Direct evidence of dust growth in L183 from MIR light scattering

Theoretical arguments suggest that dust grains should grow in the dense cold parts of molecular clouds. Evidence of larger grains has so far been gathered in near/mid infrared extinction and millimeter observations. Interpreting the data is, however, aggravated by the complex interplay of density and dust properties (as well as temperature for thermal emission). We present new Spitzer data of L183 in bands that are sensitive and insensitive to PAHs. The visual extinction AV map derived in a former paper was fitted by a series of 3D Gaussian distributions. For different dust models, we calculate the scattered MIR radiation images of structures that agree agree with the AV map and compare them to the Spitzer data. The Spitzer data of L183 show emission in the 3.6 and 4.5 micron bands, while the 5.8 micron band shows slight absorption. The emission layer of stochastically heated particles should coincide with the layer of strongest scattering of optical interstellar radiation, which is seen as an outer surface on I band images different from the emission region seen in the Spitzer images. Moreover, PAH emission is expected to strongly increase from 4.5 to 5.8 micron, which is not seen. Hence, we interpret this emission to be MIR cloudshine. Scattered light modeling when assuming interstellar medium dust grains without growth does not reproduce flux measurable by Spitzer. In contrast, models with grains growing with density yield images with a flux and pattern comparable to the Spitzer images in the bands 3.6, 4.5, and 8.0 micron.Comment: 13 pages, 11 figures, accepted for publication in Astronomy and Astrophysic

R-h-erythropoietin counteracts the inhibition of in vitro erythropoiesis by tumour necrosis factor alpha in patients with rheumatoid arthritis

Anaemia of chronic disease (ACD) is a common extra-articular manifestation of rheumatoid arthritis (RA). Tumour necrosis factor alpha (TNFα) plays an important role in the development of ACD. The objective of the present study was to assess inhibition of in vitro colony-forming unit erythrocyte (CFUe) and blast-forming unit erythrocyte (BFUe) growth by TNFα and to examine whether this suppression could be counteracted by adding increasing concentrations of recombinant human erythropoietin (EPO) (r-h-EPO) to bone marrow cultures of RA patients with ACD and without anaemia (controls). Bone marrow cells of RA patients with ACD and control patients were cultured. The cultures were incubated with increasing concentrations of r-h-EPO (0.25; 0.5; 1; 2 U/ml), each in combination with increasing quantities of TFNα (0; 50; 100; 200; 400 U/ml). CFUe and BFUe were assessed after 7 and 14 days, respectively. Dose-dependent inhibition of BFUe and CFUc by increasing concentrations of TNFα was observed in ACD and controls. Regarding CFUe (ACD patients) incubated with 0.25 U/ml EPO, 50 U/ml TNFα caused 28% suppression compared to cultures without TNFα. Increasing the concentration of r-h-EPO from 0.25 U/ml to 2 U/ml completely restored the number of CFUe. A similar pattern was observed in BFUe growth in both groups. These data demonstrated the suppressive effects of TNFα on erythropoiesis in vitro and that the suppresed erythropoiesis could be partly corrected by the addition of excess r-h-EPO to the cultures. No significant differences were observed between ACD and control RA patients. This in vitro model may help explain the clinical response to r-h-EPO therapy as documented in RA patients with ACD

IgM memory B cells: a mouse/human paradox

Humoral memory is maintained by two types of persistent cells, memory B cells and plasma cells, which have different phenotypes and functions. Long-lived plasma cells can survive for a lifespan within a complex niche in the bone marrow and provide continuous protective serum antibody levels. Memory B cells reside in secondary lymphoid organs, where they can be rapidly mobilized upon a new antigenic encounter. Surface IgG has long been taken as a surrogate marker for memory in the mouse. Recently, however, we have brought evidence for a long-lived IgM memory B cell population in the mouse, while we have also argued that, in humans, these same cells are not classical memory B cells but marginal zone (MZ) B cells which, as opposed to their mouse MZ counterpart, recirculate and carry a mutated B cell receptor. In this review, we will discuss these apparently paradoxical results

Dust-correlated cm-wavelength continuum emission on translucent clouds {\zeta} Oph and LDN 1780

