Optimisation of adaptive localisation techniques for cognitive radio

Spectrum, environment and location awareness are key characteristics of cognitive radio (CR). Knowledge of a user’s location as well as the surrounding environment type may enhance various CR tasks, such as spectrum sensing, dynamic channel allocation and interference management. This dissertation deals with the optimisation of adaptive localisation techniques for CR. The first part entails the development and evaluation of an efficient bandwidth determination (BD) model, which is a key component of the cognitive positioning system. This bandwidth efficiency is achieved using the Cramer-Rao lower bound derivations for a single-input-multiple-output (SIMO) antenna scheme. The performances of the single-input-single-output (SISO) and SIMO BD models are compared using three different generalised environmental models, viz. rural, urban and suburban areas. In the case of all three scenarios, the results reveal a marked improvement in the bandwidth efficiency for a SIMO antenna positioning scheme, especially for the 1×3 urban case, where a 62% root mean square error (RMSE) improvement over the SISO system is observed. The second part of the dissertation involves the presentation of a multiband time-of arrival (TOA) positioning technique for CR. The RMSE positional accuracy is evaluated using a fixed and dynamic bandwidth availability model. In the case of the fixed bandwidth availability model, the multiband TOA positioning model is initially evaluated using the two-step maximum-likelihood (TSML) location estimation algorithm for a scenario where line-of-sight represents the dominant signal path. Thereafter, a more realistic dynamic bandwidth availability model has been proposed, which is based on data obtained from an ultra-high frequency spectrum occupancy measurement campaign. The RMSE performance is then verified using the non-linear least squares, linear least squares and TSML location estimation techniques, using five different bandwidths. The proposed multiband positioning model performs well in poor signal-to-noise ratio conditions (-10 dB to 0 dB) when compared to a single band TOA system. These results indicate the advantage of opportunistic TOA location estimation in a CR environment.Dissertation (MEng)--University of Pretoria, 2012.Electrical, Electronic and Computer Engineeringunrestricte

A Comparative Study Between Pneumatic and Laser Lithotripsy for Proximal Ureteric Calculus

Introduction: There are various modalities of breaking urinary tract calculus. The aim of this study was to compare outcome between laser and pneumatic lithotripsy in patients with upper ureteric calculus in terms of stone free rate, proximal migration and complication. Methods: This was a prospective comparative study done in 210 patients with upper ureteric calculus. The patients were randomized into two groups (Laser Lithotripsy and Pneumatic Lithotripsy) from April 2018 to June 2019. The main objective of both the procedures was to break stone into particles less than 3 mm which was confirmed by X-ray KUB and ultrasonography of abdomen and pelvis after six weeks and to compare effectiveness in terms of immediate stone free rate, proximal migration, operative duration and post-operative complication. Results: There was no difference in age, gender and stone size in both groups. Immediate stone free rate was 99.05% in Laser Lithotripsy and 76.19% in Pneumatic Lithotripsy (p value<0.001). Proximal migration in Laser Lithotripsy was 0.95% and 23.81% in Pneumatic Lithotripsy (p<0.001). There was significantly prolonged operative duration in Pneumatic Lithotripsy (14.7±4.77 min vs 13.31±3.24 in Laser Lithotripsy, p=0.014). Complications were more in Pneumatic Lithotripsy group, which was statistically significant (p=0.017). Conclusion: Both pneumatic and laser lithotripsy are effective and safe modalities for treating upper ureteric calculus, however laser has less chances of proximal migration and higher immediate stone free rate with less complicatio

Sparse Spatial Smoothing: Reduced Complexity and Improved Beamforming Gain via Sparse Sub-Arrays

This paper addresses the problem of single snapshot Direction-of-Arrival (DOA) estimation, which is of great importance in a wide-range of applications including automotive radar. A popular approach to achieving high angular resolution when only one temporal snapshot is available is via subspace methods using spatial smoothing. This involves leveraging spatial shift-invariance in the antenna array geometry, typically a uniform linear array (ULA), to rearrange the single snapshot measurement vector into a spatially smoothed matrix that reveals the signal subspace of interest. However, conventional approaches using spatially shifted ULA sub-arrays can lead to a prohibitively high computational complexity due to the large dimensions of the resulting spatially smoothed matrix. Hence, we propose to instead employ judiciously designed sparse sub-arrays, such as nested arrays, to reduce the computational complexity of spatial smoothing while retaining the aperture and identifiability of conventional ULA-based approaches. Interestingly, this idea also suggests a novel beamforming method which linearly combines multiple spatially smoothed matrices corresponding to different sets of shifts of the sparse (nested) sub-array. This so-called shift-domain beamforming method is demonstrated to boost the effective SNR, and thereby resolution, in a desired angular region of interest, enabling single snapshot low-complexity DOA estimation with identifiability guarantees.Comment: \copyright 2024 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other work

