248 research outputs found
Choosing Between Smartphones, Tablets and Laptops: User Perspectives On Using Multiple Mobile Devices
This study describes a semi-structured interview conducted to evaluate how users with multiple mobile devices choose which device to use. The interviews were conducted at the Chapel Hill Public Library and University Mall with a total of 21 participants. Participants were asked to indicate how frequently they used a particular device, depending on the task to perform and the context. Four follow-up questions asked participants to describe how they originally intended to use their devices, how behavior has changed as they've started using them, if or when they multi-task and to summarize what each device is used for. Results indicated that smartphones are heavily used for a variety of tasks and users continue to find them increasingly useful for their ease of access and pervasiveness. Also, tablet users expressed frustration at the limitations of tablet affordances. More research is needed to determine how self-reporting of usage differs from actual usage
HER2 Status in Premalignant, Early, and Advanced Neoplastic Lesions of the Stomach
Objectives. HER2 expression in gastric cancer (GC) has received attention as
a potential target for therapy with Trastuzumab. We reviewed the current knowledge on HER2
status in premalignant gastric lesions and in early (EGC) and advanced (AGC) GC to discuss
the possible pathogenetic and prognostic roles of HER2 overexpression in GC. Results.
HER2 overexpression was documented in gastric low-grade (LG) and high-grade intraepithelial neoplasia
(HG-IEN), with higher frequency in gastric type dysplasia. HER2 overexpression was significantly
associated with disease recurrence and poor prognosis in EGC representing an independent risk
factor for lymph node metastases. HER2 overexpression was more frequent in AGC characterized
by high grade, advanced stage, and high Ki-67 labeling index. The discordance in HER2
status was evidenced between primitive GC and synchronous or metachronous
metastases. Conclusions. HER2 overexpression in premalignant gastric
lesions suggests its potential involvement in the early steps of gastric carcinogenesis.
The assessment of HER2 status in EGC may be helpful for the identification of patients
who are at low risk for developing nodal metastases. Finally, the possible discordance in
HER2 status between primary GC and its synchronous metastases support routine assessment
of HER2 both in the primary GC and in its metastatic lesions
Kaehler submanifolds with parallel pluri-mean curvature
We investigate the local geometry of a class of K\"ahler submanifolds which generalize surfaces of constant mean curvature. The role of
the mean curvature vector is played by the -part (i.e. the -components) of the second fundamental form , which we call the
pluri-mean curvature. We show that these K\"ahler submanifolds are
characterized by the existence of an associated family of isometric
submanifolds with rotated second fundamental form. Of particular interest is
the isotropic case where this associated family is trivial. We also investigate
the properties of the corresponding Gauss map which is pluriharmonic.Comment: Plain TeX, 21 page
Mind the buffering capacity of citric acid
Many microbial cultures are buffered with citric acid over a pH range of 2.5 to 7.0 since the pKa values for this triprotic acid are 3.13, 4.76 and 6.40, as shown in The Merck Index (pp 330-331, 10th Edition, Martha Windholz, ed.). However, the information about the buffering range of this weak acid is controvertial since the pKa3 value may be 5.40, as specified in Day and Underwood (Quantitative Analysis, 6th Edition, 1991, p. 662. New Jersey: Prentice Hall). With this in mind, we determined the pKa values of citric acid at concentrations ranging from 5 mM to 50 mM, concentrations which are the most employed in buffers for the culture of many microorganisms
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Risk preference and choice stochasticity during decisions for other people
In several contexts, such as finance and politics, people make choices that are relevant for others but irrelevant for oneself. Focusing on decision-making under risk, we compared monetary choices made for one’s own interest with choices made on behalf of an anonymous individual. Consistent with the previous literature, other-interest choices were characterized by an increased gambling propensity. We also investigated choice stochasticity, which captures how much decisions vary in similar conditions. An aspect related to choice stochasticity is how much decisions are tuned to the option values, and we found that this was higher during self-interest than during other-interest choices. This effect was observed only in individuals who reported a motivation to distribute rewards unequally, suggesting that it may (at least partially) depend on a motivation to make accurate decisions for others. Our results indicate that, during decision-making under risk, choices for other people are characterized by a decreased tuning to the values of the options, in addition to enhanced risk seeking
Genomics of Klebsiella pneumoniae ST16 producing NDM-1, CTX-M-15, and OXA-232
OBJECTIVES:
Genomic characterization of the internationally spread sequence type (ST) 16 carbapenem-resistant Klebsiella pneumoniae.
METHODS:
The complete genomes of three carbapenem producing ST16 K. pneumoniae from Italian patients were analysed by single-nucleotide polymorphism-based phylogeny, core genome multilocus sequence typing, resistance, plasmid, and virulence content and compared with ten genomes of ST16 strains isolated in other countries. Plasmids carrying blaNDM-1 or blaOXA-232 carbapenemase genes were assembled and sequences were analysed.
RESULTS:
The internationally spread ST16 K. pneumoniae clone showed variability in terms of distribution of NDM-1 and OXA-232 type carbapenemases. In some ST16 strains, up to six plasmids can be simultaneously present in the same cell, including ColE-like plasmids carrying blaOXA-232 and IncF plasmids carrying blaNDM-1. The differences observed in plasmid, resistance, and virulence content and core genome suggested that there is not a unique, highly conserved ST16 clone, but instead different variants of this lineage circulate worldwide.
CONCLUSIONS:
The ST16 K. pneumoniae clone has spread worldwide and may become a high-risk clone
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Dopamine Increases a Value-Independent Gambling Propensity
Although the impact of dopamine on reward learning is well documented, its influence on other aspects of behavior remains the subject of much ongoing work. Dopaminergic drugs are known to increase risk-taking behavior, but the underlying mechanisms for this effect are not clear. We probed dopamine’s role by examining the effect of its precursor L-DOPA on the choices of healthy human participants in an experimental paradigm that allowed particular components of risk to be distinguished. We show that choice behavior depended on a baseline (ie, value-independent) gambling propensity, a gambling preference scaling with the amount/variance, and a value normalization factor. Boosting dopamine levels specifically increased just the value-independent baseline gambling propensity, leaving the other components unaffected. Our results indicate that the influence of dopamine on choice behavior involves a specific modulation of the attractiveness of risky options—a finding with implications for understanding a range of reward-related psychopathologies including addiction
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