarcosâSantos P
- Marcus Hani J
- Mardare M
- Margalit A
- Mari G
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- Mariani NM
- MarieâMacron L
- Marinello P
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- Marino M
- Marino MV
- Markaryan D
- Markovic I
- Markovic V
- Marques R
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- Marqueta De Salas M
- Marra AA
- Marra E
- Marreiro A
- Marson Ella J
- Marte G
- Martel A
- Martin E
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- Martin Janet
- Martin ST
- Martinek L
- Martinez German A
- Martins dos Santos G
- Martins JordĂŁo D
- Martins A
- Martins D
- Martins R
- MartinâPerez B
- MartinâPerez E
- MartĂn Anoro LF
- MartĂn L
- MartĂnez Chicote C
- MartĂnezâHurtado E
- MartĂnezâPinedo C
- MartĂnezâPĂ©rez P
- MartĂnâArĂ©valo J
- Marx W
- Marzi F
- Marçal A
- MarĂn H
- Masciandaro A
- Mashat A
- Mashbari Hassan N
- Massey LH
- Massie E
- Massobrio A
- Mastoridis S
- Math S
- Mathew S
- MatiÄ S
- Matos Costa P
- Matute M
- Maté Mate P
- MatĂasâGarcĂa B
- Maw A
- Mazingi Dennis
- Mazzotta E
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- McAleer J
- McAree B
- McCanny A
- Mccluney S
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- McElhinney K
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- McIlmunn C
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- McIntyre J
- McKay Siobhan
- Mckay Siobhan C
- McKevitt K
- McLean Kenneth A
- McNaught C
- McNeill Alan
- McNicol F
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- Mehigan BJ
- Mehraj A
- Meimaâvan Praag EM
- Mekhael M
- MelchorâRuan J
- Melenhorst J
- Melhem S
- Memon AS
- Memos N
- Mendes F
- Mendes JR
- MendozaâMoreno F
- Meneghini S
- Mercado MĂ
- Merdrignac A
- Merh R
- Meriç S
- Messner F
- Metallidis Symeon
- Metwalli M
- Metzger J
- Michalopoulos N
- Michalski C
- Michel M
- Micic D
- Migliore M
- Mignot G
- Miguel T
- Mihanovic J
- Mihmanli M
- Miladinov M
- MilanoviÄ M
- Milic LJ
- Mills Emily C
- Mills SJ
- Milne K
- Minaya Bravo AM
- MinayaâBravo Ana
- MinayaâBravo Ana
- MinayaâBravo Ana
- Mingoli A
- Minicozzi A
- Minto G
- Mir I
- Mirabella A
- Miranda P
- Mirica RM
- Mirnezami R
- Mishra N
- Mishra S
- Mishra T
- Misra S
- Mitchell D
- Mitchell S
- Mithany R
- Mitra JK
- Mitrofan C
- Mittal R
- Mittal Rohin
- Miu V
- Mochet S
- Modolo Maria Marta
- Modolo Maria Marta
- Moftah M
- Moggia E
- Mohamed Sidek AS
- Mohammad Z
- Mohammed MM
- MohammedJibreel M
- Mohan H
- Mohan Helen M
- Mohan Helen M
- Mohd Azman ZA
- Mohd Yunus MF
- Mohsine R
- Mongelli F
- Montauban P
- Montelatici M
- Monteleone M
- Montella MT
- Montori G
- Montuori M
- Moore Rachel
- Moorthy M
- Morais H
- Moras L
- MoraâGuzmĂĄn I
- Morelli L
- Moretto G
- Morgan R
- Moritani K
- MoroâValdezate D
- Morris A
- Morsi A
- Mosley F
- Moss J
- Moszkowicz David
- Moug S
- Moug Susan
- Moug Susan
- Moura F
- Mourad M
- Mshelbwala P
- Msherghi A
- Mudawi I
- Muduly D
- Muguerza JM
- Muiesan P
- Mukherjee S
- Muller B
- Mulligan CS
- Mungo S
- Muratore A
- Murawa D
- Murgese A
- Murphy C
- Musetti S
- Mustafa A
- Mutter D
- Muzamil J
- Muñoz Camarena JM
- MuñozâAtienza V
- MuñozâBellvis L
- Naar L
- Nacif L
- Nafees Ahmed R
- Nageh MA
- Nahm C
- Najarian M
- Nally D