A practical feasibility study of a novel strategy for the Gaussian half-duplex relay channel

This paper presents a practical feasibility study of a novel two-phase three-part-message strategy for half-duplex relaying, which features superposition coding and interference-aware cancellation decoding. Aiming to analyze the performance of the proposed scheme in the non-asymptotic regime, this paper evaluates the spectral efficiency with finite block-length and discrete constellation signaling and compares it with the theoretical performance of Gaussian codes with asymptotically large block-lengths. The performance evaluation is carried out on an LTE simulation test bench. During each transmission phase, the modulation and coding scheme is adapted to the channel link qualities to enhance the overall spectral efficiency. A single-antenna source and relay, and a multi-antenna destination are assumed. The static Gaussian and two frequency selective channel models are considered for the proposed scheme. A spectral efficiency comparison with a baseline scheme (non-cooperative two-hop transmission, i.e., the source-destination link is absent) and with the point-to-point transmission strategy (no relay) is presented. The results confirm that physical-layer cooperation and multi-antennas are critical for performance enhancement in heterogeneous networks. Moreover, they show that physical layer cooperation advantages are within practical reach with existing LTE coded-modulation and interference-mitigation techniques, which are prevalent in modern user-equipment.This paper was presented at the 2015 IEEE International Conference on Communications.This work was supported in part by the Eurecom’s Industrial Partners: BMW Group Research & Technology, IABG, Monaco Telecom, Orange, SAP, ST Microelectronics, and Symantec. It was also partially funded by the EU Celtic+ Framework Program Project SHARING. Other partially funded sources include the National Research Foundation (NRF) in South Africa and the National Science Foundation. The work of R. R. Thomas was supported in part by NRF under Grant 89803, and in part by the National Research Foundation (NRF) in South Africa. The work of M. Cardone was supported by NSF under Grant 1314937 and Grant 1514531. The work of D. Tuninetti was supported by NSF under Award 1218635.http://ieeexplore.ieee.org/xpl/RecentIssue.jsp?punumber=7742hj2018Electrical, Electronic and Computer Engineerin

Early detection of soluble CD27, BTLA, and TIM-3 predicts the development of nosocomial infection in pediatric burn patients

Thermal injury induces concurrent inflammatory and immune dysfunction, which is associated with adverse clinical outcomes. However, these effects in the pediatric population are less studied and there is no standard method to identify those at risk for developing infections. Our goal was to better understand immune dysfunction and identify soluble protein markers following pediatric thermal injury. Further we wanted to determine which early inflammatory, soluble, or immune function markers are most predictive of the development of nosocomial infections (NI) after burn injury. We performed a prospective observational study at a single American Burn Association-verified Pediatric Burn Center. A total of 94 pediatric burn subjects were enrolled and twenty-three of those subjects developed a NI with a median time to diagnosis of 8 days. Whole blood samples, collected within the first 72 hours after injury, were used to compare various markers of inflammation, immune function, and soluble proteins between those who recovered without developing an infection and those who developed a NI after burn injury. Within the first three days of burn injury, innate and adaptive immune function markers (ex vivo lipopolysaccharide-induced tumor necrosis factor alpha production capacity, and ex vivo phytohemagglutinin-induced interleukin-10 production capacity, respectively) were decreased for those subjects who developed a subsequent NI. Further analysis of soluble protein targets associated with these pathways displayed significant increases in soluble CD27, BTLA, and TIM-3 for those who developed a NI. Our findings indicate that suppression of both the innate and adaptive immune function occurs concurrently within the first 72 hours following pediatric thermal injury. At the same time, subjects who developed NI have increased soluble protein biomarkers. Soluble CD27, BTLA, and TIM-3 were highly predictive of the development of subsequent infectious complications. This study identifies early soluble protein makers that are predictive of infection in pediatric burn subjects. These findings should inform future immunomodulatory therapeutic studies

Upregulation of the Oct3/4 network in basal breast cancer is associated with its metastatic potential and shows tissue dependent variability

Adaptive plasticity of Breast Cancer stem cells (BCSCs) is strongly correlated with cancer progression and resistance, leading to a poor prognosis. In this study, we report the expression profile of several pioneer transcription factors of th

