The Grizzly, November 17, 1978

Tuition, Room And Board Fees Raised • GreaseBand Slated For January • Snow Precautions Outlined • Forum Highlights • Mail Theft In New Men\u27s • Hockey Violence Must Stop • Should Ursinus Teach Moral Values? • Acapulco: Gold • Rock\u27s Lesser-Knowns Provide Fresh Sound • Audio Corner: Purchasing audio equipment • Forum Committee • GM: Looking Good For \u2779 • A History Of Accomplishment • Bear Pack Bombs At Districts • Equestrians Riding High • Letters to the Editor: Public Apology; Grading Disputedhttps://digitalcommons.ursinus.edu/grizzlynews/1007/thumbnail.jp

The Grizzly, October 20, 1978

Homecoming \u2778 Promises Color, Excitement • Judiciary Board Convicts Two • Shopping Center to Expand • On Personal Expression • Is Pledging All Fun and Games? • Ursinus\u27 Financial Aid Structure • SFARC Repairs Damage Policy • Gallagher Explores Amish • Springsteen & Dylan: Poet Laureates or Veritable Zeros? • The World\u27s Largest Hamburger • Paradise Lost: College Woods Gone Junkyard? • X-C: Dual Wins • Bears Fall Prey Again • Soccer Wins Five • News in Brief: Our New Look; Remember to Vote; Yom Kippur Celebration; Ursinus Announces Business Workshop; Library News Shortshttps://digitalcommons.ursinus.edu/grizzlynews/1003/thumbnail.jp

The Grizzly, November 10, 1978

Physical Education Program To Change • Task Force Continues Recommendations • No Funds For Bomberger • Forum: High Strung • Hockey Not Safe • Staffer Clears Misinterpretation • Dining Service Transitions • Letters to the Editor • Portrait of the Professor: Gayle A. Byerly • For Whom The Walls Toil • Egdon Heath - A New Look For Monday Night • The Good Doctor Makes House Call To Protheatre • Eighteen Named to Who\u27s Who • Free V. D. Clinic • GM: Looking Good For \u2779 • Sports Profile: Keith Kemper • Thinclads Nab Third At MAC\u27s • Soccer Kicks Moravian • Bears Blast Dickinson • Gymnastics Get New Coach • Hockey Ends • Women\u27s B-Ball Preview • News in Brief: Senior Symposium Cancelled; Deans Attend State Conventionhttps://digitalcommons.ursinus.edu/grizzlynews/1006/thumbnail.jp

Broad-Spectrum Antiviral Therapeutics

Currently there are relatively few antiviral therapeutics, and most which do exist are highly pathogen-specific or have other disadvantages. We have developed a new broad-spectrum antiviral approach, dubbed Double-stranded RNA (dsRNA) Activated Caspase Oligomerizer (DRACO) that selectively induces apoptosis in cells containing viral dsRNA, rapidly killing infected cells without harming uninfected cells. We have created DRACOs and shown that they are nontoxic in 11 mammalian cell types and effective against 15 different viruses, including dengue flavivirus, Amapari and Tacaribe arenaviruses, Guama bunyavirus, and H1N1 influenza. We have also demonstrated that DRACOs can rescue mice challenged with H1N1 influenza. DRACOs have the potential to be effective therapeutics or prophylactics for numerous clinical and priority viruses, due to the broad-spectrum sensitivity of the dsRNA detection domain, the potent activity of the apoptosis induction domain, and the novel direct linkage between the two which viruses have never encountered.National Institute of Allergy and Infectious Diseases (U.S.) (grant AI057159)New England Regional Center of Excellence for Biodefense and Emerging Infectious DiseasesUnited States. Dept. of Defense (Director of Defense Research & Engineering)United States. Defense Threat Reduction AgencyUnited States. Defense Advanced Research Projects Agenc

The Grizzly, October 27, 1978

Bomberger Tower Razed • Homecoming Brings Crowning, Presentations • Self Study Continues • Hockey Ties Nation\u27s Best • No Tickets at Door • Campus Sunshine to Set? • Ravine Paradise Revisited • Portrait of the Professor: Randy Davidson • Letters to the Editor • Springsteen & Dylan: Poet Laureates or Veritable Zeroes? • Art is a Math is an Art is a Math... • Escher Takes On New Dimension • Commencement Speaker Announced • Plea From the Press • GM: Looking Good For \u2779 • Soccer Splits: 2-2 • Sports Profile: Don Paolicelli • Thin Clads Receive Treat • Swarthmore Superior In Homecoming Game • J.V.s Romp to Win • Hockey Returns Home • News in Brief: Fire Alarm Installations Near Completion; ProTheatre to Present The Good Doctor ; Art Exhibit to Open Soonhttps://digitalcommons.ursinus.edu/grizzlynews/1004/thumbnail.jp

