Effetti biologici delle radiazioni ionizzanti: effetti non-targeted e loro implicazioni per la radioprotezione e la clinica

L'azione dlee radiazioni ionizzanti in sistemi biologici è generalmente spiegata invocando il coinvolgimento diretto o indiretto del DNA nucleare nell'interazione radiazione-cellula. In particolare, in accordo con questa descrizione, la radiazione incidente interagisce direttamente con il DNA nucleare attraverso le varie specie radicaliche originatesi dall'interazione della radiazione con l'acqua e il micro-ambiente del DNA stesso, dando luogo a una varietà di lesionialla struttura del DNA il cui successivo processamento determina l'espressione di una varietà di effetti biologici e quindi il destino finale della cellula irraggiata. recentemente si sono però accumulate evidenze sperimentali, principalmente in-vitro ma anche in vivo, che pongono in discussione la validità di questo approccio mostrando che, nel regime delle basse dosi di radiazione ionizzante, alcuni effetti biologicipossono essere indotti anche in cellule non direttamente interagenti con la radiazione incidente (effetti non-targeted). Tra questi si trovano l'ipersensibilità e la radioresistenza indotta; l'effetto bystander; l'instabilità genomica; la risposta adattiva. In questo lavoro di tesi si è dato maggiore enfasi allo studio della risposta adattiva in cellule umane (in vitro) esposte ai raggi γ e a ioni leggeri forniti da acceleratori di bassa energia.ope

Middle Pleistocene to Holocene activity of the Gondola Fault Zone (Southern Adriatic Foreland): deformation of a regional shear zone and seismotectonic implications

Recent seismicity in and around the Gargano Promontory, an uplifted portion of the Southern Adriatic Foreland domain, indicates active E–W strike-slip faulting in a region that has also been struck by large historical earthquakes, particularly along the Mattinata Fault. Seismic profiles published in the past two decades show that the pattern of tectonic deformation along the E–W-trending segment of the Gondola Fault Zone, the offshore counterpart of the Mattinata Fault, is strikingly similar to that observed onshore during the Eocene–Pliocene interval. Based on the lack of instrumental seismicity in the south Adriatic offshore, however, and on standard seismic reflection data showing an undisturbed Quaternary succession above the Gondola Fault Zone, this fault zone has been interpreted as essentially inactive since the Pliocene. Nevertheless, many investigators emphasised the genetic relationships and physical continuity between the Mattinata Fault, a positively active tectonic feature, and the Gondola Fault Zone. The seismotectonic potential of the system formed by these two faults has never been investigated in detail. Recent investigations of Quaternary sedimentary successions on the Adriatic shelf, by means of very high-resolution seismic–stratigraphic data, have led to the identification of fold growth and fault propagation in Middle–Upper Pleistocene and Holocene units. The inferred pattern of gentle folding and shallow faulting indicates that sediments deposited during the past ca. 450 ka were recurrently deformed along the E–W branch of the Gondola Fault Zone. We performed a detailed reconstruction and kinematic interpretation of the most recent deformation observed along the Gondola Fault Zone and interpret it in the broader context of the seismotectonic setting of the Southern Apennines-foreland region. We hypothesise that the entire 180 km-long Molise–Gondola Shear Zone is presently active and speculate that also its offshore portion, the Gondola Fault Zone, has a seismogenic behaviour

Temporally Resolved Intensity Contouring (TRIC) for characterization of the absolute spatio-temporal intensity distribution of a relativistic, femtosecond laser pulse

Today's high-power laser systems are capable of reaching photon intensities up to $10^{22}$ W/cm^2, generating plasmas when interacting with material. The high intensity and ultrashort laser pulse duration (fs) make direct observation of plasma dynamics a challenging task. In the field of laser-plasma physics and especially for the acceleration of ions, the spatio-temporal intensity distribution is one of the most critical aspects. We describe a novel method based on a single-shot (i.e. single laser pulse) chirped probing scheme, taking nine sequential frames at framerates up to THz. This technique, to which we refer as temporally resolved intensity contouring (TRIC) enables single-shot measurement of laser-plasma dynamics. Using TRIC, we demonstrate the reconstruction of the complete spatio-temporal intensity distribution of a high-power laser pulse in the focal plane at full pulse energy with sub picosecond resolution.Comment: Daniel Haffa, Jianhui Bin and Martin Speicher are corresponding author

Middle Pleistocene to Holocene activity of the Gondola Fault Zone (Southern Adriatic Foreland): deformation of a regional shear zone and seismotectonic implications

Recent seismicity in and around the Gargano Promontory, an uplifted portion of the southern Adriatic Foreland domain, indicates active E-W strike-slip faulting in a region that has also been struck by large historical earthquakes, particularly along the Mattinata Fault. Seismic profiles published in the past two decades show that the pattern of tectonic deformation along the E-W–trending segment of the Gondola Fault Zone, the offshore counterpart of the Mattinata Fault, is strikingly similar to that observed onshore during the Eocene-Pliocene interval. Based on the lack of instrumental seismicity in the south Adriatic offshore, however, and on standard seismic reflection data showing an undisturbed Quaternary succession above the Gondola Fault Zone, this fault zone has been interpreted as essentially inactive since the Pliocene. Nevertheless, many investigators emphasised the genetic relationships and physical continuity between the Mattinata Fault, a positively active tectonic feature, and the Gondola Fault Zone. The seismotectonic potential of the system formed by these two faults has never been investigated in detail. Recent investigations of Quaternary sedimentary successions on the Adriatic shelf, by means of very high-resolution seismic-stratigraphic data, have led to the identification of fold growth and fault propagation in Middle-Upper Pleistocene and Holocene units. The inferred pattern of gentle folding and shallow faulting indicates that sediments deposited during the past ca. 450 ka were recurrently deformed along the E-W branch of the Gondola Fault Zone. We performed a detailed reconstruction and kinematic interpretation of the most recent deformation observed along the Gondola Fault Zone and interpret it in the broader context of the seismotectonic setting of the southern Apennines-foreland region. We hypothesise that the entire 180 km-long Molise-Gondola Shear Zone is presently active and speculate that also its offshore portion, the Gondola Fault Zone, has a seismogenic behaviour

The Bathymetry of the Adriatic Sea.

not availabl

Electro-optic characterization of synthesized infrared-visible light fields

The measurement and control of light field oscillations enable the study of ultrafast phenomena on sub-cycle time scales. Electro-optic sampling (EOS) is a powerful field characterization approach, in terms of both sensitivity and dynamic range, but it has not reached beyond infrared frequencies. Here, we show the synthesis of a sub-cycle infrared-visible pulse and subsequent complete electric field characterization using EOS. The sampled bandwidth spans from 700 nm to 2700 nm (428 to 110 THz). Tailored electric-field waveforms are generated with a two-channel field synthesizer in the infrared-visible range, with a full-width at half-maximum duration as short as 3.8 fs at a central wavelength of 1.7 µm (176 THz). EOS detection of the complete bandwidth of these waveforms extends it into the visible spectral range. To demonstrate the power of our approach, we use the sub-cycle transients to inject carriers in a thin quartz sample for nonlinear photoconductive field sampling with sub-femtosecond resolution