Applications of symbolic computing methods to the dynamic analysis of large systems

Since the symbolic computing language is very well suited to the operations with algebraic equations, techniques use the transfer function concept as a tool for the analysis of large linear dynamic systems. Techniques were coded in the experimental symbolic computer language FORMAC. The first of these approaches, REDUCE 1, establishes the techniques and a computer program to symbolically reduce arbitrary block diagrams associated with large systems for desired transfer functions. Symbolic closed form solutions are determined in several forms including an expanded form in terms of the driving frequencies and system constants. Programs are also written to numerically evaluate the symbolic solutions. A second computer program, REDUCE 2, is also based on the use of symbolic computing methods and was written to accommodate large engineering systems

Implementation eines präoperativen Risikoscores zur Abschätzung der Sterblichkeit nach Implantation eines ventrikulären mechanischen Assist-Systems

Mechanische Herzunterstützungssysteme haben sich weltweit als Therapieoption zur Überbrückung bis zur Herztransplantation etabliert. Ziel dieser Arbeit war die Implementation eines Münster-spezifischen Risikoscores zur Abschätzung der postoperativen Sterblichkeit auf der Intensivstation nach VAD Implantation. Es erfolgte eine retrospektive Analyse von 194 Patienten, bei denen zwischen 1996 und 2008 in Münster ein VAD implantiert wurde. Insgesamt wurden 100 präoperative Marker pro Patient/in erhoben und ihr Einfluss auf die postoperative Sterblichkeit auf der Intensivstation untersucht. Es wurden 18 unabhängige Risikofaktoren ermittelt. Sie wurden entsprechend ihrer Odds Ratio mit unterschiedlichen Risikofaktorpunkten gewichtet. Es erfolgte eine Einteilung in drei Risikogruppen: niedrig, mittel und hoch. Die postoperative Letalitätsrate betrug in der Hochrisiko-Gruppe 92% und in der Niedrigrisiko-Gruppe 20%

Miniature loop heat pipe with flat evaporator for cooling computer CPU

This paper presents an experimental investigation on a copper miniature loop heat pipe (mLHP) with a flat disk shaped evaporator, 30mm in diameter and 10-mm thick, designed for thermal control of computer microprocessors. Tests were conducted with water as the heat transfer fluid. The device was capable of transferring a heat load of 70W through a distance up to 150mm using 2-mm diameter transport lines. For a range of power applied to the evaporator, the system demonstrated very reliable startup and was able to achieve steady state without any symptoms of wick dry-out. Unlike cylindrical evaporators, flat evaporators are easy to attach to the heat source without need of any cylinder-to-plane reducer material at the interface and thus offer very low thermal resistance to the heat acquisition process. In the horizontal configuration, under air cooling, the minimum value for the mLHP thermal resistance is 0.17degC/W with the corresponding evaporator thermal resistance of 0.06degC/W. It is concluded from the outcomes of the current study that a mLHP with flat evaporator geometry can be effectively used for the thermal control of electronic equipment including notebooks with limited space and high heat flux chipsets. The results also confirm the superior heat transfer characteristics of the copper-water configuration in mLHP

Combination of carbon nanotubes and two-photon absorbers for broadband optical limiting

New systems are required for optical limiting against broadband laser pulses. We demonstrate that the association of non-linear scattering from single-wall carbon nanotubes (SWNT) and multiphoton absorption (MPA) from organic chromophores is a promising approach to extend performances of optical limiters over broad spectral and temporal ranges. Such composites display high linear transmission and good neutral colorimetry and are particularly efficient in the nanosecond regime due to cumulative effects.Comment: 5 avril 200

Lanthanide Spectroscopic Studies of the Dinuclear and Mg(II)-Dependent PvuII Restriction Endonuclease

Type II restriction enzymes are homodimeric systems that bind four to eight base pair palindromic recognition sequences of DNA and catalyze metal ion-dependent phosphodiester cleavage. While Mg(II) is required for cleavage in these enzymes, in some systems Ca(II) promotes avid substrate binding and sequence discrimination. These properties make them useful model systems for understanding the roles of alkaline earth metal ions in nucleic acid processing. We have previously shown that two Ca(II) ions stimulate DNA binding by PvuII endonuclease and that the trivalent lanthanide ions Tb(III) and Eu(III) support subnanomolar DNA binding in this system. Here we capitalize on this behavior, employing a unique combination of luminescence spectroscopy and DNA binding assays to characterize Ln(III) binding behavior by this enzyme. Upon excitation of tyrosine residues, the emissions of both Tb(III) and Eu(III) are enhanced severalfold. This enhancement is reduced by the addition of a large excess of Ca(II), indicating that these ions bind in the active site. Poor enhancements and affinities in the presence of the active site variant E68A indicate that Glu68 is an important Ln(III) ligand, similar to that observed with Ca(II), Mg(II), and Mn(II). At low micromolar Eu(III) concentrations in the presence of enzyme (10−20 μM), Eu(III) excitation 7F0 → 5D0 spectra yield one dominant peak at 579.2 nm. A second, smaller peak at 579.4 nm is apparent at high Eu(III) concentrations (150 μM). Titration data for both Tb(III) and Eu(III) fit well to a two-site model featuring a strong site (Kd = 1−3 μM) and a much weaker site (Kd ≈ 100−200 μM). Experiments with the E68A variant indicate that the Glu68 side chain is not required for the binding of this second Ln(III) equivalent; however, the dramatic increase in DNA binding affinity around 100 μM Ln(III) for the wild-type enzyme and metal-enhanced substrate affinity for E68A are consistent with functional relevance for this weaker site. This discrimination of sites should make it possible to use lanthanide substitution and lanthanide spectroscopy to probe individual metal ion binding sites, thus adding an important tool to the study of restriction enzyme structure and function

A New FPN Cancellation Circuit for Time-Domain CMOS Image Sensors

A fixed-pattern noise correction technique for time-domain CMOS imagers with high dynamic range is presented in this chapter. Analytical derivations are presented showing how the circuit variations affect the time measured. The error in the time measured can be reduced by using lower reference voltages achieving values smaller than 4%. The fixed-pattern noise correction technique proposed is based on a new readout method for time-domain imagers employing two reference voltages for the discharge time measurement. This new technique is non-sensitive to circuit parameter variations that contribute to fixed-pattern noise such as hold voltages of transistors. A simple electronic circuit is proposed to implement the technique. Circuit and simulation results are presented to demonstrate the feasibility of the proposed technique