6 research outputs found
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado Héctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
- Al-Touny Shimaa A.
- Aladawi Omar
- Aladna Abdallah
- Alali Mahmoud
- Alam Mahmood
- Alam Mohammed Shadrul
- Alarabi Rehab
- Alawneh Yazan
- Alayande Barnabas
- Albanese Erminia
- Albayadi Eslam
- Albdour Maram
- Alconchel Felipe
- Alderazi Amer
- Alegbeleye Bamidele
- Alekberli Tural
- Alemu Misganaw Alemu Adimass
- Alexander Philip
- Alfieri Alex
- Algahtany Khaled
- Algarni Kamal
- Alhamad Ameen
- Alhamid Mohammad
- Alharmi Rawan A. Rahman
- Alharthi Mohammed
- Alhazmi Barrag
- Ali Mohamed Shafi Mahboob
- Ali Stephen
- Alibrahim Hidar
- Aljaaly Hattan
- Aljaiuossi Anas
- Aljanadi Firas
- Aljiffry Murad
- Aljirdabi Noof
- Alkahlan Mohammed
- Alkhalifa Elmustafa
- Alkhatib Sondos
- Alkhatieb Maram
- Allan Anna
- Almarshad Felwa
- Almgla Naser
- Almhimid Ali
- Almiqlash Bushray
- Almoshantaf Mohammad Badr
- Almutairi Abdulmjeed
- Alnsour Abed Alfattah Mahmoud
- Alobied Majd
- Alomar Osama
- Alonso Jesús Aarón Martínez
- Alonso Manuel Diez
- Alonso Nestor Fabian Pedraza
- Alonso Veronica
- Alqallaf Abdullah
- Alqaseer Asma
- Alrayes Bourhan
- Alsefri Maryam
- Alser Osaid
- Alsharif Mohammed
- Alsori Mohamed
- Altaf Abdulmalik
- Altinel Yuksel
- Altiner Saygin
- Altouny Ahmad
- Altun Demet
- Alvarez Natalia
- Alvarez-Lozada Luis Adrian
- Alvi Abdul
- Alwael Athari
- Alwash Mohammed
- Alyami Ziyad
- Alyousef Mohammed
- Alzahrani Saud
- Alzerwi Nasser
- Amin Shivang
- Amir Mohammed
- Ammar Ahmed Siddique
- Ammendola Michele
- Amores Remedios Revilla
- Amrayev Sultan
- Anastasiadou Sofia
- Ancans Guntis
- Anderson Caroline
- Andreani Lorenzo
- Andreotti Dario
- Andreuccetti Jacopo
- Andrianakis Alexandros
- Andro Christophe
- Anesi Alexandre
- Angamuthu Stephen
- Angeles Martina Aida
- Angelico Roberta
- Angelis Fragkiskos
- Angelou Dimitrios
- Angelou Kyveli
- Angulo Victor Pinto
- Anjum Arfa
- Anjum Muhammad Ayyub
- Annicchiarico Alfredo
- Anoldo Pietro
- Ansaloni Luca
- Anthoulakis Christos
- Antonelli Amedeo
- Anwar Mohamed
- Anwar Sumadi Lukman
- Anwer Mariyah
- Anyanwu Lofty-John
- Apostolou Christos
- Apostolou Konstantinos
- Appiah-Kubi Adu
- Aprea Giovanni
- Arbab Hana
- Archer James
- Ardura Francisco
- Aremu Muyiwa
- Arif Tahera
- Arkani Samara
- Armatura Giulia
- Armijos Daniel
- Arnaout Ali
- Arnaoutoglou Eleni
- Arnaud Alexis P.
