25 research outputs found
New insights into the genetic etiology of Alzheimer's disease and related dementias
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
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Successful Army National Guard units: A guard perspective
This project sought to identify factors contributing to a healthy Army National Guard (ARNG) unit. Its results were intended to contribute to a computerized forecasting model under development at Oak Ridge National Laboratory. The model, the ARNG Regional Recruiting Potential Model (RRPM), forecasts locations of successful new or modified Guard units. The study was expected to enhance the understanding of what constituents a healthy Guard unit. A Delphi approach was used to define criteria for healthy Guard units and to elicit rankings of those criteria. Two sets of telephone interviews were conducted with a sample of 102 individuals-two battalion-level administrative officers, or their equivalents, in each state in Washington, DC. During these telephone calls, the phrase unit supportability'' was used to express the notion of a healthy unit. The first set of interviews obtained background information and respondents' ideas of the criteria that lead to unit supportability and to a lack of supportability. The data were analyzed to develop a list of ten criteria for unit supportability. In the second interview, the same respondents were asked to rank those criteria in order of importance
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The Oak Ridge Y-12 Plant biological monitoring and abatement program for East Fork Poplar Creek
In May 1985, a National Pollutant Discharge Elimination System permit was issued for the Oak Ridge Y-12 Plant, a nuclear weapons components production facility located in Oak Ridge, Tennessee, and operated by Martin Marietta Energy Systems, Inc., for the US Department of Energy. As a condition of the permit, a Biological Monitoring and Abatement Program (BMAP) was developed to demonstrate that the effluent limitations established for the Oak Ridge Y-12 Plant protect the classified uses of the receiving stream (East Fork Poplar Creek), in particular, the growth and propagation of fish and aquatic life, as designated by the Tennessee Department of Health and Environment. A second purpose for the BMAP is to document the ecological effects resulting from implementation of a water pollution control program that will include construction of nine new wastewater treatment facilities over the next 4 years. Because of the complex nature of the effluent discharged to East Fork Poplar Creek and the temporal and spatial variability in the composition of the effluent (i.e., temporal variability related to various pollution abatement measures that will be implemented over the next several years and spatial variability caused by pollutant inputs downstream of the Oak Ridge Y-12 Plant), a comprehensive, integrated approach to biological monitoring was developed for the BMAP. 39 refs., 5 figs., 8 tabs