The Grizzly, October 27, 1978

Bomberger Tower Razed • Homecoming Brings Crowning, Presentations • Self Study Continues • Hockey Ties Nation\u27s Best • No Tickets at Door • Campus Sunshine to Set? • Ravine Paradise Revisited • Portrait of the Professor: Randy Davidson • Letters to the Editor • Springsteen & Dylan: Poet Laureates or Veritable Zeroes? • Art is a Math is an Art is a Math... • Escher Takes On New Dimension • Commencement Speaker Announced • Plea From the Press • GM: Looking Good For \u2779 • Soccer Splits: 2-2 • Sports Profile: Don Paolicelli • Thin Clads Receive Treat • Swarthmore Superior In Homecoming Game • J.V.s Romp to Win • Hockey Returns Home • News in Brief: Fire Alarm Installations Near Completion; ProTheatre to Present The Good Doctor ; Art Exhibit to Open Soonhttps://digitalcommons.ursinus.edu/grizzlynews/1004/thumbnail.jp

Galactic Globular and Open Clusters in the Sloan Digital Sky Survey. II. Test of Theoretical Stellar Isochrones

We perform an extensive test of theoretical stellar models for main-sequence stars in ugriz, using cluster fiducial sequences obtained in the previous paper of this series. We generate a set of isochrones using the Yale Rotating Evolutionary Code (YREC) with updated input physics, and derive magnitudes and colors in ugriz from MARCS model atmospheres. These models match cluster main sequences over a wide range of metallicity within the errors of the adopted cluster parameters. However, we find a large discrepancy of model colors at the lower main sequence (Teff < ~4500 K) for clusters at and above solar metallicity. We also reach similar conclusions using the theoretical isochrones of Girardi et al. and Dotter et al., but our new models are generally in better agreement with the data. Using our theoretical isochrones, we also derive main-sequence fitting distances and turn-off ages for five key globular clusters, and demonstrate the ability to derive these quantities from photometric data in the Sloan Digital Sky Survey. In particular, we exploit multiple color indices (g - r, g - i, and g - z) in the parameter estimation, which allows us to evaluate internal systematic errors. Our distance estimates, with an error of sigma(m - M) = 0.03-0.11 mag for individual clusters, are consistent with Hipparcos-based subdwarf fitting distances derived in the Johnson-Cousins or Stromgren photometric systems.Comment: 26 pages, 28 figures. Accepted for publication in ApJ. Version with high resolution figures available at http://spider.ipac.caltech.edu/~deokkeun/sdss_iso.pd

Cardiac Energetics in Patients With Aortic Stenosis and Preserved Versus Reduced Ejection Fraction.