- Namazov Ä°
- Nankivell Paul
- Narahari Krishna
- Nassa H
- Nassif M
- Natale J
- Naumann D
- Navaratne L
- Nazir S
- Neary P
- Neary PM
- Neely D
- Negoi I
- Negoi Ionut
- Negoita VM
- Nel D
- Nelli T
- Nepogodiev Dmitri
- Nepogodiev Dmitri
- Neri J
- Nespoli LC
- Nessim C
- Neville Iuri
- Newman S
- Newman T
- Newton C
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- Ng HJ
- Ng Joe
- Ng S
- Ng V
- Ng V
- Ngo CW
- NgâKamstra Joshua S
- NicolĂĄsâLĂłpez T
- Nikaj H
- Nikolaou S
- Nikolic S
- Niquen Milagros
- Nisar P
- Nitschke C
- Nogueira O
- Nogueiro J
- Nogués A
- Noiret B
- Nolan GJ
- Norcini C
- Nordberg M
- Notte F
- Nouh T
- Novello S
- Novikova A
- Nowak K
- Ntirenganya Faustin
- Nugent E
- Nunes Coelho M
- Nunes R
- NunezâGarcia B
- NunooâMensah JW
- Nuñez Del Barrio H
- Nwabuoku SE
- NĂșñez J
- Obeidat K
- Ocaña J
- OchagavĂa S
- Oguttu B
- Okafor B
- Okunlola A
- Olaogun J
- Olasehinde O
- Oldfield F
- Oliva Mompean F
- Oliveira A
- Olivier J
- Olivieri M
- Olivos Maricarmen
- Olori S
- Olson KA
- Olute A
- Omar W
- Omeroglu S
- Ong SL
- Onos L
- Oosterlinck W
- Oosterling S
- Opocher E
- Ortega VĂĄzquez I
- Ortiz de SolĂłrzano Aurusa FJ
- Ortiz LĂłpez D
- Osagie O
- Oseira A
- Osman N
- Osorio Ramos A
- Otero A
- Otoniel LR
- Oussama Kacimi
- Outani Oumaima
- Ovejero Merino E
- Owen H
- Owens P
- Oyende O
- Ozben V
- Ozcelık MF
- Ozgediz D
- Ozmen BB
- OâBrien H
- OâBrien S
- OâDonnell S
- OâMalley S
- OâRiordan J
- OâShea M
- P Delrio
- Pacheco SĂĄnchez D
- PadillaâValverde D
- Padmore G
- Pagano G
- Pajan H
- Palagi S
- Palma P
- Palmeri M
- Panahi P
- Pandey D
- Paniagua GarcĂa Señorans M
- Papaconstantinou I
- Papadopoulos V
- Papagni V
- Papatheodorou P
- Paquette N
- Parasyris S
- Pareek P
- Pareja Rene
- Parello A
- Parente A
- Parini S
- Parise P
- Park J
- Parkin E
- Parkins K
- Parlanti D
- Parmar C
- Parra Baños PA
- Parray FQ
- Parreira R
- ParreñoâSacdalan Marie Dione
- ParreñoâSacdalan Marie Dione
- Parseliunas A
- Parwaiz I
- Pasini F
- Paspaliari D
- Pata Francesco
- Pata Francesco
- Pata Francesco
- Patel Akshay
- Patel K
- Patel M
- Patel P
- Patil S
- Patrone R
- PatrĂcio B
- Pattyn P
- Pattyn P
- Pavlov M
- Pedrazzani C
- Pedro J
- Pedro V
- Peirce C
- Pejnovic L
- Pejovic I
- Pellegrino L
- Pellino G
- Pellino Gianluca
- Peluso C
- Penumadu P
- Pera R
- Peralta Ferreira M
- Pereca J
- Pereira Rodrigues A
- Pereira A
- Pereira C
- Pereira I
- Pereira R
- Perez Gonzalez M
- Perez D
- Pergolini I
- Perivoliotis K
- Peros G
- Perotto LO
- Perra T
- Perrone G
- Persad A
- Persiani R
- Pertile D
- Peteja M
- Petrillo A
- Peyroteo M
- Pezzuto AP
- Peña Ros E
- Peña Soria MJ
- Pham H
- Phan D
- Phang PT
- Phillips E
- Picardo AL
- Picciariello A
- Picciochi Maria
- Pickett L
- PicĂłn RodrĂguez R
- Pieniowski E
- Piessen G
- Pina S
- Pinilla Morales RE
- Pinkney Thomas D
- Pinotti E
- Pinto J
- Pipara A
- Piper Rory J
- Pipitone Federico NS
- Pirozzolo G
- Pirzada A
- Pisani Ceretti A
- Pisanu A
- Pius Ogolekwu I
- PlaâMarti V
- Pockney P
- Pockney Peter
- Pockney Peter
- Pockney Peter
- Podda M
- Poeze M
- Poggioli G
- Police A
- Polydorou A
- PolâFachin L
- Ponchietti L
- Popoola AA
- Porcu A
- Portinari M
- PosadasâTrujillo OE
- PosmaâBouman L
- Potter R
