662 research outputs found
BB Intermeson Potentials in the Quark Model
In this paper we derive quark model results for scattering amplitudes and
equivalent low energy potentials for heavy meson pairs, in which each meson
contains a heavy quark. This "BB" system is an attractive theoretical
laboratory for the study of the nuclear force between color singlets; the
hadronic system is relatively simple, and there are lattice gauge theory (LGT)
results for V_BB(r) which may be compared to phenomenological models. We find
that the quark model potential (after lattice smearing) has qualitative
similarities to the LGT potential in the two B*B* channels in which direct
comparison is possible, although there is evidence of a difference in length
scales. The quark model prediction of equal magnitude but opposite sign for I=0
and I=1 potentials also appears similar to LGT results at intermediate r. There
may however be a discrepancy between the LGT and quark model I=1 BB potentials.
A numerical study of the two-meson Schrodinger equations in the (bqbar)(bqbar)
and (cqbar)(cqbar) sectors with the quark model potentials finds a single
"molecule", in the I=0 BB* sector. Binding in other channels might occur if the
quark model forces are augmented by pion exchange.Comment: 30 pages, 5 figures, revtex and epsfig. Submitted to Phys. Rev.
Molecular biology of the WWOX gene that spans chromosomal fragile site FRA16D
It is now more than 20 years since the FRA16D common chromosomal fragile site was characterised and the WWOX gene spanning this site was identified. In this time, much information has been discovered about its contribution to disease; however, the normal biological role of WWOX is not yet clear. Experiments leading to the identification of the WWOX gene are recounted, revealing enigmatic relationships between the fragile site, its gene and the encoded protein. We also highlight research mainly using the genetically tractable model organism Drosophila melanogaster that has shed light on the integral role of WWOX in metabolism. In addition to this role, there are some particularly outstanding questions that remain regarding WWOX, its gene and its chromosomal location. This review, therefore, also aims to highlight two unanswered questions. Firstly, what is the biological relationship between the WWOX gene and the FRA16D common chromosomal fragile site that is located within one of its very large introns? Secondly, what is the actual substrate and product of the WWOX enzyme activity? It is likely that understanding the normal role of WWOX and its relationship to chromosomal fragility are necessary in order to understand how the perturbation of these normal roles results in disease.Cheng Shoou Lee, Amanda Choo, Sonia Dayan, Robert I. Richards and Louise V. O’Keef
Results of the BiPo-1 prototype for radiopurity measurements for the SuperNEMO double beta decay source foils
The development of BiPo detectors is dedicated to the measurement of
extremely high radiopurity in Tl and Bi for the SuperNEMO
double beta decay source foils. A modular prototype, called BiPo-1, with 0.8
of sensitive surface area, has been running in the Modane Underground
Laboratory since February, 2008. The goal of BiPo-1 is to measure the different
components of the background and in particular the surface radiopurity of the
plastic scintillators that make up the detector. The first phase of data
collection has been dedicated to the measurement of the radiopurity in
Tl. After more than one year of background measurement, a surface
activity of the scintillators of (Tl) 1.5
Bq/m is reported here. Given this level of background, a larger BiPo
detector having 12 m of active surface area, is able to qualify the
radiopurity of the SuperNEMO selenium double beta decay foils with the required
sensitivity of (Tl) 2 Bq/kg (90% C.L.) with a six
month measurement.Comment: 24 pages, submitted to N.I.M.
Spectral modeling of scintillator for the NEMO-3 and SuperNEMO detectors
We have constructed a GEANT4-based detailed software model of photon
transport in plastic scintillator blocks and have used it to study the NEMO-3
and SuperNEMO calorimeters employed in experiments designed to search for
neutrinoless double beta decay. We compare our simulations to measurements
using conversion electrons from a calibration source of and show
that the agreement is improved if wavelength-dependent properties of the
calorimeter are taken into account. In this article, we briefly describe our
modeling approach and results of our studies.Comment: 16 pages, 10 figure
Moral courage in the workplace: moving to and from the desire and decision to act
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72135/1/j.1467-8608.2007.00484.x.pd
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
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