2,272 research outputs found
Preventable suicides involving medicines: a systematic case series of coroners' reports in england and wales.
Background: In England and Wales coroners have a duty to write a report, called a Prevention of Future Deaths report or PFD, when they believe that actions should be taken to prevent future deaths. Coroners send PFDs to individuals and organisations who are required to respond within 56 days. Despite the increase in mental health concerns and growing use of medicines, deaths reported by coroners that have involved medicine-related suicides had not yet been explored. Therefore, this study aimed to systematically assess coroners’ PFD reports involving suicides in which a medicine caused or contributed to the death to identify lessons for suicide prevention.
Methods: Using the Preventable Deaths Tracker database https://preventabledeathstracker.net/), 3037 coroners’ PFD reports in England and Wales were screened for eligibility between July 2013 and December 2019. Reports were included if they involved suicide or intentional self-harm and prescribed or over-the-counter medication;
illicit drugs were excluded. Following data extraction, descriptive statistics, document and content analysis were performed to assess coroners’ concerns and the recipients of reports.
Results: There were 734 suicide-related coroner reports, with 100 (14%) reporting a medicine. Opioids (40%) were the most common class involved, followed by antidepressants (30%). There was wide geographical variation in the writing of reports; coroners in Manchester wrote the most (18%). Coroners expressed 237 concerns; the most common were procedural inadequacies (14%, n = 32), inadequate documentation and communication (10%, n = 22), and inappropriate prescription access (9%, n = 21). 203 recipients received the PFDs, with most sent to NHS trusts (31%), clinical commissioning groups (10%), and general practices (10%), of which only 58% responded to the coroner.
Conclusions: One in four coroner reports in England and Wales involved suicides, with one in seven suiciderelated deaths involving a medicine. Concerns raised by coroners highlighted gaps in care that require action from the Government, health services, and prescribers to aid suicide prevention. Coroner reports should be routinely used and monitored to inform public health policy, disseminated nationally, and responses to coroners should be transparently enforced so that actions are taken to prevent future suicides
Vibronic resonances facilitate excited state coherence in light harvesting proteins at room temperature
Until recently it was believed that photosynthesis, a fundamental process for
life on earth, could be fully understood with semi-classical models. However,
puzzling quantum phenomena have been observed in several photosynthetic
pigment-protein complexes, prompting questions regarding the nature and role of
these effects. Recent attention has focused on discrete vibrational modes that
are resonant or quasi-resonant with excitonic energy splittings and strongly
coupled to these excitonic states. Here we unambiguously identify excited state
coherent superpositions in photosynthetic light-harvesting complexes using a
new experimental approach. Decoherence on the timescale of the excited state
lifetime allows low energy (56 cm-1) oscillations on the signal intensity to be
observed. In conjunction with an appropriate model, these oscillations provide
clear and direct experimental evidence that the persistent coherences observed
require strong vibronic mixing among excited states
Judith Teixeira: emancipação e construção de uma nova identidade feminina no inĂcio do sĂ©culo XX
Esta dissertação apresenta a obra de Judith Teixeira, bem como o seu percurso de vida, esquecidos durante décadas pelas Letras Portuguesas.
Num primeiro momento desta investigação, tentamos compreender o papel da mulher na sociedade portuguesa, assim como a sua evolução durante o inĂcio do sĂ©culo XX.
Num segundo momento, direcionamos a nossa atenção para a escritora Judith Teixeira, dando a conhecer um pouco da sua obra em poesia e prosa.
Terminamos com uma análise de alguns dos elementos mais recorrentes do imaginário de Judith Teixeira, Ă© possĂvel depreender-se a relevância da temática da saudade e das cores para a construção e leitura da sua escrita.The goal of this dissertation is to present the work and life path of the Portuguese writer Judith Teixeira (1880–1959). Labelled by many as improper in her lifetime due to the sexual nature of her poetry and prose, Judith remained forgotten for decades by the Portuguese Faculties of Letters.
The first part of this investigation is based on the Portuguese society, which revolves around the portrayal of roles usually associated with women at the dawn of the twentieth century.
On a second part, we focus on the Portuguese writer and on her work (both poetry and prose).