- Pourcher G
- Powell S
- Pozotou I
- Praetorius C
- Pramesh CS
- Prando D
- Presl J
- Price C
- Price Stephen J
- Prieto Calvo M
- Prieto Nieto MI
- Pronk AJM
- Prosperi P
- Provozina A
- Pruvot FR
- Pujari R
- Pujol Cano N
- PĂ©rez SĂĄnchez MA
- PĂ©rezâSaborido B
- Qadan M
- Qasem A
- Qatora MS
- Quante M
- Quintana Martinic M
- QuirogaâValcĂĄrcel A
- Qureshi Ahmad
- Qureshi AU
- RabyâSmith W
- Radenkovic Dejan
- Raggio E
- Rai L
- Rajan S
- Rajaretnam N
- Rakvin I
- Ramachandran A
- Ramalho de Almeida F
- Ramamoorthy R
- Ramasamy S
- Ramcharan S
- Ramesh P
- Ramirez Faraco M
- Ramirez Romero P
- Ramos Bonilla A
- Ramos D
- RamosâDe la Medina Antonio
- RamosâMartĂn P
- Ramwell A
- Rao S
- Rapaport S
- Rashid A
- Rashid MM
- Rasoaherinomenjanahary F
- Rattizzato S
- Ratto C
- Raval M
- Ravindrakumar S
- Ravindran S
- Rayamajhi S
- Raymond T
- Razafindrahita JB
- Recordare A
- Reddy P
- Redfern J
- Refky B
- Rega D
- Rega D
- Regina de Sampaio L
- Reilly J
- Reim D
- Reinhard T
- Revez T
- Rey Ferro M
- Rey Valcarcel C
- Reynolds IS
- Ribeiro A
- Ribeiro CG
- Ribeiro R
- Ribolla M
- Rice D
- Richards S
- Richards T
- Richards Toby
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- Publication venue
- 'Wiley'
- Publication date
- 01/01/2022
- Field of study
AimThe SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery.MethodsThis was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4âweeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin.ResultsOverall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4âweeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, PÂ =Â 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, PâConclusionOne in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease
New insights into the genetic etiology of Alzheimerâs disease and related dementias
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- Aaltonen L.
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- Xuan Liu
- Yanbing Wang
- Yanek L.
- Yang Q.
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- Yannakoulia M.
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- Yasaman Saba
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- Yeunjoo E Song
- Yi Zhao
- Ying Wu
- Yoav Ben-Shlomo
- Yogen Patel
- Younkin S. G.
- Yu C. -E.
- Yu L.
- Yuanchao Zhang
- Yuk Yee Leung
- Yunfeng Huang
- Yunju Yang
- Zare H.
- Zdenka Pausova
- Zhang X.
- Zhang Y.
- Zhao Y.
- Zhao Y.
- Zhou W.
- Zhu C.
- Zhu X.
- Ziemann A.
- Zoia C. P.
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- Zulaica M.
- Zulma Sevillano
- Ălvarez V.
- Ă sa Hedman
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimerâs disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/âproxyâ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele
New insights into the genetic etiology of Alzheimerâs disease and related dementias
- Author
- Aaltonen Lauri
- Aaltonen Vesa
- Aarsland Dag
- Aavikko Mervi
- Abalos Mariana Sanchez
- Abdelnour Carla
- Abner Erin
- Abraham Richard
- Adams Hieab
- Adams Perrie M.
- Adarmes-GĂłmez Ad
- Adarmes-GĂłmez Astrid D.
- Aguilera Nuria
- Aguilera Nuria
- Aguirre Alyssa
- Ahmad Shahzad
- Akinyemi Rufus O.
- Al-Chalabi Ammar
- AlarcĂłn-MartĂn Emilio
- Albert Marilyn S.
- Albin Roger L.