- Arneja Jugpal
- Arrangoiz Rodrigo
- Arshad Muhammad
- Arthur Joshua
- Ashcroft James
- Ashford Bruce
- Ashraf Fariha
- Asiimwe Daniel
- Asirifi Samuel Amoako
- Asla Amir
- Aslam Ramisha
- Aspide Raffaele
- Ataya Karim
- Ateca Ibabe Villalabeitia
- Atici Semra Demirli
- Atis Gokhan
- Atkins William
- Atkinson Kate
- Attwood Joseph
- Auerkari Aino
- Augestad Knut Magne
- Augustin Goran
- Aujayeb Avinash
- Avella Pasquale
- Awad Ahmed K.
- Awad Hadeel
- Awad Rabih
- Awad Selmy
- Ayad Kusay
- Ayana Birhanu
- Aydin Yener
- Ayeni Funbi
- Aytac Erman
- Azab Ahmed
- Azami Rizwan
- Azize Diallo Abdoul
- Azzam Ahmed Y.
- Azzis Olivier
- Baba Yabasin Iddrisu
- Babis George
- Bacalbasa Nicolae
- Badiani Sarit
- Badran Saif
- Baduell Albert
- Baeesa Saleh
- Baertschiger Reto
- Bafaquh Mohammed
- Bahassan Omar Mohammed
- Bahrami-Hessari Michael
- Baia Marco
- Baidoo Ebikela Ivie
- Bailey Karen
- Baili Efstratia
- Bains Lovenish
- Baiocchi Gian Luca
- Baiocchi Glauco
- Baiyewu Lateef Ayodele
- Bajaj Ankur
- Bajunaid Khalid
- Balagobi Balasingam
- Balasubramanian Ishwarya
- Balduzzi Alberto
- Baldwin Alexander
- Balla Andrea
- Balogh Zsolt J.
- Balogun James A.
- Balogun Simon
- Baloyiannis Ioannis
- Ban Vin Shen
- Bandyopadhyay Samik Kumar
- Bandyopadhyay Soham
- Banerjee Sumit
- Banipal Gurpreet Singh
- Banky Balazs
- Bannone Elisa
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- Barberis Andrea
- Barbosa-Breda Joao
- Bareka Metaxia
- Barišić Tatjana
- Barlas Aziz Mutlu
- Barlow Ciaran
- Barmayehvar Behrad
- Baroffio Paolo
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- Barra Fabio
- Barranquero Alberto G.
- Barugola Giuliano
- Basendowah Mohammed
- Bashir Mahmod
- Basnayake Oshan
- Bass Gary Alan
- Basu Somprakas
- Bateman Antony
- Bateman Kellie
- Batista Sylvia
- Batstone Martin
- Bauer Marlies
- Bauset Juan Carlos Catalá
- Bawa Ashvind
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- Bayhan Hüseyin
- Bayo Heura Llaquet
- Bazzi Nagham
- Beamish Andrew
- Beasley Nigel
- Beatty Jasmine Winter
- Becerra Angel
- Bedada Alemayehu Ginbo
- Bedzhanyan Arkady
- Begum Farzana
- Beisenov Bekzat
- Bellio Gabriele
- Bello Usman Mohammed
- Bellés Ana Ciscar
- Belzile Etienne
- Benamar Safia
- Bence Matthew
- Benshetrit Guy
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- Bergkvist David Julià
- Beristain-Hernandez Jose-Luis
- Bernante Paolo
- Bernardi Daniele
- Beron Reinaldo Isaacs
- Berselli Bruno
- Berselli Mattia
- Bertelli Giacomo
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- Beswick Daniel
- Bette Birgit
- Bezirci Rifat
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- Bharathan Rasiah
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- Bilfaqirah Majed
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- BİŞGİN TAYFUN
- Blair James
- Blanco Jose
- Blencowe Natalie
- Bloemers Frank
- Board Timothy
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- Bohmer Rob
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- Boisson Matthieu
- Boligo Sofia
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- Bondurri Andrea
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- Bonsaana Gilbert Batieka
- Booth L.
