Knowing Better and Losing Even More: The Use of Knowledge in Hazards Management

Although loss of life from natural hazards has been declining, the property losses from those causes have been increasing. At the same time the volume of research on natural hazards and the books reviewing findings on the subject have also increased. Several major changes have occurred in the topics addressed. Emphasis has shifted from hazards to disasters. There has been increasing attention to vulnerability. Views of causation have changed. Four possible explanations are examined for the situation in which more is lost while more is known: (1) knowledge continues to be flawed by areas of ignorance; (2) knowledge is available but not used effectively; (3) knowledge is used effectively but takes a long time to have effect; and (4) knowledge is used effectively in some respects but is overwhelmed by increases in vulnerability and in population, wealth, and poverty

Shifts in evolutionary lability underlie independent gains and losses of root-nodule symbiosis in a single clade of plants

11 Pág.Root nodule symbiosis (RNS) is a complex trait that enables plants to access atmospheric nitrogen converted into usable forms through a mutualistic relationship with soil bacteria. Pinpointing the evolutionary origins of RNS is critical for understanding its genetic basis, but building this evolutionary context is complicated by data limitations and the intermittent presence of RNS in a single clade of ca. 30,000 species of flowering plants, i.e., the nitrogen-fixing clade (NFC). We developed the most extensive de novo phylogeny for the NFC and an RNS trait database to reconstruct the evolution of RNS. Our analysis identifies evolutionary rate heterogeneity associated with a two-step process: An ancestral precursor state transitioned to a more labile state from which RNS was rapidly gained at multiple points in the NFC. We illustrate how a two-step process could explain multiple independent gains and losses of RNS, contrary to recent hypotheses suggesting one gain and numerous losses, and suggest a broader phylogenetic and genetic scope may be required for genome-phenome mapping.This work was supported by DOE grant DE-SC0018247 to M.K., R.G., P.S., and D.S. and a UFBI grant (University of Florida). We thank Katharina Pawlowski for reviewing our scoring of actinorhizal symbiosis and for related discussions. We thank Colin Hughes and other members of the Legume Phylogeny Working Group for reviewing and helping to resolve taxonomy issues in Leguminosae. We thank Mark Whitten, Kelly Balmant, Chris Dervinis, Joshua Dieringer, and Henry Schmidt for help with specimen sampling.Peer reviewe

Author Correction: Shifts in evolutionary lability underlie independent gains and losses of root-nodule symbiosis in a single clade of plants

Correction to: Nature Communications https://doi.org/10.1038/s41467-024-48036-3, published online 27 May 2024 http://hdl.handle.net/10261/361232Correction to: Nature Communicationshttps://doi.org/10.1038/s41467-024-48036-3, published online 27 May 2024 In this article the funding from the ‘National Science Foundation of China (No. 31720103903)’ was omitted. The original article has been corrected.In this article the funding from the ‘National Science Foundation of China (No. 31720103903) was omitted.Peer reviewe

Low-Density Lipoprotein Has an Enormous Capacity To Bind (E)-4-Hydroxynon-2-enal (HNE): Detection and Characterization of Lysyl and Histidyl Adducts Containing Multiple Molecules of HNE

(E)-4-Hydroxynon-2-enal (HNE), an electrophilic bifunctional cytotoxic lipid peroxidation product, forms covalent adducts with nucleophilic side chains of amino acid residues. HNE-derived adducts have been implicated in many pathophysiological processes including atherosclerosis, diabetes, and Alzheimer’s disease. Tritium- and deuterium-labeled HNE (d4-HNE) were used orthogonally to study adduction with proteins and individual nucleophilic groups of histidyl, lysyl, and cysteine residues. Using tritium-labeled HNE, we detected the binding of 486 molecules of HNE per low-density lipoprotein (LDL) particle, significantly more than the total number of all reactive nucleophiles in the LDL particle. This suggests the formation of adducts that incorporate multiple molecules of HNE with some nucleophilic amino acid side chains. We also found that the reaction of a 1:1 mixture of d4-HNE and d0-HNE with N-acetylhistidine, N-acetyl-Gly-Lys-OMe, or N-acetyl cysteine generates 1:1, 2:1, and 3:1 adducts, which exhibit unique mass spectral signatures that aid in structural characterization. A domino-like reaction of initial 1:1 HNE Michael adducts of histidyl or lysyl nucleophiles with multiple additional HNE molecules forms 2:1 and 3:1 adducts that were structurally characterized by tandem mass spectrometry

The Atacama Cosmology Telescope: a measurement of the primordial power spectrum

We present constraints on the primordial power spectrum of adiabatic fluctuations using data from the 2008 Southern Survey of the Atacama Cosmology Telescope (ACT). The angular resolution of ACT provides sensitivity to scales beyond \ell = 1000 for resolution of multiple peaks in the primordial temperature power spectrum, which enables us to probe the primordial power spectrum of adiabatic scalar perturbations with wavenumbers up to k \simeq 0.2 Mpc^{-1}. We find no evidence for deviation from power-law fluctuations over two decades in scale. Matter fluctuations inferred from the primordial temperature power spectrum evolve over cosmic time and can be used to predict the matter power spectrum at late times; we illustrate the overlap of the matter power inferred from CMB measurements (which probe the power spectrum in the linear regime) with existing probes of galaxy clustering, cluster abundances and weak lensing constraints on the primordial power. This highlights the range of scales probed by current measurements of the matter power spectrum.Comment: 10 pages, 5 figures, submitted to Ap