- Alcolea Daniel
- Alegret Montserrat
- Ali Muhammad
- Allen Mariet
- Allende Irene Rosas
- Alonso MarĂa Dolores
- Alonso MarĂa Dolores
- Alvarez Ignacio
- Alvarez Lisa
- Amer-Ferrer Guillermo
- Amin Najaf
- Amouyel Philippe
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Andreassen Ole A.
- Andreoni Simona
- Antequera Martirio
- Antikainen Riitta
- Antonell Anna
- Anttonen Vuokko
- AntĂșnez Carmen
- Aparicio Hugo J.
- Apostolova Liana G.
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Armstrong Nicola
- Armstrong Nicola J.
- Arnold Steven E.
- Arosio Beatrice
- Arvas Mikko
- Assogna Francesca
- Asthana Sanjay
- Athanasiu Lavinia
- Atwood Craig S.
- Auge Franck
- Auranen Annika
- Auvinen PĂ€ivi
- Awaisa Ghazal
- Ayres Gayle
- Bacha Juan Ignacio
- Bahadori Maryam
- Bahrami Shahram
- Bailly Henri
- Baldwin Clinton T.
- Banaj Nerisa
- Baquero Miquel
- Barber Robert C.
- Barnes Lisa L.
- Barral Sandra
- Barral Sandra
- Bass Nicholas J.
- Bass Nick
- Bastiani Patrizia
- Bayer Anthony
- Beach Thomas G.
- Becker James T.
- Becker James T.
- Becker Tim
- Beecham Gary W.
- Beekly Duane
- Behrens Tim
- Beiser Alexa
- Belezhanska Diyana
- Bellenguez CĂ©line
- Below Jennifer E.
- Below Jennifer E.
- Ben-Shlomo Yoav
- Benchek Penelope
- Benchek Penelope
- Benitez Bruno A.
- Bennett David
- Benussi Alberto
- Benussi Luisa
- Bergh Sverre
- Bernardo-Harrington Mateus
- Berr Claudine
- Bertelson John
- Besse CĂ©line
- Bessi Valentina
- Betts Jo
- Bhangale Tushar
- Biessels Geert Jan
- Binetti Giuliano
- Bing Nan
- Bird Thomas D.
- Bis Joshua C.
- Biswas Shameek
- Bizarro Alessandra
- Bjerke Maria
- Blacker Deborah
- Blesa Rafael
- Blomster Timo
- Boada MercĂš
- Boecker Henning
- Boerwinkle Eric
- Boeve Bradley F.
- Boland Anne
- Borroni Barbara
- Boschi Silvia
- Bosnes Ingunn
- BossĂč Paola
- Bowen James D.
- Bowers Natalie
- Boxer Adam
- Brauer Matt
- Brayne Carol
- Brein Georg
- Bresner Catherine
- Bressler Jan
- Breteler Monique
- Brewer James
- Brice Alexis
- Brodaty Henry
- Broeckhoven Christine Van
- Bronson Paola
- Brookes KJ
- Brown Kristelle
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- Brusco Luis Ignacio
- BrÄthen Geir
- Buendia Mar
- Buiza-Rueda Dolores
- Bullido MarĂa J.
- Burguera Juan Andrés
- Burholt Vanessa
- Burke James R.
- Burns Jeffrey M.
- Bush Will S.
- Bush William S.
- Buxbaum Joseph D.
- Bûrger Katharina
- Cairns Nigel J.
- Calero Miguel
- Caliskan Minal
- Call Katherine
- Call Kathy
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- Campos-Martin Rafael
- Cano Amanda
- Cantwell Laura B.
- Cao Chuanhai
- Carlson Christopher S.
- Carlsson Cynthia M.
- Carney Regina M.
- Carpén Olli
- Carracedo Ăngel
- Carrasquillo Minerva M.
- Carrillo F.
- Carrillo FĂĄtima
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- CarriĂłn-Claro Mario
- Casajeros MarĂa JosĂ©
- Castaño Eduardo M.
- Cañabate Pilar
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- Cecchetti Roberta
- Cervera-Carles Laura
- Challis Ben
- Chang Diana
- Chapuis Julien
- Charbonnier Camille
- Chasman Daniel
- Chasse Scott
- Chatelain Clement
- Chauhan Ganesh
- Chen Chia-Yen
- Chen Hao
- Chen Hubert
- Chen Hung-Hsin
- Chen Xing
- Chene GeneviĂšve
- Chesi Alessandra
- Chesselet Marie-Francoise
- Chhibber Aparna
- Chillotti Caterina
- Chin Nathaniel A.
- Chipi Elena
- Choy David
- Chu Audrey
- Chui Helena C.