- Borg Elaine
- Borges Miguel Fróis
- Borges Nuno
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- Bowen Joel
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- Bramis Konstantinos
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- Bravo Sybil Lizanne
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- Bruzzaniti Placido
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- Cruz Ricardo Pedrini
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- Cullinane Carolyn
- Cullis Paul
- Cunha Miguel F.
- Cunningham Brian
- Currò Giuseppe
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- Cutmore Carina
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- Cáceres Freud
- D'Acapito Fabrizio
- D'Addino José Luis
- D'Amico Alessia
- D'Amore Anna
- D'Andrea Giancarlo
- D'Archi Sabatino
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- Dawson Jonathon
- Dbouk Samer
- De Alarcón Jaime Rodríguez
- De Andrés-Asenjo Beatriz
- De Bacco Marangon Gustavo
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- De Haro Joaquin
- De Jesus Labrador Hernandez Gregorio
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- Djedovic Gabriel
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- Dolci Giampiero
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- Dominguez-Rosado Ismael
- Don Cristine Pathirannehalage
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- Eiras Miguel Angel Freiria
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- Ekwen Gerald
- Ekwunife Okechukwu Hyginus
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- Elbadawy Merihan A.
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- Elnour Moheyaldien Ahmed Elamin
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- Ezenwa Ekene
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- Fahim Margo Medhat Fouad
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- Faponle Folayemi
- Farhan-Alanie Muhamed
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- Farooq Muhammad
- Fatima Mishal
- Fayad Elsayed A.
- Federer Simon
- Federico Nicoletta Sveva Pipitone
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- Gabr Abdullah
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- García Pablo Rodríguez
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- Giacometti Marco
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- Giuffrida Mario
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- Glass Nina
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- Gmati Aimen
- Goel Neha
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- Gollarte Ana Sánchez
- Gomez Eduardo Garcia-Loarte
- Gomez-Fernandez Hugo
- Gomez-Rosado Juan-Carlos
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- Gonzalez Lourdes Elorduy
- Gonzalez Luis Angel Suarez
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- González-Suárez Susana
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- Gosselink Martijn
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- Salem Moacyr
- Salisu Ibrahim
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- Strotmann Johanna Josefine
- Stroumpoulis Konstantinos
- Su Yu-Xiong
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- Subramani Yamini
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- Sue-Chue-Lam Colin
- Suer Muhammed Salih
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- Wheeler James
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- Wolde Amanuel
- Wolfenden John W. D.
- Wong Benjamin Ngie Xiong
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- Wong George Kwok Chu
- Wong Ho Ying Flora
- Wong Kai Yuen
- Wormald Justin
- Wright Deborah
- Wright Joshua
- Wu Fiona
- Wurm Markus
- Xenaki Sofia
- Yadev Ip
- Yahaya Ahmad Shuib
- Yakubu Mustapha
- Yang Wah
- Yanik Özge