BACKGROUND: Why some but not all patients with severe aortic stenosis (SevAS) develop otherwise unexplained reduced systolic function is unclear. We investigate the hypothesis that reduced creatine kinase (CK) capacity and flux is associated with this transition. METHODS: We recruited 102 participants to 5 groups: moderate aortic stenosis (ModAS) (n=13), SevAS, left ventricular (LV) ejection fraction ≥55% (SevAS-preserved ejection fraction, n=37), SevAS, LV ejection fraction 0.99). Accompanying the fall in CK flux, total CK and citrate synthase activities and the absolute activities of mitochondrial-type CK and CK-MM isoforms were also lower (P<0.02, all analyses). Median mitochondria-sarcomere diffusion distances correlated well with CK total activity (r=0.86, P=0.003). CONCLUSIONS: Total CK capacity is reduced in SevAS, with median values lowest in those with systolic failure, consistent with reduced energy supply reserve. Despite this, in vivo magnetic resonance spectroscopy measures of resting CK flux suggest that ATP delivery is reduced earlier, at the moderate AS stage, where LV function remains preserved. These findings show that significant energetic impairment is already established in moderate AS and suggest that a fall in CK flux is not by itself a necessary cause of transition to systolic failure. However, because ATP demands increase with AS severity, this could increase susceptibility to systolic failure. As such, targeting CK capacity and flux may be a therapeutic strategy to prevent and treat systolic failure in AS.This study was principally funded by a British Heart Foundation Clinical Training Research Fellowship FS/15/80/31803 (to Dr Peterzan) with support from a British Heart Foundation Program Grant (RG/18/12/34040). Drs Neubauer and Rider acknowledge support from British Heart Foundation Center of Research Excellence. Dr Neubauer acknowledges support from the National Institute of Health Research Oxford Biomedical Research Center. Dr Rodgers receives funding from the Wellcome Trust and the Royal Society (grant no. 098436/Z/12/B) and supported by the National Institute of Health Research Cambridge Biomedical Research Center. Dr Rider is funded by the British Heart Foundation FS/16/70/32157. Dr Miller was supported by a Novo Nordisk Postdoctoral Fellowship run in conjunction with the University of Oxford. The Biotechnology and Biological Sciences Research Council provided Advanced Life Sciences Research Technology Initiative 13 funding for serial block-face scanning electron microscopy through grant BB/C014122/1 (to Prof Chris Hawes, Oxford Brookes University)

Localized rest and stress human cardiac creatine kinase reaction kinetics at 3 T.

Changes in the kinetics of the creatine kinase (CK) shuttle are sensitive markers of cardiac energetics but are typically measured at rest and in the prone position. This study aims to measure CK kinetics during pharmacological stress at 3 T, with measurement in the supine position. A shorter "stressed saturation transfer" (StreST) extension to the triple repetition time saturation transfer (TRiST) method is proposed. We assess scanning in a supine position and validate the MR measurement against biopsy assay of CK activity. We report normal ranges of stress CK forward rate (kfCK ) for healthy volunteers and obese patients. TRiST measures kfCK in 40 min at 3 T. StreST extends the previously developed TRiST to also make a further kfCK measurement during <20 min of dobutamine stress. We test our TRiST implementation in skeletal muscle and myocardium in both prone and supine positions. We evaluate StreST in the myocardium of six healthy volunteers and 34 obese subjects. We validated MR-measured kfCK against biopsy assays of CK activity. TRiST kfCK values matched literature values in skeletal muscle (kfCK  = 0.25 ± 0.03 s-1 vs 0.27 ± 0.03 s-1 ) and myocardium when measured in the prone position (0.32 ± 0.15 s-1 ), but a significant difference was found for TRiST kfCK measured supine (0.24 ± 0.12 s-1 ). This difference was because of different respiratory- and cardiac-motion-induced B0 changes in the two positions. Using supine TRiST, cardiac kfCK values for normal-weight subjects were 0.15 ± 0.09 s-1 at rest and 0.17 ± 0.15 s-1 during stress. For obese subjects, kfCK was 0.16 ± 0.07 s-1 at rest and 0.17 ± 0.10 s-1 during stress. Rest myocardial kfCK and CK activity from LV biopsies of the same subjects correlated (R = 0.43, p = 0.03). We present an independent implementation of TRiST on the Siemens platform using a commercially available coil. Our extended StreST protocol enables cardiac kfCK to be measured during dobutamine-induced stress in the supine position.Funded by: a Sir Henry Dale Fellowship from the Wellcome Trust and the Royal Society [098436/Z/12/B] to CTR, the BHF Centre of Research Excellence (OJR), a BHF clinical research training fellowship [FS/15/80/31803] to MAP, a BHF fellowship [FS/14/54/30946] to JJR, an NIHR OBRC fellowship to BR, a BHF programme grant [RG/13/8/30266] to CAL and SN, and a DPhil studentship from the Medical Research Council to WTC. We acknowledge support from the Oxford NIHR Biomedical Research Centre

John squire and endothelial glycocalyx structure: an unfinished story

John Squire did not only produce leading works in the muscle field, he also significantly contributed to the vascular permeability field by ultrastructural analysis of the endothelial glycocalyx. Presented here is a review of his involvement in the field by his main collaborator C.C. Michel and his last postdoctoral researcher KP Arkill. We end on a reinterpretation of his work that arguably links to our current understanding of endothelial glycocalyx structure and composition predicting 6 glycosaminoglycans fibres per syndecan core protein, only achieved in the endothelium by dimerization