- Chung Jaeyoon
- Chung Jaeyoon
- Ciccone Simona
- Ciullo Valentina
- Claassen Jurgen A. H. R.
- Clarimon Jordi
- Clark Christopher
- Clarke Robert
- Close David
- Collinge John
- Comic Hata
- Conti Elisa
- Cores Valeria
- Corma-GĂłmez AnaĂŻs
- Costa Marcos R.
- Costantini Emanuele
- Cox Simon
- Craft Suzanne
- Craig David
- Crane Paul K.
- Cribbs David H.
- Crocco Elizabeth A.
- Crohns Marika
- Cruchaga Carlos
- Cuccaro Michael L.
- Cuccaro Michael L.
- Cuesta Carolina
- Cullum Munro
- Cummings Beryl
- Cupples Adrienne L.
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Daly Mark
- Damotte Vincent
- Daniele Antonio
- Darby Eveleen
- Dardiotis Efthimios
- Dartigues Jean-François
- Davies Chloe
- Davies Gail
- Davis Barbara
- Davis Justin Wade
- de Deyn Peter Paul
- De Jager Philip L.
- de Mendonça Alexandre
- de Munain Adolfo Lopez
- de Paiva Lopes Katia
- de Rojas Itziar
- de Witte Lot D.
- Debette Stéphanie
- DeCarli Charles
- DeCarli Charles S.
- Deckert JĂŒrgen
- del Ser Teodoro
- Deleuze Jean-François
- della Briotta Parola Pietro
- della Briotta Parolo Pietro
- Deloukas Panagiotis
- Deloukas Pangiotis
- Denning Nicola
- Deramecourt Vincent
- Deramerourt Vincent
- DeStefano Anita
- DeToledo John
- Dichgans Martin
- Dick Malcolm
- Dickson Dennis W.
- Diego Susana
- Diehl-Schmid Janine
- Diez-Fairen MĂłnica
- Diogo Dorothee
- Djurovic Srdjan
- Dombroski Beth A.
- Dongen Jasper Van
- Donner Kati
- Doody Rachelle S.
- Dowzell Kimberley
- Drichel Dmitriy
- Duara Ranjan
- Dubois Bruno
- Dufouil Carole
- Duperron Marie-Gabrielle
- Dupuis Josée
- Duron Emmanuelle
- DĂŒzel Emrah
- Eaton Susan
- Ehm Meg
- Eicher John
- Eiriksdottir Gudny
- Eklund Kari
- Elenius Klaus
- Elliott Amanda
- Engelborghs Sebastiaan
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- Vonsattel Jean-Paul
- Voutilainen Markku
- Vyhnalek Martin
- Wadhawan Samir
- Wagner Michael
- Wallon David
- Wang Clarence
- Wang Li-San
- Wang Ruiqi
- Wang Yanbing
- Warden Donald
- Waring Jeff
- Waring Jeffrey
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- Waterworth Dawn
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- Weinhold Leonie
- Weinstein Galit
- Weintraub Sandra
- Welsh-Bohmer Kathleen A.
- Whelan Christopher
- Whitehead Patrice L.
- Wichmann H-Erich
- Wigmore Eleonor
- Wijsman Ellen M.
- Wilcock Gordon
- Wilhelmsen Kirk C.
- Williams Amy
- Williams Benjamin
- Williams Dylan
- Williams Julie
- Williamson Jennifer
- Wilms Henrik
- Wiltfang Jens
- Windle Gill
- Wingo Thomas S.
- Wisniewski Thomas
- Wittfeld Katharina
- Woltjer Randall L.
- Wong Regis
- Woods Bob
- Woon Martin
- Wright Clinton B.
- Wu Chuang-Kuo
- Wu Ying
- Xia Tai-he
- Xu Ethan
- Xu Fanli
- Yanek Lisa
- Yang Qiong
- Yang Yunju
- Yannakoulia Mary
- Yaqub Amber
- Younkin Steven G.
- Yu Chang-En
- Yu Lei
- Zare Habil
- Zhang Xiaoling
- Zhang Yuanchao
- Zhao Yi
- Zhao Yi
- Zhou Wei
- Zhu Congcong
- Zhu Xiongwei
- Ziemann Adam
- Zoia Chiara Paola
- Zompo Maria Del
- Zulaica Miren
- Ălvarez Victoria
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2022
- Field of study
Characterization of the genetic landscape of Alzheimerâs disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/âproxyâ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele