Organic Carbon Burial following the Middle Eocene Climatic Optimum (MECO) in the central - western Tethys

We present trace metal geochemistry and stable isotope records for the middle Eocene Alano di Piave section, NE Italy, deposited during magnetochron C18n in the marginal Tethys Ocean. We identify a $\sim$ 500 kyr long carbon isotope perturbation event we infer to be the middle Eocene Climatic Optimum (MECO) confirming the northern hemisphere expression and global occurrence of MECO. Interpreted peak climatic conditions are followed by the rapid deposition of two organic rich intervals ($\le$3\% TOC) and contemporaneous positive $\delta^{13}$C excursions. These two intervals are associated with increases in the concentration of sulphur and redox-sensitive trace metals, and low concentrations of Mn, as well as coupled with the occurrence of pyrite. Together these changes imply low, possibly dysoxic, bottom water O$_{2}$ conditions promoting increased organic carbon burial. We hypothesize that this rapid burial of organic carbon lowered global {\it p}CO$_{2}$ following the peak warming and returned the climate system to the general Eocene cooling trend

A multi-color optical survey of the orion nebula cluster. II. The H-R diagram

We present a new analysis of the stellar population of the Orion Nebula Cluster (ONC) based on multi-band optical photometry and spectroscopy.We study the color–color diagrams in BVI, plus a narrowband filter centered at 6200 Å, finding evidence that intrinsic color scales valid for main-sequence dwarfs are incompatible with the ONC in the M spectral-type range, while a better agreement is found employing intrinsic colors derived from synthetic photometry, constraining the surface gravity value as predicted by a pre-main-sequence isochrone.We refine these model colors even further, empirically, by comparison with a selected sample of ONC stars with no accretion and no extinction. We consider the stars with known spectral types from the literature, and extend this sample with the addition of 65 newly classified stars from slit spectroscopy and 182 M-type from narrowband photometry; in this way, we isolate a sample of about 1000 stars with known spectral type. We introduce a new method to self-consistently derive the stellar reddening and the optical excess due to accretion from the location of each star in the BVI color–color diagram. This enables us to accurately determine the extinction of the ONC members, together with an estimate of their accretion luminosities. We adopt a lower distance for the Orion Nebula than previously assumed, based on recent parallax measurements. With a careful choice of also the spectral-type–temperature transformation, we produce the new Hertzsprung–Russell diagram of the ONC population, more populated than previous works. With respect to previous works, we find higher luminosity for late-type stars and a slightly lower luminosity for early types. We determine the age distribution of the population, peaking from ~2 to ~3 Myr depending on the model. We study the distribution of the members in the mass–age plane and find that taking into account selection effects due to incompleteness, removes an apparent correlation between mass and age.We derive the initial mass function for low- and intermediate mass members of the ONC, which turns out to be model dependent and shows a turnover at M ≲ 0.2 M_⊙

(Poly)phenolic content and profile and antioxidant capacity of whole-grain cookies are better estimated by simulated digestion than chemical extraction

It is widely recognized that the biological effects of phytochemicals cannot be attributed to the native compounds present in foods but rather to their metabolites endogenously released after intake. Bioavailability depends on bioaccessibility, which is the amount of the food constituent that is released from the matrix in the gastrointestinal tract. The use of chemical extraction to evaluate the content and profile of phytochemicals does not mirror the physiological situation in vivo, and their bioaccessibility should be considered while assessing their nutritional significance in human health. The current study was designed to compare the (poly)phenolic profile and content and antioxidant capacity of whole-grain (WG) cookies using chemical extraction and a more physiological approach based on simulated digestion. Three types of organic WG cookies (made with durum, Italian khorasan, or KAMUT\uae khorasan wheat) were considered, either fermented by Saccharomyces Cerevisiae or sourdough. Although the flour type and the fermentation process influenced the release of phytochemicals from the cookie matrix, in almost all samples, the simulated digestion appeared the most efficient procedure. Our results indicate that the use of chemical extraction for evaluation of the phytochemicals content and antioxidant capacity of food could lead to underestimation and underline the need for more physiological extraction methods

HST measures of Mass Accretion Rates in the Orion Nebula Cluster

The present observational understanding of the evolution of the mass accretion rates (Macc) in pre-main sequence stars is limited by the lack of accurate measurements of Macc over homogeneous and large statistical samples of young stars. Such observational effort is needed to properly constrain the theory of star formation and disk evolution. Based on HST/WFPC2 observations, we present a study of Macc for a sample of \sim 700 sources in the Orion Nebula Cluster, ranging from the Hydrogen-burning limit to M\ast \sim 2M\odot. We derive Macc from both the U-band excess and the H{\alpha} luminosity (LH{\alpha}), after determining empirically both the shape of the typical accretion spectrum across the Balmer jump and the relation between the accretion luminosity (Lacc) and LH{\alpha}, that is Lacc/L\odot = (1.31\pm0.03)\cdotLH{\alpha}/L\odot + (2.63\pm 0.13). Given our large statistical sample, we are able to accurately investigate relations between Macc and the parameters of the central star such as mass and age. We clearly find Macc to increase with stellar mass, and decrease over evolutionary time, but we also find strong evidence that the decay of Macc with stellar age occurs over longer timescales for more massive PMS stars. Our best fit relation between these parameters is given by: log(Macc/M\odot\cdotyr)=(-5.12 \pm 0.86) -(0.46 \pm 0.13) \cdot log(t/yr) -(5.75 \pm 1.47)\cdot log(M\ast/M\odot) + (1.17 \pm 0.23)\cdot log(t/yr) \cdot log(M\ast/M\odot). These results also suggest that the similarity solution model could be revised for sources with M\ast > 0.5M\odot. Finally, we do not find a clear trend indicating environmental effects on the accretion properties of the sources.Comment: 17 pages, 15 figures, accepted for publication in Ap

Imaging Modalities Role InRecurrent Acute Pancreatitis Diagnosis

Recurrent acute pancreatitis (RAP) is a potentially life-threatening pancreatic disorder. Itrequires a combination of medical and interventional skills to diagnose, determine the etiology, and treat the condition. Recurrencesoccur in 25-30% of all acute pancreatitis cases. The most common cause of RAP is gallstone (microlithiasis). Imaging modalities become an important aspect to evaluate multiple microlithiasis. In this case, we report a 52 years oldoverweight female with RAP and fatty liver ofunknown etiology.We suspected gallstone as the cause of RAP. Physical examination considered normal. Ultrasound and abdominal CT scan wasperformed in whichfatty liver were founded. Since the gallstone is not clearly found with radiologic imaging, we decide to undergoEndoscopic Retrograde Cholangiopancreatography(ERCP)procedure to evaluatea possibility of microlithiasis. ERCPresult showed a multiple microlithiasis, thus we evacuate the stones. Clinical outcome post ERCP and evacuationprocedure was good. We concluded that the best imaging modalities to evaluate microlithiasis in RAP with normal ultrasound and abdominal CT scan is ERCP

Enhacement in the dymanic response of a viscoelastic fluid flowing through a longitudinally vibrating tube

We analyzed effects of elasticity on the dynamics of fluids in porous media by studying a flow of a Maxwell fluid in a tube, which oscillates longitudinally and is subject to oscillatory pressure gradient. The present study investigates novelties brought about into the classic Biot's theory of propagation of elastic waves in a fluid-saturated porous solid by inclusion of non-Newtonian effects that are important, for example, for hydrocarbons. Using the time Fourier transform and transforming the problem into the frequency domain, we calculated: (A) the dynamic permeability and (B) the function $F(\kappa)$ that measures the deviation from Poiseuille flow friction as a function of frequency parameter $\kappa$. This provides a more complete theory of flow of Maxwell fluid through the longitudinally oscillating cylindrical tube with the oscillating pressure gradient, which has important practical applications. This study has clearly shown transition from dissipative to elastic regime in which sharp enhancements (resonances) of the flow are found

Precision determination of the dpi -> NN transition strength at threshold

An unusual but effective way to determine at threshold the dpi -> NN transition strength is to exploit the hadronic ground-state broadening in pionic deuterium, accessible by x-ray spectroscopy. The broadening is dominated by the true absorption channel dpi- -> nn, which is related to s-wave pion production pp -> dpi+ by charge symmetry and detailed balance. Using the exotic atom circumvents the problem of Coulomb corrections to the cross section as necessary in the production experiments. Our dedicated measurement finds (1171+23/-49) meV for the broadening yielding (252+5/-11) \mub.Comment: 4 pages, 2 figures, 1 tabl

Absorption, Pharmacokinetics, and Urinary Excretion of Pyridines After Consumption of Coffee and Cocoa-Based Products Containing Coffee in a Repeated Dose, Crossover Human Intervention Study

Scope: The present study assesses the absorption, pharmacokinetics, and urinary excretion of coffee pyridines and their metabolites after daily regular exposure to specific dosages of coffee or cocoa-based products containing coffee (CBPCC), considering different patterns of consumption. Methods and results: In a three-arm, crossover, randomized trial, 21 volunteers are requested to randomly consume for 1 month: one cup of espresso coffee per day, three cups of espresso coffee per day, or one cup of espresso coffee plus two CBPCC twice per day. The last day of the one-month treatment, blood and urine samples are collected for 24 h. Trigonelline, N-methylpyridinium, N-methylnicotinamide, and N-methyl-4-pyridone-5-carboxamide are quantified. Trigonelline and N-methylpyridinium absorption curves and 24-h urinary excretion reflect the daily consumption of different servings of coffee or CBPCC, showing also significant differences in main pharmacokinetic parameters. Moreover, inter-subject variability due to sex and smoking is assessed, showing sex-related differences in the metabolism of trigonelline and smoking-related ones for N-methylpyridinium. Conclusion: The daily exposure to coffee pyridines after consumption of different coffee dosages in a real-life setting is established. This data will be useful for future studies aiming at evaluating the bioactivity of coffee-derived circulating metabolites in cell experiments, mimicking more realistic experimental conditions

Spectral and Localization Properties for the One-Dimensional Bernoulli Discrete Dirac Operator

A 1D Dirac tight-binding model is considered and it is shown that its nonrelativistic limit is the 1D discrete Schr?odinger model. For random Bernoulli potentials taking two values (without correlations), for typical realizations and for all values of the mass, it is shown that its spectrum is pure point, whereas the zero mass case presents dynamical delocalization for specific values of the energy. The massive case presents dynamical localization (excluding some particular values of the energy). Finally, for general potentials the dynamical moments for distinct masses are compared, especially the massless and massive Bernoulli cases.Comment: no figure; 24 pages; to appear in Journal of Mathematical Physic

The gut–muscle axis in older subjects with low muscle mass and performance: a proof of concept study exploring fecal microbiota composition and function with shotgun metagenomics sequencing

The gut microbiota could influence the pathophysiology of age‐related sarcopenia through multiple mechanisms implying modulation of chronic inflammation and anabolic resistance. The aim of this study was to compare the fecal microbiota composition and functionality, assessed by shotgun metagenomics sequencing, between two groups of elderly outpatients, differing only for the presence of primary sarcopenia. Five sarcopenic elderly subjects and twelve non‐sarcopenic controls, classified according to lower limb function and bioimpedance‐derived skeletal muscle index, provided a stool sample, which was analyzed with shotgun metagenomics approaches, to determine the overall microbiota composition, the representation of bacteria at the species level, and the prediction of bacterial genes involved in functional metabolic pathways. Sarcopenic subjects displayed different fecal microbiota compositions at the species level, with significant depletion of two species known for their metabolic capacity of producing short‐chain fatty acids (SCFAs), Faecalibacterium prausnitzii and Roseburia inulinivorans, and of Alistipes shahii. Additionally, their fecal metagenome had different representation of genes belonging to 108 metabolic pathways, namely, depletion of genes involved in SCFA synthesis, carotenoid and isoflavone biotransformation, and amino acid interconversion. These results support the hypothesis of an association between microbiota and sarcopenia, indicating novel possible mediators, whose clinical relevance should be investigated in future studies