- Yanowsky-Reyes Guillermo
- Yassin Abubaker
- Yates Elizabeth
- Yebes Alvaro
- Yenli Edwin Mwintiereh Ta-Ang
- Yeoh Tien
- Yeung Justin
- Yiallourou Anneza
- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- Zaránd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha Horácio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
An Adaptive Cross-Layer Admission Control Mechanism for Telemedicine Services over the IEEE 802.22/WRAN Standard
- Author
- Publication venue
- 'Institute of Electronics, Information and Communications Engineers (IEICE)'
- Publication date
- 01/01/2018
- Field of study
Estimation of quality of experience (QoE) in e-Health ecosystems
- Author
- Publication venue
- 'Universidad Nacional de Colombia'
- Publication date
- 01/05/2017
- Field of study
This article proposes a framework to design and implement e- Health interventions in a comprehensive manner. We draw on complexity science to study the interplay of the ecosystem, the behavior and interactions among its agents. We provide a platform to estimate the Quality of Experience (QoE) to assess the relationship between technology and human factors involved in e-Health projects. Our aim is to estimate QoE in e-Health ecosystems from the perspective of complexity by adopting a methodology that uses fuzzy logic to study the behavior of the ecosystem’s agents. We apply the proposed framework to a remote diagnosis case by means of an ultrasound probe through a satellite link. Despite the ambiguities for determining QoE, the experiment demonstrates the applicability of the framework and allows to stressing the importance of human factors in the implementation of e-Health projects
Estimation of quality of experience (QoE) in e-Health ecosystems
- Author
- Publication venue
- Publication date
- 01/01/2017
- Field of study
This article proposes a framework to design and implement e- Health interventions in a comprehensive manner. We draw on complexity science to study the interplay of the ecosystem, the behavior and interactions among its agents. We provide a platform to estimate the Quality of Experience (QoE) to assess the relationship between technology and human factors involved in e-Health projects. Our aim is to estimate QoE in e-Health ecosystems from the perspective of complexity by adopting a methodology that uses fuzzy logic to study the behavior of the ecosystem’s agents. We apply the proposed framework to a remote diagnosis case by means of an ultrasound probe through a satellite link. Despite the ambiguities for determining QoE, the experiment demonstrates the applicability of the framework and allows to stressing the importance of human factors in the implementation of e-Health projects.En este artículo se propone un marco de referencia para diseñar e implementar intervenciones de e-Salud de una manera integral. Recurrimos a la ciencia de la complejidad para estudiar la interacción de los agentes del ecosistema. Para ello, proporcionamos una plataforma para estimar la Calidad de Experiencia (o QoE, por sus siglas en inglés) para evaluar la relación entre la tecnología y los factores humanos que intervienen en los proyectos de e-Salud. Nuestro objetivo es estimar la QoE en los ecosistemas de e-Salud desde la perspectiva de la complejidad mediante la adopción de una metodología que utiliza la lógica difusa para estudiar el comportamiento de los agentes del ecosistema. Aplicamos el marco propuesto a un caso de diagnóstico remoto por medio de una sonda de ultrasonido a través de un enlace por satélite. A pesar de las ambigüedades involucradas en la determinación de calidad de la experiencia, el experimento demuestra la aplicabilidad del marco de referencia propuesto y permite subrayar la importancia de los factores humanos en la implementación de proyectos de e-Salud