Upon further analysis, it becomes apparent that some of the most reoccurring elements in Judith Teixeira’s works are nostalgia (saudade) and the use of colours as the building blocks of her work become visible, which may be found on the last part of this research
Detection of changes in mitochondrial hydrogen sulfide (H2S) in vivo in the fish model Poecilia mexicana (Poeciliidae)
In this paper, we outline the use of a mitochondria-targeted ratiometric mass spectrometry probe, MitoA, to detect in vivo changes in mitochondrial hydrogen sulfide (H2S) in Poecilia mexicana (family Poeciliidae). MitoA is introduced via intraperitoneal injection into the animal and is taken up by mitochondria, where it reacts with H2S to form the product MitoN. The MitoN/MitoA ratio can be used to assess relative changes in the amounts of mitochondrial H2S produced over time. We describe the use of MitoA in the fish species P. mexicana to illustrate the steps for adopting the use of MitoA in a new organism, including extraction and purification of MitoA and MitoN from tissues followed by tandem mass spectrometry. In this proof-of-concept study we exposed H2S tolerant P. mexicana to 59 µM free H2S for 5 h, which resulted in increased MitoN/MitoA in brain and gills, but not in liver or muscle, demonstrating increased mitochondrial H2S levels in select tissues following whole-animal H2S exposure. This is the first time that accumulation of H2S has been observed in vivo during whole-animal exposure to free H2S using MitoA
Photometric redshifts from reconstructed QSO templates
From SDSS commissioning photometric and spectroscopic data, we investigate
the utility of photometric redshift techniques to the task of estimating QSO
redshifts. We consider empirical methods (e.g. nearest-neighbor searches and
polynomial fitting), standard spectral template fitting and hybrid approaches
(i.e. training spectral templates from spectroscopic and photometric
observations of QSOs). We find that in all cases, due to the presence of strong
emission-lines within the QSO spectra, the nearest-neighbor and template
fitting methods are superior to the polynomial fitting approach. Applying a
novel reconstruction technique, we can, from the SDSS multicolor photometry,
reconstruct a statistical representation of the underlying SEDs of the SDSS
QSOs. Although, the reconstructed templates are based on only broadband
photometry the common emission lines present within the QSO spectra can be
recovered in the resulting spectral energy distributions. The technique should
be useful in searching for spectral differences among QSOs at a given redshift,
in searching for spectral evolution of QSOs, in comparing photometric redshifts
for objects beyond the SDSS spectroscopic sample with those in the well
calibrated photometric redshifts for objects brighter than 20th magnitude and
in searching for systematic and time variable effects in the SDSS broad band
photometric and spectral photometric calibrations.Comment: 21 pages, 9 figures, LaTeX AASTeX, submitted to A
High-Redshift Quasars Found in Sloan Digital Sky Survey Commissioning Data IV: Luminosity Function from the Fall Equatorial Stripe Sampl
This is the fourth paper in a series aimed at finding high-redshift quasars
from five-color imaging data taken along the Celestial Equator by the SDSS.
during its commissioning phase. In this paper, we use the color-selected sample
of 39 luminous high-redshift quasars presented in Paper III to derive the
evolution of the quasar luminosity function over the range of 3.6<z<5.0, and
-27.5<M_1450<-25.5 (Omega=1, H_0=50 km s^-1 Mpc^-1). We use the selection
function derived in Paper III to correct for sample incompleteness. The
luminosity function is estimated using three different methods: (1) the 1/V_a
estimator; (2) a maximum likelihood solution, assuming that the density of
quasars depends exponentially on redshift and as a power law in luminosity and
(3) Lynden-Bell's non-parametric C^- estimator. All three methods give
consistent results. The luminous quasar density decreases by a factor of ~ 6
from z=3.5 to z=5.0, consistent with the decline seen from several previous
optical surveys at z<4.5. The luminosity function follows psi(L) ~ L^{-2.5} for
z~4 at the bright end, significantly flatter than the bright end luminosity
function psi(L) \propto L^{-3.5} found in previous studies for z<3, suggesting
that the shape of the quasar luminosity function evolves with redshift as well,
and that the quasar evolution from z=2 to 5 cannot be described as pure
luminosity evolution. Possible selection biases and the effect of dust
extinction on the redshift evolution of the quasar density are also discussed.Comment: AJ accepted, with minor change
Evidence for Reionization at z ~ 6: Detection of a Gunn-Peterson Trough in a z=6.28 Quasar
We present moderate resolution Keck spectroscopy of quasars at z=5.82, 5.99
and 6.28, discovered by the Sloan Digital Sky Survey (SDSS). We find that the
Ly Alpha absorption in the spectra of these quasars evolves strongly with
redshift. To z~5.7, the Ly Alpha absorption evolves as expected from an
extrapolation from lower redshifts. However, in the highest redshift object,
SDSSp J103027.10+052455.0 (z=6.28), the average transmitted flux is
0.0038+-0.0026 times that of the continuum level over 8450 A < lambda < 8710 A
(5.95<z(abs)<6.16), consistent with zero flux. Thus the flux level drops by a
factor of >150, and is consistent with zero flux in the Ly Alpha forest region
immediately blueward of the Ly Alpha emission line, compared with a drop by a
factor of ~10 at z(abs)~5.3. A similar break is seen at Ly Beta; because of the
decreased oscillator strength of this transition, this allows us to put a
considerably stronger limit, tau(eff) > 20, on the optical depth to Ly Alpha
absorption at z=6.