Gender Differences in Russian Colour Naming

In the present study we explored Russian colour naming in a web-based psycholinguistic experiment (http://www.colournaming.com). Colour singletons representing the Munsell Color Solid (N=600 in total) were presented on a computer monitor and named using an unconstrained colour-naming method. Respondents were Russian speakers (N=713). For gender-split equal-size samples (NF=333, NM=333) we estimated and compared (i) location of centroids of 12 Russian basic colour terms (BCTs); (ii) the number of words in colour descriptors; (iii) occurrences of BCTs most frequent non-BCTs. We found a close correspondence between females’ and males’ BCT centroids. Among individual BCTs, the highest inter-gender agreement was for seryj ‘grey’ and goluboj ‘light blue’, while the lowest was for sinij ‘dark blue’ and krasnyj ‘red’. Females revealed a significantly richer repertory of distinct colour descriptors, with great variety of monolexemic non-BCTs and “fancy” colour names; in comparison, males offered relatively more BCTs or their compounds. Along with these measures, we gauged denotata of most frequent CTs, reflected by linguistic segmentation of colour space, by employing a synthetic observer trained by gender-specific responses. This psycholinguistic representation revealed females’ more refined linguistic segmentation, compared to males, with higher linguistic density predominantly along the redgreen axis of colour space

Unprecedented inequivalent metal coordination environments in a mixed-ligand dicobalt complex

Bimetallic complexes of the transition metals containing mixed diimine and dithiolate ligands are of fundamental interest on account of their intriguing electronic properties. Almost always, such complexes are isolated as species in which both the metal centers are in identical coordination environments - this means that the two metals often have identical redox properties. In contrast, mixed-diimine/dithiolate bimetallic complexes of the first row transition metals where the two metals are in dissimilar coordination environments are exceedingly rare, and are only known for nickel. Herein, we report the first ever example of a mixed-diimine/dithiolate dicobalt complex where the two cobalt centers are in different coordination environments. The synthesis of this compound is straightforward, and produces a complex in which the two cobalt centers display very different redox properties

The immunopeptidome from a genomic perspective:Establishing the noncanonical landscape of MHC class I–associated peptides

G.B., D.B., K.W., A.P., R.F., T.R.H., S.K., and J.A.A. received support from Fundacja na rzecz Nauki Polskiej (FNP) (grant ID: MAB/3/2017). D.R.G. received support from Genome Canada & Genome BC (grant ID: 264PRO). D.J.H. received support from NuCana plc (grant ID: SMD0-ZIUN05). H.A. received support from Swedish Cancer Foundation (grant ID: 211709). H.G. received support from United Kingdom Research and Innovation (UKRI) (grant ID: EP/S02431X/1). C.P. received support from Fundação para a Ciência e a Tecnologia (FCT) through LASIGE Research Unit (grant ID: UIDB/00408/2020 and UIDP/00408/2020). A.L. F.M.Z., C.P., A.R., A.P., and J.A.A. received support from European Union’s Horizon 2020 research and innovation programme (grant ID: 101017453). C.B. received support from Agence Nationale de la Recherche (ANR) through GRAL LabEX (grant ID: ANR-10-LABX-49-01) and CBH-EUR-GS 32 (grant ID: ANR-17-EURE0003). S.N.S. received support from Cancer Research UK (CRUK) and the Chief Scientist's Office of Scotland (CSO): Experimental Cancer Medicine Centre (ECMC) (grant ID: ECMCQQR-2022/100017). A.L. received support from Chief Scientist's Office of Scotland (CSO) NRS Career Researcher Fellowship. R.O.N. received support from CRUK Cambridge Centre Thoracic Cancer Programme (grant ID: CTRQQR-2021\100012).Tumor antigens can emerge through multiple mechanisms, including translation of non-coding genomic regions. This non-canonical category of antigens has recently gained attention; however, our understanding of how they recur within and between cancer types is still in its infancy. Therefore, we developed a proteogenomic pipeline based on deep learning de novo mass spectrometry to enable the discovery of non-canonical MHC-associated peptides (ncMAPs) from non-coding regions. Considering that the emergence of tumor antigens can also involve post-translational modifications, we included an open search component in our pipeline. Leveraging the wealth of mass spectrometry-based immunopeptidomics, we analyzed 26 MHC class I immunopeptidomic studies of 9 different cancer types. We validated the de novo identified ncMAPs, along with the most abundant post-translational modifications, using spectral matching and controlled their false discovery rate (FDR) to 1%. Interestingly, the non-canonical presentation appeared to be 5 times enriched for the A03 HLA supertype, with a projected population coverage of 54.85%. Here, we reveal an atlas of 8,601 ncMAPs with varying levels of cancer selectivity and suggest 17 cancer-selective ncMAPs as attractive targets according to a stringent cutoff. In summary, the combination of the open-source pipeline and the atlas of ncMAPs reported herein could facilitate the identification and screening of ncMAPs as targeting agents for T-cell therapies or vaccine development.Publisher PDFPeer reviewe