PAM50 HER2-enriched subtype as an independent prognostic factor in early-stage HER2+ breast cancer following adjuvant chemotherapy plus trastuzumab in the ShortHER trial
- Author
- Balduzzi Sara
- Bisagni Giancarlo
- Brandes Alba Ariela
- Brasó Maristany Fara
- Cavanna Luigi
- Conte Pier Franco
- D'Amico Roberto
- Dieci Maria Vittoria
- Frassoldati Antonio
- Galvan Patricia
- Garrone Ornella
- Giotta Francesco
- Griguolo Gaia
- Guarneri Valentina
- Maiorana Antonino
- Musolino Antonino
- Orvieto Enrico
- Prat Aleix
- Rimanti Anita
- Urso Loredana
- Publication venue
- 'American Society of Clinical Oncology (ASCO)'
- Publication date
- 01/01/2019
- Field of study
Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study
- Author
- 't Kindt H
- Abbruzzese C
- Abel P
- Abulmagd M
- Ad\ue9n F
- Adanir T
- Afessa B
- Afifi S
- Afonso S
- Agabani H
- Aguilar G
- Aguilar L
- Aguirre G
- Agvald Ohman C
- Akan M
- Akinci I
- Al rahma H
- Alan Javier Z
- Alansary A
- Albaya A
- Albornoz H
- Aldrighi J
- Alemparte Pardavila E
- Alhashemi J
- Alheira Rocha R
- Ali A
- Almeida E
- Alsabbah A
- Alvarez M
- Alves A
- Alves M
- Amador Amerigo J
- Amaro P
- Ambike D
- Amin P
- Ammann J
- Ammons L
- Anane S
- Andrade C
- Angstwurm M
- Ant\uf3n Caraballo E
- Antonelli M
- Appadu B
- Arabi Y
- Arias Antun A
- Armaganidis A
- Arribas M
- Arroyo A
- Arvidsson S
- Assuncao M
- Atalan K
- Ates C
- Avila C
- AZOULAY E
- Azoulay E
- B\ue1rtolo A
- Bach F
- Badr A
- Bagnulo H
- Bakker J
- Bakondy R
- Bakshi C
- Balasini S
- Balciunas M
- Baldwin F
- Banerjee A
- Baptista M
- Barahona D
- Baraibar J
- Barbosa A
- Barbosa A
- Barcenilla Gaite F
- Barrera Groba C
- Barrera groba C
- Barry B
- Barsic B
- Bartkowska Sniatkowska A
- Bartosik T
- Bass F
- BASSETTI MATTEO
- Bassols A
- Bates J
- Beca J
- Becerra R
- Bechtold A
- Beer R
- Belohlavek J
- Belzberg H
- Benad H
- Berezowicz P
- Berghmans T
- Bergmans D
- Berlet T
- Bermudez Aceves E
- Bernardez D
- Bersten A
- Betsch H
- Bevilacqua C
- Bewley J
- Bhagwanjee S
- Bhagwanjee S
- Bhome A
- Biancofiore G
- Bingold T
- Binning A
- Biston P
- Bitencourt W
- Bitencourt W
- Bittinger M
- Bitzani M
- Blahut L
- Blanco Vicente A
- Blank E
- Blanloeil Y
- Bleier H
- Blesa Malpica A
- Blom H
- Blomqvist H
- Blosser S
- Blunt M
- Bocero L
- Bodmann K
- Bodur H
- Bogdanski R
- Booth M
- Borelli M
- Borg M
- Borges M
- Borrelli F
- Bosnak M
- Bothma P
- Boulanger C
- Bourgeois M
- Bouw M
- Boyden J
- Bozzetti C
- Braga M
- Brand\ue3o da Silva N
- Brandt W
- Branson R
- Breen D
- Breyer M
- Briegel J
- Briones Lopez M
- Bronchard R
- Browne B
- Bruhn A
- Brunain J
- Bruzzi de Carvalho F
- Buckley T
- Buehner U
- Bui T
- Bumbasirevic V
- Burgue\uf1o Campi\uf1ez M
- Burnstein R
- Busch J
- Busch J
- Bustamante Munguira E
- Bustinza A
- Buttner C
- Caballero lopez A
- Caballero Zirena A
- Cakar N
- Cameron L
- Camillo S
- Candiotti Herrera M
- Canevet C
- Caovilla J
- Cardonatti G
- Cardonnet L
- Cardy J
- Caridi M
- Carmo E
- Carneiro A
- Caser E
- Caspani M
- Castellanos Mateus P
- Castellanos Mateus P
- Castelo Branco Sousa M
- Castiglione G
- Cecilia P
- Celi L
- Cer\uf3n U
- Ceraso D
- Cerd\ue1 E
- Ceriani R
- Cetina M
- Chacko J
- Chalkiadaki A
- Chavarria U
- Chavez C
- Chawla R
- Cheng A
- Chertcoff F
- Chhangani S
- Chi E
- Chiappero G
- Chieregato A
- Christel A
- Chytra I
- Cieniawa T
- Clair B
- Clement R
- Clementi S
- Clouva molyvdas P
- Coelho C
- Coelho C
- Cohen J
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- CollaboratorsMargarit A
- Collin V
- Colonna S
- Comignani P
- Congshan Y
- Conrad Opel E
- Conte V
- Conti V
- Cook D
- Copotoiu S
- Coral M
- Corea M
- Corkeron M
- Corsten S
- Costa Filho R
- Costa H
- Cotogni P
- Cottini S
- Cougot P