This is a clear detection of a complete Gunn-Peterson trough, caused by
neutral hydrogen in the intergalactic medium. Even a small neutral hydrogen
fraction in the intergalactic medium would result in an undetectable flux in
the Ly Alpha forest region. Therefore, the existence of the Gunn-Peterson
trough by itself does not indicate that the quasar is observed prior to the
reionization epoch. However, the fast evolution of the mean absorption in these
high-redshift quasars suggests that the mean ionizing background along the line
of sight to this quasar has declined significantly from z~5 to 6, and the
universe is approaching the reionization epoch at z~6.Comment: Revised version (2001 Sep 4) accepted by the Astronomical Journal
(minor changes
Photometric Redshifts of Quasars
We demonstrate that the design of the Sloan Digital Sky Survey (SDSS) filter
system and the quality of the SDSS imaging data are sufficient for determining
accurate and precise photometric redshifts (``photo-z''s) of quasars. Using a
sample of 2625 quasars, we show that photo-z determination is even possible for
z<=2.2 despite the lack of a strong continuum break that robust photo-z
techniques normally require. We find that, using our empirical method on our
sample of objects known to be quasars, approximately 70% of the photometric
redshifts are correct to within delta z = 0.2; the fraction of correct
photometric redshifts is even better for z>3. The accuracy of quasar
photometric redshifts does not appear to be dependent upon magnitude to nearly
21st magnitude in i'. Careful calibration of the color-redshift relation to
21st magnitude may allow for the discovery of on the order of 10^6 quasars
candidates in addition to the 10^5 quasars that the SDSS will confirm
spectroscopically. We discuss the efficient selection of quasar candidates from
imaging data for use with the photometric redshift technique and the potential
scientific uses of a large sample of quasar candidates with photometric
redshifts.Comment: 29 pages, 8 figures, submitted to A
Efficient Photometric Selection of Quasars from the Sloan Digital Sky Survey: 100,000 z<3 Quasars from Data Release One
We present a catalog of 100,563 unresolved, UV-excess (UVX) quasar candidates
to g=21 from 2099 deg^2 of the Sloan Digital Sky Survey (SDSS) Data Release One
(DR1) imaging data. Existing spectra of 22,737 sources reveals that 22,191
(97.6%) are quasars; accounting for the magnitude dependence of this
efficiency, we estimate that 95,502 (95.0%) of the objects in the catalog are
quasars. Such a high efficiency is unprecedented in broad-band surveys of
quasars. This ``proof-of-concept'' sample is designed to be maximally
efficient, but still has 94.7% completeness to unresolved, g<~19.5, UVX quasars
from the DR1 quasar catalog. This efficient and complete selection is the
result of our application of a probability density type analysis to training
sets that describe the 4-D color distribution of stars and spectroscopically
confirmed quasars in the SDSS. Specifically, we use a non-parametric Bayesian
classification, based on kernel density estimation, to parameterize the color
distribution of astronomical sources -- allowing for fast and robust
classification. We further supplement the catalog by providing photometric
redshifts and matches to FIRST/VLA, ROSAT, and USNO-B sources. Future work
needed to extend the this selection algorithm to larger redshifts, fainter
magnitudes, and resolved sources is discussed. Finally, we examine some science
applications of the catalog, particularly a tentative quasar number counts
distribution covering the largest range in magnitude (14.2<g<21.0) ever made
within the framework of a single quasar survey.Comment: 35 pages, 11 figures (3 color), 2 tables, accepted by ApJS; higher
resolution paper and ASCII version of catalog available at
http://sdss.ncsa.uiuc.edu/qso/nbckde
The Use of Microgravity Simulators for Space Research
The spaceflight environment is known to influence biological processes ranging from stimulation of cellular metabolism to possible impacts on cellular damage repair, suppression of immune functions, and bone loss in astronauts. Microgravity is one of the most significant stress factors experienced by living organisms during spaceflight, and therefore, understanding cellular responses to altered gravity at the physiological and molecular level is critical for expanding our knowledge of life in space. Since opportunities to conduct experiments in space are scarce, various microgravity simulators and analogues have been widely used in space biology ground studies. Even though simulated microgravity conditions have produced some, but not all of the biological effects observed in the true microgravity environment, they provide test beds that are effective, affordable, and readily available to facilitate microgravity research. A Micro-g Simulator Center is being developed at Kennedy Space Center (KSC) to offer a variety of microgravity simulators and platforms for Space Biology investigators. Assistance will be provided by both KSC and external experts in molecular biology, microgravity simulation, and engineering. Comparisons between the physical differences in microgravity simulators, examples of experiments using the simulators, and scientific questions regarding the use of microgravity simulators will be discussed
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