The diffuse cm-wave IR-correlated signal, the "anomalous" CMB foreground, is thought to arise in the dust in cirrus clouds. We present Cosmic Background Imager (CBI) cm-wave data of two translucent clouds, {\zeta} Oph and LDN 1780 with the aim of characterising the anomalous emission in the translucent cloud environment. In {\zeta} Oph, the measured brightness at 31 GHz is 2.4{\sigma} higher than an extrapolation from 5 GHz measurements assuming a free-free spectrum on 8 arcmin scales. The SED of this cloud on angular scales of 1{\odot} is dominated by free-free emission in the cm-range. In LDN 1780 we detected a 3 {\sigma} excess in the SED on angular scales of 1{\odot} that can be fitted using a spinning dust model. In this cloud, there is a spatial correlation between the CBI data and IR images, which trace dust. The correlation is better with near-IR templates (IRAS 12 and 25 {\mu}m) than with IRAS 100 {\mu}m, which suggests a very small grain origin for the emission at 31 GHz. We calculated the 31 GHz emissivities in both clouds. They are similar and have intermediate values between that of cirrus clouds and dark clouds. Nevertheless, we found an indication of an inverse relationship between emissivity and column density, which further supports the VSGs origin for the cm-emission since the proportion of big relative to small grains is smaller in diffuse clouds.Comment: 13 pages, 14 figures, 7 tables. Accepted for publication in MNRA

An introductory view on archaeoastronomy

Archaeoastronomy is still a marginalised topic in academia and is described by the Sophia Centre, the only UK institution offering a broader MA containing this field, as ‘the study of the incorporation of celestial orientation, alignments or symbolism in human monuments and architecture’. By many it is associated with investigating prehistoric monuments such as Stonehenge and combining astronomy and archaeology. The following will show that archaeoastronomy is far more than just an interdisciplinary field linking archaeology and astronomy. It merges aspects of anthropology, ethno-astronomy and even educational research, and is possibly better described as cultural astronomy. In the past decades it has stepped away from its quite speculative beginnings that have led to its complete rejection by the archaeology community. Overcoming these challenges it embraced full heartedly solid scientific and statistical methodology and achieved more credibility. However, in recent times the humanistic influences of a cultural context motivate a new generation of archaeoastronomers that are modernising this subject; and humanists might find it better described as post-modern archaeoastronomy embracing the pluralism of today’s academic approach to landscape and ancient people

Sex Bias in Pathogenesis of Autoimmune Neuroinflammation: Relevance for Dimethyl Fumarate Immunomodulatory/Anti-oxidant Action

In the present study, upon showing sexual dimorphism in dimethyl fumarate (DMF) efficacy to moderate the clinical severity of experimental autoimmune encephalomyelitis (EAE) in Dark Agouti rats, cellular and molecular substrate of this dimorphism was explored. In rats of both sexes, DMF administration from the day of immunization attenuated EAE severity, but this effect was more prominent in males leading to loss of the sexual dimorphism observed in vehicle-administered controls. Consistently, in male rats, DMF was more efficient in diminishing the number of CD4+ T lymphocytes infiltrating spinal cord (SC) and their reactivation, the number of IL-17+ T lymphocytes and particularly cellularity of their highly pathogenic IFN-gamma+GM-CSF+IL-17+ subset. This was linked with changes in SC CD11b+CD45+TCR alpha beta- microglia/proinflammatory monocyte progeny, substantiated in a more prominent increase in the frequency of anti-inflammatory phygocyting CD163+ cells and the cells expressing high surface levels of immunoregulatory CD83 molecule (associated with apoptotic cells phagocytosis and implicated in downregulation of CD4+ T lymphocyte reactivation) among CD11b+CD45+TCR alpha beta- cells in male rat SC. These changes were associated with greater increase in the nuclear factor (erythroid-derived 2)-like 2 expression in male rats administered with DMF. In accordance with the previous findings, DMF diminished reactive nitrogen and oxygen species generation and consistently, SC level of advanced oxidation protein products, to the greater extent in male rats. Overall, our study indicates sex-specificity in the sensitivity of DMF cellular and molecular targets and encourages sex-based clinical research to define significance of sex for action of therapeutic agents moderating autoimmune neuroinflammation-/oxidative stress-related nervous tissue damage