- Crerar Gilbert A
- Csomos A
- Cubrilo Turek M
- Curcio D
- Curcio D
- Curcio D
- Curone M
- Cuthbertson B
- D'Hondt A
- D\uf3nofrio M
- D\uf6rr F
- Da costa R
- Daley M
- Damas P
- David C
- De Bels D
- De Blasi R
- De blasio E
- De Gasperi A
- De Jager J
- de la Torre Prados M
- De Marco F
- De Meulder A
- De negri P
- De Pont A
- De Rojas Rom\ue1n J
- De Waele J
- Dean N
- Debek A
- Del Pozo Sanchez H
- Delfs K
- DELLA ROCCA Giorgio
- Delzoppo C
- Demirkiran O
- Den Boer S
- Deutschman C
- Deutschmann C
- Devriendt J
- Di Filippo A
- Dias C
- Diaz D
- Diego Manuel R
- Dimov G
- Ditter H
- Divatia J
- Dive A
- Divekar N
- Dmitry B
- Dobb G
- Dogruer K
- Donayre Taber Z
- Donnelly M
- Dormoy D
- Du Plessis H
- Du B
- Duarte P
- Duarte P
- Duarte P
- Dube L
- Due\uf1as C
- Dummer B
- Dupont H
- Durand M
- Duranteau J
- ECHEVERRIA PM
- Eerens J
- Eftimova B
- Eggert S
- Eggimann P
- Eich G
- Eickmeyer H
- Einar V
- El Dash S
- Elahi N
- Emmi V
- Engel J
- Eric P
- Erickson S
- Ernest D
- Erno P
- Escamilla Leon I
- Escanda H
- Escriba A
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- Espinosa E
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- Esposito F
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- Publication venue
- Publication date
- 01/01/2011
- Field of study
To provide a global, up-to-date picture of the prevalence, treatment, and outcomes of Candida bloodstream infections in intensive care unit patients and compare Candida with bacterial bloodstream infection.
DESIGN:
A retrospective analysis of the Extended Prevalence of Infection in the ICU Study (EPIC II). Demographic, physiological, infection-related and therapeutic data were collected. Patients were grouped as having Candida, Gram-positive, Gram-negative, and combined Candida/bacterial bloodstream infection. Outcome data were assessed at intensive care unit and hospital discharge.
SETTING:
EPIC II included 1265 intensive care units in 76 countries.
PATIENTS:
Patients in participating intensive care units on study day.
INTERVENTIONS:
None.
MEASUREMENT AND MAIN RESULTS:
Of the 14,414 patients in EPIC II, 99 patients had Candida bloodstream infections for a prevalence of 6.9 per 1000 patients. Sixty-one patients had candidemia alone and 38 patients had combined bloodstream infections. Candida albicans (n = 70) was the predominant species. Primary therapy included monotherapy with fluconazole (n = 39), caspofungin (n = 16), and a polyene-based product (n = 12). Combination therapy was infrequently used (n = 10). Compared with patients with Gram-positive (n = 420) and Gram-negative (n = 264) bloodstream infections, patients with candidemia were more likely to have solid tumors (p < .05) and appeared to have been in an intensive care unit longer (14 days [range, 5-25 days], 8 days [range, 3-20 days], and 10 days [range, 2-23 days], respectively), but this difference was not statistically significant. Severity of illness and organ dysfunction scores were similar between groups. Patients with Candida bloodstream infections, compared with patients with Gram-positive and Gram-negative bloodstream infections, had the greatest crude intensive care unit mortality rates (42.6%, 25.3%, and 29.1%, respectively) and longer intensive care unit lengths of stay (median [interquartile range]) (33 days [18-44], 20 days [9-43], and 21 days [8-46], respectively); however, these differences were not statistically significant.
CONCLUSION:
Candidemia remains a significant problem in intensive care units patients. In the EPIC II population, Candida albicans was the most common organism and fluconazole remained the predominant antifungal agent used. Candida bloodstream infections are associated with high intensive care unit and hospital mortality rates and resource use